scholarly journals Treatment Success Rate for Mycobacterium Avium Complex (MAC): A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
G. Ebrahimi ◽  
M.J. Nasiri ◽  
S. Arefzadeh ◽  
S. Zamani ◽  
Z. Nikpor ◽  
...  
Keyword(s):  
Systematic Review ◽  
Success Rate ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Meta Analysis ◽  
Treatment Success ◽  
Treatment Success Rate

Antibiotic therapy success rate in pulmonary Mycobacterium avium complex: a systematic review and meta-analysis

2020 ◽  
Vol 18 (3) ◽  
pp. 263-273
Author(s):  
Mohammad Javad Nasiri ◽  
Golnaz Ebrahimi ◽  
Samaneh Arefzadeh ◽  
Samin Zamani ◽  
Zahra Nikpor ◽  
...  
Keyword(s):  
Systematic Review ◽  
Antibiotic Therapy ◽  
Success Rate ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Meta Analysis ◽  
Therapy Success

scholarly journals Drug-susceptible tuberculosis treatment success and associated factors in Ethiopia from 2005 to 2017: a systematic review and meta-analysis

BMJ Open ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. e022111 ◽  
Author(s):  
Mohammed Assen Seid ◽  
Mohammed Biset Ayalew ◽  
Esileman Abdela Muche ◽  
Eyob Alemayehu Gebreyohannes ◽  
Tadesse Melaku Abegaz
Keyword(s):  
Systematic Review ◽  
Treatment Outcome ◽  
Success Rate ◽  
Treatment Outcomes ◽  
Meta Analysis ◽  
Treatment Success ◽  
Systematic Search ◽  
Treatment Success Rate ◽  
Rural Residence ◽  
Tb Treatment

ObjectivesThe main aim of this study was to assess the overall tuberculosis (TB) treatment success in Ethiopia and to identify potential factors for poor TB treatment outcome.DesignA systematic review and meta-analysis of published literature was conducted. Original studies were identified through a computerised systematic search using PubMed, Google Scholar and Science Direct databases. Heterogeneity across studies was assessed using Cochran’s Q test and I2statistic. Pooled estimates of treatment success were computed using the random-effects model with 95% CI using Stata V.14 software.ResultsA total of 230 articles were identified in the systematic search. Of these 34 observational studies were eligible for systematic review and meta-analysis. It was found that 117 750 patients reported treatment outcomes. Treatment outcomes were assessed by World Health Organization (WHO) standard definitions of TB treatment outcome. The overall pooled TB treatment success rate in Ethiopia was 86% (with 95% CI 83%_88%). TB treatment success rate for each region showed that, Addis Ababa (93%), Oromia (84%), Amhara (86%), Southern Nations (83%), Tigray (85%) and Afar (86%). Mainly old age, HIV co-infection, retreatment cases and rural residence were the most frequently identified factors associated with poor TB treatment outcome.ConclusionThe result of this study revealed that the overall TB treatment success rate in Ethiopia was below the threshold suggested by WHO (90%). There was also a discrepancy in TB treatment success rate among different regions of Ethiopia. In addition to these, HIV co-infection, older age, retreatment cases and rural residence were associated with poor treatment outcome. In order to further improve the treatment success rate, it is strategic to give special consideration for regions which had low TB treatment success and patients with TB with HIV co-infection, older age, rural residence and retreatment cases.

Association Between Duration of Aminoglycoside Treatment and Outcome of Cavitary Mycobacterium avium Complex Lung Disease

2018 ◽  
Vol 68 (11) ◽  
pp. 1870-1876 ◽  
Author(s):  
Ock-Hwa Kim ◽  
Byoung Soo Kwon ◽  
Minkyu Han ◽  
Younsuck Koh ◽  
Woo-Sung Kim ◽  
...  
Keyword(s):  
Lung Disease ◽  
Success Rate ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Treatment Success ◽  
Treatment Success Rate ◽  
Duration Of Treatment ◽  
Tertiary Referral Center ◽  
End Of Treatment ◽  
Attending Physician

Abstract Background Although aminoglycosides are recommended for cavitary Mycobacterium avium complex lung disease (MAC-LD), the optimal duration of treatment is unclear. We investigated the association between duration of aminoglycoside treatment and outcomes in cavitary MAC-LD. Methods Among patients diagnosed with macrolide-susceptible cavitary MAC-LD between 2000 and 2013, 101 who received treatment up to August 2017 with a regimen containing aminoglycosides were enrolled at a tertiary referral center in South Korea. Their medical records were retrospectively reviewed. The duration of aminoglycoside treatment was at the discretion of the attending physician. Results A total of 75 patients (74.3%) were administered aminoglycosides for ≥3 months (median 164 days), whereas the remaining 26 patients (25.7%) received treatment for <3 months (median 59 days). The overall treatment success rate was 63.4% (64/101). Patients treated with aminoglycosides for ≥3 months had a significantly higher success rate than those treated for <3 months (69.3% vs 46.2%; P = .035). Multivariate analysis revealed that aminoglycoside treatment for ≥3 months was a significant factor for treatment success (adjusted odds ratio, 3.602; 95% confidence interval, 1.249–10.390; P = .018). Recurrence occurred in 8 (22.9%) of 35 patients who were followed up for at least 3 years after the end of treatment; all 8 patients received aminoglycosides for ≥3 months. Conclusions Patients with cavitary MAC-LD treated with aminoglycosides for ≥3 months showed higher treatment success rate than those treated for <3 months. However, treatment for ≥3 months was not associated with the development of recurrence.

scholarly journals Comparison of Rifabutin-Based Versus Rifampin-Based Regimens for the Treatment of Mycobacterium avium Complex: A meta-Analysis Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Bahareh Hajikhani ◽  
Mohammad Javad Nasiri ◽  
Brian C. Adkinson ◽  
Taher Azimi ◽  
Farima Khalili ◽  
...  
Keyword(s):  
Publication Bias ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Meta Analysis ◽  
Treatment Success ◽  
Random Effect ◽  
Random Effect Model ◽  
P Value ◽  
Double Blind ◽  
Similar Treatment

Background: The incidence of Mycobacterium avium complex (MAC) increases as immunosuppressed conditions become more common. MAC's standard treatment regimen includes a macrolide, ethambutol, and a rifamycin, among which rifampin and rifabutin are the most commonly used. Although current guidelines recommend initial therapy for MAC with rifampin, it has been theorized to be less efficacious than rifabutin.Methods: We reviewed the relevant scientific literature published up to February 18, 2020. Statistical analyses were performed with Comprehensive Meta-Analysis Software Version 2.0 (Biostat, Englewood, NJ). The pooled frequency with 95% confidence intervals (CI) was assessed using a random-effect model. We considered P <0.05 as statistically significant for publication bias.Results: After reviewing 3665 records, we identified 24 studies that satisfied the inclusion criteria. Among these studies, 8 had rifabutin in their regimens (rifabutin group) and 16 had rifampin in their regimens (rifampin group). The estimated pooled treatment success rate was found to be 54.7% (95% CI 41.0-67.0%) in rifabutin groups and 67.5% (95% CI 55.7-77.4%) in rifampin groups. There was no evidence of publication bias among the included studies (Egger’s test p-value was 0.7).Conclusion: In this study, it was shown that in comparison to Rifabutin, rifampin has similar treatment success rates in treating MAC. In order to determine the exact preference of each of these drugs, double-blind clinical trial studies are recommended.

scholarly journals Medical thoracoscopy treatment for pleural infections: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Michele Mondoni ◽  
Laura Saderi ◽  
Federica Trogu ◽  
Silvia Terraneo ◽  
Paolo Carlucci ◽  
...  
Keyword(s):  
Systematic Review ◽  
Success Rate ◽  
Observational Studies ◽  
Meta Analysis ◽  
Scientific Evidence ◽  
Treatment Success ◽  
Cochrane Central Register ◽  
Medical Thoracoscopy ◽  
Central Register ◽  
Advanced Stages

Abstract Background Complicated parapneumonic effusions and empyema represent advanced stages of pleural infections and are characterized by a high mortality. Medical thoracoscopy is a safe and minimally invasive endoscopic technique prescribed to treat severe pleural infections. However, only a few studies evaluated its success rate. A systematic review of observational studies was performed to assess the efficacy of medical thoracoscopy in patients with complicated parapneumonic effusions and empyema, as well as its predictive factors. Methods A search of the scientific evidence was carried out using PubMed, EMBASE, and Cochrane Central Register of Controlled Trials. Articles describing observational studies on medical thoracoscopy in patients with parapneumonic effusions and empyema were selected. Results Eight studies met the inclusion criteria. The pooled treatment success rate of thoracoscopy was 85% (95% CI 80.0–90.0%; I2: 61.8%) when used as first-line intervention or after failure of chest tube. The pooled complication rate was 9.0% (95% CI 6.0–14.0%; I2: 58.8%). A pooled difference of treatment success of 9.0% (95% CI 1.0–18.0%) was found when post-thoracoscopy intra-pleural fibrinolysis was prescribed. Pooled success rate was higher in cases with pleural fluid culture negativity (pooled difference: 14.0%; 95% CI 4.0–24.0%). Conclusions Medical thoracoscopy is effective and safe when prescribed for complicated parapneumonic effusions and empyema. Bacteriological negativity of pleural effusion specimens and administration of adjuvant intra-pleural fibrinolysis after the procedure are associated with a higher success rate.

scholarly journals Treatment Outcomes of Mycobacterium avium Complex Lung Disease: A Systematic Review and Meta-analysis

2017 ◽  
Vol 65 (7) ◽  
pp. 1077-1084 ◽  
Author(s):  
Nakwon Kwak ◽  
Jimyung Park ◽  
Eunyoung Kim ◽  
Chang-Hoon Lee ◽  
Sung Koo Han ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lung Disease ◽  
Treatment Outcomes ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Meta Analysis

Treatment of Paranasal Sinus Fungus Ball: A Systematic Review and Meta-Analysis

2021 ◽  
pp. 000348942110024
Author(s):  
Gian Luca Fadda ◽  
Fabiana Allevi ◽  
Cecilia Rosso ◽  
Federica Martino ◽  
Carlotta Pipolo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Success Rate ◽  
Paranasal Sinus ◽  
Endoscopic Sinus Surgery ◽  
Meta Analysis ◽  
Treatment Success ◽  
Sinus Surgery ◽  
Treatment Modalities ◽  
Fungus Ball ◽  
Success Rates

Objectives: Paranasal sinus fungus ball is a common non-invasive mycosis with excellent long-term surgical treatment results. The present systematic review and meta-analysis were undertaken to define current treatment concepts and success rates in paranasal sinus fungus ball treatment. Methods: Systematic searches were performed in multiple databases with criteria designed to include all studies published until May 2020 focusing on paranasal sinuses fungus ball treatment in humans. We selected studies including at least 10 patients, specifying treatment modalities, providing a minimum 6-month follow-up, and objectivating treatment success. After duplicate removal, abstract and full-text selection, and quality assessment, we reviewed eligible articles for treatment modalities and success rates. Success rates were pooled in a random effect meta-analysis and compared according to the use of intraoperative sinus lavages and postoperative antibiotics. Results: Among 740 unique citations, 14 studies were deemed eligible. Most (n = 11) were retrospective case series. All studies relied on endoscopic sinus surgery. Intraoperative lavages were proposed in 10 studies and postoperative antibiotics in 7 (for all patients in 5 studies and for selected patients in 2). No significant heterogeneity was observed between results (Cochran’s Q P = .639, I2 test = 0). Treatment success rate was 98.4% (95% confidence interval 97.4%-99.3%). Intraoperative sinus toilette and postoperative antibiotics didn’t significantly improve the success rate. Conclusion: Endoscopic sinus surgery shows excellent results in fungus ball treatment. Further prospective studies might help further reducing antibiotics prescriptions in these patients and improve their management.

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