scholarly journals HIF1α-mediated TRAIL Expression Regulates Lacrimal Gland Inflammation in Dry Eye Disease

2020 ◽  
Vol 61 (1) ◽  
pp. 3
Author(s):  
Yong Woo Ji ◽  
Joon H. Lee ◽  
Eun Young Choi ◽  
Hyun Goo Kang ◽  
Kyoung Yul Seo ◽  
...  
Keyword(s):  
Dry Eye ◽  
Lacrimal Gland ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Trail Expression

scholarly journals Lacrimal Gland Myoepithelial Cells Are Altered in a Mouse Model of Dry Eye Disease

2020 ◽  
Vol 190 (10) ◽  
pp. 2067-2079 ◽  
Author(s):  
Laura García-Posadas ◽  
Robin R. Hodges ◽  
Tor P. Utheim ◽  
Ole Kristoffer Olstad ◽  
Vanessa Delcroix ◽  
...  
Keyword(s):  
Mouse Model ◽  
Dry Eye ◽  
Lacrimal Gland ◽  
Myoepithelial Cells ◽  
Dry Eye Disease ◽  
Eye Disease

scholarly journals Denervation of the Lacrimal Gland Leads to Corneal Hypoalgesia in a Novel Rat Model of Aqueous Dry Eye Disease

2015 ◽  
Vol 56 (11) ◽  
pp. 6981 ◽  
Author(s):  
Sue A. Aicher ◽  
Sam M. Hermes ◽  
Deborah M. Hegarty
Keyword(s):  
Dry Eye ◽  
Lacrimal Gland ◽  
Rat Model ◽  
Dry Eye Disease ◽  
Eye Disease

scholarly journals A Ligation of the Lacrimal Excretory Duct in Mouse Induces Lacrimal Gland Inflammation with Proliferative Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Ying Liu ◽  
Masatoshi Hirayama ◽  
Tetsuya Kawakita ◽  
Kazuo Tsubota
Keyword(s):  
Dry Eye ◽  
Lacrimal Gland ◽  
Ocular Surface ◽  
Tissue Injury ◽  
Dry Eye Disease ◽  
Excretory Duct ◽  
Eye Disease ◽  
Injury Model ◽  
Duct Ligation ◽  
Number Of Patients

The lacrimal gland secretes tear fluids to ocular surface, which plays an indispensable role in maintaining the health of the ocular epithelia and protecting the ocular surface from the external environment. The dysfunction of the lacrimal glands causes dry eye disease due to a reduction in tear volume. The dry eye disease is becoming a popular public disease, for the number of patients is increasing, who have subjective symptom and loss of vision, which affect the quality of life. Inflammatory change in the damaged lacrimal gland has been reported; however, a major challenge is to establish a simple animal model to observe the changes. Here, we demonstrated an injury model by ligating the main excretory duct of the lacrimal gland, which is a simple and stable way to clearly understand the mechanism of lacrimal gland inflammation. We observed the process of injury and proliferation of the lacrimal gland and detected a population of lacrimal gland epithelial cells with proliferation potential which were also nestin-positive cells following duct ligation. This study successfully established an injury model to observe the tissue injury process of the lacrimal gland, and this model will be useful for analysis of the inflammation and proliferation mechanism in the future.

scholarly journals Effect of Dry Eye Disease on the Kinetics of Lacrimal Gland Dendritic Cells as Visualized by Intravital Multi-Photon Microscopy

2020 ◽  
Vol 11 ◽  
Author(s):  
Gustavo Ortiz ◽  
Cecilia Chao ◽  
Arsia Jamali ◽  
Yashar Seyed-Razavi ◽  
Brendan Kenyon ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Dry Eye ◽  
Lacrimal Gland ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Kinetics Of

scholarly journals MSC Transplantation Improves Lacrimal Gland Regeneration after Surgically Induced Dry Eye Disease in Mice

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Jana Dietrich ◽  
Lolita Ott ◽  
Mathias Roth ◽  
Joana Witt ◽  
Gerd Geerling ◽  
...  
Keyword(s):  
Dry Eye ◽  
Lacrimal Gland ◽  
Immune Reaction ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Duct Ligation ◽  
Promising Therapeutic Approach ◽  
High Prevalence ◽  
Surgically Induced

AbstractDry eye disease (DED) is a multifactorial disease characterized by a disrupted tear film homeostasis and inflammation leading to visual impairments and pain in patients. Aqueous-deficient dry eye (ADDE) causes the most severe progressions and depends mainly on the loss of functional lacrimal gland (LG) tissue. Despite a high prevalence, therapies remain palliative. Therefore, it is of great interest to develop new approaches to curatively treat ADDE. Mesenchymal stem/stromal cells (MSC) have been shown to induce tissue regeneration and cease inflammation. Moreover, an increasing amount of MSC was found in the regenerating LG of mice. Therefore, this study investigated the therapeutic effect of MSC transplantation on damaged LGs using duct ligation induced ADDE in mice. Due to the transplantation of sex-mismatched and eGFP-expressing MSC, MSC could be identified and detected until day 21. MSC transplantation significantly improved LG regeneration, as the amount of vital acinar structures was significantly increased above the intrinsic regeneration capacity of control. Additionally, MSC transplantation modulated the immune reaction as macrophage infiltration was delayed and TNFα expression decreased, accompanied by an increased IL-6 expression. Thus, the application of MSC appears to be a promising therapeutic approach to induce LG regeneration in patients suffering from severe DED/ADDE.

Comparative analysis on the dynamic of lacrimal gland damage and regeneration after Interleukin-1α or duct ligation induced dry eye disease in mice

2018 ◽  
Vol 172 ◽  
pp. 66-77 ◽  
Author(s):  
Jana Dietrich ◽  
Carlo Schlegel ◽  
Mathias Roth ◽  
Joana Witt ◽  
Gerd Geerling ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Dry Eye ◽  
Lacrimal Gland ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Duct Ligation ◽  
Interleukin 1Α

scholarly journals The Protective Effect of Topical Spermidine on Dry Eye Disease with Retinal Damage Induced by Diesel Particulate Matter2.5

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1439
Author(s):  
Hyesook Lee ◽  
Da Hye Kim ◽  
Hyun Hwangbo ◽  
So Young Kim ◽  
Seon Yeong Ji ◽  
...  
Keyword(s):  
Protective Effect ◽  
Dry Eye ◽  
Lacrimal Gland ◽  
Cell Loss ◽  
Dry Eye Disease ◽  
Histological Evaluation ◽  
Eye Disease ◽  
Interleukin 17 ◽  
Eye Drops ◽  
Lipid Metabolism Disorder

Air pollutants, especially ambient fine particulate matter2.5, may contribute to various ocular surface disorders, including dry eye disease, keratitis and conjunctivitis. A natural polyamine spermidine has a protective effect on the retina and optic nerve; however, no study has been conducted on the application of spermidine in particulate matter2.5-induced dry eye disease. In the present study, we investigated the effect of spermidine eye drops in topically exposed particulate matter2.5-induced dry eye models of Sprague-Dawley rats, by hematological, biochemical and histological evaluation. Spermidine eye drops attenuated the particulate matter2.5 exposure-induced reduction of tear secretion and corneal epithelial damage. Furthermore, spermidine protected against conjunctival goblet cell loss and retinal ganglion cell loss induced by particulate matter2.5. Additionally, spermidine markedly prevented particulate matter2.5-induced infiltration of cluster of differentiation3+ and cluster of differentiation4+ T lymphocytes and F4/80+ macrophages on lacrimal gland. Moreover, over expression of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin-6 and interleukin-17 in the lacrimal gland and cornea. Meanwhile, the levels of serum total cholesterol and low-density lipoprotein cholesterol were markedly increased by topical exposure to particulate matter2.5, but this change in the lipid profile was decreased by spermidine. Taken together, spermidine may have protective effects against particulate matter2.5-induced dry eye symptoms via stabilization of the tear film and suppression of inflammation and may in part contribute to improving retinal function and lipid metabolism disorder.

scholarly journals Therapeutical approach to dry eye syndrome

2010 ◽  
Vol 63 (11-12) ◽  
pp. 793-800 ◽  
Author(s):  
Gordana Stankovic-Babic ◽  
Gordana Zlatanovic ◽  
Jasmina Djordjevic-Jocic ◽  
Sonja Cekic ◽  
Milena Vujanovic
Keyword(s):  
Dry Eye ◽  
Lacrimal Gland ◽  
Ocular Surface ◽  
Cell Damage ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Inflammatory Disorder ◽  
Therapeutic Modalities ◽  
Third Line

Introduction. Dry eye disease or dysfunctional tear syndrome is among the most frequently established diagnoses in ophthalmology. It can be defined as a disorder of the tear film resulting in changes in the ocular surface. Mechanisms in development of dry eye disease. There are many factors causing dry eye and they can be related to deficiency in any of the components of the tear film. It has been suggested that dry eye is an inflammatory disorder that affects the ocular surface and lacrimal gland. Inflammation is the most important mechanism of corneal and conjunctival cell damage, which is responsible for the symptoms and signs of ocular surface pathology. Hormonal imbalance (particularly androgens), neural dysfunction, increased levels of pro-inflammatory cytokines and loss of immune homeostasis of the lacrimal gland and ocular surface could be possible mechanisms in the pathogenesis of dry eye disease. Discussion. The aim of this paper was to review the advances in the pathogenesis and management of the dry eye disease. The appropriate dry eye treatment presupposes knowledge of all existing pharmacologic and non-pharmacologic therapeutic modalities. The mainstay of therapy is still artificial tears, with anti-inflammatory therapy and punctual occlusion therapy as second and third line therapies.

The lacrimal gland and dry-eye disease

2010 ◽  
pp. 105-113 ◽  
Author(s):  
Darlene A Dartt
Keyword(s):  
Dry Eye ◽  
Lacrimal Gland ◽  
Dry Eye Disease ◽  
Eye Disease

scholarly journals Evaluation of Accessory Lacrimal Gland in Muller’s Muscle Conjunctival Resection Specimens for Precursor Cell Markers and Biological Markers of Dry Eye Disease

2016 ◽  
Vol 42 (4) ◽  
pp. 491-497 ◽  
Author(s):  
Marwan Ali ◽  
Dhara Shah ◽  
Zeeshan Pasha ◽  
Sarmad H. Jassim ◽  
Assraa Jassim Jaboori ◽  
...  
Keyword(s):  
Dry Eye ◽  
Lacrimal Gland ◽  
Biological Markers ◽  
Dry Eye Disease ◽  
Precursor Cell ◽  
Eye Disease ◽  
Cell Markers ◽  
And Biological Markers ◽  
Müller’S Muscle
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