Gadolinium-Loaded Solid Lipid Nanoparticles as a Tumor-Absorbable Contrast Agent for Early Diagnosis of Colorectal Tumors Using Magnetic Resonance Colonography

The current study aims to investigate the possibility of using solid lipid nanoparticles (SLNs)-enhanced magnetic resonance (MR) colonography to diagnose colorectal cancer. Gd-FITC-SLNs were synthesized by loading gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) and fluorescein isothiocyanate (FITC) simultaneously. Twenty mice received azoxymethane/dextran sulfate sodium (AOM/DSS) to induce adenocarcinoma of the colon and were divided into 4 groups, and 5 in per group. MR colonography were performed at different time periods before and after enema or intravenous injection of Gd-FITC-SLNs or Gd-DTPA. The results demonstrated SNR (signal-to-noise ratio) significantly increased from 1.56- to 1.76-fold within the colorectal tumors after the enema of Gd-FITC-SLNs (p < 0.001). No differences in SNR were observed after the enema of Gd-DTPA (p > 0.05). Besides, SNR increased from 1.54- to 1.72-fold within the colorectal tumors after the intravenous injection of Gd-FITC-SLNs (p < 0.001) while SNR increased from 1.39to 1.57-fold within the colorectal tumors after the injection of Gd-DTPA (p < 0.001). In addition, SNR within colorectal tumors significantly increased ranging from 20th to 140th min, and lasted for about 120 min (p < 0.05) after the enema of Gd-FITC-SLNs and SNR within colorectal tumors also significantly increased ranging from 0th hour to 8th hour, lasted for about 8 hour (p < 0.05) after the injection of Gd-FITC-SLNs. However, after the injection of Gd-DTPA, SNR within colorectal tumors significantly increased only ranging from 0th min to 20th min after administration (p < 0.01). Furthermore, hematoxylin and eosin (H&E) staining revealed that all mice developed adenocarcinoma of the colon. In summary, it is feasible by using Gd-FITC-SLNs in MR colonography to diagnose colorectal cancer. Enema of Gd-FITC-SLNs can provide marked enhancement of colorectal tumors quickly, and safer while intravenous injection of Gd-FITC-SLNs can provide a long-lasting enhancement of colorectal tumors in MR colonography. These findings present a potential clinical application of Gd-FITC-SLNs on MR colonography.

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Enhancement of oral bioavailability of pentoxifylline by solid lipid nanoparticles

Journal of Liposome Research ◽

10.1080/08982100903161456 ◽

2009 ◽

Vol 00 (00) ◽

pp. 090820062440031-9 ◽

Cited By ~ 1

Author(s):

Jaleh Varshosaz ◽

Mohsen Minayian ◽

Elaheh Moazen

Keyword(s):

Solid Lipid Nanoparticles ◽

Oral Bioavailability ◽

Lipid Nanoparticles ◽

Solid Lipid

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Development and optimization of solid lipid nanoparticles of amikacin by central composite design

Journal of Liposome Research ◽

10.1080/08982100903103904 ◽

2009 ◽

Vol 00 (00) ◽

pp. 090721051030036-8

Author(s):

Jaleh Varshosaz ◽

Solmaz Ghaffari ◽

Mohammad Reza Khoshayand ◽

Fatemeh Atyabi ◽

Shirzad Azarmi ◽

...

Keyword(s):

Central Composite Design ◽

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Solid Lipid ◽

Central Composite

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Solid lipid nanoparticles for oral delivery of curcumin

Planta Medica ◽

10.1055/s-0033-1352358 ◽

2013 ◽

Vol 79 (13) ◽

Author(s):

C Righeschi ◽

M Bergonzi ◽

B Isacchi ◽

A Bilia

Keyword(s):

Solid Lipid Nanoparticles ◽

Oral Delivery ◽

Lipid Nanoparticles ◽

Solid Lipid

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SOLID LIPID NANOPARTICLES FOR ORAL DELIVERY OF SILIBININ: FORMULATION, CHARACTERIZATION AND EVALUATION USING PAMPA AND CACO-2 CELL MODELS

10.1055/s-0037-1608582 ◽

2017 ◽

Author(s):

V Piazzini ◽

G Graverini ◽

G Vanti ◽

E Bigagli ◽

L Cinci ◽

...

Keyword(s):

Solid Lipid Nanoparticles ◽

Oral Delivery ◽

Lipid Nanoparticles ◽

Cell Models ◽

Solid Lipid

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Development of Solid Lipid Nanoparticles of Lamivudine for Brain Targeting

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v1i1.8837 ◽

2009 ◽

Vol 1 (1) ◽

Cited By ~ 1

Author(s):

Pravin Patil ◽

Anil Sharma ◽

Subhash Dadarwal ◽

Vijay Sharma

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Solid Lipid Nanoparticles ◽

Rotation Speed ◽

Lipid Nanoparticles ◽

Brain Targeting ◽

Brain Penetration ◽

Solid Lipid ◽

Diffusion Technique

The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time.

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Optimization and evaluation of topical gel containing solid lipid nanoparticles loaded with luliconazole and its anti-fungal activity

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2020.sp2.169 ◽

2020 ◽

Vol 12 (sp2) ◽

Keyword(s):

Solid Lipid Nanoparticles ◽

Lipid Nanoparticles ◽

Topical Gel ◽

Solid Lipid ◽

Fungal Activity ◽

Anti Fungal

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Solid Lipid Nanoparticles: A Promising Drug Delivery Technology

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2009.2.2.3 ◽

2009 ◽

Vol 2 (2) ◽

pp. 509-516

Author(s):

S. Pragati ◽

S. Kuldeep ◽

S. Ashok ◽

M. Satheesh

Keyword(s):

Drug Delivery ◽

Solid Lipid Nanoparticles ◽

Large Scale ◽

Colloidal Particles ◽

Scale Up ◽

Lipid Nanoparticles ◽

Scale Production ◽

Research Activity ◽

New Approach ◽

Solid Lipid

One of the situations in the treatment of disease is the delivery of efficacious medication of appropriate concentration to the site of action in a controlled and continual manner. Nanoparticle represents an important particulate carrier system, developed accordingly. Nanoparticles are solid colloidal particles ranging in size from 1 to 1000 nm and composed of macromolecular material. Nanoparticles could be polymeric or lipidic (SLNs). Industry estimates suggest that approximately 40% of lipophilic drug candidates fail due to solubility and formulation stability issues, prompting significant research activity in advanced lipophile delivery technologies. Solid lipid nanoparticle technology represents a promising new approach to lipophile drug delivery. Solid lipid nanoparticles (SLNs) are important advancement in this area. The bioacceptable and biodegradable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. Supplemented with small size which prolongs the circulation time in blood, feasible scale up for large scale production and absence of burst effect makes them interesting candidates for study. In this present review this new approach is discussed in terms of their preparation, advantages, characterization and special features.

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