scholarly journals Observations of the first GameSense-branded responsible gambling centre in a US casino

2019 ◽  
Vol 79 (1) ◽  
pp. 104-120 ◽  
Author(s):  
Heather M Gray ◽  
Layne Keating ◽  
Howard J Shaffer ◽  
Debi A LaPlante
Keyword(s):  
Responsible Gambling ◽  
Gambling Behaviour ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Comprehensive Description ◽  
Time Limits ◽  
The Usa ◽  
Casino Patrons ◽  
Programme Exposure ◽  
Programme Staff

Objective: To help mitigate potential gambling harm, responsible gambling information centres are launching across casino venues in North America. The launch of the first such centre in the USA provided an opportunity to achieve three goals: (1) document the centre’s reach among casino patrons, (2) generate a comprehensive description of services provided, and (3) explore the potential for a dose–response relationship between centre exposure and gambling beliefs and behaviour. Design: We documented services provided and surveyed consecutive centre visitors. Setting: We achieved these goals at the GameSense Info Center, located in the first Massachusetts casino. Method: Programme staff recorded their services via electronic checklist and administered one-page surveys to visitors with whom they discussed problem or responsible gambling. Results: Programme staff reported engaging directly with approximately 1% of daily patrons. About 70% of their interactions were casual. During conversations that did move beyond a casual nature, programme staff typically provided information about responsible gambling, consistent with patrons’ self-reported needs and concerns. Finally, among a sample of patrons who repeatedly engaged with programme staff at the most involved level ( N = 129), those with relatively little programme exposure were more likely to hold an accurate gambling belief but less likely to report having set time limits on their casino visits. Conclusion: We did not observe support for the notion that using an on-site information centre to teach patrons about important gambling concepts is associated with more responsible gambling behaviour.

scholarly journals Did the elimination of lead from petrol reduce crime in the USA in the 1990s?

F1000Research ◽  
2013 ◽  
Vol 2 ◽  
pp. 156 ◽  
Author(s):  
Wayne Hall
Keyword(s):  
Young Adulthood ◽  
Lead Exposure ◽  
Epidemiological Studies ◽  
Crime Rates ◽  
Unintended Consequence ◽  
Biological Plausibility ◽  
Response Relationship ◽  
Ecological Studies ◽  
Dose Response Relationship ◽  
The Usa

This article assesses the evidence for the hypothesis that a decline in all types of crime since the early 1990s in the USA was an unintended consequence of removing lead from petrol between 1975 and 1985. It describes ecological and econometric studies that have generally but not always found correlations between lead exposures in childhood and some types of crime 20 years later; a small number of epidemiological studies that have found a dose-response relationship between lead exposure in childhood and self-reported and officially recorded criminal offences in young adulthood; and evidence for the biological plausibility of a causal relationship. The major anomaly in the evidence is that the associations reported in ecological studies are much stronger (explaining 56-90% of the variation in crime rates) than the weaker relationships found in the cohort studies (that typically explain less than 1% of the variance in offending).  Suggestions are made for research that will better assess the contribution that reduced lead exposure has made to declining crime rates in the USA.

scholarly journals Did the elimination of lead from petrol reduce crime in the USA in the 1990s?

F1000Research ◽  
2013 ◽  
Vol 2 ◽  
pp. 156
Author(s):  
Wayne Hall
Keyword(s):  
Young Adulthood ◽  
Lead Exposure ◽  
Epidemiological Studies ◽  
Crime Rates ◽  
Biological Plausibility ◽  
Response Relationship ◽  
Ecological Studies ◽  
Dose Response Relationship ◽  
The Usa ◽  
Very High

This article assesses the evidence for the hypothesis that a decline in all types of crime since the early 1990s in the USA was a consequence of removing lead from petrol between 1975 and 1985. It describes ecological and econometric studies that have generally but not always found correlations between lead exposures in childhood and some types of crime 20 years later; a small number of epidemiological studies that have found a dose-response relationship between lead exposure in childhood and self-reported and officially recorded criminal offences in young adulthood; and evidence for the biological plausibility of a causal relationship. Lead exposure in childhood may have played a small role in rising and falling crime rates in the USA but it is unlikely to account for the very high percentage of the decline suggested by the ecological studies. The major anomaly in the evidence is that the associations reported in ecological studies are much stronger (explaining 56-90% of the variation in crime rates) than the weaker relationships found in the cohort studies (that typically explain less than 1% of the variance in offending).  Suggestions are made for research that will better assess the contribution that reduced lead exposure has made to declining crime rates in the USA.

A SUBCUTANEOUS INJECTION ASSAY FOR ANTI-ANDROGENS IN THE CHICK

1962 ◽  
Vol 41 (2) ◽  
pp. 268-273 ◽  
Author(s):  
Ralph I. Dorfman
Keyword(s):  
Dose Response ◽  
Subcutaneous Injection ◽  
Response Relationship ◽  
Dose Response Relationship

ABSTRACT The stimulating action of testosterone on the chick's comb can be inhibited by the subcutaneous injection of 0.1 mg of norethisterone or Ro 2-7239 (2-acetyl-7-oxo-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene), 0.5 mg of cortisol or progesterone, and by 4.5 mg of Mer-25 (1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenyl ethanol). No dose response relationship could be established. Norethisterone was the most active anti-androgen by this test.

Mathematical Interpretation of the Pharmacodynamics of Homoeopathic Medicines

2021 ◽  
Vol 34 (01) ◽  
pp. 003-016
Author(s):  
John Michel Warner
Keyword(s):  
Immune System ◽  
Immune Responses ◽  
Dose Response ◽  
Oral Route ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Force Line ◽  
Administration Routes ◽  
Medicinal Substances ◽  
Medicine Administration

AbstractAccording to Hahnemann, homoeopathic medicines must be great immune responses inducers. In crude states, these medicines pose severe threats to the immune system. So, the immune-system of an organism backfires against the molecules of the medicinal substances. The complex immune response mechanism activated by the medicinal molecules can handle any threats which are similar to the threats posed by the medicinal molecules. The intersectional operation of the two sets, medicine-induced immune responses and immune responses necessary to cure diseases, shows that any effective homoeopathic medicine, which is effective against any disease, can induce immune responses which are necessary to cure the specific disease. In this article, this mechanism has been exemplified by the action of Silicea in human body. Also, a neuroimmunological assessment of the route of medicine administration shows that the oral cavity and the nasal cavity are two administration-routes where the smallest doses (sometimes even few molecules) of a particular homoeopathic medicine induce the most effective and sufficient (in amount) purgatory immune responses. Administering the smallest unitary doses of Silicea in the oral route can make significant changes in the vital force line on the dose–response relationship graph. The dose–response relationship graph further implicates that the most effective dose of a medicine must be below the lethality threshold. If multiple doses of any medicine are administered at same intervals, the immune-system primarily engages with the medicinal molecules; but along the passage of time, the engagement line splits into two: one engages with the medicinal molecules and another engages with diseases. The immune system's engagement with the diseases increases along the passage of time, though the engagement with the medicinal molecules gradually falls with the administration of descending doses. Necessarily, I have shown through mathematical logic that the descending doses, though they seem to be funny, can effectively induce the most effective immune responses.

Optimizing Outcomes in Multiple Sclerosis – A Consensus Initiative

2009 ◽  
Vol 15 (2_suppl) ◽  
pp. 5-35 ◽  
Author(s):  
P Coyle ◽  
B Arnason ◽  
B Hurwitz ◽  
F Lublin
Keyword(s):  
Disease Progression ◽  
Online Survey ◽  
Initial Therapy ◽  
Clinically Isolated Syndrome ◽  
Optimal Management ◽  
Disease Course ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Key Issues ◽  
Delay Progression

Background Initiation of immunomodulators in patients experiencing a clinically isolated syndrome (CIS) may delay progression to clinically definite MS. However, lack of consensus remains on many issues affecting optimal management of MS. Method A panel of 21 MS experts met during 9 meetings to explore key issues in MS and CIS. Meetings addressed 3 phases: 1. CIS definition and diagnosis; 2. initial therapy; and 3. monitoring disease progression and treatment efficacy. Newsletters covering each phase were sent to 5000 U.S.-based neurologists who were invited to participate in an online survey on key issues. Results Most panel members agreed that early treatment may minimize neurodegeneration and most would recommend it for patients; that a dose-response relationship exists for beta-interferon therapy; that more aggressive therapy was most effective early in the disease course; and, that MRI has a role in monitoring disease progression. In face of suboptimal response, most would switch patients to a different therapy; while combination therapy would be reserved for those failing monotherapy regimes. Most online survey respondents agreed with these positions. Conclusions There was uniform consensus from this panel of MS experts that early initiation of immunomodulator therapy was beneficial for CIS patients.

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