Deep Transfer Learning for Histopathological Diagnosis of Cervical Cancer Using Convolutional Neural Networks with Visualization Schemes

2020 ◽  
Vol 10 (2) ◽  
pp. 391-400 ◽  
Author(s):  
Ying Chen ◽  
Xiaomin Qin ◽  
Jingyu Xiong ◽  
Shugong Xu ◽  
Jun Shi ◽  
...  
Keyword(s):  
Neural Networks ◽  
Cervical Cancer ◽  
Learning Strategies ◽  
Transfer Learning ◽  
Convolutional Neural Networks ◽  
Characteristic Curve ◽  
Disease Classification ◽  
Natural Image ◽  
Histopathological Diagnosis ◽  
The Impact

This study aimed to propose a deep transfer learning framework for histopathological image analysis by using convolutional neural networks (CNNs) with visualization schemes, and to evaluate its usage for automated and interpretable diagnosis of cervical cancer. First, in order to examine the potential of the transfer learning for classifying cervix histopathological images, we pre-trained three state-of-the-art CNN architectures on large-size natural image datasets and then fine-tuned them on small-size histopathological datasets. Second, we investigated the impact of three learning strategies on classification accuracy. Third, we visualized both the multiple-layer convolutional kernels of CNNs and the regions of interest so as to increase the clinical interpretability of the networks. Our method was evaluated on a database of 4993 cervical histological images (2503 benign and 2490 malignant). The experimental results demonstrated that our method achieved 95.88% sensitivity, 98.93% specificity, 97.42% accuracy, 94.81% Youden's index and 99.71% area under the receiver operating characteristic curve. Our method can reduce the cognitive burden on pathologists for cervical disease classification and improve their diagnostic efficiency and accuracy. It may be potentially used in clinical routine for histopathological diagnosis of cervical cancer.

scholarly journals Detection of liver cirrhosis in standard T2-weighted MRI using deep transfer learning

2021 ◽  
Author(s):  
Sebastian Nowak ◽  
Narine Mesropyan ◽  
Anton Faron ◽  
Wolfgang Block ◽  
Martin Reuter ◽  
...  
Keyword(s):  
Neural Networks ◽  
Liver Cirrhosis ◽  
Transfer Learning ◽  
Convolutional Neural Networks ◽  
Classification Accuracy ◽  
Automatic Segmentation ◽  
Analysis Data ◽  
Caudate Lobe ◽  
Natural Image ◽  
Liver Segmentation

Abstract Objectives To investigate the diagnostic performance of deep transfer learning (DTL) to detect liver cirrhosis from clinical MRI. Methods The dataset for this retrospective analysis consisted of 713 (343 female) patients who underwent liver MRI between 2017 and 2019. In total, 553 of these subjects had a confirmed diagnosis of liver cirrhosis, while the remainder had no history of liver disease. T2-weighted MRI slices at the level of the caudate lobe were manually exported for DTL analysis. Data were randomly split into training, validation, and test sets (70%/15%/15%). A ResNet50 convolutional neural network (CNN) pre-trained on the ImageNet archive was used for cirrhosis detection with and without upstream liver segmentation. Classification performance for detection of liver cirrhosis was compared to two radiologists with different levels of experience (4th-year resident, board-certified radiologist). Segmentation was performed using a U-Net architecture built on a pre-trained ResNet34 encoder. Differences in classification accuracy were assessed by the χ2-test. Results Dice coefficients for automatic segmentation were above 0.98 for both validation and test data. The classification accuracy of liver cirrhosis on validation (vACC) and test (tACC) data for the DTL pipeline with upstream liver segmentation (vACC = 0.99, tACC = 0.96) was significantly higher compared to the resident (vACC = 0.88, p < 0.01; tACC = 0.91, p = 0.01) and to the board-certified radiologist (vACC = 0.96, p < 0.01; tACC = 0.90, p < 0.01). Conclusion This proof-of-principle study demonstrates the potential of DTL for detecting cirrhosis based on standard T2-weighted MRI. The presented method for image-based diagnosis of liver cirrhosis demonstrated expert-level classification accuracy. Key Points • A pipeline consisting of two convolutional neural networks (CNNs) pre-trained on an extensive natural image database (ImageNet archive) enables detection of liver cirrhosis on standard T2-weighted MRI. • High classification accuracy can be achieved even without altering the pre-trained parameters of the convolutional neural networks. • Other abdominal structures apart from the liver were relevant for detection when the network was trained on unsegmented images.

scholarly journals Fusion High-Resolution Network for Diagnosing ChestX-ray Images

Electronics ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 190 ◽  
Author(s):  
Zhiwei Huang ◽  
Jinzhao Lin ◽  
Liming Xu ◽  
Huiqian Wang ◽  
Tong Bai ◽  
...  
Keyword(s):  
Neural Networks ◽  
Deep Learning ◽  
High Resolution ◽  
Convolutional Neural Networks ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Disease Classification ◽  
Deep Convolutional Neural Networks ◽  
Learning Methods ◽  
Global And Local

The application of deep convolutional neural networks (CNN) in the field of medical image processing has attracted extensive attention and demonstrated remarkable progress. An increasing number of deep learning methods have been devoted to classifying ChestX-ray (CXR) images, and most of the existing deep learning methods are based on classic pretrained models, trained by global ChestX-ray images. In this paper, we are interested in diagnosing ChestX-ray images using our proposed Fusion High-Resolution Network (FHRNet). The FHRNet concatenates the global average pooling layers of the global and local feature extractors—it consists of three branch convolutional neural networks and is fine-tuned for thorax disease classification. Compared with the results of other available methods, our experimental results showed that the proposed model yields a better disease classification performance for the ChestX-ray 14 dataset, according to the receiver operating characteristic curve and area-under-the-curve score. An ablation study further confirmed the effectiveness of the global and local branch networks in improving the classification accuracy of thorax diseases.

scholarly journals Dual Self-Paced Graph Convolutional Network: Towards Reducing Attribute Distortions Induced by Topology

2019 ◽  
Author(s):  
Liang Yang ◽  
Zhiyang Chen ◽  
Junhua Gu ◽  
Yuanfang Guo
Keyword(s):  
Neural Networks ◽  
Learning Strategies ◽  
Convolutional Neural Networks ◽  
Training Process ◽  
Training Set ◽  
Convolutional Network ◽  
Attribute Information ◽  
Topology Information ◽  
Node Classification ◽  
The Impact

The success of graph convolutional neural networks (GCNNs) based semi-supervised node classification is credited to the attribute smoothing (propagating) over the topology. However, the attributes may be interfered by the utilization of the topology information. This distortion will induce a certain amount of misclassifications of the nodes, which can be correctly predicted with only the attributes. By analyzing the impact of the edges in attribute propagations, the simple edges, which connect two nodes with similar attributes, should be given priority during the training process compared to the complex ones according to curriculum learning. To reduce the distortions induced by the topology while exploit more potentials of the attribute information, Dual Self-Paced Graph Convolutional Network (DSP-GCN) is proposed in this paper. Specifically, the unlabelled nodes with confidently predicted labels are gradually added into the training set in the node-level self-paced learning, while edges are gradually, from the simple edges to the complex ones, added into the graph during the training process in the edge-level self-paced learning. These two learning strategies are designed to mutually reinforce each other by coupling the selections of the edges and unlabelled nodes. Experimental results of transductive semi-supervised node classification on many real networks indicate that the proposed DSP-GCN has successfully reduced the attribute distortions induced by the topology while it gives superior performances with only one graph convolutional layer.

scholarly journals Evaluation of Transfer Learning with Deep Convolutional Neural Networks for Screening Osteoporosis in Dental Panoramic Radiographs

2020 ◽  
Vol 9 (2) ◽  
pp. 392 ◽  
Author(s):  
Ki-Sun Lee ◽  
Seok-Ki Jung ◽  
Jae-Jun Ryu ◽  
Sang-Wan Shin ◽  
Jinwook Choi
Keyword(s):  
Neural Networks ◽  
Learning Strategies ◽  
Transfer Learning ◽  
Convolutional Neural Networks ◽  
Learning Model ◽  
Fine Tuning ◽  
Mapping Technique ◽  
Deep Convolutional Neural Networks ◽  
Panoramic Radiographs ◽  
Deep Cnn

Dental panoramic radiographs (DPRs) provide information required to potentially evaluate bone density changes through a textural and morphological feature analysis on a mandible. This study aims to evaluate the discriminating performance of deep convolutional neural networks (CNNs), employed with various transfer learning strategies, on the classification of specific features of osteoporosis in DPRs. For objective labeling, we collected a dataset containing 680 images from different patients who underwent both skeletal bone mineral density and digital panoramic radiographic examinations at the Korea University Ansan Hospital between 2009 and 2018. Four study groups were used to evaluate the impact of various transfer learning strategies on deep CNN models as follows: a basic CNN model with three convolutional layers (CNN3), visual geometry group deep CNN model (VGG-16), transfer learning model from VGG-16 (VGG-16_TF), and fine-tuning with the transfer learning model (VGG-16_TF_FT). The best performing model achieved an overall area under the receiver operating characteristic of 0.858. In this study, transfer learning and fine-tuning improved the performance of a deep CNN for screening osteoporosis in DPR images. In addition, using the gradient-weighted class activation mapping technique, a visual interpretation of the best performing deep CNN model indicated that the model relied on image features in the lower left and right border of the mandibular. This result suggests that deep learning-based assessment of DPR images could be useful and reliable in the automated screening of osteoporosis patients.

scholarly journals Interpretation of Swedish Sign Language Using Convolutional Neural Networks and Transfer Learning

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Gustaf Halvardsson ◽  
Johanna Peterson ◽  
César Soto-Valero ◽  
Benoit Baudry
Keyword(s):  
Neural Networks ◽  
Sign Language ◽  
Transfer Learning ◽  
Convolutional Neural Networks ◽  
Web Application ◽  
Training Dataset ◽  
Motion Processing ◽  
Image Perception ◽  
Sign Languages ◽  
High Level

AbstractThe automatic interpretation of sign languages is a challenging task, as it requires the usage of high-level vision and high-level motion processing systems for providing accurate image perception. In this paper, we use Convolutional Neural Networks (CNNs) and transfer learning to make computers able to interpret signs of the Swedish Sign Language (SSL) hand alphabet. Our model consists of the implementation of a pre-trained InceptionV3 network, and the usage of the mini-batch gradient descent optimization algorithm. We rely on transfer learning during the pre-training of the model and its data. The final accuracy of the model, based on 8 study subjects and 9400 images, is 85%. Our results indicate that the usage of CNNs is a promising approach to interpret sign languages, and transfer learning can be used to achieve high testing accuracy despite using a small training dataset. Furthermore, we describe the implementation details of our model to interpret signs as a user-friendly web application.

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