Comparison of Isotonic Seawater Nasal Spray Containing Chamomile Liquid Extract and Other Isotonic Seawater Nasal Washing Solutions for Allergic Rhinitis

Objective: We aim to demonstrate the effect of an isotonic seawater spray containing chamomile liquid extract on symptoms and nasal mucociliary clearance in patients with allergic rhinitis by comparing it with other isotonic seawater nasal washing solutions. Methods: The study included 123 patients. Based on Allergic Rhinitis and its Impact on Asthma guidelines, mometasone furoate intranasal spray treatment was started for all patients in the group diagnosed with allergic rhinitis. In addition to this treatment, isotonic seawater spray with chamomile liquid extract was added to Group A, isotonic seawater spray to Group B, and isotonic seawater nasal irrigation to Group C. The fourth group (Group D) was given only nasal steroid spray without nasal washing treatment. Before and after treatment in all patients, the Sino-Nasal Outcome Test-22 was performed, and nasal mucociliary clearance times were measured by the saccharin test. Results: The differences in duration of nasal mucociliary clearance and Sino-Nasal Outcome Test-22 values were taken before and after treatment. In Group A, B, C, and D the Sino-Nasal Outcome Test-22 differences were statistically significant ( P ≤.001; P ≤ .001; P ≤ .001, and P = .048, respectively). Only Group A and Group B experienced a significant difference in nasal mucociliary clearance times ( P ≤ .001; P = .010, respectively). When the Sino-nasal Outcome Test-22 score and nasal mucociliary clearance time differences before and after treatment were compared between all groups, the Sino-Nasal Outcome Test-22 score difference was higher in Group A than in Groups B, C, and D, the differences were found as statistically significant ( P = .010; P = .003; P ≤ .001, respectively). The nasal mucociliary clearance time difference was higher in Group A than in Groups C and D, the differences were found as statistically significant ( P = .010; P = .001, respectively). Conclusion: Isotonic seawater spray containing chamomile liquid extract is seen as a good alternative treatment option for allergic rhinitis patients.

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Comparison by Objective Parameters in Patients with Chronic Rhinosinusitis Managed Medically and Surgically (with and without Powered Instruments)

Allergy & Rhinology ◽

10.2500/ar.2016.7.0169 ◽

2016 ◽

Vol 7 (3) ◽

pp. ar.2016.7.0169

Author(s):

Samarendra Behera ◽

Satyawati Mohindra ◽

Sourabha K. Patro ◽

Ashok K. Gupta

Keyword(s):

Chronic Rhinosinusitis ◽

Test Scores ◽

Mucociliary Clearance ◽

Sinus Surgery ◽

Clearance Time ◽

Significant Difference ◽

Group A ◽

Group B ◽

Treatment Surgery

Objective To compare mucociliary clearance time and quality of life in patients who underwent sinus surgery using conventional and powered instruments, and in patients who were treated nonsurgically. Methods A total of 151 patients with chronic rhinosinusitis were included. Fifty-four patients were treated conservatively, 48 patients were managed surgically by using conventional instruments and 49 patients were managed by using a microdebrider. Kupferberg nasal endoscopy grades, 20-item Sino-Nasal Outcome Test scores, Lund-Mackay scores, and mucociliary clearance time were analyzed. Results On comparison among the groups, it was found that there was a significant difference between group A (nonsurgically treated) compared with group B (surgery by conventional means) or group C (surgery with microdebrider) in nasal endoscopic grades, Lund-Mackay scores, 20-item Sino-Nasal Outcome Test scores, and mucociliary clearance time. However, in comparison between groups B and C, there was no statistically significant difference. Conclusion Mucociliary clearance time tended to recover after starting treatment for chronic rhinosinusitis both after conservative treatment and after surgical treatment. Surgery provided better improvement in different objective scores in chronic rhinosinusitis. There exists no statistical difference in parameters independent of the instrument used for surgery.

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A comparative study of effect of deviated nasal septum on nasal mucociliary clearance and to comprehend the effect of septal and turbinate surgeries on restoring the mucociliary clearance

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20181868 ◽

2018 ◽

Vol 4 (3) ◽

pp. 764

Author(s):

Smitha B. C. Chandra ◽

Kiran Bylappa

Keyword(s):

Nasal Septum ◽

Mucociliary Clearance ◽

Concave Side ◽

Control Group ◽

Convex Side ◽

Clearance Time ◽

Deviated Nasal Septum ◽

Group A ◽

Group B ◽

Nasal Mucociliary Clearance

Background: One of the important functions of nose is mucociliary transport by its epithelium. Any structural abnormalities of nose like deviated nasal septum, turbinate hypertrophy and polyps can easily damage the mucociliary clearance. This can lead to increased inflammation leading to osteomeatal complex obstruction and sinusitis. The purpose of the study is to determine the nasal mucociliary clearance time (NMC) in patients with deviated nasal septum. And to compare the changes in nasal mucociliary clearance time before and after septoplasty and septoplasty with turbinectomy.Methods: Nasal mucociliary clearance time was measured preoperatively in patients with deviated nasal septum on concave and convex side. Post operatively it was again recorded after septoplasty in group A and septoplasty with turbinectomy in group B. These values were compared with the control group C. Results: Postoperatively group A patients NMC time was 11.11±2.76 on convex side, 14.01±2.39 on concave side. In group B patients NMC time was 11.18±1.91 on convex side and 12.62±1.42 on concave side.Conclusions: Nasal septal deviation and hypertrophied inferior turbinates can cause considerable impairment of nasal mucociliary clearance. Septoplasty combined with partial inferior turbinectomy of compensatory hypertrophied inferior turbinate on concave side preserves the normal NMC mechanism on both the sides of nasal cavity than just septoplasty.

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The evaluation of nasal mucociliary clearance in patients with Helicobacter pylori infection

The Journal of Laryngology & Otology ◽

10.1017/s0022215119000136 ◽

2019 ◽

Vol 133 (03) ◽

pp. 220-223

Author(s):

S Üstün Bezgin ◽

T Çakabay ◽

K Irak ◽

M Koçyiğit ◽

B Serin Keskineğe ◽

...

Keyword(s):

Helicobacter Pylori ◽

Mucociliary Clearance ◽

Endoscopic Examination ◽

Control Group ◽

Clearance Time ◽

Saccharine Test ◽

Significant Difference ◽

And Gender ◽

H Pylori ◽

Nasal Mucociliary Clearance

AbstractObjectiveThis study aimed to examine nasal mucociliary clearance time in patients with Helicobacter pylori infection.MethodsFifty patients who were newly diagnosed with H pylori infection using gastric biopsy in the gastroenterology out-patient clinic, and 50 age- and gender-matched healthy adults who were admitted to the otorhinolaryngology out-patient clinic, were included in this study. After an otorhinolaryngological examination (anterior rhinoscopy and nasal endoscopic examination), the nasal mucociliary clearance time of each subject was calculated using the saccharine test.ResultsThe mean mucociliary clearance time was 06:29 ± 3:31 minutes (range, 00:55–15:19 minutes) in the control group and 10:12 ± 06:09 minutes (range, 01:28–32:00 minutes) in the study group. Comparisons of the two groups revealed a statistically significant difference (p = 0.002).ConclusionNasal mucociliary clearance time was significantly increased in patients with H pylori infection. The results suggest that H pylori infection may have an unfavourable effect on nasal mucociliary clearance.

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Comparison of montelukast and mometasone furoate in the prevention of recurrent nasal polyps

Therapeutic Advances in Respiratory Disease ◽

10.1177/1753465811427577 ◽

2011 ◽

Vol 6 (1) ◽

pp. 5-10 ◽

Cited By ~ 21

Author(s):

Erkan Vuralkan ◽

Cem Saka ◽

Istemihan Akin ◽

Sema Hucumenoglu ◽

Binnur Uzmez Unal ◽

...

Keyword(s):

Recurrence Rate ◽

Nasal Spray ◽

Peripheral Blood ◽

Nasal Polyposis ◽

Mometasone Furoate ◽

Significant Difference ◽

Before And After ◽

Group A ◽

Group B ◽

Snot 22

Background: The aim of our study was to compare the effects of montelukast and mometasone furoate nasal spray on the postoperative course of patients with nasal polyposis. Patients and methods: Fifty patients diagnosed with nasal polyposis between March 2006 and August 2007 were included in the study. All patients underwent bilateral endoscopic sphenoethmoidectomy and were randomized postoperatively into two groups. Group A ( n = 25) received 10 mg montelukast per day and group B ( n = 25) received 400 µg mometasone furoate nasal spray twice daily. All patients were followed up for 6 months. Sino-Nasal Outcome Test (SNOT)-22 scores, polyp grades, computerized tomography (CT) scores (Lund–Mackay), eosinophils in peripheral blood and polyp tissue were evaluated before and after surgery. Results: There was a significant reduction in SNOT-22 scores in both groups throughout the study period. There was a significant difference in the recurrence rate between both groups with a marginal advantage of mometasone furoate nasal spray. Eosinophils in peripheral blood were found to be effective on the recurrence rate ( p < 0.05). Conclusions: In conclusion, both drugs seem to have a complementary action and further studies are needed to determine which patients should receive which treatment.

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Nasal Mucociliary Clearance in Allergic Rhinitis in Children

Clinical Rhinology An International Journal ◽

10.5005/jp-journals-10013-1035 ◽

2010 ◽

Vol 3 (2) ◽

pp. 93-95

Author(s):

Rupender K Ranga ◽

Jyoti Yadav ◽

Jagat Singh

Keyword(s):

Allergic Rhinitis ◽

Mucociliary Clearance ◽

Pulmonary Diseases ◽

Healthy Controls ◽

Clearance Time ◽

Uncommon Disease ◽

Significant Impairment ◽

Nasal Mucociliary Clearance ◽

Age And Sex

Abstract Allergic rhinitis in children is not an uncommon disease in India. Our objective was to evaluate the effect of allergic rhinitis on nasal mucociliary clearance. The nasal mucociliary clearance time (NMC) was studied using Andersen's saccharin method in fifty controls and fifty age and sex matched patients of allergic rhinitis. The nasal mucociliary clearance time in healthy controls was found to be 5.11 ± 1.51 minutes. A significant impairment (p < 0.01) in nasal mucociliary clearance time of 12.46 ± 3.74 minutes was observed in children suffering with allergic rhinitis, signifying that allergic rhinitis may predispose to sinusitis and pulmonary diseases.

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Impact of isotonic and hypertonic saline solutions on mucociliary activity in various nasal pathologies: clinical study

The Journal of Laryngology & Otology ◽

10.1017/s0022215108003964 ◽

2008 ◽

Vol 123 (5) ◽

pp. 517-521 ◽

Cited By ~ 34

Author(s):

A Ural ◽

T Kocak Oktemer ◽

Y Kizil ◽

F Ileri ◽

S Uslu

Keyword(s):

Allergic Rhinitis ◽

Hypertonic Saline ◽

Mucociliary Clearance ◽

Chronic Sinusitis ◽

Acute Sinusitis ◽

Clearance Time ◽

Nasal Irrigation ◽

Before And After ◽

Saline Solutions ◽

The Impact

AbstractObjective:To investigate the impact of nasal irrigation with isotonic or hypertonic sodium chloride solution on mucociliary clearance time in patients with allergic rhinitis, acute sinusitis and chronic sinusitis.Patients and methods:Mucociliary clearance time was measured using the saccharine clearance test on 132 adults before and after 10 days' application of intranasal isotonic or hypertonic saline. Patient numbers were as follows: controls, 45; allergic rhinitis, 21; acute sinusitis, 24; and chronic sinusitis, 42. The results before and after irrigation were compared using the Wilcoxon t-test.Results:Before application of saline solutions, mucociliary clearance times in the three patient treatment groups were found to be significantly delayed, compared with the control group. Irrigation with hypertonic saline restored impaired mucociliary clearance in chronic sinusitis patients (p < 0.05), while isotonic saline improved mucociliary clearance times significantly in allergic rhinitis and acute sinusitis patients (p < 0.05).Conclusion:Nasal irrigation with isotonic or hypertonic saline can improve mucociliary clearance time in various nasal pathologies. However, these solutions should be selectively prescribed rather than used based on anecdotal evidence. Further studies should be conducted to develop a protocol for standardised use of saline solution irrigation in various nasal pathologies.

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Effect of Esophageal Endoscopic Submucosal Dissection on Motility and Symptoms: A Prospective Study

Gastroenterology Research and Practice ◽

10.1155/2018/3735473 ◽

2018 ◽

Vol 2018 ◽

pp. 1-10

Author(s):

Tsutomu Takeda ◽

Kenshi Matsumoto ◽

Akihito Nagahara ◽

Hiroyuki Komori ◽

Yoichi Akazawa ◽

...

Keyword(s):

Endoscopic Submucosal Dissection ◽

Symptom Score ◽

Esophageal Motility ◽

High Resolution Manometry ◽

Submucosal Dissection ◽

Significant Difference ◽

Before And After ◽

Group A ◽

Integrated Relaxation Pressure ◽

Group B

Background.Endoscopic submucosal dissection (ESD) of esophageal tumors can cause stenosis, yet the effect of esophageal ESD on motility remains unclarified. This study aimed to compare esophageal motility and symptoms, before and after ESD, using high-resolution manometry (HRM) and symptom scoring.Methods.Twenty-eight patients with 35 cT1a cancers were prospectively enrolled between December 2014 and February 2016. Pre- and post-ESD symptom score and HRM were recorded. Based on circumferential resection (CR), patients were divided into group A (n=17, <2/3 CR) or B (n=11, 2/3 CR or greater). HRM parameters evaluated were distal contractile integral (DCI), contractile front velocity (CFV), intrabolus pressure, integrated relaxation pressure, distal latency, and peristaltic breaks.Results.Symptom scores worsened after ESD in 8/11 patients in group B, and 0/17 patients in group A. There was no significant difference in any HRM parameter after ESD in the whole study group but mean DCI tended to increase (p=0.07). In group B, DCI increased significantly after ESD (p=0.04), and CFV tended to decrease after ESD (p=0.08).Conclusions.DCI tended to increase after esophageal ESD. ESD affected the symptom score and esophageal motility in cases with 2/3 CR or greater. This trial is registered withUMIN000015829.

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Strain-Specific Differences in House Dust Mite (Dermatophagoides farinae)-Induced Mouse Models of Allergic Rhinitis

Clinical and Experimental Otorhinolaryngology ◽

10.21053/ceo.2019.01837 ◽

2020 ◽

Vol 13 (4) ◽

pp. 396-406 ◽

Cited By ~ 1

Author(s):

Ki-Il Lee ◽

Jun-Sang Bae ◽

Eun Hee Kim ◽

Ji Hye Kim ◽

Lele Lyu ◽

...

Keyword(s):

Allergic Rhinitis ◽

Mouse Models ◽

Neutrophil Infiltration ◽

Suitable Model ◽

Mrna Levels ◽

Dermatophagoides Farinae ◽

Th2 Response ◽

Significant Difference ◽

Group A ◽

Group B

Objectives. Limited information is available regarding strain-related differences in mouse models of allergic rhinitis induced by Dermatophagoides farinae (Der f1). In this study, we compared differences between two mouse strains and determined the optimal dose of Der f1 for allergic rhinitis mouse models.Methods. Forty-eight mice were assigned to the following six groups (n=8 per group): group A (control, BALB/c), group B (Der f1-sensitized BALB/c, 25 µg), group C (Der f1-sensitized BALB/c, 100 µg), group D (control, C57BL/6), group E (Der f1-sensitized C57BL/6, 25 µg), and group F (Der f1-sensitized C57BL/6, 100 µg). Allergic inflammation was induced with Der f1 and alum sensitization, followed by an intranasal challenge with Der f1. Rubbing and sneezing scores, eosinophil and neutrophil infiltration, and immunoglobulin, cytokine, and chemokine levels in the nasal mucosa and from splenocyte cultures were assessed.Results. Rubbing and sneezing scores were higher in groups B, C, E, and F than in groups A and D, with a similar pattern in both strains (i.e., group B vs. E and group C vs. F). Serum immunoglobulin levels were significantly elevated compared to the control in groups B and C, but not in groups E and F. Eosinophil and neutrophil infiltration increased (all P<0.05) after the Der f1 challenge (groups B, C, E, and F) compared to the control (groups A and D) in both the BALB/c and C57BL/6 strains, without any significant difference between the two strains (group A vs. D, group B vs. E, and group C vs. F) (P>0.05). BALB/c mice (group B) showed a greater elevation of splenic interleukin (IL)-4 (P<0.01), IL-5 (P<0.01), and IL-6 levels (P<0.05) and nasal IL-4 mRNA levels (P<0.001) than the C57BL/6 mice (group E). Interestingly, mice treated with 100 µg Der f1 showed a weaker allergic response than those treated with 25 µg.Conclusion. We found 25 µg to be a more appropriate dose for Der f1 sensitization. BALB/c mice are more biased toward a Th2 response and are a more suitable model for allergic rhinitis than C57BL/6 mice. This study provides information on the appropriate choice of a mouse model for allergic rhinitis.

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Efficacy of Korean Medicine Combination Treatment on Recurrent Neck Pain After Medical Procedures: A Retrospective Study

Journal of Acupuncture Research ◽

10.13045/jar.2020.00262 ◽

2021 ◽

Vol 38 (1) ◽

pp. 32-40

Author(s):

Hyo-Seung Huh ◽

Wu-Jin Jeong ◽

Ki-Tae Park ◽

Sun-Ho Lee ◽

Sun-A Kim ◽

...

Keyword(s):

Cervical Spine ◽

Neck Pain ◽

Combination Treatment ◽

Medical Procedures ◽

Korean Medicine ◽

Significant Difference ◽

Before And After ◽

Group A ◽

Group B ◽

Admission Group

Background: The aim of this study was to evaluate the efficacy of Korean medicine combination treatment on recurrent neck pain after medical procedures.Methods: This retrospective study included 158 inpatients of the Daejeon Jaseng Hospital of Korean Medicine who were diagnosed with “Cervical disc disorder with radiculopathy (M50.1)” between December 14th, 2017 and May 29th, 2019. The patients were assigned to 1 of 2 groups based on whether they received medical procedures on the cervical spine at least once. Korean medicine combination treatment was evaluated using EuroQol-5 dimensions index (EQ-5D), numeric rating scale (NRS), and neck disability index (NDI) scores.Results: Before and after treatment, the patients who received medical procedures on the cervical spine at least once before admission (Group A) showed a statistically significant difference in the NDI and NRS scores but not in the EQ-5D scores. This was similar to the patients who had not received medical procedures on the cervical spine before admission (Group B) they showed a statistically significant difference in the NDI and NRS scores but not in the EQ-5D scores. When comparing the results of Group A and Group B before and after treatment, no statistically significant differences were observed in the EQ-5D, NDI, and NRS scores.Conclusion: Korean medicine combination treatment improves the neck functional disability of patients who suffer from recurrent neck pain despite patients having undergone medical procedures.

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A comparative study to evaluate the effects of intranasal steroid spray, isotonic saline nasal irrigation and combination therapy in patients with allergic rhinitis

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20212123 ◽

2021 ◽

Vol 7 (6) ◽

pp. 1004

Author(s):

Smitha Soubhagya Gangaraju ◽

Nikitha Pillai ◽

Vijaylaxmi Manthal

Keyword(s):

Allergic Rhinitis ◽

Combination Therapy ◽

Isotonic Saline ◽

Treatment Modalities ◽

Nasal Irrigation ◽

Intranasal Corticosteroids ◽

Nasal Symptoms ◽

Before And After ◽

Group A ◽

Group B

Background: Allergic rhinitis (AR) is characterized by inflammatory changes in the nasal mucosa caused by exposure to inhaled allergens. AR clinically having 2 or more symptoms of anterior or posterior rhinorrhea, sneezing, nasal blockage or itching of the nose during two or more consecutive days for more than 1 hour on most days which are caused by allergen exposure leading to an IgE mediated reaction. Nasal steroids and antihistamines are considered as gold standard treatment of choice in moderate to severe AR. This study was taken to evaluate the efficacy of intranasal steroid spray, isotonic saline nasal irrigation, combination therapy and to compare all 3 treatment modalities.Methods: 75 patients of AR who met inclusion criteria were sequentially divided into 3 groups. Group A was intranasal steroid spray, group B was isotonic saline nasal irrigation, group C was combination of both intranasal steroid spray and saline nasal irrigation. Total nasal symptoms score was compared before and after 1 month of treatment.Results: Mean total nasal symptoms score before treatment in groups A, B and C was found to be 13.72, 12.96 and 13.68 respectively and after 1 month of treatment total nasal symptoms score was seen 8.28, 8.76 and 3.72 respectively.Conclusions: The combined use of saline nasal irrigation along with intranasal corticosteroids is found to be more effective in reducing the symptoms of patients with allergic rhinitis when compared to individual therapies.

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