scholarly journals Bone marrow mesenchymal cells for haemophilia A gene therapy using retroviral vectors with modified long-terminal repeats

Haemophilia ◽  
2003 ◽  
Vol 9 (3) ◽  
pp. 345-345 ◽  
Author(s):  
A. Van Damme ◽  
M. K. L. Chuah ◽  
F. Dell'accio ◽  
C. De Bari ◽  
F. Luyten ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Bone Marrow ◽  
Retroviral Vectors ◽  
Mesenchymal Cells ◽  
Haemophilia A ◽  
Long Terminal Repeats ◽  
Terminal Repeats ◽  
Bone Marrow Mesenchymal Cells

Bone marrow mesenchymal cells for haemophilia A gene therapy using retroviral vectors with modified long-terminal repeats

Haemophilia ◽  
2003 ◽  
Vol 9 (1) ◽  
pp. 94-103 ◽  
Author(s):  
A. Van Damme ◽  
M. K. L. Chuah ◽  
F. Dell'accio ◽  
C. De Bari ◽  
F. Luyten ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Bone Marrow ◽  
Retroviral Vectors ◽  
Mesenchymal Cells ◽  
Haemophilia A ◽  
Long Terminal Repeats ◽  
Terminal Repeats ◽  
Bone Marrow Mesenchymal Cells

miR-26b Regulates Osteoactivin (OA)-Induced Bone Marrow Mesenchymal Cells (BMSCs) Osteogenic Differentiation by Targeting Fms-Like Tyrosine Kinase 3 (FLT3)/AXL

2021 ◽  
Vol 11 (9) ◽  
pp. 1774-1779
Author(s):  
Feng Sun ◽  
Tianwen Huang ◽  
Jianhui Shi ◽  
Tianli Wei ◽  
Haiwei Zhang
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Tyrosine Kinase ◽  
Osteogenic Differentiation ◽  
Signaling Pathway ◽  
Formation Process ◽  
Mesenchymal Cells ◽  
Mrna Levels ◽  
Qrt Pcr ◽  
Bone Marrow Mesenchymal Cells

Osteoactivin (OA) plays a key role in osteogenic differentiation. miR-26b is elevated in the bone formation process of BMSCs, but whether it is involved in this process is unclear. Bone formation is regulated by FLT3/AXL signaling pathway, which may be a potential target of miR-26b. qRT-PCR detected miR-26b mRNA levels and bone formation-related genes or FLT3/AXL signaling pathway-related genes. Bone formation was analyzed by staining and FLT3/AXL signaling was evaluated along with analysis of miR-26b’s relation with LT3/AXL. miR-26b was significantly elevated in OA-induced bone formation of BMSCs, which can be promoted by miR-26b mimics. When miR-26b was overexpressed, FLT3/AXL signaling pathway was activated. miR-26b can ameliorate Dex-induced osteo-inhibition. miR-26b promotes bone formation of BMSCs by directly targeting FLT3/AXL signaling pathway, suggesting that miR-26b might be a target for inducing osteogenic differentiation.

scholarly journals A new waterborne chitosan-based polyurethane hydrogel as a vehicle to transplant bone marrow mesenchymal cells improved wound healing of ulcers in a diabetic rat model

2020 ◽  
Vol 231 ◽  
pp. 115734 ◽  
Author(s):  
Christian Viezzer ◽  
Rafael Mazzuca ◽  
Denise Cantarelli Machado ◽  
Maria Madalena de Camargo Forte ◽  
José Luis Gómez Ribelles
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Rat Model ◽  
Mesenchymal Cells ◽  
Diabetic Rat ◽  
Polyurethane Hydrogel ◽  
Bone Marrow Mesenchymal Cells ◽  
Diabetic Rat Model

4:51146. Nell-1 Induces Osteoblastic Differentiation of Bone Marrow Mesenchymal Cells In Vitro and Bone Formation In Vivo

2006 ◽  
Vol 6 (5) ◽  
pp. 74S
Author(s):  
Tara Aghaloo ◽  
Xinquan Jiang ◽  
Xinli Zhang ◽  
Zhang Zhiyuang ◽  
Jeffrey C. Wang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Osteoblastic Differentiation ◽  
Mesenchymal Cells ◽  
Bone Marrow Mesenchymal Cells
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