First reported case of a histiocytic sarcoma in an Armenian hamster (Cricetulus migratorius)

2021 ◽  
pp. 002367722110336
Author(s):  
Christopher Cheleuitte-Nieves ◽  
Sarah V Kitz ◽  
Sébastien Monette
Keyword(s):  
Soft Tissue Sarcomas ◽  
Mitotic Rate ◽  
Histiocytic Sarcoma ◽  
Cheek Pouch ◽  
Neoplastic Cells ◽  
Presumptive Diagnosis ◽  
Moderate Amount ◽  
Histiocytic Cell ◽  
Multinucleated Cells ◽  
First Case

A 14-month-old male Armenian hamster ( Cricetulus migratorius) presented with a spontaneous, subcutaneous, firm mass (4.0 × 2.0 × 1.5 cm) on the ventral neck extending towards the cheek pouch causing multifocal small oral ulcerations. This animal was immunized subcutaneously on the dorsal neck for the development of monoclonal antibodies seven months before presentation. The animal was euthanized and necropsy was performed. Histopathology of the mass showed a well demarcated, multilobulated, unencapsulated, highly cellular, neoplastic mass composed of spindle cells arranged in interlacing streams and bundles, with a moderate amount of fibrovascular stroma. The neoplastic cells exhibited indistinct cell borders and a moderate to large amount of eosinophilic, fibrillar cytoplasm, marked anisocytosis and anisokaryosis, binucleated and multinucleated cells, and high mitotic rate. Based on the histomorphologic features of the mass, and the presence of renal tubular hyaline globules and myeloid hyperplasia in the bone marrow, a diagnosis of histiocytic sarcoma was made. The presumptive diagnosis was confirmed by immunohistochemistry, upon which the neoplastic cells showed strong immunoreactivity for the histiocytic cell markers Iba1 and CD11b. Histiocytic sarcomas have been reported in Syrian ( Mesocricetus auratus) and Siberian dwarf ( Phodopus sungorus) hamsters but, to our knowledge, the current report represents the first case of histiocytic sarcoma described in an Armenian hamster. It is plausible to consider the animal’s experimental immunization history and the development of the histiocytic sarcoma to be related. An association between adjuvanted vaccines and soft-tissue sarcomas has been described in cats and referred to as feline injection-site sarcomas.

scholarly journals Nodal histiocytic sarcoma with prominent eosinophilic infiltration: expression of eotaxin-2 on tumor cells

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Rintaro Ohe ◽  
Takanobu Kabasawa ◽  
Aya Utsunomiya ◽  
Yuka Urano ◽  
Takumi Kitaoka ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Lymphatic Vessel ◽  
Tumor Biology ◽  
Lower Abdominal Pain ◽  
Inflammatory Cells ◽  
Histiocytic Sarcoma ◽  
Eosinophilic Infiltration ◽  
Neoplastic Cells ◽  
Multinucleated Cells ◽  
Mesenteric Tumors

Abstract Background Histiocytic sarcoma (HS) is a rare neoplasm showing morphological and immunophenotypic features of mature tissue histiocytes. We report a patient with nodal HS exhibiting prominent reactive eosinophilic infiltration. Case presentation A 68-year-old man presented with intermittent left lower abdominal pain and weight loss over 3 months. A computed tomography scan revealed multiple abdominal nodules. Open biopsy of the mesenteric tumors was performed for definitive diagnosis. Histologically, the tumor was comprised of a diffuse noncohesive proliferation of pleomorphic large cells, including multinucleated cells. Neoplastic cells were positive for histiocytic markers (CD68, CD163, and LIGHT) and PD-L1 but lacked markers of Langerhans cells, follicular dendritic cells, and epithelial cells. Frequent reactive inflammatory cells were intermingled in the background. Interestingly, prominent eosinophilic infiltration was also noted. Spindle neoplastic cells were prone to be present around areas with little to no eosinophilic infiltration and exhibiting fibrosis and lymphatic vessel proliferation. Conversely, polygonal neoplastic cells were prone to be present around areas with relatively large amounts of eosinophilic infiltration without fibrosis or lymphatic vessel proliferation. Immunohistochemically, the tumor cells and reactive eosinophils expressed eotaxin-2 and eotaxin-3, respectively. Conclusion We revealed that eotaxins induced the selective migration of eosinophils into tissues in this case. These eosinophils may affect the tumor remodeling and tumor biology characteristics of HS, such as fibrosis and lymphatic vessel proliferation.

Primary stromal sarcoma of breast: A case report and literature review

2021 ◽  
pp. 1-7
Author(s):  
Mohammad Al-Wiswasy ◽  
Mahmoud Al-Balas ◽  
Raith Al-Saffar ◽  
Hamzeh Al-Balas
Keyword(s):  
Malignant Tumors ◽  
Histopathological Examination ◽  
Prognostic Significance ◽  
Total Duration ◽  
Young Patients ◽  
Soft Tissue Sarcomas ◽  
Breast Mass ◽  
Resection Margins ◽  
Stromal Sarcoma ◽  
First Case

INTRODUCTION: Primary breast sarcoma (PBS) was first described in 1887 as a rare heterogeneous neoplasm arising from the mesenchymal tissue of the mammary gland accounting for less than 5% of all body soft-tissue sarcomas and less than 0.1% of all malignant tumors of the breast. CASE PRESENTATION: A 31-year old lady presented with left breast mass which she felt four years before during which the mass increased in size from 1 to 6 cm in the largest diameter, diagnosed clinically as a benign fibroadenoma without any further cytological or histopathological confirmation. Histopathological examination of the excised breast mass reveals undifferentiated, primary stromal sarcoma of the breast (PSSB), which was followed by mastectomy three weeks later with reconstructive breast surgery with a total duration of follow-up of 3 years thereafter. This is the first case of PSSB reported in Jordan. DISCUSSION/CONCLUSION: PSSB is the generic term given to malignant breast tumors thought to arise from the specialized mesenchymal stroma of the breast but lacking an epithelial component with a phylloides pattern. PSSB is difficult to diagnose preoperatively due to its rarity and inadequate imaging methods to establish an exact diagnosis. The histology of the patient mass may be the leading factor for the management of these tumors. Even in very young patients, a progressively growing breast mass should alert the clinician to investigate for malignancy and verify the results by biopsy. Surgery with adequate resection margins represents the only potentially curative modality with prognostic significance. Adjuvant chemotherapy and radiotherapy are not very beneficial. The prognosis is dismal for patients with lymph node involvement and the size of the tumor has a lesser bearing on the outcome.

scholarly journals Larva migrans in the oral mucosa: report of two cases

2011 ◽  
Vol 22 (2) ◽  
pp. 166-170 ◽  
Author(s):  
José Humberto Damante ◽  
Luiz Eduardo Montenegro Chinellato ◽  
Fernando Toledo de Oliveira ◽  
Cleverson Teixeira Soares ◽  
Raul Negrão Fleury
Keyword(s):  
Oral Mucosa ◽  
Larva Migrans ◽  
Common Disease ◽  
Erythematous Plaque ◽  
Presumptive Diagnosis ◽  
Tropical Regions ◽  
Linear Pattern ◽  
First Case ◽  
Histological Characteristics ◽  
Posterior Direction

Cutaneous Larva migrans is a very common disease in tropical regions. In the oral mucosa, the infection occurs in the same way as in the skin, but it is rarer. This report describes two cases of Larva migrans in the oral mucosa. The first case was in a 27-year-old woman who presented an erythematous plaque located on the buccal mucosa, extending to a posterior direction, following a linear pattern, to other areas of the mouth. After incisional biopsy of the anterior-most portion of the lesion, morphological details obtained in multiple examined sections suggested Necator or Ancylostoma braziliense larvae as the cause of infection. The second case was in a 35-year-old male who presented a fusiform erythematous plaque in the palatal mucosa. This area was removed and submitted to microscopic examination under a presumptive diagnosis of "parasite migratory stomatitis". The histological characteristics were suggestive of a larva pathway. In both cases the lesion disappeared after biopsy and the patients were symptom-free.

Pazopanib-related secondary polycythemia in metastatic myxofibrosarcoma: A case report and review of the literature

2020 ◽  
pp. 107815522095044
Author(s):  
Martina Fanelli ◽  
Francesco Caputo ◽  
Krisida Cerma ◽  
Fabio Gelsomino ◽  
Alessia Bari ◽  
...  
Keyword(s):  
Case Report ◽  
Kinase Inhibitor ◽  
Smoking Habit ◽  
Soft Tissue Sarcomas ◽  
Drug Discontinuation ◽  
Surgical Removal ◽  
Related Condition ◽  
Distant Relapse ◽  
First Case ◽  
Secondary Polycythemia

Introduction Pazopanib, a tyrosine kinase inhibitor (TKI), is a standard treatment for various tumours, including metastatic non-adipocytic soft-tissue sarcomas. In literature, erythrocytosis has been described as a TKI-related condition. Case report A 59-year-old man underwent surgical removal of a sub-scapular mass consistent with myxofibrosarcoma. After distant relapse, he first started chemotherapy, and then Pazopanib. He was found to have increased levels of hemoglobin (Hb) and hematocrit (Hct). He was asymphtomatic, with no history of pulmonary disease nor smoking habit. Erythropoietin (EPO) level was higher than normal. A polycythemia vera was ruled out. Management & outcome: The patient started a prophylactic therapy with lysine acetylsalicylate, and we observed a reduction of Hb, but not Hct. Due to disease progression, we interrupted Pazopanib. After a week from drug discontinuation, Hb levels got back to the normal range, Hct was lowering. We decided not to perform phlebotomy, considering the declining trend in Hb and Hct values and the absence of symptoms. Discussion We postulated a Pazopanib-related secondary erythrocytosis, since Hb and Hct levels increased from baseline during treatment, then normalized when Pazopanib was discontinued. We used the Naranjo Nomogram to assess the correlation between the adverse effect and Pazopanib, the correlation was “Probable”, a score of 5. To the best of our knowledge, this is the first case report of Pazopanib-related secondary polycythemia in a patient with sarcoma. It is important to pay attention to blood count and to any symptoms potentially related to erythrocytosis in patients treated with TKIs.

scholarly journals Invasive Ductal Carcinoma of the Mammary Gland in a Mare

2003 ◽  
Vol 40 (1) ◽  
pp. 86-91 ◽  
Author(s):  
K. Hirayama ◽  
Y. Honda ◽  
T. Sako ◽  
M. Okamoto ◽  
N. Tsunoda ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Smooth Muscle Actin ◽  
Neoplastic Cells ◽  
Moderate Amount ◽  
Regional Lymph Nodes ◽  
Solid Carcinoma ◽  
Multiple Metastases ◽  
Cytokeratin 14

A 21-year-old thoroughbred mare had a 35 X 14 X 10 cm mass involving the mammary gland. Metastases were found in the kidneys, lungs, skeletal muscles, and regional lymph nodes. Histopathologic examination of the tumor revealed a ductal solid carcinoma with extensive intraductal and intralobular involvement and focal infiltration of the adjacent stroma. The intralobular neoplasms were divided into irregularly shaped islands and sheets of polygonal and spindle-shaped epithelial cells by thick or thin fibrous connective tissue bundles. The neoplastic cells had a small or moderate amount of cytoplasm that stained faintly with eosin and round or oval hyperchromatic nuclei. Immunohistochemically, the neoplastic cells were strongly positive for Lu-5, weakly positive for AE1/AE3, vimentin, and glial fibrillary acidic protein, and negative for cytokeratin 8, cytokeratin 14, a-smooth muscle actin, calponin, and S100. The neoplasm was diagnosed as an invasive ductal carcinoma of the mammary gland with multiple metastases.

scholarly journals Macrofollicular variant of papillary carcinoma, a potential diagnostic pitfall: A report of two cases including a review of literature

CytoJournal ◽  
2013 ◽  
Vol 10 ◽  
pp. 16 ◽  
Author(s):  
Maria Luisa C. Policarpio-Nicolas ◽  
Deepika Sirohi
Keyword(s):  
Papillary Carcinoma ◽  
Follicular Neoplasm ◽  
Intranuclear Inclusions ◽  
Review Of Literature ◽  
Review Of The Literature ◽  
Follicular Cells ◽  
Moderate Amount ◽  
Diagnostic Pitfall ◽  
First Case ◽  
Histologic Types

Macrofollicular variant of papillary thyroid carcinoma (MFVPTC) is one of the rarest histologic types of papillary carcinoma. This tumor may mimic an adenomatoid/colloid nodule or follicular neoplasm (macrofollicular type) both on histology and cytology. There are very few articles describing the cytologic features of MFVPTC. We report the cytologic findings of two surgically confirmed MFVPTC. The first case showed abundant thin colloid with moderate amount of follicular cells arranged in a honeycombed and syncytial pattern. Some but not all the follicular cells showed enlarged round to ovoid nuclei, overlapping nuclei, few nuclear grooves and rare intranuclear inclusions. The second case showed abundant thin colloid and predominantly benign appearing follicular cells with few overlapping nuclei, enlarged round to ovoid nuclei and rare nuclear grooves. No intranuclear inclusions were identified. A review of the literature was done and the cytologic findings of MFVPTC including our two cases were tabulated. The cytologic findings showed moderate to abundant thin with focally thick colloid in 75% of cases and sheet like arrangement of follicular cells in 76%. Although nuclear features such as chromatin clearing, overlapping and grooves were present in majority of cases, the quantity varied from rare to focal. Small to prominent nucleoli were present in all of the evaluable cases. Intranuclear inclusions were seen only in 45% of patients. Hence, the cytologic features of macrofollicular variant of papillary carcinoma though present can be subtle and intranuclear inclusions may not be present always.

scholarly journals Severe deforming dermatitis in a kitten caused by Caryospora bigenetica

2021 ◽  
Vol 63 (1) ◽  
Author(s):  
Seppo Saari ◽  
Kirsti Schildt ◽  
Sanna Malkamäki ◽  
Ulla Andersin ◽  
Antti Sukura
Keyword(s):  
Natural Infection ◽  
Protozoan Parasite ◽  
Cell Types ◽  
Presumptive Diagnosis ◽  
Nasal Bridge ◽  
Case Presentation ◽  
First Case ◽  
Transmission Electron ◽  
Polymerase Chain ◽  
Intracellular Protozoan Parasite

Abstract Background Caryospora bigenetica is an intracellular protozoan parasite, which in its primary hosts, typically snakes, is found it the intestine. Extraintestinal multiplication with the development of tissue cysts takes place in secondary hosts, which are normally prey for snakes. Natural infection in domestic animals has been reported only in dogs; this is the first report of C. bigenetica infection in a cat. Case presentation A stray kitten developed nodular dermatitis after being adopted by a shelter. Firm swelling, nodules, and crusts were present mainly on the nasal bridge, eyelids, and pinnae. Histopathology and cytology revealed severe pyogranulomatous inflammation with abundant intracellular organisms suggestive of apicomplexan protozoa. Treatment with clindamycin 13 mg/kg twice daily was initiated, but the cat was euthanized because of the worsening condition. Transmission electron microscopy confirmed parasite’s apicomplexan origin postmortem, and the causative agent was identified as C. bigenetica by polymerase chain reaction and DNA sequencing. Conclusions We present the first case of a naturally occurring infection with C. bigenetica in a cat. Although the definitive etiological diagnosis relied on molecular identification, the abundance of unsporulated oocysts and caryocysts and the parasite's effective reproduction within macrophages and in several other cell types might have enabled differentiation from other protozoal infections and allowed a presumptive diagnosis through cytology and histopathology.

Myeloperoxidase-Positive Intravascular Large B-Cell Lymphoma

2001 ◽  
Vol 125 (7) ◽  
pp. 948-950
Author(s):  
Phillip A. Conlin ◽  
Mageline B. Orden ◽  
Tiffany R. Hough ◽  
David L. Morgan
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large Cell ◽  
Molecular Techniques ◽  
Neoplastic Cells ◽  
Non Hodgkin Lymphoma ◽  
Large B Cell Lymphoma ◽  
First Case ◽  
Large B Cell

Abstract Intravascular large B-cell lymphoma (IVLBL) is an uncommon form of non-Hodgkin lymphoma that is also known as malignant angioendotheliosis, intravascular lymphomatosis, and angiotropic large-cell lymphoma. The disease is characterized by a bizarre population of neoplastic cells, which are found systemically within vascular lumina. Although originally thought to be a neoplastic process of the endothelial cells, it has since been demonstrated, by molecular techniques and immunohistochemistry, that the neoplastic cells are of lymphoid origin. The differential diagnosis of these lesions includes granulocytic sarcomas that can be distinguished from IVLBL or other lymphomas by the presence of immunohistochemical positivity for myeloperoxidase. We describe a patient with a history of a myelodysplastic syndrome who subsequently developed IVLBL, which demonstrated immunohistochemical positivity for myeloperoxidase. To our knowledge, this represents the first case of a malignant lymphoma to demonstrate such findings.

Rare Presentation of Retroperitoneal Leiomyosarcoma Mimicking a Myoma in a 46-year-old Woman: A Case Report

2021 ◽  
Author(s):  
Setareh Akhavan ◽  
Mohadese Peydayesh ◽  
shima alizadeh ◽  
Fatemeh Zamani ◽  
Narges Zamani
Keyword(s):  
Case Report ◽  
Broad Ligament ◽  
Soft Tissue Sarcomas ◽  
Ureteral Injury ◽  
Iliac Vein ◽  
Mitotic Rate ◽  
Rare Presentation ◽  
Dense Adhesion ◽  
Internal Iliac ◽  
Grade Ii

Abstract Background: Retroperitoneal sarcoma (RPS) are relatively uncommon, constituting only 10 to 15 percent of all soft tissue sarcomas. Case presentation: We share our experience in encountering RPL with vascular and urethral adhesion in the operation room in a 46-year-old woman, whom was scheduled for surgery as a case of leiomyoma.Huge solid retroperitoneal mass (16*12*11 cm) was detected in right broad ligament which was attached to the pelvic floor and seemed to be separated from uterus. Because of a dense adhesion of the tumor to the ureter and vessels tearing of internal iliac vein and ureteral injury occurred during dissection that was repaired. Pathologic examination revealed grade II / III leiomyosarcoma with mitotic rate 12 / 10 HPF, including atypical forms. she candidates for radiation. Conclusion: This case report describes the clinical, imaging, surgical and histopathological findings of retroperitoneal leiomyosarcoma. Due to the rarity of these tumors and the complexity of treatment, evaluation and management should ideally be carried out in a center with multidisciplinary expertise in the treatment of sarcomas.

Composite Nodular Sclerosis Hodgkin and Diffuse Large B Cell Non-Hodgkin Lymphoma Arising from the Thymus.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4432-4432
Author(s):  
Luis D. Sumoza ◽  
Jeffrey L. Jorgensen ◽  
Ilia R. Sumoza
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Mitotic Rate ◽  
Nodular Sclerosis ◽  
Non Hodgkin Lymphoma ◽  
Large B Cell Lymphoma ◽  
First Case ◽  
Large B Cell

Abstract We report the first case of composite Nodular Sclerosis Hodgkin and Diffuse Large B-Cell Non-hodgkin’s lymphoma of the mediastinum. We present a case of an inmunocompetent patient operated on for a mediastinal tumor similar to a Thymoma, which the histological examination morphological, and immunophenotyping were performed and confirmed the existence of 2 independent, unrelated tumors. The pathology blocks submitted show a composite lymphoma, with components of both classical Hodgkin lymphoma (Hodgkin’s disease), nodular sclerosis type, grade 2 of 2 in all three blocks. One block also shows non-Hodgkin lymphoma, namely diffuse large B-cell lymphoma, with a distinct immunophenotype. The Hodgkin-Reed-Sternberg cells were positive for CD15, CD20, CD30, PAX-5 (weak/partial), and EBV (EBERs), and negative for CD45. In contrast, the large B-cells are positive for CD20, PAX-5 (strong), CD45, and CD30 (very focal), and negative for CD15 and EBERs. The large B-cell area had an increased mitotic rate. Taken together, these data indicate that these Hodgkin and the Non-Hodgkin’ lymphomas arose as a consequence of independent malignant transformation events.

Sign in / Sign up

Export Citation Format

Share Document