Mianserin Hydrochloride: A New Anti-Depressant Drug

1978 ◽  
Vol 23 (2) ◽  
pp. 173-175 ◽  
Author(s):  
E. H. Bennie
Keyword(s):  
Clinical Study ◽  
Side Effect ◽  
Rating Scale ◽  
Self Assessment ◽  
Self Rating ◽  
Depressant Action ◽  
Hamilton Rating Scale ◽  
Depressant Drug

The tetracyclic anti-depressant drug mianserin hydrochloride has been assessed in an open clinical study in 24 psychiatric out-patients, who were prescribed 30 mg. mianserin daily, an d were rated on the Hamilton Rating Scale and on the Wakefield Self-Assessment Inventory on day 0, before starting therapy, and on days 7 and 28 of their treatment. The results support the view that mianserin has anti-depressant properties, and the patients' self-rating scores confirm that the level of anti-depressant action is similar to amitriptyline. Drowsiness was the only side effect reported.

A Japanese Scale to Assess Anxiety Severity: Development and Psychometric Evaluation

2011 ◽  
Vol 41 (1) ◽  
pp. 29-45 ◽  
Author(s):  
Chizu Mimura ◽  
Miho Nishioka ◽  
Noriyuki Sato ◽  
Ryoko Hasegawa ◽  
Ryu Horikoshi ◽  
...  
Keyword(s):  
Psychometric Properties ◽  
Rating Scale ◽  
Dynamic Range ◽  
Psychiatric Patients ◽  
Psychometric Evaluation ◽  
Anxiety Scale ◽  
Self Rating ◽  
Confirmatory Factor ◽  
Interview Guide ◽  
Hamilton Rating Scale

Objective: This study developed a Japanese self-rating anxiety scale, the Himorogi Self-rating Anxiety Scale (HSAS), and tested psychometric properties of its use in Japanese psychiatric patients. Methods: The process of developing the scale consisted of an intensive literature review, assessment of existing instruments, and detailed discussion on the content of the newly developed scale. Data for psychometric evaluation were collected from 419 outpatients of psychiatric clinics. The Hamilton Rating Scale for Anxiety Interview Guide (HAMA-IG) and the Sheehan Patient Rated Anxiety Scale (SPRAS) were used as standards against which the HSAS was compared. Results: Confirmatory factor analysis revealed a unifactorial nature for the HSAS and fewer insignificant items in the HSAS than the HAMA-IG and the SPRAS. Cronbach's alpha and test-retest coefficients indicated sufficient reliability. High correlation with the HAMA-IG and the SPRAS indicated evidence of convergence for the HSAS. ROC analysis showed high ability to distinguish between the presence and absence or remission of anxiety. Analysis of descriptive data suggested a larger dynamic range for the HSAS than the HAMA-IG and the SPRAS. Conclusions: The HSAS is a brief scale to assess anxiety severity, demonstrating evidence of good psychometric properties. It is recommended for use in research and clinical practice.

Validity of the Zung Self-rating Depression Scale

1978 ◽  
Vol 132 (4) ◽  
pp. 381-385 ◽  
Author(s):  
John T. Biggs ◽  
Laurence T. Wylie ◽  
Vincent E. Ziegler
Keyword(s):  
Direct Relationship ◽  
Rating Scale ◽  
Depression Scale ◽  
Tricyclic Antidepressant ◽  
Clinical Severity ◽  
Global Rating ◽  
Self Rating ◽  
Continued Use ◽  
Larger Sample ◽  
Hamilton Rating Scale

SummaryThe Zung Self-Rating Depression Scale (ZSDS) correlated well (0·69) with the treating physician's global rating in 26 depressed out-patients during the six weeks of treatment with a tricyclic antidepressant. In a larger sample of 41 patients, a high correlation was found between the ZSDS and the Hamilton Rating Scale. The sensitivity of the ZSDS was found to be adequate. The scale was able to differentiate, at the 0·05 level, four severity groups classified on the basis of the global rating. The importance of the direct relationship between the range of severity studied and the value of the correlation coefficient was discussed. Previous investigations and the results of this study indicate that the ZSDS is a valid and sensitive measure of clinical severity in depressed patients and support its continued use as a research instrument.

scholarly journals Antidepressant Side Effects in Depression Patients Treated in a Naturalistic Setting: A Study of Bupropion, Moclobemide, Paroxetine, Sertraline, and Venlafaxine

2002 ◽  
Vol 47 (2) ◽  
pp. 174-180 ◽  
Author(s):  
JD Vanderkooy ◽  
Sid ney H Ken nedy ◽  
R Mi chael Bagby
Keyword(s):  
Central Nervous System ◽  
Side Effects ◽  
Side Effect ◽  
Clinical Utility ◽  
Rating Scale ◽  
The Other ◽  
Sexual Side Effects ◽  
Naturalistic Setting ◽  
Accepted Standard ◽  
Hamilton Rating Scale

Objective: There is no commonly accepted standard for comparing antidepressant- induced side effects. This study evaluates a clinician- administered scale, the Toronto Side Effect Scale (TSES), in a natural practice clinic. Method: We used the TSES to assess side effects in 193 depression patients who completed 8 weeks of treatment with either bupropion, mo clobe mide, paroxetine, ser tra line, or venlafaxine. Results: Rates of remission (Hamilton Rating Scale for Depression [HRSD] < 7) did not differ across drugs after 8 weeks of treatment. Paired drug comparisons yielded significant differences in 16 of the 32 side effects. We present differences between pairs of the 5 antidepressants in Central Nervous System (CNS), gastrointestinal (GI), and sexual side effects. A measure of side-effect intensity distinguished paroxetine from the other antidepressants on a measure of sexual dysfunction. Conclusions: These results con firm the clinical utility of the TSES as a simple, clinician-administered antidepressant side-effect scale.

Assessment of the severity of primary depressive illness: Wakefield self-assessment depression inventory

1971 ◽  
Vol 1 (2) ◽  
pp. 143-149 ◽  
Author(s):  
R. P. Snaith ◽  
S. N. Ahmed ◽  
S. Mehta ◽  
Max Hamilton
Keyword(s):  
Rating Scale ◽  
Depressive Illness ◽  
Practical Significance ◽  
Self Assessment ◽  
Male And Female ◽  
Positive Correlation ◽  
Female Patients ◽  
The Mean ◽  
Further Development ◽  
Hamilton Rating Scale

SUMMARYA self-assessment inventory for measuring severity of depressive illness is described, Its chief merits are brevity and simplicity. The correlation with the Hamilton Rating Scale is +0·87. At a cut-off level of 14–15 points 3% of patients and 7·5% of ‘Normals’ are misclassified. The mean scores for male and female patients do not differ significantly and the small positive correlation of score with age is of little practical significance. The limitations in this inventory are discussed but, despite them, it has practical value and merits further development.

scholarly journals Use of the Hamilton rating scale for depression and the Carroll self-rating scale in adolescents

1985 ◽  
Vol 14 (2) ◽  
pp. 123-129 ◽  
Author(s):  
Douglas R. Robbins ◽  
Norman E. Alessi ◽  
Marit V. Colfer ◽  
Gordon W. Yanchyshyn
Keyword(s):  
Rating Scale ◽  
Self Rating ◽  
Hamilton Rating Scale

A Self-Rating Scale for Measuring Neuroleptic Side-Effects

1995 ◽  
Vol 166 (5) ◽  
pp. 650-653 ◽  
Author(s):  
Jennifer C. Day ◽  
Graham Wood ◽  
Mike Dewey ◽  
Richard P. Bentall
Keyword(s):  
Side Effects ◽  
Side Effect ◽  
Concurrent Validity ◽  
Roc Analysis ◽  
Rating Scale ◽  
Neuroleptic Drugs ◽  
Retest Reliability ◽  
Self Rating ◽  
Schizophrenic Patients ◽  
Test Retest Reliability

BackgroundA study was conducted to validate a comprehensive self-rating scale for measuring side-effects of neuroleptic drugs.MethodThe Liverpool University Neuroleptic Side Effect Rating Scale (LUNSERS), which includes ‘red herring’ items, was twice administered to 50 DSM–III–R schizophrenic patients, who were also interviewed using the UKU side-effect rating scale; 50 unmedicated controls also completed the LUNSERS.ResultsThe test-retest reliability of the LUNSERS was good (r = 0.811, P< 0.001) as was its concurrent validity against the UKU (r = 0.828, P< 0.001). Scores correlated with chlorpromazine equivalent doses (r = 0.310, P< 0.02). ROC analysis demonstrated that the scale discriminated between patients and non-medicated controls, who scored differently for real side-effects but not for ‘red herring’ items.ConclusionsThe LUNSERS is an efficient, reliable and valid method of assessing neuroleptic side-effects.

UKU Side Effect Rating Scale--Self-Rating Version

2001 ◽  
Author(s):  
Eva Lindström ◽  
Tommy Lewander ◽  
Ulf Malm ◽  
Ulrik Fredrik Malt ◽  
Henrik Lublin ◽  
...  
Keyword(s):  
Side Effect ◽  
Rating Scale ◽  
Self Rating

Patient's Self Assessment of Stressors and Adjustment to Home Hemodialysis and CAPD

1985 ◽  
Vol 5 (1) ◽  
pp. 36-39 ◽  
Author(s):  
Stepben A. Kline ◽  
Howard J. Burton ◽  
A. Kaplan De-Nour ◽  
Hildo Bolley
Keyword(s):  
Treatment Modality ◽  
Rating Scale ◽  
Self Assessment ◽  
Home Hemodialysis ◽  
Self Rating ◽  
Item Questionnaire ◽  
Physical Wellbeing ◽  
Patient Self Assessment ◽  
Physical Weakness

We studied adaptability to the stresses of bome bemodialysis and CAPD programs by asking patients (143 on bemodialysis; 53 on CAPD) to assess particular treatment -associated stressors. A 14-item questionnaire was constructed to measure areas in which the patients felt stress and the intensity of the stress. Also we used a self-rating scale to obtain information about both the patient's overall and bis or ber physical wellbeing. The majority of patients complained of physical weakness and an inability to sleep. This paper outlines stressors for each treatment modality, and based on patient self-assessment concludes that the two modes of treatment are comparable.

A Short Clinical Diagnostic Self-rating Scale for Psychoneurotic Patients

1966 ◽  
Vol 112 (490) ◽  
pp. 917-923 ◽  
Author(s):  
Sidney Crown ◽  
A. H. Crisp
Keyword(s):  
Psychiatric Illness ◽  
Rating Scale ◽  
One Dimension ◽  
Self Assessment ◽  
Diagnostic Categories ◽  
Self Rating ◽  
Taylor Manifest Anxiety Scale ◽  
Middlesex Hospital ◽  
Wide Variability ◽  
Manifest Anxiety

In the practice of our department at the Middlesex Hospital, the need has been felt for a means of rapid quantification of common symptoms and traits relevant to the conventional diagnostic categories of psychoneurotic illness. Until now, none of the available British scales have fulfilled this requirement. The most widely used is the Maudsley Personality Inventory (Eysenck, 1959) with its subsequent modifications. This, however, although scientifically based, is limited to the assessment of broad categories such as “neuroticism” and “extraversion” which appear to go only a small way towards describing the wide variability of psychoneurotic disturbances. Foulds and his co-workers (Foulds, 1965) have for a number of years developed personality scales in which clinical sophistication and a rigorous methodology are combined. Their Symptom-Sign Inventory, however, consists of eighty questions which have to be presented orally. Furthermore, although the inventory covers psychotic disturbances, it is necessary to use an additional questionnaire, the Hysteroid-Obsessoid Questionnaire (Caine & Hawkins, 1963) to complete the spectrum of psychoneurotic illness. Moreover, the concept of psychiatric illness developed by these workers is individual rather than conventional in a number of respects. The Tavistock Self-Assessment Inventory (Sandler, 1954) is too long for the present purposes (876 items in six booklets). The Taylor Manifest Anxiety Scale (Taylor, 1953) is short and convenient, but it measures one dimension only. As many doctors, including psychiatrists, find it useful to think in terms of orthodox clinical categories for diagnostic, therapeutic, prognostic and research purposes, it was decided to design and attempt to validate a self-rating scale adapted to these categories, taking the patient 5–10 minutes to complete and capable of being rapidly scored by the doctor or an assistant.

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