Analysis of Gabapentin’s Efficacy in Tinnitus Treatment: A Systematic Review

Annals of Otology Rhinology & Laryngology ◽

10.1177/00034894211018921 ◽

2021 ◽

pp. 000348942110189

Author(s):

Matheus Pedrosa Tavares ◽

Fayez Bahmad

Keyword(s):

Systematic Review ◽

Controlled Trial ◽

Critical Evaluation ◽

Outcome Study ◽

Qualitative Synthesis ◽

Eligibility Criteria ◽

Double Blind ◽

Randomized Controlled ◽

Study Selection ◽

Tinnitus Treatment

Objectives: Tinnitus can be a chronic symptom that brings disability and distress. Some studies suggested that gabapentin might be effective on tinnitus relief. The objective of the study is to perform a systematic review in order to evaluate the efficacy of oral gabapentin in patients with tinnitus. Methods: A literature search was conducted in English and following the recommendations from PRISMA. The terms used were: (“tinnitus” OR “subjective tinnitus”) AND (“gabapentin”). The study selection was performed following the eligibility criteria in accordance to the PICOS (population, intervention, comparison, outcome, study design) strategy—patients with tinnitus; oral gabapentin; placebo; reduction of tinnitus severity questionnaires scores; prospective, double-blind, randomized controlled trial, respectively. The selected studies were included in qualitative synthesis. The studies were analyzed according to Joanna Briggs Institute’s critical appraisal checklist for randomized controlled trials. Results: One hundred twenty-one studies were found in 9 databases and 8 studies were found in gray literature. After study selection, 6 articles were read in full. Then, 2 studies were excluded and 4 were included in qualitative synthesis. All 4 articles were analyzed according to critical evaluation checklist. Conclusions: There is insufficient evidence to recommend the use of gabapentin for patients with tinnitus.

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Lactobacillus Reuteri DSM 17938 in Infantile Colic: A Systematic Review and Meta-Analysis

BioScientia Medicina ◽

10.37275/bsm.v6i3.457 ◽

2022 ◽

Vol 6 (3) ◽

pp. 1446-1454

Author(s):

Burhannudin Ichsan ◽

Nining Lestari ◽

Sulistyani

Keyword(s):

Systematic Review ◽

Lactobacillus Reuteri ◽

Controlled Trial ◽

Meta Analysis ◽

Forest Plot ◽

Infantile Colic ◽

Eligibility Criteria ◽

Randomized Controlled ◽

Infant Colic ◽

Systematic Synthesis

Background. Infantile colic, defined as paroxysmal, excessive, and consolable crying without an identifiable cause. It is common in the first 3 months of life. There have been many RCT studies conducted. A systematic synthesis is required to summarize the results of these RCTs. This study was aimed to systematically analyze the benefits of Lactobacillus reuteri DSM 17938 for infantile colic. Methods. This systematic review and meta-analysis used keywords: (“infantile colic” OR “abdominal cramps” OR “abdominal cramp” OR “infant colic”) AND “lactobacillus reuteri” AND (placebo OR placebos) AND (“randomized controlled trial” OR RCT). The databases used were: pubmed, science direct, and google scholar. Meta-analysis was conducted to combine the articles. The eligibility criteria were: patient with infantile colic, intervention with L. reuteri DSM 17938, control was placebo, RCT study design, outcome with dichotomous scale, all races, all ethnicities, all countries, all genders, in English, and not limited by year. Results. The search resulted in 800 articles. After reducing duplication, the number of articles was 747. Screening with titles and abstracts resulted in 13 full teks articles. Six articles fitted the eligibility criteria. The results of the meta-analysis were as follows. The forest plot showed that the combined effect of the six articles showed an RR of 0.47 and was statistically significant (p <0.001). Conclusion. Based on the results of this meta-analysis, L. reuteri DSM 17938 is recommended for infants with infantile colic. There were no significant side effects with the use of L. reuteri DSM 17938 on infantile colic.

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Antiviral Treatment for COVID-19: A Systematic Review

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2020/v32i3230932 ◽

2020 ◽

pp. 39-51

Author(s):

Francisco A. Arias ◽

Pier Teran- Chavez ◽

Alessandra Maggi- Panato ◽

Diego Flores- Ortega ◽

Alex Rojas- Ortega

Keyword(s):

Systematic Review ◽

Clinical Improvement ◽

Controlled Trial ◽

Antiviral Treatment ◽

Research Database ◽

Randomized Controlled ◽

Mesh Terms ◽

Study Selection ◽

Full Text Review ◽

New Type

Aim: In December 2019, there were reports of a new type of coronavirus that affects the different health systems of the world. We have carried out a systematic review of the possible antivirals studied that could be useful in this public health catastrophe. Data Sources: A search strategy with MESH terms was performed in PubMed, Web of Science, and Scopus. Also, RCTs published in clinicaltrials.gov were reviewed. The databases were searched between April and June 2020. Study Selection: We selected all Randomized Controlled Trials evaluating the effects of antivirals and 5 studies were included from a research database of 280 articles collected between. After removing duplicated articles, 43 were selected for review. Finally, 5 articles were eligible for full-text review and included in the article. Results: Current randomized controlled trial data showed no clinical improvement in terms of mortality, need for oxygen support or need for intubation in patients who used antivirals versus those who did not. No clinical improvement was demonstrated. It was observed that there is difficulty in calculating clinical improvement, this large difference makes the eligible studies difficult to compare. Conclusion: These predictors, however, need further work to validate reliability. More clinical trials involving antivirals are needed to observe a relationship between clinical improvement or mortality from SARS-CoV-19.

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Tratamento de anquiloglossia parcial através de frenectomia: relato de caso

ARCHIVES OF HEALTH INVESTIGATION ◽

10.21270/archi.v8i9.3351 ◽

2020 ◽

Vol 8 (9) ◽

Author(s):

Bruno Firmino de Oliveira ◽

José Henrique de Araújo Cruz ◽

Raquel Lira Braga da Silva ◽

Douglas Benício Barros Henrique

Keyword(s):

Systematic Review ◽

Randomized Controlled Trial ◽

Case Report ◽

Surgical Treatment ◽

Rio De Janeiro ◽

Controlled Trial ◽

Diagnosis And Treatment ◽

Double Blind ◽

Randomized Controlled ◽

Head Neck

Introdução: A anquiloglossia é uma anormalidade de desenvolvimento, dificultando a amplitude de movimentos da língua e impede que esta cumpra a sua função, traduz-se pela inserção anormal do frênulo lingual na região de ápice lingual. Objetivo: Relatar um caso clínico de anquiloglossia parcial sob tratamento de frenectomia lingual convencional para reabilitação. Relato do Caso: Após exame clínico realizou-se antessepsia intraoral com através do bochecho com solução de clorexidina a 0,2% e extraoral com clorexidina a 2%. Posteriormente, sob efeito de anestesia bilateral com Cloridrato de Lidocaína a 2% associado à Epinefrina 1:100.000, laçou-se com fio de sutura seda 3.0 para estabilização pinçou-se com pinça hemostática, então efetuou-se a incisão com lâmina de bisturi nº 15. Em seguida, divulsionou-se com tesoura metzenbaum e a sutura foi feita com fio de sutura seda 4.0. Conclusão: O tratamento é realizado por profissionais como cirurgiões dentistas o qual pode ser realizado por meio de intervenções cirúrgicas, como a frenectomia lingual, que consiste na liberação do frênulo lingual por meio de uma incisão quando parcial. O pós operatório deste procedimento demonstra rápida recuperação e previsibilidade positiva quando associada a tratamento fonoaudiológico para uma reeducação.Descritores: Anquiloglossia; Freio Lingual; Odontologia.ReferênciasVargas BC, Monnerat, LHP, Favilla EE, Pinto LAPF, Gandelmann IHA, Cavalcante MAA. Anquiloglossia: quando indicar a frenectomia lingual? Rev Uningá. 2008;18(1):195-204.Silva MC, Costa MLVCM, Nemr K, Marchesan IQ. Frênulo de língua alterado e interferência na mastigação. Rev CEFAC. 2009;11(Suppl3):363-69.Melo NSFO, Lima AAS, Fernandes A, Silva RPGVC. Anquiloglossia: Relato de caso. Rev Sul-Bras Odontol. 2011;8(1):102-7.Marchesan IQ. Frênulo lingual: proposta de avaliação quantitativa. Rev CEFAC. 2004;6(3):288-93.Marchesan IQ, Teixeira AN, Cattoni DM. Correlações entre diferentes frênulos linguais e alterações na fala. Disturb Comun. 2010;22(3):195-200.Segal LM, Stephenson R, Dawes M, Feldman P. Prevalence, diagnosis and treatment of ankyloglossia: methodologic review. Can Fam Physician. 2007;53(6):1027-33.Geddes DT, Langton DB, Gollow I, Jacobs LA, Hartmann PE, Simmer K. Frenutolomy for breastfeeding infants with ankyloglossia: effect on milk removal and sucking mechanism as imaged by ultrasound. Pediatrics. 2008;122(1):e188-94.Brito SF, Marchesan IQ, Bosco CM. Frênulo lingual: classificação e conduta segundo ótica fonoaudiológica, odontológica e otorrinolaringológica. Rev CEFAC. 2008;10(3):343-51.Manfro ARG, Manfro R, Bortoluzzi MC. Surgical treatment of ankyloglossia in babies – case report. Int J Oral Maxillofac Surg. 2010;39(11):1130-32.Feres MA. Componentes do aparelho estomatognático. In: Petrelli E (ed.). Ortodontia para fonoaudiologia. São Paulo: Lovise; 1994.Saconato M, Guedes ZCF. Estudo da mastigação e da deglutição em crianças e adolescentes com seqüência de Möbius. Rev Soc Bras Fonoaudiol. 2009;14(2):165-71.Beutnmuller G, Camera V. Reequilíbrio da musculatura orofacial. Rio de Janeiro: Enelivros; 1989.Kotlow L. Ankyloglossia (tongue-tie): a diagnostic and treatment quandary. Quintessence Int. 1999;30(4):259-62.Webb AN, Hao W, Hong P. The effect of tongue-tie division on breastfeeding and speech articulation: a systematic review. Int J Pediatr Otorhinolaryngol. 2013;77(5):635-46.Messner AH, Lalakea ML. The effect of ankyloglossia on speech in children. Otolaryngol Head Neck Surg. 2002;127(6):539-45.Berry J, Griffiths M, Westcot C. A double-blind, randomized, controlled trial of tongue-tie division and its immediate effect on breastfeeding. Breastfeed Med. 2012; 7(3):189-93.Marchesan IQ. Frênulo da língua: classificação e interferência na fala. Rev CEFAC. 2003;5(3):341-45.Marchesan IQ, Martinelli RLC, Gusmão RJ. Frênulo lingual: modificações após frenectomia. J Soc Bras Fonoaudiol. 2012;24(4):409-12.Gomes E, Araújo FB, Rodrigues JA. Freio lingual: abordagem clínica interdisciplinar da Fonoaudiologia e Odontopediatria. Rev Assoc Paul Cir Dent 2015;69(1):20-4.Ferreira LSR, Rosalvo JBN, Abreu LMS, Lacerda MCFV, Silva MFBC, Ribeiro EL. anquiloglossia: revisão de literatura. Ciênc Biol Saúde - UNIT. 2018;3(3):93-8.

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Relationship between Headache and Myofascial Pain: Systematic Review

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i52b33596 ◽

2021 ◽

pp. 37-52

Author(s):

May Wathiq Alkhudhairy ◽

Ashwag Saleem Aldafiri ◽

Yara Hamed Alsayegh ◽

Wesam Saad Bin Saeed ◽

Nadia Kamal Albather

Keyword(s):

Systematic Review ◽

Myofascial Pain ◽

Maxillofacial Surgery ◽

Oral And Maxillofacial Surgery ◽

Qualitative Synthesis ◽

Eligibility Criteria ◽

Double Blind ◽

Headache Disability ◽

Meta Analyses ◽

The Relationship

Aims: To systematically investigate the relationship between headache and myofascial. Study design: Systematic Review. Place and Duration of Study: Department of Oral and Maxillofacial surgery, Riyadh Elm University, Riyadh, Saudi Arabia. Between June 2020 and November 2021. Methodology: A systematic search of the literature was conducted between 2006 and 2019 in seven electronic databases (Brain, Pub Med, ScienceDirect database, NCBI, Web of Science Core Collection, Google Scholar, Scopus, and Saudi digital library). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was followed and the clinical question in PICO format was the relationship between headache and myofascial pain. The initial search resulted in 663 articles. Only 9 studies were selected for qualitative synthesis after fulfilling the eligibility criteria (three double blind Randomized Controlled Trials RCTs and one retrospective cohort study). The results showed that there is a consistent trend in the literature supporting the relationship between headache and MFP. Results: The first search showed 663 articles. A total of 110 duplicates were eliminated. After filtering by reading titles and abstracts and discarding any extraneous topics or goals that are not directly connected to this systematic review, the first phase comprised 49 publications. There were 14 papers that needed to be reviewed and evaluated for eligibility. Nine articles were chosen for the final evaluation after full text screening. Conclusion: The findings point to a significant association between headache disability and musculoskeletal disorders of the head and neck. The absence of an agreement in Orofacial Pain research methodology, unified approaches, has an impact on the optimal collecting requirements for a systematic review.

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