Serial, Non-Invasive, In-Vivo Quantification Of Post-Pneumonectomy Compensatory Lung Growth With Hyperpolarized 3He Diffusion Magnetic Resonance Imaging

2011 ◽  
Author(s):  
Nguyet Nguyen ◽  
Wei Wang ◽  
Rich Pierce ◽  
Dmitriy A. Yablonskiy ◽  
Rodney Kowalewski ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Diffusion Magnetic Resonance Imaging ◽  
Lung Growth ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Compensatory Lung Growth

scholarly journals Non-invasive diagnostics in fossils - Magnetic Resonance Imaging of pathological belemnites

2005 ◽  
Vol 2 (2) ◽  
pp. 133-140 ◽  
Author(s):  
D. Mietchen ◽  
H. Keupp ◽  
B. Manz ◽  
F. Volke
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Soft Tissue ◽  
Clinical Diagnostics ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Physiological Processes ◽  
Magnetic Resonance Imaging Mri ◽  
Invasive Diagnostics

Abstract. For more than a decade, Magnetic Resonance Imaging (MRI) has been routinely employed in clinical diagnostics because it allows non-invasive studies of anatomical structures and physiological processes in vivo and to differentiate between healthy and pathological states, particularly of soft tissue. Here, we demonstrate that MRI can likewise be applied to fossilized biological samples and help in elucidating paleopathological and paleoecological questions: Five anomalous guards of Jurassic and Cretaceous belemnites are presented along with putative paleopathological diagnoses directly derived from 3D MR images with microscopic resolution. Syn vivo deformities of both the mineralized internal rostrum and the surrounding former soft tissue can be traced back in part to traumatic events of predator-prey-interactions, and partly to parasitism. Besides, evidence is presented that the frequently observed anomalous apical collar might be indicative of an inflammatory disease. These findings highlight the potential of Magnetic Resonance techniques for further paleontological applications.

scholarly journals Early Increases in Breast Tumor Xenograft Water Mobility in Response to Paclitaxel Therapy Detected by Non-Invasive Diffusion Magnetic Resonance Imaging

Neoplasia ◽  
1999 ◽  
Vol 1 (2) ◽  
pp. 113-117 ◽  
Author(s):  
Jean-Philippe Galons ◽  
Maria I. Altbach ◽  
Gillian D. Paine-Murrieta ◽  
Charles W. Taylor ◽  
Robert J. Gillies
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Breast Tumor ◽  
Diffusion Magnetic Resonance Imaging ◽  
Tumor Xenograft ◽  
Water Mobility ◽  
Resonance Imaging ◽  
Non Invasive

Non-invasive tracking of human haemopoietic CD34+ stem cells in vivo in immunodeficient mice by using magnetic resonance imaging

2010 ◽  
Vol 20 (9) ◽  
pp. 2184-2193 ◽  
Author(s):  
Markus Niemeyer ◽  
Robert A. J. Oostendorp ◽  
Markus Kremer ◽  
Sandra Hippauf ◽  
Volker R. Jacobs ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Stem Cells ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Immunodeficient Mice ◽  
Non Invasive

scholarly journals Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure–function relationship

2020 ◽  
Vol 117 (52) ◽  
pp. 33649-33659
Author(s):  
Mariam Andersson ◽  
Hans Martin Kjer ◽  
Jonathan Rafael-Patino ◽  
Alexandra Pacureanu ◽  
Bente Pakkenberg ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Structure Function ◽  
Conduction Velocity ◽  
Diffusion Magnetic Resonance Imaging ◽  
Resonance Imaging ◽  
Axon Diameter ◽  
Structure Function Relationship ◽  
Function Relationship

Axonal conduction velocity, which ensures efficient function of the brain network, is related to axon diameter. Noninvasive, in vivo axon diameter estimates can be made with diffusion magnetic resonance imaging, but the technique requires three-dimensional (3D) validation. Here, high-resolution, 3D synchrotron X-ray nano-holotomography images of white matter samples from the corpus callosum of a monkey brain reveal that blood vessels, cells, and vacuoles affect axonal diameter and trajectory. Within single axons, we find that the variation in diameter and conduction velocity correlates with the mean diameter, contesting the value of precise diameter determination in larger axons. These complex 3D axon morphologies drive previously reported 2D trends in axon diameter and g-ratio. Furthermore, we find that these morphologies bias the estimates of axon diameter with diffusion magnetic resonance imaging and, ultimately, impact the investigation and formulation of the axon structure–function relationship.

POLYMER-MODIFIED GADOLINIUM NANOPARTICLES FOR TARGETED MAGNETIC RESONANCE IMAGING AND THERAPY

Nano LIFE ◽  
2010 ◽  
Vol 01 (03n04) ◽  
pp. 263-275 ◽  
Author(s):  
STEPHEN G. BOYES ◽  
MISTY D. ROWE ◽  
NATALIE J. SERKOVA ◽  
FERNANDO J. KIM ◽  
JAMES R. LAMBERT ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Molecular Imaging ◽  
Magnetic Resonance ◽  
Molecular Probes ◽  
Imaging Agents ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Gene And Protein Expression ◽  
Wide Range

Functional imaging is a novel area in radiological sciences and allows for the non-invasive assessment and visualization of specific targets such as gene and protein expression, metabolic rates, and drug delivery in intact living subjects. As such, the field of molecular imaging has been defined as the non-invasive, quantitative, and repetitive imaging of biomolecules and biological processes in living organisms. For example, cancer cells may be genetically altered to attract molecules that alter the magnetic susceptibility, thereby permitting their identification by magnetic resonance imaging. These contrast agents and/or molecular reporters are seen as essential to the task of molecular medicine to increase both sensitivity and specificity of imaging. Therefore, there are five general principles which need to be fulfilled in order to conduct a successful in vivo molecular imaging study: (1) selection of appropriate cellular and subcellular targets; (2) development of suitable in vivo affinity ligands (molecular probes); (3) delivery of these probes to the target organ; (4) amplification strategies able to detect minimal target concentrations; and (5) development of imaging systems with high resolution. Although there has been a wide range of routes taken to incorporate both imaging agents and a disease-targeting moiety into diagnostic devices, arguably the most interesting of these routes employs the use of nanoparticles. Nanoscale diagnostic systems that incorporate molecular targeting agents and diagnostic imaging capabilities are emerging as the next-generation imaging agents and have the potential to dramatically improve the outcome of the imaging, diagnosis, and treatment of a wide range of diseases. The present review addresses chemical aspects in development of molecular probes based upon gadolinium nanoparticles and their potential role in translational clinical imaging and therapy.

scholarly journals Magnetic resonance imaging for non-invasive clinical evaluation of normal and regenerated cartilage

2021 ◽  
Vol 8 (5) ◽  
Author(s):  
Xian Xu ◽  
Jingming Gao ◽  
Shuyun Liu ◽  
Liang Chen ◽  
Min Chen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
T2 Mapping ◽  
Mri Imaging ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Biomaterial Scaffold ◽  
Significant Difference

Abstract With the development of tissue engineering and regenerative medicine, it is much desired to establish bioimaging techniques to monitor the real-time regeneration efficacy in vivo in a non-invasive way. Herein, we tried magnetic resonance imaging (MRI) to evaluate knee cartilage regeneration after implanting a biomaterial scaffold seeded with chondrocytes, namely, matrix-induced autologous chondrocyte implantation (MACI). After summary of the T2 mapping and the T1-related delayed gadolinium-enhanced MRI imaging of cartilage (dGEMRIC) in vitro and in vivo in the literature, these two MRI techniques were tried clinically. In this study, 18 patients were followed up for 1 year. It was found that there was a significant difference between the regeneration site and the neighboring normal site (control), and the difference gradually diminished with regeneration time up to 1 year according to both the quantitative T1 and T2 MRI methods. We further established the correlation between the quantitative evaluation of MRI and the clinical Lysholm scores for the first time. Hence, the MRI technique was confirmed to be a feasible semi-quantitative yet non-invasive way to evaluate the in vivo regeneration of knee articular cartilage.

Assessment of in vitro vs. in vivo lung structure using hyperpolarized helium-3 diffusion magnetic resonance imaging

2009 ◽  
Vol 27 (6) ◽  
pp. 845-851 ◽  
Author(s):  
Jaime F. Mata ◽  
Talissa A. Altes ◽  
Kai Ruppert ◽  
Klaus D. Hagspiel ◽  
Grady W. Miller ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Diffusion Magnetic Resonance Imaging ◽  
Resonance Imaging ◽  
Hyperpolarized Helium ◽  
Lung Structure ◽  
Helium 3
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