Effects of Sizes and Anisotropy Constants of Magnetic Nanoparticles on Hyperthermia Temperature Increase with Time

2021 ◽  
Vol 13 (4) ◽  
pp. 718-723
Author(s):  
Dongkai Qiao ◽  
Yu Deng ◽  
Chia-Chieh Ho ◽  
Ching-Yen Ho ◽  
Bor-Chyuan Chen ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Experimental Data ◽  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Temperature Variation ◽  
Temperature Rise ◽  
Temperature Increase ◽  
Normal Tissue ◽  
Anisotropy Constant ◽  
Hysteresis Heat

Cancer cells can be killed by magnetic-nanoparticles-induced hysteresis heat under an external alternating magnetic field. However, the hysteresis heat-induced temperature must be precisely controlled to prevent damages to the ambient normal tissue from cancer cells. Therefore, this study employs a heat model to analyze the variation of temperature with time in magnetic nanoparticles within cancer. Results show that the temperature increase with time predicted from this study is consistent with the available experimental data. The effect of anisotropy constant on temperature rise with time is presented. The anisotropy constant makes the behaviours of temperature variation significantly different.

Temperature Measurements of a Gold Nanosphere Solution in Response to Light-Induced Hyperthermia

2013 ◽  
Author(s):  
Jun Kai Wong ◽  
Robert Taylor ◽  
Sungchul Baek ◽  
Yasitha Hewakuruppu ◽  
Xuchuan Jiang ◽  
...  
Keyword(s):  
Experimental Data ◽  
Thermal Treatment ◽  
Light Intensity ◽  
Cancer Cells ◽  
High Power ◽  
Temperature Rise ◽  
Plasmon Resonance ◽  
Resonance Wavelength ◽  
Set Up ◽  
Lamp Source

Gold nanospheres (GNSs), biocompatible nanoparticles that can be designed to absorb visible and near-infrared light, have shown great potential in induced thermal treatment of cancer cells via Plasmonic Photothermal Therapy (PPTT) [3]. In this study, light induced heating of a water-based dispersion of 20 nm diameter GNSs was investigated at their plasmon resonance wavelength (λ = 520 nm). Temperature changes of the solution at the point of light irradiation were measured experimentally. A heat transfer model was used to verify the experimental data. The effect of two key parameters, light intensity and particle concentration, on the solution’s temperature was investigated. The experimental results showed a significant temperature rise of the GNS solution compared to de-ionized water. The temperature rise of GNS solution was linearly proportional to the concentration of GNS (from 0.25–1.0 C, C = 1×1013 particles per ml) and the light intensity (from 0.25 to 0.5 W cm−2). The experimental data matches the modeling results adequately. Overall, it can be concluded that the hyperthermic ablation of cancer cells via GNS can be achieved by controlled by the light intensity and GNS concentration. A novel component of this study is that a high power lamp source was used instead of a high power laser. This means that only low cost components were used in the current experimental set-up. Moreover, by using suitable filters and white light from the high power lamp source, it is possible to obtain light in many wavelength bands for the study of other nanoparticles with different plasmon wavelength ranges. The current results represtent just one example in this versatile experimental set-up developed. It should be noted, however, the plasmon resonance wavelength used in this study is not within the therapeutic window (750–1300 nm) [13]. Therefore, the GNSs used in this experiment are only applicable to the surface induced thermal treatment of cancer cells, for instance, in the skin.

scholarly journals Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy

Nanoscale ◽  
2015 ◽  
Vol 7 (39) ◽  
pp. 16470-16480 ◽  
Author(s):  
Hyun-Chul Kim ◽  
Eunjoo Kim ◽  
Sang Won Jeong ◽  
Tae-Lin Ha ◽  
Sang-Im Park ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Synergistic Effect ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Magnetic Nanoparticle ◽  
Polymeric Micelles ◽  
Alternating Magnetic Field ◽  
Rapid Release

The cytotoxicity of magnetic nanoparticles-conjugated polymeric micelles encapsulated with an anticancer drug on cancer cells was enhanced by the synergistic effect of heat and the rapid release of the drug under an alternating magnetic field.

Biodegradation of Nanoparticles in a Body from Mössbauer and Magnetization Measurements

2012 ◽  
Vol 190 ◽  
pp. 725-728 ◽  
Author(s):  
Mikhail Chuev ◽  
Valery Cherepanov ◽  
Maxim P. Nikitin ◽  
Mikhail Polikarpov
Keyword(s):  
Magnetic Field ◽  
Experimental Data ◽  
Magnetic Nanoparticles ◽  
External Magnetic Field ◽  
Chemical Transformation ◽  
Living Organism ◽  
Quantitative Information ◽  
Spectral Shape ◽  
Magnetization Curves ◽  
Field Dependent

In order to extract a quantitative information about characteristics of the magnetic nanoparticles injected into a living organism one has to define a model of the magnetic dynamics in order to fit self-consistently the whole set of the experimental data, particularly, the evolution of Mössbauer spectral shape with temperature and external magnetic field as well as the magnetization curves. We have developed such a model and performed such an analysis of the temperature-and magnetic field-dependent spectra and magnetization curves of nanoparticles injected into a mice. This allowed us to reliably evaluate changes in the residual nanoparticles characteristics and their chemical transformation to paramagnetic ferritin-like forms in different mouses organs as a function of time after injection of nanoparticles. Actually, the approach allows one to quantitatively characterize biodegradation and biotransformation of magnetic nanoparticles injected into a body.

Nonlinear Temperature Characteristics in Magnetic Nanoparticles Due to Alternating Magnetic Field-Induced Hysteresis Heat

2018 ◽  
Vol 10 (10) ◽  
pp. 1484-1488 ◽  
Author(s):  
Ching-Yen Ho ◽  
Bor-Chyuan Chen ◽  
Song-Feng Wan ◽  
Long-Gen Li ◽  
Si-Li Fan ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Alternating Magnetic Field ◽  
Temperature Characteristics ◽  
Nonlinear Temperature ◽  
Hysteresis Heat

scholarly journals Detection of breast cancer cells using targeted magnetic nanoparticles and ultra-sensitive magnetic field sensors

2011 ◽  
Vol 13 (5) ◽  
Author(s):  
Helen J Hathaway ◽  
Kimberly S Butler ◽  
Natalie L Adolphi ◽  
Debbie M Lovato ◽  
Robert Belfon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Magnetic Field Sensors

Polyaniline shell cross-linked Fe3O4 magnetic nanoparticles for heat activated killing of cancer cells

2014 ◽  
Vol 43 (32) ◽  
pp. 12263-12271 ◽  
Author(s):  
Suman Rana ◽  
Neena V. Jadhav ◽  
K. C. Barick ◽  
B. N. Pandey ◽  
P. A. Hassan
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Fe3o4 Magnetic Nanoparticles ◽  
Ac Magnetic Field

Enhancement in heat activated killing of cancer cells under an AC magnetic field using polyaniline shell cross-linked Fe3O4 magnetic nanoparticles.

scholarly journals In Vivo Cancer Cells Elimination Guided by Aptamer-Functionalized Gold-Coated Magnetic Nanoparticles and Controlled with Low Frequency Alternating Magnetic Field

Theranostics ◽  
2017 ◽  
Vol 7 (13) ◽  
pp. 3326-3337 ◽  
Author(s):  
Irina V. Belyanina ◽  
Tatiana N. Zamay ◽  
Galina S. Zamay ◽  
Sergey S. Zamay ◽  
Olga S. Kolovskaya ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Low Frequency ◽  
Alternating Magnetic Field

Resveratrol as an Adjuvant for Normal Tissues Protection and Tumor Sensitization

2020 ◽  
Vol 20 (2) ◽  
pp. 130-145 ◽  
Author(s):  
Keywan Mortezaee ◽  
Masoud Najafi ◽  
Bagher Farhood ◽  
Amirhossein Ahmadi ◽  
Dheyauldeen Shabeeb ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Clinical Studies ◽  
Normal Tissue ◽  
Medical Science ◽  
Treatment Modalities ◽  
Radiation Toxicity ◽  
Normal Tissues ◽  
Normal Tissue Toxicity

Cancer is one of the most complicated diseases in present-day medical science. Yearly, several studies suggest various strategies for preventing carcinogenesis. Furthermore, experiments for the treatment of cancer with low side effects are ongoing. Chemotherapy, targeted therapy, radiotherapy and immunotherapy are the most common non-invasive strategies for cancer treatment. One of the most challenging issues encountered with these modalities is low effectiveness, as well as normal tissue toxicity for chemo-radiation therapy. The use of some agents as adjuvants has been suggested to improve tumor responses and also alleviate normal tissue toxicity. Resveratrol, a natural flavonoid, has attracted a lot of attention for the management of both tumor and normal tissue responses to various modalities of cancer therapy. As an antioxidant and anti-inflammatory agent, in vitro and in vivo studies show that it is able to mitigate chemo-radiation toxicity in normal tissues. However, clinical studies to confirm the usage of resveratrol as a chemo-radioprotector are lacking. In addition, it can sensitize various types of cancer cells to both chemotherapy drugs and radiation. In recent years, some clinical studies suggested that resveratrol may have an effect on inducing cancer cell killing. Yet, clinical translation of resveratrol has not yielded desirable results for the combination of resveratrol with radiotherapy, targeted therapy or immunotherapy. In this paper, we review the potential role of resveratrol for preserving normal tissues and sensitization of cancer cells in combination with different cancer treatment modalities.

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