scholarly journals Increased Mean Platelet Volume after Oestrogen Replacement Therapy

1996 ◽  
Vol 33 (6) ◽  
pp. 555-560 ◽  
Author(s):  
L R Ranganath ◽  
J Christofides ◽  
M J Semple
Keyword(s):  
Linoleic Acid ◽  
Replacement Therapy ◽  
Mean Platelet Volume ◽  
Platelet Reactivity ◽  
Platelet Rich Plasma ◽  
Hormone Replacement ◽  
Platelet Membrane ◽  
Gas Liquid Chromatography ◽  
Platelet Volume ◽  
Post Menopausal

The effect of hormone replacement therapy (HRT) on platelet size was examined in 38 post-menopausal women before and at end of a 6 week period of HRT. Subjects were treated with cyclical L-norgestrel 75 mg daily from days 17 to 28 of a 28-day cycle combined with continuous conjugated equine oestrogens 0.625 mg daily. Platelet-rich plasma was obtained to measure platelet indices by Coulter analysis. Plasma measurements of luteinizing hormone, follicle stimulating hormone and 17β-oestradiol were measured by immunoassays. Platelet membrane fatty acids were measured by gas-liquid chromatography. A significant reduction in platelet membrane linoleic acid, di-homo-γ-linoleic acid and arachidonic acid of 8.1%, 14.3% and 17.8%, respectively was noted after 6 weeks of HRT ( P < 0.01). There was an increase in the platelet count (not significant) and platelet volume (MPV) ( P < 0.05) after 6 weeks of hormone therapy. HRT appears to increase mean platelet volume which may indicate an increase in platelet reactivity. There was no correlation between the changes in mean platelet volume and membrane fatty acid changes in platelets after such therapy.

scholarly journals Effects of oral hormone replacement therapy on mean platelet volume in postmenopausal women

2014 ◽  
Vol 44 ◽  
pp. 980-984 ◽  
Author(s):  
İkbal KAYGUSUZ ◽  
Serap Aynur SİMAVLI ◽  
Ayla ESER ◽  
İlknur İNEGÖL GÜMÜŞ ◽  
Selcen YÜKSEL ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Mean Platelet Volume ◽  
Hormone Replacement ◽  
Platelet Volume

Effects of hormone replacement therapy on platelet membrane fatty acid composition

1996 ◽  
Vol 148 (2) ◽  
pp. 207-212 ◽  
Author(s):  
L R Ranganath ◽  
J A Christofides ◽  
J W Wright ◽  
V Marks
Keyword(s):  
Fatty Acids ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Hormone Replacement ◽  
Saturated Fatty Acids ◽  
Platelet Membrane ◽  
Gas Liquid Chromatography ◽  
Serum Lipoproteins ◽  
Membrane Fatty Acids

Abstract Oestrogen replacement therapy has been shown to protect postmenopausal women from ischaemic heart disease, strokes and hypertension. The mechanism of protection conferred by oestrogen, although partly attributable to changes in serum lipoproteins, is not fully understood. The present study was undertaken to assess the effect of hormone replacement therapy on the composition of platelet membrane fatty acids in postmenopausal women. These were analysed by gas-liquid chromatography before and six weeks after continuous conjugated equine oestrogen therapy (0·625 mg daily) combined with cyclical therapy with 75 μg l-norgestrel from day 17 to 28 of a 28-day cycle. Each subject acted as her own control. The principal findings of the study were that, following treatment, there was a 16·2% reduction in platelet membrane polyunsaturated fatty acids (P<0·001), an increase of 9·1 and 7·1% in saturated fatty acids and monounsaturated fatty acids respectively (P<0·001) and a 17·8% reduction in arachidonic acid (P<0·003). There was no correlation between changes in membrane fatty acids and serum lipoproteins. This suggests that the changes in membrane composition noted in this study may be a primary effect of hormone replacement therapy, especially oestrogen. Journal of Endocrinology (1996) 148, 207–212

Does hormone replacement therapy in post-menopausal women have any effect upon nasal physiology?

2008 ◽  
Vol 122 (7) ◽  
pp. 707-710 ◽  
Author(s):  
D C Wild ◽  
C M Philpott ◽  
C R Wolstenholme ◽  
G E Murty
Keyword(s):  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Oral Contraceptive Pill ◽  
Life Questionnaire ◽  
Female Hormone ◽  
Menopausal Women ◽  
Nasal Physiology ◽  
Post Menopausal ◽  
Age Range

AbstractBackground:Previous studies have suggested that the female menstrual cycle, pregnancy and the oral contraceptive pill have an effect upon nasal physiology.Objectives:This study aimed to assess the effects upon nasal physiology of female hormone replacement therapy in post-menopausal women. This has not been previously studied.Methods:Twenty post-menopausal women (age range 36 to 70 years; mean age 57.0 years) underwent measurements of the nasal airway, including anterior rhinoscopy, peak nasal inspiratory flow rate, acoustic rhinometry, anterior rhinomanometry, mucociliary clearance time and rhinitis quality of life questionnaire. Measurements of nasal patency were recorded prior to commencing hormone replacement therapy and at a time point 77–195 days (mean 101.9 days) following commencement.Results:There was no statistical difference found for any of the variables, using the paired t-test (p > 0.05 for all).Conclusions:Female hormone replacement therapy has no discernable effect upon nasal physiology and should not be considered a cause of rhinitic symptoms.

Elevated Concentrations of Soluble Adhesion Molecules and Large Platelets in Diabetic Patients: Are They Markers of Vascular Disease and Diabetic Nephropathy?

2007 ◽  
Vol 13 (4) ◽  
pp. 391-397 ◽  
Author(s):  
N. Bavbek ◽  
A. Kargili ◽  
O. Kaftan ◽  
F. Karakurt ◽  
A. Kosar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Mean Platelet Volume ◽  
Plasma Levels ◽  
Platelet Reactivity ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Platelet Volume ◽  
Soluble Adhesion Molecules ◽  
Protein Excretion

P-selectin, E-selectin, and mean platelet volume are markers associated with platelet reactivity that have been demonstrated to be increased in diabetes. We were particularly interested to see if there was a difference in mean platelet volume and selectins between diabetics and nondiabetics, and in diabetics with and without nephropathy, and whether there was a correlation between mean platelet volume and selectins. One hundred and fourteen diabetic patients and 31 healthy controls were investigated. Plasma levels of P-selectin and E-selectin were higher in the diabetic group than in controls ( P = .001 and P = .007, respectively) and in diabetic patients with proteinuria than in patients without proteinuria ( P = .002 and P = .004, respectively). Protein excretion was lower in patients with low mean platelet volume values ( P = .004). In conclusion, elevated platelet volume and high selectin values may play a role in the development of vasculopathies and complications in diabetes mellitus. Further studies are needed to prove these results.

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