scholarly journals A Comparison of Three Methods for the Estimation of Capillary Blood Glucose in Filter Paper Spots

1982 ◽  
Vol 19 (1) ◽  
pp. 22-25 ◽  
Author(s):  
R P Taylor ◽  
C A Pennock
Keyword(s):  
Blood Glucose ◽  
Filter Paper ◽  
Trichloroacetic Acid ◽  
Dried Blood Spots ◽  
Capillary Blood ◽  
Glucose Measurement ◽  
Diabetic Patients ◽  
Capillary Blood Glucose ◽  
Blood Spots ◽  
Heavy Workload

A comparison has been made between three methods for measuring capillary blood glucose collected on filter paper, including a new method using a Beckman glucose analyser 2. The methods are suitable for use with capillary blood spots collected onto filter paper for monitoring the control of diabetic patients. Their accuracy, precision, and recovery of glucose were similar. Glucose measurement with the Beckman glucose analyser 2 involves elution of the dried blood spots with 2% trichloroacetic acid and injection of a fraction of the eluate into the analyser. The method provides a simple and rapid alternative procedure for laboratories that do not have a heavy workload for this type of assay.

scholarly journals Effect of Body Lotions on Capillary Blood Glucose Measurement – Interference of Hydroquinone-containing Body Lotion with Capillary Glucose Measurement

2018 ◽  
Vol 14 (1) ◽  
pp. 44
Author(s):  
Andrea MA Omengue ◽  
Eugène Sobngwi ◽  
Mesmin Dehayem ◽  
Eric V Balt ◽  
Anne MO Boli ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glucose Level ◽  
Capillary Blood ◽  
Glucose Measurement ◽  
Capillary Blood Glucose ◽  
Almond Oil ◽  
Patients With Diabetes ◽  
Capillary Glucose ◽  
The Impact ◽  
Sweet Almond

The reliability of capillary blood glucose measurements is tremendously important for patients’ care and follow-up. Some factors independent of glucose control could however affect readings during ambulatory monitoring of capillary glucose levels in patients with diabetes mellitus. We sought to evaluate the impact of three body lotions commonly used in Cameroon on different strata of glycaemia. We explored their influence over time on measured capillary glucose values. We enrolled 16 participants. Eligible individuals were adult patients with diabetes (n=12) stratified into three levels of capillary glucose values (100 ± 40 mg/dL [5.55 ± 2.22 mmol/L], 200 ± 40 mg/dL [11.1 ± 2.22 mmol/L] and 300 ± 40 mg/dL [16.65 ± 2.22 mmol/L]) and normoglycaemic individuals (n=4). We measured capillary blood glucose before application, immediately after, then 5, 30 and 60 minutes after application of sweet almond oil, corticosteroid cream and hydroquinone lotion. The measurements made on impregnated body lotion-permeated fingers were compared to that of a clean finger. We observed a significant increase (delta [95% confidence interval, CI]: 119.5% [77.4–222.1]) of capillary glucose level immediately after administration of hydroquinone-containing body lotion (p<0.001). Capillary glucose values after the use of corticoid cream and sweet almond oil was stable 5, 30 and 60 minutes after application (p=0.875 and p=0.883 respectively). In the case of the hydroquinone-containing body lotion, there was a significant difference between capillary glucose level at 5 minutes (delta [95%CI]: 81.6% [55.3–214.2]; p<0.001), 30 minutes (delta [95%CI]: 71.6% [21.8–134.6]; p<0.001) and 60 minutes (delta [95%CI]: 58.3% [2.8–133.3]; p=0.013) after application compared to the value obtained from the clean finger. We observed from our study that there were significant variations in capillary blood glucose measurements induced by the use of hydroquinone lotion.

scholarly journals Gingival Crevicular Blood as a Potential Screening Tool: A Cross Sectional Comparative Study

2020 ◽  
Vol 17 (20) ◽  
pp. 7356
Author(s):  
Biagio Rapone ◽  
Elisabetta Ferrara ◽  
Luigi Santacroce ◽  
Skender Topi ◽  
Ilaria Converti ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Screening Tool ◽  
Capillary Blood ◽  
Blood Levels ◽  
Diabetic Patients ◽  
Capillary Blood Glucose ◽  
Cross Sectional ◽  
Finger Stick

Background: Diabetes is known to be one of the major global epidemic diseases, significantly associated with mortality and morbidity worldwide, conferring a substantial burden to the health care system. The epidemiological transition of this chronic disease tends to worsen unless preventive health strategies are implemented. Appropriate screening devices and standardized methods are crucial to prevent this potentially inauspicious life condition. Currently, the glucometer is the conventional device employed for blood glucose level determination that outputs the blood glucose reading. Glucometer performed in the dental office may be an important device in screening diabetes, so it can be addressed during a periodontal examination. Because gingival blood is a useful source to detect the glucose level, the focus is placed on the opportunity that might provide valuable diagnostic information. This study aimed to compare gingival crevicular blood with finger-stick blood glucose measurements using a self-monitoring glucometer, to evaluate whether gingival crevicular blood could be an alternative to allow accurate chairside glucose testing. Methods: A cross-sectional comparative study was performed among a 31–67-year-old population. Seventy participants with diagnosed type 2 diabetes and seventy healthy subjects, all with positive bleeding on probing, were enrolled. The gingival crevicular blood was collected using a glucometer to estimate the blood glucose level and compared with finger-stick blood glucose level. Results: The mean capillary blood glucose and gingival crevicular blood levels from all samples were, respectively, 160.42 ± 31.31 mg/dL and 161.64 ± 31.56 mg/dL for diabetic participants and 93.51 ± 10.35 mg/dL and 94.47 ± 9.91 mg/dL for healthy patients. In both groups, the difference between gingival crevicular blood and capillary blood glucose levels was non-significant (P < 0.05). The highly significant correlation between capillary blood glucose and gingival crevicular blood (r = 0.9834 for diabetic patients and r = 0.8153 for healthy participants) in both the groups was found. Conclusions: Gingival crevicular blood test was demonstrated as a feasible and useful primary screening tool test for detecting diabetes and for glucose estimation in non-diabetic patients. Use of gingival crevicular blood for screening is an attractive way of identifying a reasonable option of finger-stick blood glucose measurement under the appropriate circumstances. Rapid assessment may precede diagnostic evaluation in diabetic as well as healthy patients with acute severe bleeding. In addition, gingival crevicular blood levels may be needed to monitor the diabetic output.

INTRAOPERATIVE GLUCOSE LEVELIN NON-DIABETIC PATIENT UNDERGOING ELECTIVE MAJOR SURGERY UNDER GENERALANAESTHESIA RECEIVING DIFFERENT CRYSTALLOID SOLUTIONS AS MAINTENANCE FLUID (A COMPARISON BETWEEN NS AND RL)

2021 ◽  
pp. 30-32
Author(s):  
Saunak Nath ◽  
Niladri Sekhar Mukhopadhyay ◽  
Avinab Das
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Capillary Blood ◽  
Major Surgery ◽  
Diabetic Patients ◽  
Capillary Blood Glucose ◽  
Glucose Levels ◽  
Dence Interval ◽  
The Mean

INTRODUCTION: The present study was undertaken to observe the effect of different maintenance uid regimen on intraoperative blood glucose levels in non-diabetic patients undergoing elective major surgery under general anesthesia. AIMS AND OBJECTIVES: This study was conducted to observe the effect of different maintenance uids in intraoperative blood glucose levels of non-diabetic patients undergoing elective major non-cardiac surgery under general anesthesia. MATERIALS AND METHODS: The present study was conducted in the Department of Anesthesiology of Assam Medical College, Dibrugarh for a period of one year. Hospital based observational study. Patients undergoing elective major surgeries at operation theatres of Department of General Surgery of Assam Medical College & Hospital, Dibrugarh. One (1) year from July 2015 to June 2016. RESULT: The mean difference of capillary blood glucose level between baseline and 1.5 hours after intubation for those procedures lasted that long in Group N was 22.87 mg/dl with a 95% condence interval of 103.83-108.61 while in Group R it was 26.82 mg/dl with a 95% condence interval of 108.41-111.59. The mean difference of capillary blood glucose level between baseline and 2 hours after intubation for those procedures lasted that long in Group N was 34.14 mg/dl with a 95% condence interval of 117.29–117.71 while in Group R it was 34.07 with a 95% condence interval of 116.38–118.12. CONCLUSION: This study we can come to a conclusion that though there is a rising trend in change in intraoperative capillary blood glucose level in both the solutions used perioperatively, yet the mean change in intraoperative capillary blood glucose level in non-diabetic patients undergoing major surgeries under general anaesthesia receiving either 0.9% sodium chloride or Ringer's lactate solutions as maintenance uid perioperatively, is comparable, yet needs larger groups of study

Comparison of Glucose Values of Blood Samples Taken in Three Different Ways

2017 ◽  
Vol 28 (4) ◽  
pp. 436-455 ◽  
Author(s):  
Tulay Sagkal Midilli ◽  
Eda Ergın ◽  
Ebru Baysal ◽  
Zeki Arı
Keyword(s):  
Blood Glucose ◽  
Venous Blood ◽  
Middle Finger ◽  
Blood Glucose Measurement ◽  
Capillary Blood ◽  
Glucose Measurement ◽  
Capillary Blood Glucose ◽  
Blood Samples ◽  
Left Hand ◽  
The Right

The purpose of the study was to determine differences and correlations between the blood glucose values of venous blood and the first and second drops of capillary blood samples taken in three different ways. Blood samples were (a) venous blood, (b) the first and second drops of capillary blood from the middle finger of the right hand (only washed with soap and water), and (c) the first and second drops of capillary blood from the middle finger of the left hand (washed with soap and water and cleaned with alcohol). It was concluded that the fasting capillary blood glucose values could be used in place of venous blood glucose values, that only washing the hands with neutral soap and water for 30 s could be sufficient for capillary blood glucose measurement, and that the first or second blood drop from a clean hand could be used for capillary blood glucose measurement.

scholarly journals Measurement of capillary blood glucose in filter-paper spots: an aid to the assessment of diabetic control.

BMJ ◽  
1978 ◽  
Vol 2 (6135) ◽  
pp. 468-469 ◽  
Author(s):  
K Wakelin ◽  
D J Goldie ◽  
M Hartog ◽  
A P Robinson
Keyword(s):  
Blood Glucose ◽  
Filter Paper ◽  
Diabetic Control ◽  
Capillary Blood ◽  
Capillary Blood Glucose

scholarly journals MON-699 Artifactual Hypoglycemia in a Patient with Prolonged Hospital Stay for Neuroleptic Malignant Syndrome

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Janya Swami
Keyword(s):  
Blood Glucose ◽  
Neuroleptic Malignant Syndrome ◽  
Plasma Glucose ◽  
Paranoid Schizophrenia ◽  
Clinical Signs ◽  
Tube Feeding ◽  
Care Facility ◽  
Capillary Blood ◽  
Glucose Measurement ◽  
Capillary Blood Glucose

Abstract Background: Hypoglycemia is rare in patients without diabetes. A low capillary glucose concentration is not sufficient to make a diagnosis of a hypoglycemic disorder. In fact, this has multiple sources of error. Fulfillment of Whipple’s triad is an essential step for establishing the diagnosis of a hypoglycemic disorder. Clinical case: A 47-year old Caucasian male with past medical history of paranoid schizophrenia was admitted to the ICU from an outside facility with catatonia and apneic spells following an acute change in mental status. He was diagnosed with neuroleptic malignant syndrome and Endocrinology was consulted after 137 days in the hospital for concerns of severe and recurrent hypoglycemia. The patient was non-verbal on evaluation and despite multiple capillary blood glucose readings of &lt;70 mg/dL, including measurements as low as 29 mg/dL, he remained asymptomatic with absence of any clinical signs of an adrenergic response to hypoglycemic episodes. He was on continuous tube feeding through a PEG tube. The low capillary blood glucose measurements prompted rapid management with intravenous or oral dextrose based on the hypoglycemia protocol designed by the hospital. As a last resort, the patient was placed on a continuous dextrose infusion in addition to tube feeding to prevent hypoglycemia.Diagnostic evaluation: Following consultation, we ordered for a corresponding plasma glucose measurement to be done with any capillary blood glucose measurement of &lt; 55 mg/dL prior to correction for hypoglycemia. For a capillary blood glucose measured at 48 mg/dL, corresponding plasma glucose was 95 mg/dL. Whipple’s triad was not fulfilled and no additional work up was pursued. We recommended calibration of the glucose monitors for the hospital unit where the patient was admitted with recommendations to stop monitoring capillary blood glucose in this patient in the absence of diabetes, signs/symptoms of hypoglycemia, medications implicated to cause hypoglycemia and ongoing nutrition with tube feeding. Follow-up: The patient remains in the hospital and is waiting placement at an extended care facility. Plasma blood glucose measurements remain within normal range.Clinical lesson: Artifactual hypoglycemia, though uncommon, is an important consideration when evaluating and managing hypoglycemia. Whipple’s triad is essential to make a diagnosis of true hypoglycemia. Several factors; patient, operator and machine-related, can impact measurements of capillary blood glucose measurements and often result in unnecessary treatment measures often causing inefficient and often preventable wastage of hospital resources and sometimes even harm the patient.

scholarly journals Use of filter paper for sample collection and transport in steroid pharmacology

1997 ◽  
Vol 43 (8) ◽  
pp. 1408-1415 ◽  
Author(s):  
Christopher J Howe ◽  
David J Handelsman
Keyword(s):  
Filter Paper ◽  
Pharmacological Study ◽  
Venous Blood ◽  
Field Studies ◽  
Dried Blood Spots ◽  
Capillary Blood ◽  
Sample Collection ◽  
Blood Spots ◽  
Adverse Environmental Conditions ◽  
Good Agreement

Abstract Field studies of androgen pharmacology are complicated by the necessity to collect, process, and store blood samples in a central facility. We have assessed the feasibility of using capillary blood spots collected by fingerprick and dried on filter paper for pharmacokinetics and pharmacodynamic measurements with nandrolone and testosterone RIAs modified for extracts from capillary blood spots. Assays on punched spots of 7.9-mm diameter (14.9 μL of dried blood) permitted accurate quantification of testosterone down to 0.4 nmol/L from a single spot and nandrolone down to 0.9 nmol/L from two spots. Stability of the steroids in dried blood spots to adverse environmental conditions, notably increased temperatures, was investigated both in the laboratory and in field studies of dried spots sent through the postal system. Storage or postal transport under moderate conditions appeared to have no deleterious effects on apparent androgen concentrations. However, under extreme conditions of storage at 50 °C for a week or more, or transport to a very hot tropical location, a rise in the final concentration of nandrolone, and, to a lesser extent, testosterone when corrected for tracer recovery, was noticed. These effects were largely due to apparent susceptibility of tritiated tracer, but not unlabeled androgens, to thermal degradation. In a pilot pharmacological study involving intramuscular injection of 100 mg of nandrolone decanoate in 1 mL of arachis oil, nandrolone concentrations in concurrently collected plasma as well as venous and capillary blood spots showed good agreement. Testosterone concentrations in contemporaneously collected plasma and venous blood spots also showed very good agreement. We propose that these methods may allow patients and experimental subjects to self-collect samples at remote or field locations for convenient mailing to a central laboratory for androgen assay. Applications of this methodology are now under way.

scholarly journals How Much Accuracy of Interstitial Glucose Measurement Is Enough? Is There a Need for New Evidence?

2016 ◽  
Vol 11 (2) ◽  
pp. 296-298 ◽  
Author(s):  
Norbert Hermanns ◽  
Dominic Ehrmann ◽  
Bernhard Kulzer
Keyword(s):  
Blood Glucose ◽  
Point Of Care ◽  
Glucose Monitoring ◽  
Blood Glucose Measurement ◽  
Capillary Blood ◽  
Glucose Measurement ◽  
Capillary Blood Glucose ◽  
Measurement Systems ◽  
Interstitial Glucose ◽  
New Evidence

This analytical comment discusses what standards are needed for the evaluation of the accuracy of glucose measurement systems continuously measuring glucose in the interstitial fluid. Since accuracy standards for continuous glucose monitoring (CGM)/flash glucose monitoring (FGM) systems are currently based on modeling studies or consensus of experts, we raised the question whether non-inferiority trials evaluating the safety and efficacy of CGM/FGM measurements compared to capillary blood glucose measurement with point-of-care devices could help to establish clarity about the needed accuracy standards of CGM/FGM. Such trials could also support the replacement of capillary blood glucose measurements by modern CGM/FGM systems.

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