Primary hyperparathyroidism misdiagnosed as metastatic disease, with trans-oral endoscopic surgical management

2021 ◽  
pp. 004947552110352
Author(s):  
Ankur Jain ◽  
Nishtha Yadav ◽  
Ashutosh Silodia ◽  
Namrata Khandelwal ◽  
Sanjay Kumar Yadav
Keyword(s):  
Primary Hyperparathyroidism ◽  
Surgical Management ◽  
Metastatic Disease ◽  
Primary Source ◽  
Unknown Primary ◽  
Osteitis Fibrosa Cystica ◽  
Bony Metastases ◽  
Biochemical Testing ◽  
Asymptomatic Disease ◽  
Symptomatic Form

Primary hyperparathyroidism is not so uncommon a disease. In high-income countries, with the introduction of routine biochemical testing in 1980s, it is diagnosed early, and the majority are seen as asymptomatic disease. However, in India, a severe symptomatic form is still seen, and many times patients are undiagnosed, thus continuing to suffer debilitating disease. Here, we report such a patient who was being treated as having bony metastases from an unknown primary source, when in fact he had osteitis fibrosa cystica due to primary hyperparathyroidism and was cured after surgery.

scholarly journals Survival of patients with synchronous brain metastases: an epidemiological study in southeastern Michigan

2000 ◽  
Vol 9 (2) ◽  
pp. 1-5 ◽  
Author(s):  
Ajith J. Thomas ◽  
Jack P. Rock ◽  
Christine C. Johnson ◽  
Linda Weiss ◽  
Gordon Jacobsen ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Median Survival ◽  
Cancer Diagnosis ◽  
Systemic Disease ◽  
Primary Source ◽  
Primary Site ◽  
Unknown Primary ◽  
Primary Cancer ◽  
Significant Difference ◽  
Frequent Site

Object It has been suggested that synchronous brain metastases (that is, those occurring within 2 months of primary cancer diagnosis) are associated with a shorter survival time compared with metachronous lesions (those occurring greater than 2 months after primary cancer diagnosis). In this study the authors used data obtained from the National Cancer Institute's Surveillance, Epidemiology, and End Results Program to determine the incidence of synchronous brain metastases and length of survival of patients in a defined population of southeastern Michigan residents. Methods Data obtained in 2682 patients with synchronous brain metastases treated from 1973 to 1995 were reviewed. Study criteria included patients in whom at least one brain metastasis was diagnosed within 2 months of the diagnosis of primary cancer and those with an unknown primary source. The incidence per 100,000 increased fivefold, from 0.69 in 1973 to 3.83 in 1995. The most frequent site for the primary cancer was the lung (75.4%). The second largest group (10.7%) consisted of patients in whom the primary site was unknown. The median survival length was 3.3 months. There was no significant difference in the median survival in patients with primary lung/bronchus and those with an unknown primary site (3.2 months and 3.4 months, respectively). Conclusions Patients who present with synchronous lesions have a poor prognosis, and the predominant cause of death, in greater than 90% of cases, is related to systemic disease; however, despite poor median survival lengths, certain patients will experience prolonged survival.

Effect of Parathyroid Adenoma Resection on Bone Density in Primary Hyperparathyroidism and Osteitis Fibrosa Cystica

Orthopedics ◽  
2001 ◽  
Vol 24 (10) ◽  
pp. 1000-1002
Author(s):  
Treyce S Knee ◽  
Almond J Drake ◽  
David Turton ◽  
K M Mohamed Shakir
Keyword(s):  
Bone Density ◽  
Primary Hyperparathyroidism ◽  
Parathyroid Adenoma ◽  
Osteitis Fibrosa ◽  
Osteitis Fibrosa Cystica

scholarly journals Primary versus Metastatic Gastrointestinal Melanoma: A Rare Case and Review of Current Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Malorie Simons ◽  
Jason Ferreira ◽  
Rashna Meunier ◽  
Steven Moss
Keyword(s):  
Current Literature ◽  
Rare Case ◽  
Recent Literature ◽  
Primary Source ◽  
Unknown Origin ◽  
Primary Lesion ◽  
Unknown Primary ◽  
Gi Tract

Gastrointestinal (GI) melanomas are a rare diagnostic entity. Although there have been cases of melanomas solely in the GI tract, many debate their true origin: the gut versus a distant, undetected primary lesion that regressed known as melanoma of unknown primary. We present a case that involved diagnosing a GI melanoma and then backtracking to find a possible primary source. We review the most recent literature regarding possible etiologies of primary GI melanomas and how to differentiate whether it has a primary, metastatic, or unknown origin.

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