scholarly journals Reactive Oxygen Species Induce Antiviral Innate Immune Response through IFN-λ Regulation in Human Nasal Epithelial Cells

2013 ◽  
Vol 49 (5) ◽  
pp. 855-865 ◽  
Author(s):  
Hyun Jik Kim ◽  
Chang-Hoon Kim ◽  
Ji-Hwan Ryu ◽  
Min-Ji Kim ◽  
Chong Yoon Park ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Immune Response ◽  
Epithelial Cells ◽  
Innate Immune Response ◽  
Reactive Oxygen ◽  
Innate Immune ◽  
Oxygen Species ◽  
Nasal Epithelial Cells ◽  
Human Nasal Epithelial Cells

scholarly journals Leptospira interrogans Catalase Is Required for Resistance to H2O2and for Virulence

2012 ◽  
Vol 80 (11) ◽  
pp. 3892-3899 ◽  
Author(s):  
Azad Eshghi ◽  
Kristel Lourdault ◽  
Gerald L. Murray ◽  
Thanatchaporn Bartpho ◽  
Rasana W. Sermswan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Immune Response ◽  
Innate Immune Response ◽  
Reactive Oxygen ◽  
Innate Immune ◽  
Leptospira Interrogans ◽  
Oxygen Species ◽  
Content Type ◽  
Host Innate Immune Response

ABSTRACTPathogenicLeptospiraspp. are likely to encounter higher concentrations of reactive oxygen species induced by the host innate immune response. In this study, we characterizedLeptospira interroganscatalase (KatE), the only annotated catalase found within pathogenicLeptospiraspecies, by assessing its role in resistance to H2O2-induced oxidative stress and during infection in hamsters. PathogenicL. interrogansbacteria had a 50-fold-higher survival rate under H2O2-induced oxidative stress than did saprophyticL. biflexabacteria, and this was predominantly catalase dependent. We also characterized KatE, the only annotated catalase found within pathogenicLeptospiraspecies. Catalase assays performed with recombinant KatE confirmed specific catalase activity, while protein fractionation experiments localized KatE to the bacterial periplasmic space. The insertional inactivation ofkatEin pathogenicLeptospirabacteria drastically diminished leptospiral viability in the presence of extracellular H2O2and reduced virulence in an acute-infection model. Combined, these results suggest thatL. interrogansKatE confersin vivoresistance to reactive oxygen species induced by the host innate immune response.

SOD2 Facilitates the Antiviral Innate Immune Response by Scavenging Reactive Oxygen Species

2017 ◽  
Vol 30 (8) ◽  
pp. 582-589 ◽  
Author(s):  
Wan Wang ◽  
Yufei Jin ◽  
Ningxiang Zeng ◽  
Qingwei Ruan ◽  
Feng Qian
Keyword(s):  
Reactive Oxygen Species ◽  
Immune Response ◽  
Innate Immune Response ◽  
Reactive Oxygen ◽  
Innate Immune ◽  
Oxygen Species

scholarly journals Heme Amplifies the Innate Immune Response to Microbial Molecules through Spleen Tyrosine Kinase (Syk)-dependent Reactive Oxygen Species Generation

2010 ◽  
Vol 285 (43) ◽  
pp. 32844-32851 ◽  
Author(s):  
Patricia L. Fernandez ◽  
Fabianno F. Dutra ◽  
Letícia Alves ◽  
Rodrigo T. Figueiredo ◽  
Diego Mourão-Sa ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Immune Response ◽  
Tyrosine Kinase ◽  
Innate Immune Response ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Innate Immune ◽  
Oxygen Species ◽  
Spleen Tyrosine Kinase

scholarly journals Reactive Oxygen Species: Do They Play a Role in Adaptive Immunity?

2021 ◽  
Vol 12 ◽  
Author(s):  
Essen Yonca Bassoy ◽  
Michael Walch ◽  
Denis Martinvalet
Keyword(s):  
Reactive Oxygen Species ◽  
Immune Response ◽  
Immune System ◽  
Adaptive Immunity ◽  
Cell Biology ◽  
Reactive Oxygen ◽  
Innate Immune ◽  
Inflammasome Activation ◽  
Oxygen Species ◽  
Adaptive Immune

The immune system protects the host from a plethora of microorganisms and toxins through its unique ability to distinguish self from non-self. To perform this delicate but essential task, the immune system relies on two lines of defense. The innate immune system, which is by nature fast acting, represents the first line of defense. It involves anatomical barriers, physiological factors as well as a subset of haematopoietically-derived cells generically call leukocytes. Activation of the innate immune response leads to a state of inflammation that serves to both warn about and combat the ongoing infection and delivers the antigenic information of the invading pathogens to initiate the slower but highly potent and specific second line of defense, the adaptive immune system. The adaptive immune response calls on T lymphocytes as well as the B lymphocytes essential for the elimination of pathogens and the establishment of the immunological memory. Reactive oxygen species (ROS) have been implicated in many aspects of the immune responses to pathogens, mostly in innate immune functions, such as the respiratory burst and inflammasome activation. Here in this mini review, we focus on the role of ROS in adaptive immunity. We examine how ROS contribute to T-cell biology and discuss whether this activity can be extrapolated to B cells.

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