Diagnostic Value of 3.0T MRI in Cartilage Injury Grading of Knee Osteoarthritis

2020 ◽  
Vol 10 (12) ◽  
pp. 2979-2984
Author(s):  
Xiaoming Zhang ◽  
Haiyang Tong ◽  
Jin Zhang ◽  
Jinyong Xu ◽  
Shiyong Xia
Keyword(s):  
Articular Cartilage ◽  
Knee Osteoarthritis ◽  
Femoral Condyle ◽  
Cartilage Volume ◽  
Cartilage Thickness ◽  
Signal Value ◽  
Tibial Condyle ◽  
Injury Grade ◽  
The Difference ◽  
Femur Condyle

Objective: At present, the grading diagnosis of knee osteoarthritis is mostly subjective evaluation, and lack of quantitative criteria, which brings some difficulty to diagnosis. To solve this problem, this study selected easily quantifiable indicators, such as cartilage thickness, cartilage volume and signal value, and analyzes their application value in grading diagnosis of cartilage injury by observing their change characteristics under MRI. Methods: Clinical data were collected from 54 patients with osteoarthritis of the knee (KOA) and 12 healthy volunteers, including 27 males and 39 females; age 38–63 years, with an average age of 47 ± 6.9 years. A total of 110 knee joints were tested, including 86 affected and 24 healthy joints. MRI data were collected, including patella, medial and lateral femoral condyle, medial and lateral tibial condyle, and for grading. The results were compared with those of arthroscopy to analyze the consistency of the two diagnostic methods. The 110 knee joints were divided into 5 groups according to the arthroscopic grading (0–IV grade), and compare the differences of cartilage thickness, cartilage volume and signal value under MRI among groups. Result: Among them, in terms of MRI grading, there were 15 cases of I grade, 21 cases of II grade, 26 cases of III grade, and 24 cases of IV grade. In terms of arthroscopy grading, there were 16 cases of I grade, 23 cases of II grade, 25 cases of III grade, and 22 cases of IV grade. The kappa value of the two diagnostic methods was 0.91, with high consistency (P < 0.01). According to the results of arthroscopic grading diagnosis and analysis of the corresponding MRI data, it was found that the average thickness of normal articular cartilage in the patella, lateral tibia condyle, medial tibia condyle, lateral femur condyle, medial femur condyle is gradually thinning, and the thickness of articular cartilage in each part gradually thinned with the increase of injury grade. The difference between I grade and 0 grade was not statistically significant, and except for that, among other groups there were statistically significant (P < 0.01); The volume of normal articular cartilage decreased from medial femoral condyle, lateral femoral condyle, patella, lateral tibial condyle and medial tibial condyle in turn, and the volume decreased gradually with the increase of injury grade. Except for the difference between I grade and 0 grade, there were statistical significance between other groups (P < 0.01); signal value of normal articular cartilage decreased from medial tibial condyle, lateral femur condyle, medial femur condyle, lateral tibial condyle and patella in turn. Signal value increased with the increase of injury grade. Except for the difference between III grade and IV grade, there were statistical significance between other groups (P < 0.01). Conclusion : MRI grading of cartilage injury in knee osteoarthritis is highly consistent with arthroscopy, with high accuracy. In MRI grading, reference to cartilage thickness, cartilage volume and signal value can effectively improve the diagnosis rate.

scholarly journals Efficacy and safety of sprifermin injection for knee osteoarthritis treatment: a meta-analysis

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Ni Zeng ◽  
Xin-Yuan Chen ◽  
Zhi-Peng Yan ◽  
Jie-Ting Li ◽  
Tao Liao ◽  
...  
Keyword(s):  
Adverse Events ◽  
Knee Osteoarthritis ◽  
Meta Analysis ◽  
Placebo Treatment ◽  
Cartilage Volume ◽  
Cartilage Thickness ◽  
Random Effects Models ◽  
Structural Progression ◽  
Significant Difference ◽  
Mean Differences

Abstract Objective To perform a meta-analysis comparing the structural progression and clinical symptom outcomes as well as adverse events experienced from intra-articular injections of sprifermin compared to a placebo treatment for patients with knee osteoarthritis (KOA). Method We systematically searched the literature for studies that compared long-term outcomes between sprifermin and placebo injections for KOA treatment. Meta-analysis was performed with RevMan5.3 using an inverse variance approach with fixed or random effects models. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. Results Eight studies were included. Overall, there was significantly less improvement of WOMAC total scores in patients receiving sprifermin, compared with the placebo (mean difference (MD) = 3.23, 95% CI 0.76–5.69; I2 = 0%; P = 0.01). Further, sprifermin injection patients gained more, and lost less, cartilage thickness and volume in total femorotibial joint (cartilage thickness: standardized mean differences (SMD) = 0.55, 95% CI 0.26–0.84; I2 = 78%; P = 0.0002; cartilage volume: SMD = 0.39, 95% CI 0.20–0.58; I2 = 49%; P < 0.0001). Changes in the cartilage surface morphology of the medial tibio-femoral joint (MD = −0.30, 95% CI −0.44 to −0.16; I2 = 0%; P < 0.0001) and patello-femoral joint (MD = −0.22; 95% CI −0.37 to −0.07; I2 = 0%; P = 0.004) showed a significant difference between the sprifermin and placebo injections. Moreover, there were no significant differences between sprifermin and the placebo in the risk of treatment-emergent adverse events (OR = 1.05; 95% CI 0.52–2.14; I2 = 48%; P = 0.89). Conclusion The data from the included studies provide strong evidence to determine the effect of intra-articular sprifermin on joint structure in individuals with KOA and show no specific adverse effects. Nevertheless, intra-articular sprifermin did not likely have any positive effect on symptom alleviation.

scholarly journals ARTICULAR CARTILAGE THICKNESS OF THE PEDIATRIC KNEE: IMPLICATIONS FOR CARTILAGE IMPLANTATIONS

2019 ◽  
Vol 7 (3_suppl) ◽  
pp. 2325967119S0018
Author(s):  
Audrey Rustad ◽  
Nicolas G. Anchustegui ◽  
Stockton Troyer ◽  
Cooper Shea ◽  
Aleksei Dingel ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Tibial Plateau ◽  
Femoral Condyle ◽  
Ct Images ◽  
Cartilage Thickness ◽  
Coronal Plane ◽  
Average Thickness ◽  
Text Figure ◽  
Pediatric Knee ◽  
Femoral Condyles

Background: While access to pediatric tissue for cartilage conditions is limited, recent research on the use of pediatric cartilage tissue for implantation has shown promising results. These pediatric grafts may include bulk osteochondral allografts, morselized cartilage, or cellular manipulation products. The purpose of this study was to evaluate the parameters of cartilage thickness in different regions of the pediatric knee from a larger pediatric knee specimen research database. Methods: CT Scans of 12 skeletally immature knees ranging from ages 7 to 11 were evaluated. Cartilage thickness measurements were taking in the following regions: 1. Femoral Condyles - Cahill Zones 1, 2, 4, and 5 (Fig. 1) on coronal plane CT images, the region of greatest cartilage thickness on medial and lateral femoral condyles using coronal plane CT images, and Cahill Zones A, B, and C on sagittal plane CT images (Fig. 2). 2. Tibial Plateau – the region of greatest cartilage thickness identified on the medial and lateral sides of the tibial plateau using coronal plane CT images (Fig. 1). 3. Patella – the region of greatest cartilage thickness identified on axial and sagittal CT images (Fig. 3 and 4). Results: The cartilage on the medial femoral condyle had an average thickness of 4.86 mm ± 0.61 mm at its thickest point and the cartilage on lateral femoral condyle had an average thickness of 3.71 mm ± 0.52 mm at its thickest point. The cartilage on the medial tibial plateau had an average thickness of 2.80 mm ± 0.26 mm at its thickest point and the cartilage on the lateral tibial plateau had an average thickness of 3.29 mm ± 0.45 mm at its thickets point. The cartilage on the midpoints of Cahill zones 1, 2, 3, and 4 had an average thickness of 2.93 mm ± 0.62 mm, 3.42 mm ± 0.66 mm, 2.81 mm ± 0.46 mm, and 3.30 mm ± 0.73 mm respectively. The cartilage on the midpoints of Cahill zones A, B, and C had an average thickness of 3.81 mm ± 0.68 mm, 4.40 mm ± 0.49 mm, and 3.82 mm ± 0.68 mm respectively. The cartilage at its thickest point on the patella had an average thickness of 4.53 mm ± 0.38 mm from an axial view and 4.40 mm ± 0.49 mm from a sagittal view (Fig. 5 and 6). Conclusion: Pediatric knees demonstrate relatively thick cartilage regions in multiple zone of the knee, compared with adult specimens. Increasing access to and use of this tissue for cartilage grafts, non-manipulated tissue, and manipulated tissue offer significant opportunity to address cartilage loss. Osteochondral allograft procedures may benefit from access to such tissue, with relatively high volume and thickness of normal articular cartilage. [Figure: see text][Figure: see text][Figure: see text][Figure: see text][Figure: see text][Figure: see text]

scholarly journals PO-034 Effect of Voluntary Exercise on Cartilage Morphology of Knee Osteoarthritis in Obese Mice Induced by High-fat Diet

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Wenhao Zong ◽  
Yang Liu ◽  
Lulu Dai ◽  
Guijun Dong
Keyword(s):  
Articular Cartilage ◽  
Knee Osteoarthritis ◽  
High Fat Diet ◽  
Wheel Running ◽  
Cartilage Thickness ◽  
Obese Mice ◽  
High Fat ◽  
Voluntary Wheel Running ◽  
Running Exercise ◽  
Voluntary Wheel

Objective To examine the effect of voluntary wheel-running exercise on cartilage morphology of knee osteoarthritis(KOA) in obese mice induced by high-fat diet,and explore the protective role of 4 weeks voluntary wheel-running exercise on KOA,finally providing effective experimental evidence for clinical treatment of knee osteoarthritis. Methods C57BL/6J mice were randomly assigned to the C-Sed group,C-Ex group,HF-Sed group and HF-Ex group.The control groups were fed a control diet(13.5% kcal from fat),and the high-fat groups were fed a high-fat diet(60% kcal from fat).After feeding 8 weeks different diets,the exercise groups were starting running.In order to examine the effect of voluntary wheel-running exercise on cartilage morphology of KOA,the joint of knee were harvested to be fixed,decalcified and embedded in paraffin,and the four-micrometer-thick sections were stained with both HE and toluidine blue . Results After feeding twelve weeks different diets,the body mass of the high-fat diet group mice has a significant increase,which demonstrates that high-fat diet could successfully induce the mice obese.From the results of HE and toluidine blue,in comparison to the C-Sed group,the surface of the knee articular cartilage in the HF-Sed group was not intact and smooth,and the thickness of articular cartilage has a significant decrease（p<0.001）;contrary to the HF-Sed group,the surface of the knee articular cartilage in HF-Ex group was slightly smooth,and there was significant increase in cartilage thickness. Conclusions Four weeks voluntary wheel-running exercise can increase cartilage thickness ,decrease the Mankin’s score and delay the degeneration of knee cartilage in obese mice.To conclude,the short-term wheel-running exercise protects against obesity-induced KOA.

scholarly journals Thickness of the Stifle Joint Articular Cartilage in Different Large Animal Models of Cartilage Repair and Regeneration

Cartilage ◽  
2020 ◽  
pp. 194760352097676 ◽  
Author(s):  
Tina Ruediger ◽  
Victoria Horbert ◽  
Anne Reuther ◽  
Pavan Kumar Kalla ◽  
Rainer H. Burgkart ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Animal Models ◽  
Cartilage Repair ◽  
Femoral Condyle ◽  
Cartilage Thickness ◽  
Large Animal ◽  
3 Dimensional ◽  
Large Animal Models ◽  
Stifle Joint ◽  
Regulatory Guidelines

Objective Regulatory guidelines for preclinical cartilage repair studies suggest large animal models (e.g., sheep, goat, [mini]-pig, or horse) to obtain results representative for humans. However, information about the 3-dimensional thickness of articular cartilage at different implantation sites in these models is limited. Design To identify the most suitable site for experimental surgery, cartilage thickness at the medial femoral condyle (MFC), lateral femoral condyle (LFC), and trochlea in ovine, caprine, and porcine cadaver stifle joints was systematically measured using hematoxylin-eosin staining of 6 µm paraffin sections and software-based image analysis. Results Regarding all ventral-dorsal regions of the MFC, goat showed the thickest articular cartilage (maximal mean thickness: 1299 µm), followed by sheep (1096 µm) and mini-pig (604 µm), with the highest values in the most ventral and dorsal regions. Also for the LFC, the most ventral regions showed the thickest cartilage in goat (maximal mean thickness: 1118 µm), followed by sheep (678 µm) and mini-pig (607 µm). Except for the mini-pig, however, the cartilage thickness on the LFC was consistently lower than that on the MFC. The 3 species also differed along the transversal measuring points on the MFC and LFC. In contrast, there were no consistent differences for the regional cartilage thickness of the trochlea among goat and sheep (≥780 µm) and mini-pig (≤500 µm). Conclusions Based on their cartilage thickness, experimental defects on goat and sheep MFC may be viable options for preclinical cartilage repair studies, in addition to well-established horse models.

scholarly journals The Association between Dietary Magnesium Intake and Magnetic Resonance Parameters for Knee Osteoarthritis

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1387 ◽  
Author(s):  
Nicola Veronese ◽  
Luciana La Tegola ◽  
Maria Gabriella Caruso ◽  
Stefania Maggi ◽  
Giuseppe Guglielmi
Keyword(s):  
Knee Osteoarthritis ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Cartilage Volume ◽  
Cartilage Thickness ◽  
Cross Sectional ◽  
Knee Oa ◽  
Dietary Magnesium ◽  
Magnetic Resonance Parameters ◽  
Osteoarthritis Initiative

The aim of the study was to evaluate the relationship between dietary magnesium (Mg) intake and prevalence of knee osteoarthritis (OA), a topic poorly explored in the literature. Overall, 783 people participating in the Osteoarthritis Initiative (59.8% females; mean age: 62.3 years) and having an MRI assessment were enrolled in this cross-sectional study. Mg intake was measured with a semi-quantitative food frequency questionnaire, and its association with knee OA was evaluated for an increased intake of 100 mg/day. Using an adjusted linear regression analysis, a higher Mg intake (i.e., increase of 100 mg/day) corresponded to a significant increase in mean cartilage thickness, cartilage volume at medial tibia, cartilage volume and mean cartilage thickness at central medial femur, and cartilage volume and mean cartilage thickness in the central medial tibiofemoral compartment. In conclusion, an increased Mg dietary intake is associated with a better knee cartilage architecture, also when adjusting for potential confounders, suggesting a potential role of Mg in the prevention and treatment of knee OA.

The articular cartilage preservative effects of genistein in an experimental model of knees osteoarthritis

2021 ◽  
Author(s):  
Xiangjun Cheng ◽  
Peilian Xu
Keyword(s):  
Articular Cartilage ◽  
Knee Osteoarthritis ◽  
Experimental Model ◽  
Femoral Condyle ◽  
Cartilage Damage ◽  
Control Group ◽  
Articular Cartilage Damage ◽  
Genistein Treatment ◽  
Male Wistar Rats ◽  
Monosodium Iodoacetate

The study aimed to investigate the preservative effects of genistein on articular cartilage in an experimental model of knee osteoarthritis in rats. Thirty male Wistar rats were assigned to three equal groups: the sham group (SG), osteoarthritis control group (OAG), and genistein-treated osteoarthritis group (GTG). Intra-articular injections of monosodium iodoacetate were used for osteoarthritis induction. After two weeks of rest for the induction of the inflammatory process, genistein (30 mg/kg/day) vs. saline gavage was administered for eight weeks. The expression of matrix metalloproteinase (MMP) 8 and 13, Sox5/Sox6, Indian hedgehog (IHH), and Col2 were evaluated in medial femoral condyle sections by immunohistochemical staining. The number of chondrocytes and cartilage thicknesses were also measured and compared among the groups. No significant change in cartilage thickness was observed in GTG compared with OAG (p=0.188). Chondrocyte count was significantly higher in the articular cartilage of GTG compared with OAG (p=0.006). Induction of OA significantly increased the expression of MMP-8, MMP-13, and IHH, but decreased Col2, Sox5, and Sox6 expression (p<0.001); these were partially prevented in the GTG. Our findings support the effectiveness of genistein treatment in the prevention of articular cartilage damage in the experimental model of knee osteoarthritis. The proposed mechanism of action is through the suppression of the MMP, IHH, Col2 pathways, besides the induction of Sox5 and Sox6 expression. Novelty: -Genistein prevent articular cartilage damage in the experimental model of knee osteoarthritis. -The osteoprotective effect is trough modulation of expression of MMP, Sox, IHH, and Col2 proteins.

A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee

2006 ◽  
Vol 19 (03) ◽  
pp. 142-146 ◽  
Author(s):  
D. D. Frisbie ◽  
M. W. Cross ◽  
C. W. McIlwraith
Keyword(s):  
Articular Cartilage ◽  
Subchondral Bone ◽  
Clinical Studies ◽  
Femoral Condyle ◽  
Cartilage Thickness ◽  
Bone Plate ◽  
Subchondral Bone Plate ◽  
Femoral Trochlea ◽  
Human Knee ◽  
Calcified Cartilage

SummaryHistological measurements of the thickness of non-calcified and calcified cartilage, as well as the subchondral bone plate in five locations on the femoral trochlea and medial femoral condyles of species were used in preclinical studies of articular cartilage and compared to those of the human knee. Cadaver specimens were obtained of six human knees, as well as six equine, six goat, six dog, six sheep and six rabbit stifle joints (the animal equivalent of the human knee). Specimens were taken from the lateral trochlear ridge, medial trochlear ridge and medial femoral condyle. After histopathological processing, the thickness of non-calcified and calcified cartilage layers, as well as the subchondral bone plate, was measured. Average articular cartilage thickness over five locations were 2.2–2.5 mm for human, 0.3 mm for rabbit, 0.4–0.5 mm for sheep, 0.6–1.3 mm for dog, 0.7–1.5 mm for goat and 1.5–2 mm for horse. The horse provides the closest approximation to humans in terms of articular cartilage thickness, and this approximation is considered relevant in pre-clinical studies of cartilage healing.

scholarly journals ARTICULAR CARTILAGE THICKNESS IN PEDIATRIC AND ADOLESCENT KNEES DECREASES WITH AGE AND SKELETAL MATURITY: IMPLICATIONS FOR OSTEOCHONDRAL GRAFTING PROCEDURES

2020 ◽  
Vol 8 (4_suppl3) ◽  
pp. 2325967120S0019
Author(s):  
Sreetha Sidharthan ◽  
Annie Yau ◽  
Bryan Aristega Almeida ◽  
Kevin G. Shea ◽  
Kristofer J. Jones ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Linear Regression ◽  
Skeletal Maturity ◽  
Femoral Condyle ◽  
Cartilage Thickness ◽  
Medial Femoral Condyle ◽  
Lateral Femoral Condyle ◽  
Cartilage Restoration ◽  
Text Figure ◽  
Mri Scans

Background: Quantifying native cartilage thickness in pediatric and adolescent knees can help match donor and recipient sites for articular cartilage restoration procedures such as osteochondral autograft transplantation (OATS) and osteochondral allograft transplantation (OCA). Hypothesis/Purpose: The purpose of the current study was to quantify articular cartilage thickness in pediatric and adolescent knees using magnetic resonance imaging (MRI). We hypothesized that cartilage thickness is inversely correlated with skeletal maturity and age. Methods: One hundred and twenty MRI scans were evaluated in a cohort of patients 9 to 18 years old without osteochondral lesions, chondral wear or pathology, intraarticular fractures, history of knee surgery, or inflammatory arthropathy. Measurements of articular cartilage thickness at the medial femoral condyle, lateral femoral condyle, lateral trochlea, and patella were made on axial, coronal, and sagittal MRI scans (Figure 1). Skeletal maturity was categorized as ‘open’, ‘closing’, or ‘closed’ based on the status of the proximal tibial and distal femoral growth plates. Descriptive statistics was used to evaluate cartilage thickness by age and sex. Independent samples t-test, analysis of variance (ANOVA), and linear regression were performed to investigate for associations with sex, skeletal maturity, and age. Results: On the femur, cartilage was thickest at the lateral trochlea with mean articular thickness of 4.2 ± 1.4 mm in males and 3.6 ± 1.3 mm in females ( p=0.015) (Table 1). Skeletally immature patients with open physes had significantly thicker cartilage at the medial femoral condyle, lateral femoral condyle, and lateral trochlea compared to patients with closing and closed physes (Figure 2). Linear regression analysis also revealed a significant association between femoral cartilage thickness and age (Figure 3). Age explained 63% of the variance at the medial femoral condyle (B=6.1, p<0.001), 64% of the variance at the lateral femoral condyle (B=4.9, p<0.001), and 68% of the variance at the lateral trochlea (B=8.2, p<0.001) (Table 2). In contrast, cartilage thickness at the patella did not significantly vary by age, sex, or skeletal maturity (Figures 2 and 4). Conclusion: There is a strong inverse association between increasing age and cartilage thickness of the femoral condyles and lateral trochlea. In particular, pediatric knees demonstrate relatively thick cartilage at the lateral trochlea that decreases with age. This information will help surgeons understand recipient site anatomy and identify appropriate donor site tissue for articular cartilage restoration procedures such as OATS and OCA in children and adolescents. Tables: [Table: see text][Table: see text] Figures: [Figure: see text][Figure: see text][Figure: see text][Figure: see text]

Sign in / Sign up

Export Citation Format

Share Document