CD8+T Cell Subsets and Chronic Obstructive Pulmonary Disease

1999 ◽  
Vol 160 (supplement_1) ◽  
pp. S33-S37 ◽  
Author(s):  
DAVID M. KEMENY ◽  
BEEJAL VYAS ◽  
MILICA VUKMANOVIC-STEJIC ◽  
MATTHEW J. THOMAS ◽  
ALISTAIR NOBLE ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
T Cell ◽  
Pulmonary Disease ◽  
Cd8 T Cell ◽  
T Cell Subsets ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Changes in Th1/Th2-producing cytokines during acute exacerbation chronic obstructive pulmonary disease

2018 ◽  
Vol 46 (9) ◽  
pp. 3890-3902 ◽  
Author(s):  
Bing Wei ◽  
Chun Sheng Li
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Chronic Obstructive Lung Disease ◽  
Serum Levels ◽  
T Cell Subsets ◽  
Th2 Cells ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Ifn Γ

Objective This study aimed to explore cytokine serum levels and the ratio of type 1 T helper (Th1)/Th2 cells in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total 245 patients diagnosed with AECOPD and 193 patients who progressed to stable COPD after the initiation of treatment in hospital were selected, while a further 50 healthy individuals served as controls. All patients with COPD were diagnosed using Global Initiative for Chronic Obstructive Lung Disease criteria. Serum concentrations of interleukin (IL)-2, interferon (IFN)-γ, IL-4, IL-10, IL-17, and immunoglobulin (Ig)E were measured using enzyme-linked immunosorbent assays. Results AECOPD patients had higher levels of IL-2, IFN-γ, IL-4, IL-10, IL-17, and IgE than those with stable COPD or controls. Intriguingly, the ratios of Th1/Th2 and IL-17/IgE were lower in AECOPD patients compared with the other two groups. These data suggest that AECOPD patients produce more IgE and have more differentiated Th2 cells than other groups. Conclusion Our findings suggest that an imbalance of circulating CD4+ T cell subsets correlates with AECOPD, and that a shift of Th1/Th2 and IL-17/IgE ratios may be caused by increased Th2 cell production.

scholarly journals Peripheral T Cell Functions Correlate with the Severity of Chronic Obstructive Pulmonary Disease

2009 ◽  
Vol 182 (5) ◽  
pp. 3270-3277 ◽  
Author(s):  
Xuehai Zhu ◽  
Aneal S. Gadgil ◽  
Rachel Givelber ◽  
M. Patricia George ◽  
Michael W. Stoner ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
T Cell ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Cell Functions
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