The Risk of Lymph Node Involvement in Malignant Cutaneous Adnexal Tumors

2014 ◽  
Vol 80 (3) ◽  
pp. 270-274 ◽  
Author(s):  
Meredith Barnes ◽  
Andrea Hestley ◽  
Douglas R. Murray ◽  
Grant W. Carlson ◽  
Doug Parker ◽  
...  
Keyword(s):  
Lymph Node ◽  
Local Recurrence ◽  
Treatment Algorithm ◽  
Retrospective Chart Review ◽  
Lymph Node Involvement ◽  
Lymph Node Biopsy ◽  
Sebaceous Carcinoma ◽  
Node Involvement ◽  
Adnexal Tumors

Malignant cutaneous adnexal tumors (MCATs) are rare neoplasms that do not have a well-studied treatment algorithm. They are generally treated by excision alone. Given its successful application in other cutaneous malignancies, sentinel lymph node biopsy (SLNB) has been advocated by some for use in MCATs. A retrospective chart review was performed. Clinicopathological factors, recurrence patterns, and long-term follow-up were documented. Survival analysis was performed. Forty-eight subjects were identified. Mean age was 69 years with locations on the face (52%), including periocular sites (16%), extremities (25%), and all other sites (7%). Histologic distribution was sebaceous carcinoma (56%), porocarcinoma (17%), eccrine carcinoma (13%), adenocarcinoma (10%), and hidradenocarcinoma (4%). Mean follow-up was 3.9 years (range, 0 to 17 years). Nine subjects (18.8%) recurred locally, and recurrence was inversely associated with age ( P = 0.04). Four (8.3%) demonstrated lymph node involvement, none without first developing local recurrence. Five-year disease-specific survival was 97 per cent (confidence interval, 81.4 to 99.6%). Despite being one of the largest reported analyses of MCATs, this study is limited by the small number of subjects. MCATs seemingly develop nodal recurrence only after demonstrating aggressive local biology. SLNB may best be applied selectively, possibly only in patients with local recurrence.

scholarly journals Surgical management of urachal tumors: Can the umbilicus be sparred in localized disease?

Rare Tumors ◽  
2019 ◽  
Vol 11 ◽  
pp. 203636131984728
Author(s):  
Cristian Pavelescu ◽  
Alexandra Pavelescu ◽  
Cristian Surcel ◽  
Cristian Mirvald ◽  
Mario Alvarez-Maestro ◽  
...  
Keyword(s):  
Lymph Node ◽  
Surgical Treatment ◽  
Local Recurrence ◽  
Distant Metastasis ◽  
Lymph Node Involvement ◽  
Partial Cystectomy ◽  
En Bloc ◽  
Node Involvement ◽  
Urachal Adenocarcinoma

Urachal adenocarcinoma represents the third most common histological type of non-urotelial bladder cancer. A very low incidence of this disease and the lack of prospective studies have led to a rich and heterogeneous treatment history. Currently, the standard of care for these patients is represented by partial cystectomy en bloc with resection of the urachal ligament and total omphalectomy. The aim of this article is to present our experience and results in the management of patients with urachal adenocarcinoma. Between 2005 and 2015, 16 patients have undergone surgical treatment for urachal adenocarcinoma in “Fundeni” Clinical Institute and Madrid University Hospital “Infanta Sofia.” Partial cystectomy was performed in 11 (68.76%) patients, while radical cystectomy en bloc with omphalectomy was performed in 5 (31.25%) patients, which were not amendable to a limited resection. The Sheldon classification was used, as it provides appropriate disease staging and is the most commonly utilized. Postoperative pathological results showed that 7 (43.75%) patients had localized tumors, and more than one-third (37.5%) of the patients had locally advanced Sheldon III disease, while 3 patients had distant metastasis at the time of surgery. Lymph node involvement was present in 3 patients (18.75%). Mean follow-up time was 2.5 years, ranging from 4 months to 7.6 years. Three patients (18.75%) were lost to follow-up, without any documented signs of local or systemic recurrence and were cancer free at the time of the last evaluation. In cases with lymph node involvement, local recurrence or distant metastasis, patients underwent cisplatin- or 5-fluorouracil-based salvage chemotherapy. Surgical treatment represents the gold standard, while adjuvant chemotherapy has a limited impact on overall survival. The utility of navel resection is questionable due to the rarity of direct invasion or local recurrence.

scholarly journals Eosinophilic vasculitis: A Rare Presentation of Whipple’s Disease

2007 ◽  
Vol 21 (3) ◽  
pp. 189-191 ◽  
Author(s):  
Waleed Al-hamoudi ◽  
Fadi Habbab ◽  
Carmine Nudo ◽  
Ayoub Nahal ◽  
Kenneth Flegel
Keyword(s):  
Lymph Node ◽  
Lymph Node Involvement ◽  
Lymph Node Biopsy ◽  
Whipple’S Disease ◽  
Whipple's Disease ◽  
Rare Presentation ◽  
Negative Results ◽  
Mild Anemia ◽  
Node Involvement ◽  
Foamy Macrophages

Whipple’s disease is a multisystem infectious disease caused by the bacteriumTropheryma whippelii. A case with an unusual presentation is reported. A 66-year-old man presented with a febrile vasculitic rash on his forearms. An extensive rheumatological, hematological and infectious workup gave negative results, apart from mild anemia and eosinophilia. An abdominal computed tomography revealed a retroperitoneal lymphadenopathy, and a skin biopsy revealed an eosinophilic vasculitis. This diverted the work toward ruling out a lymphoma or a vasculitic process. A lymph node biopsy was then performed and showed a diffuse neutrophilic inflammation with abundant foamy macrophages, fat necrosis and lipogranuloma formation. These findings were considered to be nonspecific and no further pathological investigation was carried out. After a course of corticosteroids, diarrhea and weight loss predominated and subsequently a diagnosis of Whipple’s disease was confirmed on a small-bowel biopsy. Lymph node involvement was then confirmed on re-evaluation using the appropriate stains.

Histology as a Prognostic Factor in Early Gastric Cancer

1992 ◽  
Vol 78 (3) ◽  
pp. 181-184
Author(s):  
Massimo Ferrari ◽  
Enrico Ghislandi ◽  
Giuseppe Landonio ◽  
Margherita Majno ◽  
Tiziano Porretta ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Early Gastric Cancer ◽  
Lymph Node Involvement ◽  
Depth Of Invasion ◽  
Undifferentiated Histology ◽  
Node Involvement

Of 431 patients with gastric cancer observed in our Istitution, 23 (5.3 %) had early gastric cancer (EGC). Macroscopic presentation, histology, depth of invasion, and lymph node involvement were evaluated in all the cases. All patients underwent surgery and an intensive follow-up was performed. Five of the 23 patients progressed, and the risk factors were examined. Histology seemed to be the main prognostic factor in our study, since intestinal type of EGC was associated to a significantly better prognosis. Total gastrectomy is indicated in the proximal localization of EGC, and should perhaps be performed also in cases presenting undifferentiated histology.

Lymphography in Sarcoidosis.

1974 ◽  
Vol 60 (4) ◽  
pp. 317-323 ◽  
Author(s):  
Renato Musumeci ◽  
Carlo Uslenghi
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Pulmonary Involvement ◽  
Lymph Node Involvement ◽  
Lymph Node Biopsy ◽  
Pathological Findings ◽  
Node Biopsy ◽  
Node Involvement ◽  
Extensive Lymph Node

Abdominal lymphography was performed in 30 patients, 12 males and 18 females, with sarcoidosis. The diagnosis of disease was in every case histological, after mediastinal biopsy in 16 cases and after biopsy of lymph nodes in various sites in 14 cases. Mediastino-pulmonary involvement of varying degree was present in 23 patients. Lymphography revealed involvement of the inguinoretroperitoneal lymph nodes in 18 cases, bilateral in 15 of them. Lymphographic diagnosis of sarcoidosis is fairly arduous because the pattern elicited is very similar to that of lymphomas. The pathological findings were graded into 4 groups. No correlation between lymphographic pattern and duration and extent of the disease was demonstrated. In 5 patients with pathological lymphography lymph node biopsy confirmed the diagnosis. The routine use of lymphography in patients with sarcoidosis is not to be racommended because the demonstration of extensive lymph node involvement does not affect the treatment in any way.

Relationship of immunohistochemical biomarker expression and lymph node involvement in patients undergoing surgical treatment of NSCLC with long-term follow-up

Tumor Biology ◽  
2014 ◽  
Vol 35 (5) ◽  
pp. 4551-4559 ◽  
Author(s):  
Ana María Gómez ◽  
Jose Ramón Jarabo Sarceda ◽  
Jose Antonio L. García-Asenjo ◽  
Cristina Fernandez ◽  
Susana Hernandez ◽  
...  
Keyword(s):  
Lymph Node ◽  
Surgical Treatment ◽  
Lymph Node Involvement ◽  
Long Term Follow Up ◽  
Node Involvement ◽  
Relationship Of

scholarly journals Sentinel Lymph Node Biopsy in Breast Cancer: Predictors of Axillary and Non-Sentinel Lymph Node Involvement

2013 ◽  
Vol 30 (4) ◽  
pp. 415-421 ◽  
Author(s):  
Hakan Postacı ◽  
Baha Zengel ◽  
Ulkem Yararbas ◽  
Adam Uslu ◽  
Nukhet Eliyatkin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Lymph Node Involvement ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Node Involvement

scholarly journals Clinicopathological Profile of Thyroid Carcinoma in Young Patients: An Indonesian Single-Center Study

2022 ◽  
Vol 2022 ◽  
pp. 1-8
Author(s):  
Agnes Stephanie Harahap ◽  
Desty Gusti Sari ◽  
Marini Stephanie ◽  
Alvita Dewi Siswoyo ◽  
Litta Septina Mahmelia Zaid ◽  
...  
Keyword(s):  
Lymph Node ◽  
Mortality Rate ◽  
Thyroid Carcinoma ◽  
Distant Metastasis ◽  
Disease Recurrence ◽  
Lymph Node Involvement ◽  
Common Type ◽  
Thyroid Malignancy ◽  
Node Involvement

Introduction. Thyroid cancer is the third most common cancer that occurs in children and adolescents. Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. Although the mortality rate of thyroid malignancy in children is usually low, the disease recurrence is higher in children with more severe clinical presentation than in adults. This study aimed to determine the demographic and clinicopathological characteristics and outcome of pediatric and adolescent patients with thyroid malignancy in Indonesia. Methods. The retrospective study included all patients diagnosed with thyroid carcinoma aged <20 years, from January 1, 2015, to December 31, 2019. Twenty-nine subjects fulfilled the inclusion and exclusion criteria. We retrieved baseline characteristics, pathology features, TSH and fT4 status, radioactive iodine therapy data, and patients’ outcomes. Then, data were analyzed using the chi-square or Fisher’s exact method. Results. We identified 29 eligible subjects, including 3 boys and 26 girls. The most common type of thyroid carcinoma was PTC (96.5%), and follicular type (31%) was the predominant variant of PTC. Lymph node involvement occurred in 24% of patients, while distant metastasis occurred in 17.2% of patients with PTC. Twenty-four (82.7%) patients had stage 1 disease. Disease recurrence was recorded in 31% of patients during the study period with a median follow-up time of 24 months. Conclusion. PTC is the most frequent type of thyroid carcinoma among children and adolescents. This malignancy has a low mortality rate, but the recurrence rate remains high among younger patients than adults even during a short-term follow-up analysis. Distant metastasis and lymph node involvement are commonly found in this age group.

scholarly journals Tuberculosis in patients with chronic renal failure

1987 ◽  
Vol 29 (3) ◽  
pp. 127-130 ◽  
Author(s):  
Flávio Jota de Paula ◽  
Luiz Sérgio Fonseca de Azevedo ◽  
Luiz Estevam Ianhez ◽  
João Egidio Romão Júnior ◽  
Pedro Renato Chocair ◽  
...  
Keyword(s):  
Lymph Node ◽  
Pulmonary Involvement ◽  
Lymph Node Involvement ◽  
Immunosuppressive Drugs ◽  
Lymph Node Biopsy ◽  
The Other ◽  
Pleural Biopsy ◽  
Node Biopsy ◽  
Node Involvement ◽  
Cervical Lymph Node Biopsy

Nine cases of tuberculosis (TB) were diagnosed among 800 uremic patients, followed-up during 11 years, a prevalence of 1125%, 2.5 times higher than that in the general population. Six patients (66.7%) had lymph node involvement (4 cervical and 2 mediastinal). Three patients (33.3%) had pulmonary involvement (2 pleuro-pulmonary and 1 bilateral apical pulmonary). Eight patients were undergoing dialysis and 1 was pre-dialytic. The duration of dialysis ranged from 1 to 60 months. Three patients had previously received immunosuppressive drugs for unsuccessful renal transplantation. Daily fever was present in all but one patient; he was asymptomatic and TB was suspected after routine chest radiography. Biopsy was the diagnostic procedure in 7 patients (77.8%), four by direct cervical lymph node biopsy, 2 by mediastinal, performed by mediastinoscopy and 1 by pleural biopsy. In 2 other patients TB was confirmed by the presence of tubercle bacilli; in sputum (1 patient) and in a bronchial flushing specimen (the other patient). Triple therapy was used in all patients (isoniazid and ethambutol in all), plus rifampicin in 8 and streptomycin in 1. One patient had jaundice and another had optical neuritis. Five patients were cured. The other four died during treatment of causes unrelated to TB or its treatment.

Is local lymph node involvement a prognostic factor in paediatric renal cell carcinoma?

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 20014-20014
Author(s):  
P. Indolfi ◽  
G. Bisogno ◽  
G. Cecchetto ◽  
A. Ferrari ◽  
L. Piva ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Lymph Node Involvement ◽  
Number Of Patients ◽  
Node Involvement ◽  
Local Lymph Node

20014 Background: RCC in childhood is rare. Children with RCC tend to have a similar overall prognosis when compared with adults, where prognosis worsens with increasing stage, although direct comparisons of adult and paediatric data isn’t easy. The aim of our study is to identify the prognostic significance of local lymph node involvement in children with Renal Cell Carcinoma (RCC). Methods: On the basis of a retrospective study, the recently founded Italian Association for Paediatric Hematology and Oncology-Rare Tumors Paediatric Age (AIEOP-TREP) identified 16 patients (9 females) with RCC and local lymph node involvement at 10 of these centers. The cases were observed among 59 paediatric RCC, corresponding to 27.1% of RCC presenting in Italy from January 1973 to May 2006. Results: Overall, 9 patients were alive and disease free at last follow-up: eight patients had regional lymph node dissection (RLND) from the diaphragm at the aortic bifurcation, and one had the para-aortic lymph nodes removal. Six patients died: one had RLND (died from progression of disease), three had the renal hilum lymph nodes removal, and two the para-aortic lymph nodes dissection. One patient was lost to follow-up after relapse: this patient had para-aortic lymph node removal at diagnosis. Estimated 25-year DFS and OS rates for all patients were 64.2% and 50.5%, respectively. Given the small number of patients, little can be said about the value, if any, of adjuvant immunotherapy in this group of RCC. Conclusions: Children with lymph node positive RCC had a relatively unfavourable long- term prognosis. In our experience the RLND improves the prognosis. Further investigation of the biologic differences is warranted. Because of the very low incidence of paediatric RCC, an international clinical trial will be required to establish optimal therapy for children with RCC. No significant financial relationships to disclose.

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