Ultrasonographic Bioinformatics Analysis of Uterus After Myomectomy

2020 ◽  
Vol 10 (6) ◽  
pp. 1374-1378
Author(s):  
Lili Jiang ◽  
Chuanxin Cheng ◽  
Xinmei Sheng
Keyword(s):  
Blood Flow ◽  
Bioinformatics Analysis ◽  
Uterine Wall ◽  
Before And After ◽  
The Mean

Objective: The myomectomy will affect the shape of uterine wall. Ultrasound can analyze the bioinformatics characteristics of uterus such as shape and blood flow in vivo. The aim of this study is to analyze the ultrasonographic bioinformatics of uterus after myomectomy. Methods: A total of 127 patients underwent myomectomy were examined by ultrasonography before operation, and 7 d, 1 m, 3 m, and 6 m after operation. The changes of uterine echo and blood signals were observed and recorded. Results: The mean volume of uterus was (152 ± 64) cm3 before myomectomy. During 6 m after operation, the uterus volume in all patients was decreased gradually. At 7 d and 1 m after operation, the mean volume of uterus was (73 ± 22) cm3 and (54 ± 23) cm3, respectively (about 48% and 36% of volume before operation). Different degree of scar echo appeared in 43 patients (33.8%). The diameter of scars was decreased remarkably during 6 months after myomectomy, especially 1 month after operation. Conclusion: The bioinformatics characteristics of uterus changed obviously before and after myomectomy. Ultrasonography is useful to evaluate these changed.

Effects of NO-Donors on Thrombus Formation and Microcirculation in Cerebral Vessels of the Rat

1996 ◽  
Vol 76 (01) ◽  
pp. 111-117 ◽  
Author(s):  
Yasuto Sasaki ◽  
Junji Seki ◽  
John C Giddings ◽  
Junichiro Yamamoto
Keyword(s):  
Blood Flow ◽  
Thrombus Formation ◽  
Dependent Manner ◽  
Red Cell ◽  
Cell Velocity ◽  
Red Cell Velocity ◽  
The Mean ◽  
Wall Shear ◽  
Dose Dependent

SummarySodium nitroprusside (SNP) and 3-morpholinosydnonimine (SIN-1), are known to liberate nitric oxide (NO). In this study the effects of SNP and SIN-1 on thrombus formation in rat cerebral arterioles and venules in vivo were assessed using a helium-neon (He-Ne) laser. SNP infused at doses from 10 Μg/kg/h significantly inhibited thrombus formation in a dose dependent manner. This inhibition of thrombus formation was suppressed by methylene blue. SIN-1 at a dose of 100 Μg/kg/h also demonstrated a significant antithrombotic effect. Moreover, treatment with SNP increased vessel diameter in a dose dependent manner and enhanced the mean red cell velocity measured with a fiber-optic laser-Doppler anemometer microscope (FLDAM). Blood flow, calculated from the mean red cell velocity and vessel diameters was increased significantly during infusion. In contrast, mean wall shear rates in the arterioles and venules were not changed by SNP infusion. The results indicated that SNP and SIN-1 possessed potent antithrombotic activities, whilst SNP increased cerebral blood flow without changing wall shear rate. The findings suggest that the NO released by SNP and SIN-1 may be beneficial for the treatment and protection of cerebral infarction

Peak calf blood flow estimates are higher with Dohn than with Whitney plethysmograph

1996 ◽  
Vol 81 (3) ◽  
pp. 1418-1422 ◽  
Author(s):  
D. N. Proctor ◽  
J. R. Halliwill ◽  
P. H. Shen ◽  
N. E. Vlahakis ◽  
M. J. Joyner
Keyword(s):  
Blood Flow ◽  
Reactive Hyperemia ◽  
Arterial Occlusion ◽  
Venous Occlusion ◽  
Calf Blood Flow ◽  
Absolute Flow ◽  
Wide Range ◽  
Before And After ◽  
The Mean ◽  
Highly Correlated

Estimates of calf blood flow with venous occlusion plethysmography vary widely between studies, perhaps due to the use of different plethysmographs. Consequently, we compared calf blood flow estimates at rest and during reactive hyperemia in eight healthy subjects (four men and four women) with two commonly used plethysmographs: the mercury-in-silastic (Whitney) strain gauge and Dohn air-filled cuff. To minimize technical variability, flow estimates were compared with a Whitney gauge and a Dohn cuff on opposite calves before and after 10 min of bilateral femoral arterial occlusion. To account for any differences between limbs, a second trial was conducted in which the plethysmographs were switched. Resting flows did not differ between the plethysmographs (P = 0.096), but a trend toward lower values with the Whitney was apparent. Peak flows averaged 37% lower with the Whitney (27.8 +/- 2.8 ml.dl-1.min-1) than with the Dohn plethysmograph (44.4 +/- 2.8 ml.dl-1.min-1; P < 0.05). Peak flow expressed as a multiple above baseline was also lower with the Whitney (10-fold) than with the Dohn plethysmograph (14.5-fold; P = 0.02). Across all flows at rest and during reactive hyperemia, estimates were highly correlated between the plethysmographs in all subjects (r2 = 0.96-0.99). However, the mean slope for the Whitney-Dohn relationship was only 60 +/- 2%, indicating that over a wide range of flows the Whitney gauge estimate was 40% lower than that for the Dohn cuff. These results demonstrate that the same qualitative results can be obtained with either plethysmograph but that absolute flow values will generally be lower with Whitney gauges.

Hemodynamic effects of leukotriene C4 in ovine fetus

1990 ◽  
Vol 259 (6) ◽  
pp. E851-E855
Author(s):  
B. A. Meyer ◽  
S. W. Walsh ◽  
V. M. Parisi
Keyword(s):  
Blood Flow ◽  
Vena Cava ◽  
Cardiovascular Effects ◽  
In Vivo Studies ◽  
Leukotriene C4 ◽  
Blood Flows ◽  
Before And After ◽  
Placental Blood ◽  
Near Term

Leukotrienes are synthesized during pregnancy and produce cardiovascular effects in adults. We hypothesized that leukotriene C4 would cause vasoconstriction in the fetus and placenta. Eight near-term, unanesthetized ovine fetuses were studied before and after infusion of 10 micrograms leukotriene C4 (LTC4) into the fetal vena cava. Cardiovascular monitoring of maternal and fetal arterial pressures and heart rates was performed. Fetal blood flows were measured by the radioactive-microsphere technique. Sustained elevations in systolic and diastolic blood pressure and decreased fetal heart rate began by 1 min and returned to baseline by 30 min. Arterial pH fell from 7.33 +/- 0.01 to 7.29 +/- 0.01 at 15 min (P less than 0.05) and to 7.29 +/- 0.01 at 30 min (P less than 0.05), with a significant increase in base deficit from 0.7 +/- 0.7 to 3.5 +/- 0.7 at 15 min (P less than 0.05) and to 2.9 +/- 1.0 at 30 min (P less than 0.05). Fetal PO2 and PCO2 were unchanged. Significant decreases in blood flow and resistance were seen in the umbilical placental circulation as well as in fetal skeletal muscle and intestine. Blood flow and resistance were unchanged in the renal and adrenal vascular beds. Fetal administration of LTC4 caused no changes in maternal cardiovascular parameters. These findings represent the first in vivo studies of the effects of a lipoxygenase metabolite on fetal-placental blood flow.

Effect of Honey and Green Tea Solutions on Streptococcus mutans

2015 ◽  
Vol 39 (5) ◽  
pp. 435-441
Author(s):  
F Abdelmegid ◽  
M Al-Agamy ◽  
A Alwohaibi ◽  
H Ka'abi ◽  
F Salama
Keyword(s):  
Streptococcus Mutans ◽  
Green Tea ◽  
Saliva Sample ◽  
Post Intervention ◽  
Cross Sectional ◽  
Colony Forming Unit ◽  
Before And After ◽  
The Mean ◽  
Mouth Rinsing

Objectives: The aim of this cross-sectional in vivo study was to assess the effect of green tea and honey solutions on the level of salivary Streptococcus mutans. Study design: A convenient sample of 30 Saudi boys aged 7–10 years were randomly assigned into 2 groups of 15 each. Saliva sample was collected for analysis of level of S. mutans before rinsing. Commercial honey and green tea were prepared for use and each child was asked to rinse for two minutes using 10 mL of the prepared honey or green tea solutions according to their group. Saliva samples were collected again after rinsing. The collected saliva samples were prepared and colony forming unit (CFU) of S. mutans per mL of saliva was calculated. Results: The mean number of S. mutans before and after rinsing with honey and green tea solutions were 2.28* 108(2.622*108), 5.64 *107(1.03*108), 1.17*109(2.012*109) and 2.59*108 (3.668*108) respectively. A statistically significant reduction in the average number of S. mutans at baseline and post intervention in the children who were assigned to the honey (P=0.001) and green tea (P=0.001) groups was found. Conclusions: A single time mouth rinsing with honey and green tea solutions for two minutes effectively reduced the number of salivary S. mutans of 7–10 years old boys.

scholarly journals In vivo exposure for fear of pain and avoidance of movement in low back pain

2020 ◽  
Vol 73 (5) ◽  
Author(s):  
Érica Brandão de Moraes ◽  
Francisco Farias Martins Júnior ◽  
Cibele Andrucioli de Mattos-Pimenta
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Daily Living ◽  
Low Back ◽  
Fear Of Pain ◽  
Before And After ◽  
Quasi Experimental ◽  
The Mean ◽  
Fear And Anxiety

ABSTRACT Objectives: to verify the effects of hierarchization and in vivo exposure for fear of pain, avoidance of movement, and anxiety in chronic low back pain. Methods: quasi-experimental study. The 27 patients who participated graded the damage associated with the movements in each of the 40 activities of daily living depicted in pictures using a scale from 0 to 100. The patients chose five out of all the activities that received a score higher than 50 to carry out the exposure. The intensities of fear and anxiety were measured before and after each exposure session. Results: the frequencies of the gender were equal, and the mean age was 44.9 years. The activities chosen more frequently for the exposure were shoveling (33.3%) and running (33.3%). There was reduction of fear and anxiety before and after exposure (p<0.001). Conclusions: hierarchization and in vivo exposure were effective in reducing fear and anxiety.

Effects of indomethacin on PMA-induced pulmonary endothelial enzyme dysfunction in vivo

1992 ◽  
Vol 262 (2) ◽  
pp. L153-L162 ◽  
Author(s):  
X. Chen ◽  
S. E. Orfanos ◽  
J. D. Catravas
Keyword(s):  
Blood Flow ◽  
Left Lung ◽  
Substrate Utilization ◽  
Endothelial Damage ◽  
Metabolic Dysfunction ◽  
Before And After ◽  
Entire Lung ◽  
Metabolically Healthy ◽  
Microvascular Recruitment

We investigated the effects of phorbol myristate acetate (PMA) on metabolic pulmonary endothelial ectoenzyme dysfunction. Anesthetized rabbits were placed on total heart bypass, and the single-pass transpulmonary metabolism of [3H]benzoyl-Phe-Ala-Pro (BPAP) by endothelial-bound angiotensin-converting enzyme (ACE) and [14C]adenosine 5'-monophosphate (AMP) by 5'-nucleotidase (NCT) was calculated before and after PMA (10 micrograms/kg iv), a dose that does not produce histologically evident endothelial damage. Under conditions of partial microvascular recruitment (blood flow = 400 ml/min through the entire lung), PMA, but not the vehicle, significantly reduced substrate utilization of both BPAP and adenosine 5'-monophosphate (AMP) and increased the apparent Michaelis constant (Km) values of ACE for BPAP, indicative of metabolic dysfunction. These changes were completely prevented by pretreatment with indomethacin. Under conditions of near full microvascular recruitment (blood flow = 640 ml/min through the left lung only), PMA similarly reduced substrate utilization and increased the apparent Km of ACE for BPAP. In this case, however, indomethacin failed to prevent the observed PMA-induced metabolic dysfunction. We conclude that PMA alters endothelial ectoenzyme substrate metabolism independently from changes in pulmonary blood flow; indomethacin appears to antagonize the effects of PMA under conditions of partial microvascular recruitment only, perhaps by diverting flow to previously unperfused, unexposed to PMA, and hence metabolically healthy vessels.

Sodium channels are required during in vivo sodium chloride hyperosmolarity to stimulate increase in intestinal endothelial nitric oxide production

2005 ◽  
Vol 288 (1) ◽  
pp. H89-H95 ◽  
Author(s):  
Brett G. Zani ◽  
H. Glenn Bohlen
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Blood Flow ◽  
Intestinal Blood Flow ◽  
No Production ◽  
Sodium Ions ◽  
Major Mechanism ◽  
Before And After ◽  
Endothelial Nitric Oxide

NaCl hyperosmolarity increases intestinal blood flow during food absorption due in large part to increased NO production. We hypothesized that in vivo, sodium ions enter endothelial cells during NaCl hyperosmolarity as the first step to stimulate an increase in intestinal endothelial NO production. Perivascular NO concentration ([NO]) and blood flow were determined in the in vivo rat intestinal microvasculature at rest and under hyperosmotic conditions, 330 and 380 mosM, respectively, before and after application of bumetanide (Na+-K+-2Cl− cotransporter inhibitor) or amiloride (Na+/H+ exchange channel inhibitor). Suppressing amiloride-sensitive Na+/H+ exchange channels diminished hypertonicity-linked increases in vascular [NO], whereas blockade of Na+-K+-2Cl− channels greatly suppressed increases in vascular [NO] and intestinal blood flow. In additional experiments we examined the effect of sodium ion entry into endothelial cells. We proposed that the Na+/Ca2+ exchanger extrudes Na+ in exchange for Ca2+, thereby leading to the calcium-dependent activation of endothelial nitric oxide synthase (eNOS). We blocked the activity of the Na+/Ca2+ exchanger during 360 mosM NaCl hyperosmolarity with KB-R7943; complete blockade of increased vascular [NO] and intestinal blood flow to hyperosmolarity occurred. These results indicate that during NaCl hyperosmolarity, sodium ions enter endothelial cells predominantly through Na+-K+-2Cl− channels. The Na+/Ca2+ exchanger then extrudes Na+ and increases endothelial Ca2+. The increase in endothelial Ca2+ causes an increase in eNOS activity, and the resultant increase in NO increases intestinal arteriolar diameter and blood flow during NaCl hyperosmolarity. This appears to be the major mechanism by which intestinal nutrient absorption is coupled to increased blood flow.

scholarly journals Microtubules in cone myoid elongation in the teleost retina.

1978 ◽  
Vol 78 (1) ◽  
pp. 247-259 ◽  
Author(s):  
R H Warren ◽  
B Brunside
Keyword(s):  
Serial Section ◽  
Dark Adaptation ◽  
Cone Cells ◽  
Before And After ◽  
Teleost Retina ◽  
The Mean ◽  
Retinal Cone

The myoids of retinal cone cells of the blue-striped grunt (Haemulon sciurus) undergo significant elongation during dark adaptation of the retina. Longitudinally oriented microtubules are present in myoids both before and after elongation. Injection of colchicine into the vitreous of the eye in vivo disrupts the microtubules in the myoids and prevents dark-adaptive myoid elongation. Counts of microtubules in transverse sections along the lengths of elongating myoids show that there is a uniform decrease in the number of microtubules at any one point along the myoid as the myoid elongates. The magnitude of the decrease is proportional to the extent of the elogation. The product of the mean myoid microtubule number (determined from counts at progressive intervals along the myoid) and the myoid length remains essentially constant during myoid elongation, indicating that the total quantity of microtubules in the myoid does not increase with elogation. Serial section tracings of the microtubules along the myoids suggest that individual microtubules do not extend the length of the myoid and that the myoid microtubular apparatus consists of bundles of overlapping shorter microtubules. We propose that elongation of the myoid is accompanied by sliding redistribution of microtubules along the length of the myoid, and that the sliding may be generated by interaction between microtubules in regions where they closely overlap in bundles. We find no evidence for the involvement of discrete, electron-dense microtubular organizing centers in myoid elogation.

scholarly journals Cerebral Blood Flow and Brain Oxygenation in Rats Breathing Oxygen under Pressure

2005 ◽  
Vol 25 (10) ◽  
pp. 1288-1300 ◽  
Author(s):  
Ivan T Demchenko ◽  
Yuriy I Luchakov ◽  
Alexander N Moskvin ◽  
Diana R Gutsaeva ◽  
Barry W Allen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Platinum Electrodes ◽  
Brain Oxygenation ◽  
Before And After ◽  
Scatter Plots ◽  
Opposing Effects ◽  
Breathing Room

Hyperbaric oxygen (HBO2) increases oxygen tension (PO2) in blood but reduces blood flow by means of O2-induced vasoconstriction. Here we report the first quantitative evaluation of these opposing effects on tissue PO2 in brain, using anesthetized rats exposed to HBO2 at 2 to 6 atmospheres absolute (ATA). We assessed the contribution of regional cerebral blood flow (rCBF) to brain PO2 as inspired PO2 (PiO2) exceeds 1 ATA. We measured rCBF and local PO2 simultaneously in striatum using collocated platinum electrodes. Cerebral blood flow was computed from H2 clearance curves in vivo and PO2 from electrodes calibrated in vitro, before and after insertion. Arterial PCO2 was controlled, and body temperature, blood pressure, and EEG were monitored. Scatter plots of rCBF versus pO2 were nonlinear ( R2 = 0.75) for rats breathing room air but nearly linear ( R2 = 0.88–0.91) for O2 at 2 to 6 ATA. The contribution of rCBF to brain PO2 was estimated at constant inspired PO2, by increasing rCBF with acetazolamide (AZA) or decreasing it with N-nitro-l-arginine methyl ester (l-NAME). At basal rCBF (78 mL/100 g min), local PO2 increased 7- to 33-fold at 2 to 6 ATA, compared with room air. A doubling of rCBF increased striatal PO2 not quite two-fold in rats breathing room air but 13- to 64-fold in those breathing HBO2 at 2 to 6 ATA. These findings support our hypothesis that HBO2 increases PO2 in brain in direct proportion to rCBF.

scholarly journals Effect of Phototherapy on Stroke Volume in Newborn Infants with Jaundice

2020 ◽  
Vol 09 (03) ◽  
pp. 207-209
Author(s):  
Majid Firouzi ◽  
Hamidreza Sherkatolabbasieh ◽  
Alireza Nezami ◽  
Shiva Shafizadeh
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Ejection Fraction ◽  
Stroke Volume ◽  
Newborn Infants ◽  
Before And After ◽  
The Mean

AbstractOne of the rare complications associated with phototherapy include redistribution of blood flow that can alter cardiac output in infants. The aim of this study was to evaluate the effects of phototherapy on left ejection fraction in infants with jaundice. Twenty-nine infants admitted in Shahid Madani Children Hospital for receiving phototherapy were included in this study. Echocardiography was performed in the participants, immediately before and 24 hours after the treatment. Nineteen infants were reported to have decrease in the stroke volume following the treatment. The mean levels of stroke volume before and after phototherapy were 6.99 ± 2.17 and 6.55 ± 1.85 L/m2, respectively (p = 0.011). Phototherapy can reduce left ejection fraction in newborn infants with hyperbilirubinemia.

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