Relationship Between Retinal Layer Thickness and Focal Macular Electroretinogram Components After Epiretinal Membrane Surgery

Purpose We investigated the correlation between visual acuity (VA) and individual retinal layer thickness in the foveal, parafoveal, and perifoveal regions of patients with an idiopathic epiretinal membrane (ERM). Methods One hundred and five subjects presenting with unilateral idiopathic ERM were included in this study. We segmented each patient’s optical coherence tomography (OCT) image into seven layers and calculated the mean layer thickness in the foveal, parafoveal, and perifoveal regions using the Iowa Reference Algorithm. In 105 patients with ERM, we detected correlations between their macular regions’ individual retinal layer thickness and their best corrected VA. Thirty-one of the 105 patients with ERM underwent vitrectomy and completed six months of follow-up. We then compared the 31 surgical patients’ preoperative and postoperative individual retinal layer thickness in each macular region. Additionally, the association between preoperative individual retinal layer thickness in each macular region and VA six months post-surgery in patients with ≥ two Snellen lines of visual improvement was determined. Results Multiple linear regression analysis showed that the inner nuclear layer (INL) thickness in the foveal, parafoveal, and perifoveal region were all associated with VA in the 105 patients (R2 = 0.344, P < 0.001; R2 = 0.427, P < 0.001; and R2 = 0.340, P < 0.001, respectively). Thirty-one surgical patients 6 months post-surgery showed significantly decreased thicknesses (P ≤ 0.012) of the foveal INL, inner plexiform layer (IPL), and outer nuclear layer (ONL); the parafoveal retina nerve fiber layer (RNFL), IPL, INL, and ONL; and the perifoveal RNFL, IPL, INL, ganglion cell layer (GCL), outer plexiform layer (OPL), and photoreceptor layer (PRL). We found a weak correlation between postoperative VA and preoperative foveal and perifoveal RNFL thickness (r = 0.404 and r = 0.359, respectively), and a moderate correlation between postoperative VA and preoperative foveal and parafoveal INL thickness (r = 0.529 and r = 0.583, respectively) in the 31 surgical patients (P ≤ 0.047). The preoperative INL thickness in the foveal, parafoveal, and perifoveal regions showed a moderate to strong correlation (r = 0.507, 0.644, and 0.548, respectively), with postoperative VA in patients with ≥ 2 lines of visual improvement (P ≤ 0.038). Conclusion We detected a correlation between retinal damage and VA in the parafoveal, perifoveal, and foveal regions. Our results suggest that INL thickness in all macular regions may be a prognostic factor for postoperative VA in ERM patients.

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Long-Term Outcome of Epiretinal Membrane Surgery in Patients with Internal Limiting Membrane Dehiscence

Journal of Clinical Medicine ◽

10.3390/jcm9082470 ◽

2020 ◽

Vol 9 (8) ◽

pp. 2470

Author(s):

Min-Woo Lee ◽

Il Jung ◽

Yong-Yeon Song ◽

Seung-Kook Baek ◽

Young-Hoon Lee

Keyword(s):

Layer Thickness ◽

Surgical Outcomes ◽

Epiretinal Membrane ◽

Internal Limiting Membrane ◽

Common Finding ◽

Retinal Layer ◽

Term Outcome ◽

Long Term Outcome ◽

Factors Affecting ◽

Group 1

Purpose: To identify the effect of internal limiting membrane (ILM) dehiscence on surgical outcomes in eyes that have undergone epiretinal membrane (ERM) removal. Methods: Consecutive eyes with performed vitrectomy for ERM removal were included. Subjects were divided into two groups: patients with ILM dehiscence (group 1) and without ILM dehiscence (group 2). The best-corrected visual acuity (BCVA) and retinal layer thickness before and after surgery were compared between the two groups. Results: A total of 86 eyes were enrolled. Forty-six eyes (53.5%) showed ILM dehiscence before surgery. The baseline BCVAs were 0.46 ± 0.29 and 0.45 ± 0.25 in groups 1 and 2, respectively (p = 0.801). The BCVAs at 3, 6, and 12 months after surgery differed significantly between the two groups. The subfoveal thickness and inner retinal layer thickness (IRLT) of group 1 vs. 2 were 507.4 ± 80.0 vs. 417.6 ± 63.6 μm, and 270.2 ± 74.3 vs. 182.6 ± 60.4 μm, respectively (both p < 0.001). These differences between the groups remained significant until 12 months after surgery. In multivariate analyses, the location of ILM dehiscence (B = −0.105, p = 0.034) and final IRLT (B = 0.001, p = 0.046) were significant factors affecting the final BCVA. Conclusions: ILM dehiscence is a relatively common finding and associated with preoperative and postoperative increased IRLT, which results in worse surgical outcomes compared to the absence of ILM dehiscence in patients with ERM. Additionally, the final BCVA was significantly affected by its location and final IRLT in patients with ILM dehiscence.

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Inner retinal layer thickness is the major determinant of visual acuity in patients with idiopathic epiretinal membrane

Acta Ophthalmologica ◽

10.1111/aos.12017 ◽

2012 ◽

Vol 91 (3) ◽

pp. e242-e243 ◽

Cited By ~ 34

Author(s):

Soo Geun Joe ◽

Kyung Sub Lee ◽

Joo Yong Lee ◽

Jong-uk Hwang ◽

June-Gone Kim ◽

...

Keyword(s):

Visual Acuity ◽

Layer Thickness ◽

Epiretinal Membrane ◽

Major Determinant ◽

Retinal Layer ◽

Idiopathic Epiretinal Membrane

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The Associations among Metamorphopsia, Orientation Discrimination Threshold, and Retinal Layer Thickness in Patients with Idiopathic Epiretinal Membrane

Current Eye Research ◽

10.1080/02713683.2018.1481515 ◽

2018 ◽

Vol 43 (9) ◽

pp. 1151-1159 ◽

Cited By ~ 1

Author(s):

Tianyu Chen ◽

Binbin Su ◽

Zheyi Chen ◽

JianLiang Tong ◽

Harold Bedell ◽

...

Keyword(s):

Layer Thickness ◽

Epiretinal Membrane ◽

Discrimination Threshold ◽

Orientation Discrimination ◽

Retinal Layer ◽

Idiopathic Epiretinal Membrane

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Comparison of Retinal Layer Thickness and Capillary Vessel Density in the Patients with Spontaneously Resolved Acute Central Serous Chorioretinopathy

Journal of Clinical Medicine ◽

10.3390/jcm10010045 ◽

2020 ◽

Vol 10 (1) ◽

pp. 45

Author(s):

Kyu Jin Han ◽

Hyeong Ju Kim ◽

Je Moon Woo ◽

Jung Kee Min

Keyword(s):

Visual Acuity ◽

Layer Thickness ◽

Central Serous Chorioretinopathy ◽

Subretinal Fluid ◽

Vessel Density ◽

Foveal Avascular Zone ◽

Retinal Layer ◽

Healthy Controls ◽

Retrospective Case ◽

Capillary Vessel

We investigate retinal layer thickness and capillary vessel density (VD) in the patients with central serous chorioretinopathy (CSC) who recovered spontaneously and evaluate the correlation between the changes in these values and visual outcomes using swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA). This retrospective case–control study included 34 eyes of 34 patients with spontaneously resolved acute CSC. The changes in retinal layer thickness and capillary VD were examined using SS-OCT and OCTA after complete resolution of subretinal fluid (SRF). The fellow eyes and 34 healthy eyes were used as controls. In the eyes with CSC, the outer retinal layer was significantly thinner than in the eyes of fellow and healthy controls. The foveal avascular zone area and VDs in the superficial and deep capillary plexus in the eyes with CSC were not significantly different from those in the eyes of fellow and healthy controls. The VD of the choriocapillaris in the eyes with CSC was significantly lower than that in the eyes of fellow and healthy controls. Correlation analyses revealed that the outer retinal layer thickness and initial visual acuity were positively correlated with the final visual acuity. Furthermore, the initial SRF area and height were negatively correlated with the outer retinal layer thickness after SRF resolution. Attenuation of outer retinal layer thickness and decreased VD of the choriocapillaris were observed in the eyes with spontaneously resolved acute CSC. The outer retinal layer thickness could be an important visual predictor of CSC.

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The effect of hemodialysis on individual retinal layer thickness

International Ophthalmology ◽

10.1007/s10792-020-01677-x ◽

2021 ◽

Author(s):

Idit Maharshak ◽

Idan Hecht ◽

Lihi Mankuta ◽

Asaf Achiron ◽

Oriel Spierer ◽

...

Keyword(s):

Layer Thickness ◽

Retinal Layer

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Changes in retinal microvasculature and retinal layer thickness in association with apolipoprotein E genotype in Alzheimer’s disease

Scientific Reports ◽

10.1038/s41598-020-80892-z ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Joo Youn Shin ◽

Eun Young Choi ◽

Min Kim ◽

Hyung Keun Lee ◽

Suk Ho Byeon

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Layer Thickness ◽

Structural Changes ◽

Foveal Avascular Zone ◽

Retinal Layer ◽

Inner Plexiform Layer ◽

Apoe Ε4 ◽

Retinal Microvasculature ◽

Capillary Plexus

AbstractBiomarker tests of Alzheimer’s disease (AD) are invasive and expensive. Recent developments in optical coherence tomography (OCT) and OCT angiography (OCTA) have enabled noninvasive, cost-effective characterization of retinal layer vasculature and thickness. Using OCTA and OCT, we characterized retinal microvascular changes in the mild cognitive impairment (MCI) stage of AD and assessed their correlation with structural changes in each retinal neuronal layer. We also evaluated the effect of the APOE-ε4 genotype on retinal microvasculature and layer thickness. Retinal layer thickness did not differ between MCI patients (40 eyes) and controls (37 eyes, all p > 0.05). MCI patients had lower vessel density (VD) (p = 0.003) of the superficial capillary plexus (SCP) and larger foveal avascular zone area (p = 0.01) of the deep capillary plexus (DCP) than those of controls. VD of the SCP correlated with the ganglion cell layer (r = 0.358, p = 0.03) and inner plexiform layer thickness (r = 0.437, p = 0.007) in MCI patients. APOE-ε4-carrying MCI patients had a lower VD of the DCP than non-carriers (p = 0.03). In conclusion, retinal microvasculature was reduced in patients with AD-associated MCI, but retinal thickness was not changed; these changes might be affected by the APOE genotype. OCTA of the retinal microvasculature may be useful to detect vascular changes in AD.

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Inner and outer retinal layer thickness alterations in pediatric and juvenile craniopharyngioma

Scientific Reports ◽

10.1038/s41598-021-82107-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Ga-In Lee ◽

Kyung-Ah Park ◽

Sei Yeul Oh ◽

Doo-Sik Kong ◽

Sang Duk Hong

Keyword(s):

Layer Thickness ◽

Outer Nuclear Layer ◽

Plexiform Layer ◽

Visual Field Defects ◽

Retinal Layer ◽

Inner Plexiform Layer ◽

Healthy Controls ◽

Fiber Layer ◽

Photoreceptor Layer ◽

Chiasmal Compression

AbstractWe evaluated postoperative retinal thickness in pediatric and juvenile craniopharyngioma (CP) patients with chiasmal compression using optical coherence tomography (OCT) auto-segmentation. We included 18 eyes of 18 pediatric or juvenile patients with CP and 20 healthy controls. Each thickness of the macular retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer, outer plexiform layer, outer nuclear layer, and photoreceptor layer was compared between the CP patients and healthy controls. There was significant thinning in the macular RNFL (estimates [μm], superior, − 10.68; inferior, − 7.24; nasal, − 14.22), all quadrants of GCL (superior, − 16.53; inferior, − 14.37; nasal, − 24.34; temporal, − 9.91) and IPL (superior, − 11.45; inferior, − 9.76; nasal, − 15.25; temporal, − 4.97) in pediatric and juvenile CP patients postoperatively compared to healthy control eyes after adjusting for age and refractive errors. Thickness reduction in the average and nasal quadrant of RNFL, GCL, and IPL was associated with peripapillary RNFL thickness, and reduced nasal quadrant GCL and IPL thicknesses were associated with postoperative visual field defects. In pediatric and juvenile patients with CP, decreased inner retinal layer thickness following chiasmal compression was observed. The changes in retinal structures were closely related to peripapillary RNFL thinning and functional outcomes.

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Assessment of Global and Local Alterations in Retinal Layer Thickness in Ins2 (Akita) Diabetic Mice by Spectral Domain Optical Coherence Tomography

Journal of Ophthalmology ◽

10.1155/2018/7253498 ◽

2018 ◽

Vol 2018 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Andrew W. Francis ◽

Justin Wanek ◽

Mahnaz Shahidi

Keyword(s):

Optical Coherence Tomography ◽

Mouse Model ◽

Layer Thickness ◽

Retinal Thickness ◽

Normative Values ◽

Retinal Layer ◽

Wild Type ◽

Global And Local ◽

Akita Mice ◽

Sd Oct

Purpose/Aim. The Ins2 (Akita) mouse is a spontaneous diabetic mouse model with a heterozygous mutation in the insulin 2 gene that results in sustained hyperglycemia. The purpose of the study was to assess global and local retinal layer thickness alterations in Akita mice by analysis of spectral domain optical coherence tomography (SD-OCT) images.Materials and Methods. SD-OCT imaging was performed in Akita and wild-type mice at 12 and 24 weeks of age. Inner retinal thickness (IRT), outer retinal thickness (ORT), total retinal thickness (TRT), and photoreceptor outer segment length (OSL) were measured. Mean global thickness values were compared between Akita and wild-type mice. Local thickness variations in Akita mice were assessed based on normative values in wild-type mice.Results. Akita mice had higher blood glucose levels and lower body weights (p<0.001). On average, IRT, ORT, and TRT were approximately 2% lower in Akita mice than in wild-type mice (p≤0.02). In Akita mice, the percent difference between retinal areas with thickness below and above normative values for IRT, ORT, and TRT was 22%, 32%, and 38%, respectively.Conclusions. These findings support the use of the Akita mouse model to study the retinal neurodegenerative effects of hyperglycemia.

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