Mycobacterium Tuberculosis Infection Induces Non-Apoptotic Cell Death Of Human Monocyte-Derived Dendritic Cells

2012 ◽  
Author(s):  
Mary P. O'Sullivan ◽  
Ruth C. Ryan ◽  
Joseph M. Keane
Keyword(s):  
Cell Death ◽  
Dendritic Cells ◽  
Mycobacterium Tuberculosis ◽  
Apoptotic Cell ◽  
Human Monocyte ◽  
Apoptotic Cell Death ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection

scholarly journals Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway

2000 ◽  
Vol 12 (11) ◽  
pp. 1539-1546 ◽  
Author(s):  
Sreyashi Basu ◽  
Robert J. Binder ◽  
Ryuichiro Suto ◽  
Kirstin M. Anderson ◽  
Pramod K. Srivastava
Keyword(s):  
Cell Death ◽  
Dendritic Cells ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Shock Proteins

scholarly journals Polarization of Human Monocyte-Derived Cells With Vitamin D Promotes Control of Mycobacterium tuberculosis Infection

2020 ◽  
Vol 10 ◽  
Author(s):  
Jagadeeswara Rao Muvva ◽  
Venkata Ramanarao Parasa ◽  
Maria Lerm ◽  
Mattias Svensson ◽  
Susanna Brighenti
Keyword(s):  
Vitamin D ◽  
Mycobacterium Tuberculosis ◽  
Human Monocyte ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection

scholarly journals Die another way: Ferroptosis drives tuberculosis pathology

2019 ◽  
Vol 216 (3) ◽  
pp. 471-473 ◽  
Author(s):  
Etienne Meunier ◽  
Olivier Neyrolles
Keyword(s):  
Cell Death ◽  
Mycobacterium Tuberculosis ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Regulated Cell Death

In this issue of JEM, Amaral et al. (https://doi.org/10.1084/jem.20181776) provide the first evidence that ferroptosis, a newly described form of regulated cell death, is detrimental for the host during a Mycobacterium tuberculosis infection. This finding has important implications for the development of host-directed therapies for tuberculosis.

scholarly journals Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rβ1 isoform that enhances DC migration

2010 ◽  
Vol 207 (3) ◽  
pp. 591-605 ◽  
Author(s):  
Richard T. Robinson ◽  
Shabaana A. Khader ◽  
Cynthia A. Martino ◽  
Jeffrey J. Fountain ◽  
Maria Teixeira-Coelho ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Mycobacterium Tuberculosis ◽  
T Cell Activation ◽  
Rna Splicing ◽  
Cell Activation ◽  
Transmembrane Domain ◽  
Tuberculosis Infection ◽  
Terminal Sequence ◽  
Mycobacterium Tuberculosis Infection

RNA splicing is an increasingly recognized regulator of immunity. Here, we demonstrate that after Mycobacterium tuberculosis infection (mRNA) il12rb1 is spliced by dendritic cells (DCs) to form an alternative (mRNA) il12rb1Δtm that encodes the protein IL-12Rβ1ΔTM. Compared with IL-12Rβ1, IL-12Rβ1ΔTM contains an altered C-terminal sequence and lacks a transmembrane domain. Expression of IL-12Rβ1ΔTM occurs in CD11c+ cells in the lungs during M. tuberculosis infection. Selective reconstitution of il12rb1−/− DCs with (mRNA) il12rb1 and/or (mRNA) il12rb1Δtm demonstrates that IL-12Rβ1ΔTM augments IL-12Rβ1-dependent DC migration and activation of M. tuberculosis-specific T cells. It cannot mediate these activities independently of IL12Rβ1. We hypothesize that M. tuberculosis-exposed DCs express IL-12Rβ1ΔTM to enhance IL-12Rβ1-dependent migration and promote M. tuberculosis–specific T cell activation. IL-12Rβ1ΔTM thus represents a novel positive-regulator of IL12Rβ1-dependent DC function and of the immune response to M. tuberculosis.

scholarly journals Protective Immunity to Mycobacterium tuberculosis Infection by Chemokine and Cytokine Conditioned CFP-10 Differentiated Dendritic Cells

PLoS ONE ◽  
2008 ◽  
Vol 3 (8) ◽  
pp. e2869 ◽  
Author(s):  
Nasir Salam ◽  
Shashank Gupta ◽  
Sachin Sharma ◽  
Shweta Pahujani ◽  
Aprajita Sinha ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Mycobacterium Tuberculosis ◽  
Protective Immunity ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection
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