A cis-Diol/pH Dual-Responsive Upconversion Nanoplatform: Synthesis, Characterization, and In Vitro Demonstration

2019 ◽  
Vol 15 (3) ◽  
pp. 487-499
Author(s):  
Hui Cui ◽  
Bowen Zhang ◽  
Haolin Ding ◽  
Youming Hu ◽  
Xianhua Wang ◽  
...  
Keyword(s):  
Dual Responsive

In Vitro Efficacy of Paclitaxel-Loaded Dual-Responsive Shell Cross-Linked Polymer Nanoparticles Having Orthogonally Degradable Disulfide Cross-Linked Corona and Polyester Core Domains

2013 ◽  
Vol 10 (3) ◽  
pp. 1092-1099 ◽  
Author(s):  
Sandani Samarajeewa ◽  
Ritu Shrestha ◽  
Mahmoud Elsabahy ◽  
Amolkumar Karwa ◽  
Ang Li ◽  
...  
Keyword(s):  
Polymer Nanoparticles ◽  
Dual Responsive

Fabrication and in vitro performance of a dual responsive lactate and glucose biosensor

2018 ◽  
Vol 267 ◽  
pp. 71-79 ◽  
Author(s):  
Christian N. Kotanen ◽  
Olukayode Karunwi ◽  
Fouzan Alam ◽  
Catherine F.T. Uyehara ◽  
Anthony Guiseppi-Elie
Keyword(s):  
Glucose Biosensor ◽  
Dual Responsive ◽  
In Vitro Performance

Poly(N-isopropylacrylamide)-b-Poly(L-lysine)-b-Poly(L-histidine) Triblock Amphiphilic Copolymer Nanomicelles for Dual-Responsive Anticancer Drug Delivery

2020 ◽  
Vol 20 (11) ◽  
pp. 6959-6967
Author(s):  
Rimesh Augustine ◽  
Dae-Kyoung Kim ◽  
Ho An Kim ◽  
Jae Ho Kim ◽  
Il Kim
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Loading ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Micellar Aggregates ◽  
Reversible Addition ◽  
Hydrogen Carbonate ◽  
Copolymer Micelle

A series of ABC triblock poly(N-isopropylacrylamide)75-block-poly(L-lysine)35-block-poly(L-histidine)n (p(NIPAM)75-b-p(Lys)35-b-p(His)N) (N = 35,50,75,100) copolymer bio-conjugates were prepared by combining reversible addition-fragmentation chain transfer polymerization and fast ring-opening polymerization of N-carboxyanhydride a-amino acid using 1,3-dicyclohexylimidazolium hydrogen carbonate as a catalyst. All the resulting triblock copolymers self-assembled into spherical micellar aggregates in aqueous solution, irrespective of the chain length of the histidine block. The micellar aggregates encapsulated the anticancer drug doxorubicin (Dox) and exhibited high drug loading efficiency. Temperature and pH stimuli were applied to investigate the controlled release of Dox. The non-cytotoxic nature of the polymers was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cellular uptake of the Dox-loaded micelles revealed that the micelles successfully release Dox in cancer cells in response to pH- and temperature-induced morphological change. In-vitro studies further confirmed that the Dox-loaded triblock copolymer micelle is an excellent platform for drug delivery.

scholarly journals Dual-responsive doxorubicin-loaded nanomicelles for enhanced cancer therapy

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Xinyi Zhang ◽  
Tiantian Zhu ◽  
Yaxin Miao ◽  
Lu Zhou ◽  
Weifang Zhang
Keyword(s):  
Drug Release ◽  
Cellular Uptake ◽  
Polymeric Micelle ◽  
Oxygen Species ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Tocopheryl Succinate ◽  
Delivery Platform

Abstract Background The enhancement of tumor retention and cellular uptake of drugs are important factors in maximizing anticancer therapy and minimizing side effects of encapsulated drugs. Herein, a delivery nanoplatform, armed with a pH-triggered charge-reversal capability and self-amplifiable reactive oxygen species (ROS)-induced drug release, is constructed by encapsulating doxorubicin (DOX) in pH/ROS-responsive polymeric micelle. Results The surface charge of this system was converted from negative to positive from pH 7.4 to pH 6.8, which facilitated the cellular uptake. In addition, methionine-based system was dissociated in a ROS-rich and acidic intracellular environment, resulting in the release of DOX and α-tocopheryl succinate (TOS). Then, the exposed TOS segments further induced the generation of ROS, leading to self-amplifiable disassembly of the micelles and drug release. Conclusions We confirms efficient DOX delivery into cancer cells, upregulation of tumoral ROS level and induction of the apoptotic capability in vitro. The system exhibits outstanding tumor inhibition capability in vivo, indicating that dual stimuli nano-system has great potential to function as an anticancer drug delivery platform.

Injectable pH and redox dual responsive hydrogels based on self-assembled peptides for anti-tumor drug delivery

2020 ◽  
Vol 8 (19) ◽  
pp. 5415-5426
Author(s):  
Ying Zhu ◽  
Liying Wang ◽  
Yiping Li ◽  
Zhewei Huang ◽  
Shiyao Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antitumor Drugs ◽  
Dual Responsive ◽  
Tumor Drug Delivery ◽  
Self Assembled ◽  
Peptide Hydrogels ◽  
Responsive Hydrogels

Dual responsive and injectable peptide hydrogels that form gels in vitro control the release of antitumor drugs in vivo.

scholarly journals A Rapid Dual-Responsive Releasing Nano-Carrier by Decomposing the Copolymer and Reversing the Core Dissolution

2021 ◽  
Vol 9 ◽  
Author(s):  
Sen Liu ◽  
Can Shen ◽  
Cheng Qian ◽  
Jianquan Wang ◽  
Zhihao Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Disulfide Bonds ◽  
Water Soluble ◽  
Drug Release Rate ◽  
The Core ◽  
Dual Responsive ◽  
Dual Response ◽  
Effective Drugs

The accumulation of nanotechnology-based drugs has been realized in various ways. However, the concentration of drugs encapsulated by nanomaterials is not equal to the concentration of effective drugs; often, the drugs become effective only when they are released from the nanomaterials as free drugs. This means only when the drugs are rapidly released after the accumulated drug-encapsulating nanomaterials can they truly achieve the purpose of increasing the concentration of drugs in the tumor. Therefore, we herein report a dual-response nano-carrier of glutathione and acid to achieve the rapid release of encapsulated drug and increase the effective drug concentration in the tumor. The nano-carrier was constructed using a dual-responsive amphiphilic copolymer, composed of polyethylene glycol and hydrophobic acetylated dextran and connected by a disulfide bond. In the tumor microenvironment, disulfide bonds could be biodegraded by glutathione that is overexpressed in the tumor, exposing the core of nano-carrier composed of acetylated dextran. Then the acidic environment would induce the deacetylation of acetylated dextran into water-soluble dextran. In this way, the nano-carrier will degrade quickly, realizing the purpose of rapid drug release. The results showed that the drug release rate of dual-responsive nano-carrier was much higher than that of glutathione or acid-responsive nano-carrier alone. Furthermore, both in vitro and in vivo experiments confirmed that dual-responsive nano-carrier possessed more efficient anti-tumor effects. Therefore, we believe that dual-responsive nano-carriers have better clinical application prospects.

TEMPERATURE AND PH RESPONSIVE POLYMERIC NANOPARTICLES FOR TARGETED OXALIPLATIN DELIVERY

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (11) ◽  
pp. 74-77
Author(s):  
A. S Patil ◽  
◽  
A. P. Gadad
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Ph Responsive ◽  
In Vitro Drug Release ◽  
Dual Responsive ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

In the present study temperature and pH responsive co-polymer chitosan-g-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) was synthesized, characterized and efficiently loaded with oxaliplatin. Nanoparticles were evaluated for their physicochemical properties. The drug loaded nanoparticles showed smooth and spherical morphology with loading efficiency and drug content of about 80.7% and 48.7%, respectively. The in vitro drug release was significantly higher at tumor extracellular pH and temperature when compared to physiological pH and temperature. In conclusion, the developed nanoparticulate system is an effective dual responsive targeted drug delivery system for oxaliplatin with low toxic side effects.

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