Pathology Consultation Low-Grade and High-Grade Adenocarcinomas of the Salivary Duct System

1989 ◽  
Vol 98 (2) ◽  
pp. 162-163 ◽  
Author(s):  
John G. Batsakis ◽  
Mario A. Luna
Keyword(s):  
Oral Cavity ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Low Grade ◽  
High Grade ◽  
Duct System ◽  
Salivary Duct ◽  
Adenoid Cystic ◽  
Major Salivary Glands

Adenocarcinomas of salivary glands are encountered less frequently than adenoid cystic or mucoepidermoid carcinomas. They fall into two well-defined clinicopathologic groups: 1) those arising from intercalated ducts and 2) those from the excretory and interlobular ducts. The former, designated terminal duct adenocarcinomas, are low-grade malignancies found preponderantly in the oral cavity, especially the palate. The latter, designated salivary duct carcinomas, are high-grade neoplasms and arise almost exclusively in major salivary glands, especially the parotid gland.

scholarly journals Polymorphous low grade adenocarcinoma of the parotid gland: A case report with cytohistological correlation and its immunohistochemical study

2012 ◽  
Vol 2 (4) ◽  
pp. 331-334
Author(s):  
S Shrestha ◽  
CB Pun ◽  
R Basyal ◽  
T Pathak ◽  
S Bastola ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Malignant Tumor ◽  
Immunohistochemical Study ◽  
Low Grade ◽  
Minor Salivary Glands ◽  
Major Salivary Glands

Polymorphous low-grade adenocarcinoma is a rare salivary gland malignant tumor of low aggressiveness, commonly occurring in minor salivary glands. Its origin in major salivary glands is considered exceedingly rare. We report a case of polymorphous low grade adenocarcinoma arising from left parotid in a 21-yearold female patient.Journal of Pathology of Nepal (2012) Vol. 2, 331-334DOI: http://dx.doi.org/10.3126/jpn.v2i4.6890

Primary Malignant Lymphoma of the Salivary Glands

1986 ◽  
Vol 72 (5) ◽  
pp. 491-497 ◽  
Author(s):  
Lisbet Hjorth ◽  
Hans Dommerby ◽  
Steen Kruse ◽  
Annemarie Nielsen
Keyword(s):  
Parotid Gland ◽  
Malignant Lymphoma ◽  
Salivary Glands ◽  
Low Grade ◽  
High Grade ◽  
Malignant Lymphomas ◽  
Localized Disease ◽  
Grade Malignancy ◽  
Disseminated Disease ◽  
High Grade Malignancy

Five cases of primary malignant lymphomas of the salivary glands are reported. Four lymphomas arose in the parotid gland and one in the submandibular gland. All were non-Hodgkin lymphomas. In 4 cases the lymphomas were of low-grade malignancy, viz. 2 immunocytomas and 2 centroblastic/centrocytic malignant lymphomas, and 1 was a T-immunoblastic malignant lymphoma of high-grade malignancy. Four patients with localized disease were treated with radiotherapy and 1 patient with disseminated disease was treated with chemotherapy. One patient died from a disease unrelated to the malignant lymphoma, and 4 patients were alive at 66-136 months after treatment.

Dermal Eccrine Cylindroma

1989 ◽  
Vol 98 (12) ◽  
pp. 991-992 ◽  
Author(s):  
John G. Batsakis
Keyword(s):  
Head And Neck ◽  
Salivary Glands ◽  
Recurrence Rate ◽  
Malignant Change ◽  
High Recurrence Rate ◽  
High Grade ◽  
Duct System ◽  
Salivary Duct ◽  
High Grade Carcinoma

Certain dermal appendage tumors have a striking histologic and clinical homology with some tumors arising from the salivary duct system. The dermal eccrine cylindroma is an exemplar. Arising from the eccrine ducts, this neoplasm is only occasionally found outside the head and neck, has a recurrence rate of over 40%, and in its malignant form is a high-grade carcinoma. Its counterpart in salivary glands the dermal analogue tumor, manifests a histologic similarity, if not identity, also has a relatively high recurrence rate, and can also undergo malignant change.

Terminal duct adenocarcinomas of the parotid gland

1995 ◽  
Vol 109 (5) ◽  
pp. 466-468 ◽  
Author(s):  
Bonnie L. Kemp ◽  
John G. Batsakis ◽  
Adel K. El-Naggar ◽  
Sophia N. Kotliar ◽  
Mario A. Luna
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Salivary Glands ◽  
Minor Salivary Gland ◽  
Low Grade ◽  
Minor Salivary Glands ◽  
Biological Behaviour ◽  
Parotid Neoplasms ◽  
Clinicopathological Study

AbstractThe major salivary glands are considered to rarely be the sites of primary terminal duct adenocarcinomas, a neoplasm with a considerable predilection for origin from intraoral minor salivary glands. We present a clinicopathological study of 22 terminal duct adenocarcinomas of the parotid gland, the largest single series to date. A comparison between the parotid neoplasms and over 200 minor salivary gland terminal duct adenocarcinomas indicates there is little difference in biological behaviour and confirms the low-grade quality of the carcinomas, regardless of site of origin.

scholarly journals Adenoid Basal Carcinoma of Cervix: A Rare Case Report

2020 ◽  
Vol 3 (2) ◽  
pp. 392-394
Author(s):  
Alina Karna ◽  
Nisha Sharma
Keyword(s):  
Pap Smear ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Low Grade ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Adenoid Cystic ◽  
Carcinoma Of Cervix ◽  
Rare Case Report ◽  
Intraepithelial Lesion

Adenoid basal carcinoma of the uterine cervix is a rare low-grade tumor and its cell origin is still obscure. Adenoid basal carcinoma can be confused with adenoid basal hyperplasia, adenoid cystic carcinoma, and basaloid squamous cell carcinoma of the cervix. We present here a case of a 59 year-old-female who initially presented with a high-grade squamous intraepithelial lesion on Pap smear. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. Histopathology revealed focal invasive adenoid basal carcinoma with extensive areas of a high-grade squamous intraepithelial lesion involving the endocervical gland. The immunohistochemical stain was positive for p16.

scholarly journals Dedifferentiated Acinic Cell Carcinoma of the Parotid Gland With Myoepithelial Features

2002 ◽  
Vol 126 (9) ◽  
pp. 1104-1105 ◽  
Author(s):  
Simonetta Piana ◽  
Alberto Cavazza ◽  
Corrado Pedroni ◽  
Rosa Scotti ◽  
Luigi Serra ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Clinical Course ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
High Grade ◽  
Epithelial Proliferation ◽  
Acinic Cell

Abstract Dedifferentiated acinic cell carcinoma of the salivary gland is an uncommon variant of acinic cell carcinoma, characterized by the coexistence of both an usual low-grade acinic cell carcinoma and a high-grade dedifferentiated component, as well as by an accelerated clinical course. We describe a case of acinic cell carcinoma of the parotid gland in a 67-year-old woman, which recurred 4 times after surgery and radiotherapy. The recurrences consisted of residual foci of acinic cell carcinoma intermingled with a high-grade epithelial proliferation; the latter was focally constituted by cells with morphologic and immunohistochemical features of myoepithelium.

Cysts of the parotid gland

1975 ◽  
Vol 89 (4) ◽  
pp. 435-444 ◽  
Author(s):  
N. A. Shaheen ◽  
G. T. Harboyan ◽  
R. I. Nassif
Keyword(s):  
Parotid Gland ◽  
Salivary Glands ◽  
Diagnosis And Treatment ◽  
Cystic Lesions ◽  
Definite Diagnosis ◽  
Radical Mastoidectomy ◽  
Major Salivary Glands ◽  
Congenital Origin ◽  
Benign Tumours ◽  
Extensive Surgery

SummaryCYSTS of the major salivary glands are most frequent in the parotid where they form a small percentage of its benign tumours. They can be congenital or acquired and of parotid or extraparotid origin. Two unusual cysts are reported: a cholesteatoma arising from the ipsilateral mastoid, twenty years after successful radical mastoidectomy, and a deeply located cyst of probable congenital origin. The literature is reviewed and the management discussed. Parotidectomy, often with extensive dissection, remains in general the treatment of choice.Cysts in the parotid gland represent a small percentage of benign parotid masses. They usually arise within the gland from salivary or non-salivary parotid tissue, and may be congenital or acquired. Some, however, may arise from surrounding structures.Unless the cyst is superficial and therefore readily amenable to proper examination, it usually escapes a definite diagnosis even with the help of sialography or more sophisticated procedures. Exploration is eventually resorted to for diagnosis and treatment. That is why the surgeon should be ready to perform extensive surgery if the findings at exploration necessitate it.The purpose of this article is to present two cystic lesions of the parotid. The first is a rarity, a cholesteatoma originating from the ipsilateral mastoid; and the second an unusually deeply located cyst. These cases illustrate well the problems met with in the management of preauricular masses.

The Myoepithelial Immunophenotype in 135 Benign and Malignant Salivary Gland Tumors Other Than Pleomorphic Adenoma

1999 ◽  
Vol 123 (9) ◽  
pp. 801-806 ◽  
Author(s):  
Anil R. Prasad ◽  
Adnan T. Savera ◽  
Allen M. Gown ◽  
Richard J. Zarbo
Keyword(s):  
Smooth Muscle ◽  
Salivary Gland ◽  
Salivary Gland Tumors ◽  
Low Grade ◽  
Salivary Duct ◽  
Not Otherwise Specified ◽  
Adenoid Cystic ◽  
Myoepithelial Differentiation ◽  
Specific Proteins ◽  
Malignant Salivary Gland Tumors

Abstract Background.—We have previously studied the immunoreactivity of 3 novel smooth muscle–specific proteins, α-smooth muscle actin, smooth muscle myosin heavy chains, and calponin, to assess myoepithelial differentiation in pleomorphic adenomas. Objective.—To further expand our knowledge of myoepithelial differentiation in other benign and malignant salivary gland tumors. Design.—Formalin-fixed paraffin sections of 135 salivary gland tumors with associated normal glands were stained with monoclonal antibodies using the avidin-biotin complex immunoperoxidase method and enzymatic and microwave heat–induced epitope retrieval. Results.—In adenoid cystic carcinomas and epithelial-myoepithelial carcinomas, all 3 markers exclusively highlighted the myoepithelial cell components and the epithelial cells were entirely negative. No immunostaining was detected in canalicular adenomas, oncocytomas, Warthin tumors, acinic cell carcinomas, mucoepidermoid carcinomas, squamous cell carcinomas, and polymorphous low-grade adenocarcinomas. Salivary duct carcinomas and adenocarcinomas, not otherwise specified had a distinctive pattern of uniform periductal staining of reactive myofibroblastic cells, and in salivary duct carcinomas some ducts retained a peripheral immunoreactive myoepithelial cell layer. Conclusion.—Immunoreactivity for these 3 smooth muscle–specific proteins confirms the known neoplastic myoepithelial component of adenoid cystic carcinomas and epithelial-myoepithelial carcinomas. The consistently positive staining pattern in adenoid cystic carcinomas may be diagnostically useful in discriminating histologically similar but consistently negative polymorphous low-grade adenocarcinomas. Periductal linear staining in adenocarcinoma, not otherwise specified and salivary duct carcinomas is distinctive and appears to represent a tight cuff of myofibroblasts associated with the infiltrating glands.

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