scholarly journals Magnetic resonance imaging for non-invasive clinical evaluation of normal and regenerated cartilage

2021 ◽  
Vol 8 (5) ◽  
Author(s):  
Xian Xu ◽  
Jingming Gao ◽  
Shuyun Liu ◽  
Liang Chen ◽  
Min Chen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
T2 Mapping ◽  
Mri Imaging ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Biomaterial Scaffold ◽  
Significant Difference

Abstract With the development of tissue engineering and regenerative medicine, it is much desired to establish bioimaging techniques to monitor the real-time regeneration efficacy in vivo in a non-invasive way. Herein, we tried magnetic resonance imaging (MRI) to evaluate knee cartilage regeneration after implanting a biomaterial scaffold seeded with chondrocytes, namely, matrix-induced autologous chondrocyte implantation (MACI). After summary of the T2 mapping and the T1-related delayed gadolinium-enhanced MRI imaging of cartilage (dGEMRIC) in vitro and in vivo in the literature, these two MRI techniques were tried clinically. In this study, 18 patients were followed up for 1 year. It was found that there was a significant difference between the regeneration site and the neighboring normal site (control), and the difference gradually diminished with regeneration time up to 1 year according to both the quantitative T1 and T2 MRI methods. We further established the correlation between the quantitative evaluation of MRI and the clinical Lysholm scores for the first time. Hence, the MRI technique was confirmed to be a feasible semi-quantitative yet non-invasive way to evaluate the in vivo regeneration of knee articular cartilage.

scholarly journals Size and Number of Food Boluses in the Stomach after Eating Different Meals: Magnetic Resonance Imaging Insights in Healthy Humans

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3626
Author(s):  
Hannah Hornby ◽  
Mar Collado-González ◽  
Xue Zhang ◽  
Nichola Abrehart ◽  
Meshari Alshammari ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Median Number ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Healthy Humans ◽  
Magnetic Resonance Imaging Mri ◽  
First Time

Oral processing of food results in the formation of food boluses, which are then swallowed and reach the stomach for further digestion. The number, size and surface properties of the boluses will affect their processing and emptying from the stomach. Knowledge of these parameters, however, is incomplete due to limitations of the techniques used. In this work, non-invasive magnetic resonance imaging (MRI) was used for the first time to measure boluses in the stomach a few minutes after swallowing. Three groups of nine healthy participants were fed three different meals: chicken and roasted vegetables (Meal 1), bread and jam (Meal 2) and cheese and yogurt (Meal 3), and then, their stomach content was imaged. The median number of boluses within the stomach was 282, 106 and 9 for Meal 1, Meal 2 and Meal 3 (p < 0.0001) with an average volume of 0.47 mL, 2.4 mL and 13.6 mL, respectively (p < 0.0001). The cohesiveness as well as the meal composition seem to play a key role in the resulting boluses. These new in vivo data from undisturbed organ imaging can improve knowledge of the digestion process, which will, in turn, inform in vitro and in silico modelling of digestion, thus improving their in vitro/in vivo relevance.

scholarly journals Non-invasive diagnostics in fossils - Magnetic Resonance Imaging of pathological belemnites

2005 ◽  
Vol 2 (2) ◽  
pp. 133-140 ◽  
Author(s):  
D. Mietchen ◽  
H. Keupp ◽  
B. Manz ◽  
F. Volke
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Soft Tissue ◽  
Clinical Diagnostics ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Physiological Processes ◽  
Magnetic Resonance Imaging Mri ◽  
Invasive Diagnostics

Abstract. For more than a decade, Magnetic Resonance Imaging (MRI) has been routinely employed in clinical diagnostics because it allows non-invasive studies of anatomical structures and physiological processes in vivo and to differentiate between healthy and pathological states, particularly of soft tissue. Here, we demonstrate that MRI can likewise be applied to fossilized biological samples and help in elucidating paleopathological and paleoecological questions: Five anomalous guards of Jurassic and Cretaceous belemnites are presented along with putative paleopathological diagnoses directly derived from 3D MR images with microscopic resolution. Syn vivo deformities of both the mineralized internal rostrum and the surrounding former soft tissue can be traced back in part to traumatic events of predator-prey-interactions, and partly to parasitism. Besides, evidence is presented that the frequently observed anomalous apical collar might be indicative of an inflammatory disease. These findings highlight the potential of Magnetic Resonance techniques for further paleontological applications.

scholarly journals Monitoring ferumoxide-labelled neural progenitor cells and lesion evolution by magnetic resonance imaging in a model of cell transplantation in cerebral ischaemia

F1000Research ◽  
2014 ◽  
Vol 2 ◽  
pp. 252
Author(s):  
Rachael A Panizzo ◽  
David G Gadian ◽  
Jane C Sowden ◽  
Jack A Wells ◽  
Mark F Lythgoe ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Cerebral Ischaemia ◽  
Mri Contrast Agent ◽  
Lesion Volume ◽  
Mri Imaging ◽  
Resonance Imaging ◽  
Protamine Sulphate

Efficacy of neural stem/progenitor cell (NPC) therapies after cerebral ischaemia could be better evaluated by monitoring in vivo migration and distribution of cells post-engraftment in parallel with analysis of lesion volume and functional recovery. Magnetic resonance imaging (MRI) is ideally placed to achieve this, but still poses several challenges. We show that combining the ferumoxide MRI contrast agent Endorem with protamine sulphate (FePro) improves iron oxide uptake in cells compared to Endorem alone and is non-toxic. Hence FePro complex is a better contrast agent than Endorem for monitoring NPCs. FePro complex-labelled NPCs proliferated and differentiated normally in vitro, and upon grafting into the brain 48 hours post-ischaemia they were detected in vivo by MRI. Imaging over four weeks showed the development of a confounding endogenous hypointense contrast evolution at later timepoints within the lesioned tissue. This was at least partly due to accumulation within the lesion of macrophages and endogenous iron. Neither significant NPC migration, assessed by MRI and histologically, nor a reduction in the ischaemic lesion volume was observed in NPC-grafted brains.  Crucially, while MRI provides reliable information on engrafted cell location early after an ischaemic insult, pathophysiological changes to ischaemic lesions can interfere with cellular imaging at later timepoints.

Multi-functional NaErF4:Yb nanorods: enhanced red upconversion emission, in vitro cell, in vivo X-ray, and T2-weighted magnetic resonance imaging

Nanoscale ◽  
2014 ◽  
Vol 6 (5) ◽  
pp. 2855-2860 ◽  
Author(s):  
Haibo Wang ◽  
Wei Lu ◽  
Tianmei Zeng ◽  
Zhigao Yi ◽  
Ling Rao ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Upconversion Emission ◽  
Resonance Imaging ◽  
X Ray ◽  
Weighted Magnetic Resonance Imaging ◽  
New Type ◽  
First Time

A new type of multi-functional NaErF4 nanoprobe with enhanced red upconversion emission was developed and used for in vitro cell, in vivo X-ray and T2-weighted magnetic resonance imaging for the first time.

Visualization of USPIO-Labeled Melt-Electrowritten Scaffolds by Non-Invasive Magnetic Resonance Imaging

2021 ◽  
Author(s):  
Kilian Maria Arthur Mueller ◽  
Geoffrey Topping ◽  
Sebastian Patrick Schwaminger ◽  
Younzhe Zou ◽  
Diana Marcela Rojas-González ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Tissue Engineering ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Digital Fabrication ◽  
Resonance Imaging ◽  
Non Invasive ◽  
Forming Technology

Melt electrowriting (MEW) is a high-resolution fiber-forming technology for the digital fabrication of complex micro-structured scaffolds for tissue engineering, which has convincingly shown its potential in in vitro and in...

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