3D Printing of Differentiated Bone Marrow Mesenchymal Cells as a New Method for Liver Tissue Engineering

2016 ◽  
Vol 6 (8) ◽  
pp. 642-648 ◽  
Author(s):  
Zhong Cheng ◽  
. Shanqiaonan ◽  
Zhuang Runzhou ◽  
Zhou Lin ◽  
Xu Xiao ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Marrow ◽  
3D Printing ◽  
Liver Tissue ◽  
Mesenchymal Cells ◽  
New Method ◽  
Liver Tissue Engineering ◽  
Bone Marrow Mesenchymal Cells

Liver tissue engineering via hyperbranched polypyrrole scaffolds

2019 ◽  
Vol 69 (17) ◽  
pp. 1112-1122 ◽  
Author(s):  
Maryam Hatamzadeh ◽  
Raana Sarvari ◽  
Bakhshali Massoumi ◽  
Samira Agbolaghi ◽  
Fatemeh Samadian
Keyword(s):  
Tissue Engineering ◽  
Liver Tissue ◽  
Liver Tissue Engineering

miR-26b Regulates Osteoactivin (OA)-Induced Bone Marrow Mesenchymal Cells (BMSCs) Osteogenic Differentiation by Targeting Fms-Like Tyrosine Kinase 3 (FLT3)/AXL

2021 ◽  
Vol 11 (9) ◽  
pp. 1774-1779
Author(s):  
Feng Sun ◽  
Tianwen Huang ◽  
Jianhui Shi ◽  
Tianli Wei ◽  
Haiwei Zhang
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Tyrosine Kinase ◽  
Osteogenic Differentiation ◽  
Signaling Pathway ◽  
Formation Process ◽  
Mesenchymal Cells ◽  
Mrna Levels ◽  
Qrt Pcr ◽  
Bone Marrow Mesenchymal Cells

Osteoactivin (OA) plays a key role in osteogenic differentiation. miR-26b is elevated in the bone formation process of BMSCs, but whether it is involved in this process is unclear. Bone formation is regulated by FLT3/AXL signaling pathway, which may be a potential target of miR-26b. qRT-PCR detected miR-26b mRNA levels and bone formation-related genes or FLT3/AXL signaling pathway-related genes. Bone formation was analyzed by staining and FLT3/AXL signaling was evaluated along with analysis of miR-26b’s relation with LT3/AXL. miR-26b was significantly elevated in OA-induced bone formation of BMSCs, which can be promoted by miR-26b mimics. When miR-26b was overexpressed, FLT3/AXL signaling pathway was activated. miR-26b can ameliorate Dex-induced osteo-inhibition. miR-26b promotes bone formation of BMSCs by directly targeting FLT3/AXL signaling pathway, suggesting that miR-26b might be a target for inducing osteogenic differentiation.

scholarly journals Graphene-based 3D scaffolds in tissue engineering: fabrication, applications, and future scope in liver tissue engineering

2019 ◽  
Vol Volume 14 ◽  
pp. 5753-5783 ◽  
Author(s):  
Renu Geetha Bai ◽  
Kasturi Muthoosamy ◽  
Sivakumar Manickam ◽  
Ali Hilal-Alnaqbi
Keyword(s):  
Tissue Engineering ◽  
Liver Tissue ◽  
3D Scaffolds ◽  
Liver Tissue Engineering

scholarly journals Hydrogels for Liver Tissue Engineering

2019 ◽  
Vol 6 (3) ◽  
pp. 59 ◽  
Author(s):  
Shicheng Ye ◽  
Jochem W.B. Boeter ◽  
Louis C. Penning ◽  
Bart Spee ◽  
Kerstin Schneeberger
Keyword(s):  
Tissue Engineering ◽  
Liver Tissue ◽  
Drug Testing ◽  
In Vitro Models ◽  
Liver Tissue Engineering ◽  
Synthetic Materials ◽  
Toxicological Studies ◽  
End Stage

Bioengineered livers are promising in vitro models for drug testing, toxicological studies, and as disease models, and might in the future be an alternative for donor organs to treat end-stage liver diseases. Liver tissue engineering (LTE) aims to construct liver models that are physiologically relevant. To make bioengineered livers, the two most important ingredients are hepatic cells and supportive materials such as hydrogels. In the past decades, dozens of hydrogels have been developed to act as supportive materials, and some have been used for in vitro models and formed functional liver constructs. However, currently none of the used hydrogels are suitable for in vivo transplantation. Here, the histology of the human liver and its relationship with LTE is introduced. After that, significant characteristics of hydrogels are described focusing on LTE. Then, both natural and synthetic materials utilized in hydrogels for LTE are reviewed individually. Finally, a conclusion is drawn on a comparison of the different hydrogels and their characteristics and ideal hydrogels are proposed to promote LTE.

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