Laryngeal Involvement in Neurofibromatosis

1993 ◽  
Vol 72 (12) ◽  
pp. 811-815 ◽  
Author(s):  
Thomas O. Willcox ◽  
Seth I. Rosenberg ◽  
Steven D. Handler
Keyword(s):  
Differential Diagnosis ◽  
Poor Prognosis ◽  
Plexiform Neurofibroma ◽  
Surgical Excision ◽  
Incomplete Excision ◽  
Complete Surgical Excision ◽  
Sarcomatous Degeneration ◽  
Laryngeal Involvement

Neurofibromas of the larynx are an uncommon component of neurofibromatosis, but should be considered in the differential diagnosis of patients with a submucosal supraglottic mass. Complete surgical excision is the treatment of choice; however, incomplete excision may be preferable to aggressive debilitatingsurgery. Plexiform neurofibromadiffers from non-plexiform neurofibroma in that it is poorly circumscribed and highly infiltrative. Tracheostomymaybe necessary. Sarcomatous degeneration is reportedandcarries a poor prognosis.

scholarly journals Extensive parapharyngeal and skull base neuroglial ectopia; a challenge for differential diagnosis and treatment: case report

2010 ◽  
Vol 128 (5) ◽  
pp. 302-305 ◽  
Author(s):  
Giulianno Molina de Melo ◽  
Gabrielle do Nascimento Holanda Gonçalves ◽  
Ricardo Antenor de Souza e Souza ◽  
Danilo Anunciatto Sguillar
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Skull Base ◽  
Infratemporal Fossa ◽  
Newborn Infants ◽  
Surgical Excision ◽  
Neck Mass ◽  
Oral Feeding ◽  
Feeding Difficulties ◽  
Complete Surgical Excision

CONTEXT: Neuroglial ectopia has been defined as a mass composed of differentiated neuroectodermal tissue isolated from the spinal canal or cranial cavity and remains rare. This lesion has to be considered in the differential diagnosis among newborn infants with classical symptoms of respiratory distress, neck mass and feeding difficulties. We present a rare case of extensive parapharyngeal and skull base neuroglial ectopia in 6-month-old girl who presented respiratory and feeding obstruction at birth. CASE REPORT: A six-month-old girl who presented upper respiratory and feeding obstruction at birth and was using tracheostomy and gastrostomy tubes was referred to our institution. Complete surgical excision of the mass consisted of a transcervical-transparotid approach with extension to the infratemporal fossa by means of a lateral transzygomatic incision, allowing preservation of all vital neurovascular structures. The anatomopathological examination showed a solid mass with nests of neural tissue, with some neurons embedded in poorly encapsulated fibrovascular stroma, without mitotic areas, and with presence of functioning choroid plexus in the immunohistochemistry assay. Neurovascular function was preserved, thus allowing postoperative decannulation and oral feeding. Despite the large size of the mass, the child has completed one year and six months of follow-up without complications or recurrence. Neuroglial ectopia needs to be considered in diagnosing airway obstruction among newborns. Surgical treatment is the best choice and should be performed on clinically stable patients. An algorithm to guide the differential diagnosis and improve the treatment was proposed.

scholarly journals Angioleiomyoma of the Larynx: A Case Report and Literature Review

2020 ◽  
Vol 99 (10) ◽  
pp. 658-663
Author(s):  
Federica Perardi ◽  
Giuseppe Abbate ◽  
Leonardo R. Iannuzzelli ◽  
Rossella Contini ◽  
Manuela De Munari ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Case Report ◽  
Gold Standard ◽  
Carbon Dioxide Laser ◽  
Standard Treatment ◽  
Surgical Excision ◽  
Laser Technology ◽  
Complete Surgical Excision

Angioleiomyoma is a benign smooth muscle and vessel tumor; laryngeal localization is extremely rare with only 24 cases described in the literature; moreover, it should be considered in the differential diagnosis of laryngeal mass. Endoscopic complete surgical excision with dissection along capsule is now considered the gold-standard treatment for small and well-circumscribed laryngeal angioleiomyoma. We present a case of laryngeal angioleiomyoma successfully treated with carbon dioxide laser technology which resulted in a bleeding reduction and adequate hemostasis with less tissue damage and good functional outcome.

The Nasolabial Cyst-Nasal Hamartoma

1987 ◽  
Vol 96 (3) ◽  
pp. 268-272 ◽  
Author(s):  
Daniel B. Kuriloff
Keyword(s):  
New York ◽  
Differential Diagnosis ◽  
Nasal Obstruction ◽  
Maxillary Sinusitis ◽  
Surgical Excision ◽  
Odontogenic Cysts ◽  
Facial Deformity ◽  
Developmental Origin ◽  
Complete Surgical Excision

The nasolabial cyst is an uncommon midfacial cyst. Twenty-six patients with nasolabial cysts were treated at the New York Eye and Ear infirmary from 1969 to 1986. Most of these lesions manifested facial deformity, unilateral nasal obstruction, and pain when infected. The nasolabial cyst is often unrecognized or confused with other intranasal masses, or fissural and odontogenic cysts. Infection of these lesions—which occurred in 50% of the patients—may mimic facial cellulitis, periodontal abscess, acute maxillary sinusitis, or nasal furuncies. This cyst is considered to be a hamartoma because of its developmental origin from entrapped epithelium in an embryonic fusion plane. Simple aspiration invariably leads to recurrence, and complete surgical excision is the accepted treatment. The nasolabial cyst should be considered in the differential diagnosis of intranasal masses, midface infections, and swelling in the nasolabial area.

The effect of Acemannan Immunostimulant in combination with surgery and radiation therapy on spontaneous canine and feline fibrosarcomas

1995 ◽  
Vol 31 (5) ◽  
pp. 439-447 ◽  
Author(s):  
GK King ◽  
KM Yates ◽  
PG Greenlee ◽  
KR Pierce ◽  
CR Ford ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Median Survival Time ◽  
Poor Prognosis ◽  
Previous Treatment ◽  
Surgical Excision ◽  
Tumor Shrinkage ◽  
Complete Surgical Excision ◽  
Notable Increase ◽  
One Year ◽  
Effective Adjunct

Eight dogs and five cats with histopathologically confirmed fibrosarcomas were treated with Acemannan Immunostimulanta in combination with surgery and radiation therapy. These animals had recurring disease that had failed previous treatment, a poor prognosis for survival, or both. Following four to seven weekly acemannan treatments, tumor shrinkage occurred in four (greater than 50%; n = 2) of 12 animals, with tumors accessible to measurement. A notable increase in necrosis and inflammation was observed. Complete surgical excision was performed on all animals between the fourth and seventh week following initiation of acemannan therapy. Radiation therapy was instituted immediately after surgery. Acemannan treatments were continued monthly for one year. Seven of the 13 animals remain alive and tumor-free (range, 440+ to 603+ days) with a median survival time of 372 days. The data suggests that Acemannan Immunostimulant may be an effective adjunct to surgery and radiation therapy in the treatment of canine and feline fibrosarcomas.

A LARGE SCALP MYXOID NEUROFIBROMA AN UNUSUAL PRESENTATION IN A MIDDLE- AGED PATIENT: A RARE CASE REPORT

2021 ◽  
pp. 18-20
Author(s):  
Subhabrata Das ◽  
Mala Mistri ◽  
Sukanta Sikdar
Keyword(s):  
Differential Diagnosis ◽  
S100 Protein ◽  
Surgical Excision ◽  
Fluctuation Test ◽  
Complete Surgical Excision ◽  
Rare Case Report ◽  
Choice Of Treatment ◽  
The Face ◽  
Scalp Location ◽  
Giant Size

The transformed cells in a neoplasm, whether benign or malignant, often resemble each other, as though all had been derived from a single progenitor, consistent with the monoclonal origin of the tumor. Myxoid neurobroma (MN) is a benign tumor of perineural origin, which is demonstrated by positive immunohistochemical staining for S100 protein. The most common locations are the face, shoulder, anus, periungual, and feet. To our knowledge, this is the first report of an MN in the scalp, which is a very rare location that has been reported earlier. The differential diagnosis of the tumor at this location MN should be kept in mind. This 56 years old male who presented with a large swelling in the scalp (occipital region) which extended to the nape of nack for last 3 years which is gradually increasing in size along with heaviness, intermittent severe pain in the head. Clinically (25x20) cm size swelling in the occipital area and extending to the nape of the neck. The swelling is nontender. It is ovoid in shape . Soft cystic in consistency, the surface is smooth, margins are well dened, the mobility is absent. Fluctuation test is negative but the swelling is brilliantly transilluminant. CONCLUSION: We report this case because of the rarity of both the tumor and its scalp location and also a giant size and to provide a review of the literature. This case study illustrates that any slowly progressing swelling in an unusual location should have been properly investigated and complete surgical excision is the preferred choice of treatment for future recurrence. The MN should be included in the differential diagnosis of tumors at this location.

scholarly journals Conjunctival keratoacanthoma

2004 ◽  
Vol 59 (3) ◽  
pp. 135-137 ◽  
Author(s):  
Fernanda Braga Perdigão ◽  
Paulo de Tarso P. Pierre-Filho ◽  
Renato José Mendonça Natalino ◽  
Roberto Caldato ◽  
Marcelo Torigoe ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Safety Margin ◽  
Surgical Excision ◽  
Complete Surgical Excision ◽  
Rare Differential Diagnosis

Keratoacanthoma generally occurs on the skin; it is rarely found in the conjunctiva. A case of a 34-year-old woman with a rapidly growing conjunctival mass is reported. The tumor was excised with a safety margin to exclude squamous cell carcinoma. Histopathologically it was crateriform and consistent with atypical keratoacanthoma. There has been no recurrence in 2 years of follow-up. Conjunctival keratoacanthoma is rare; differential diagnosis of conventional squamous cell carcinoma and keratoacanthoma can be difficult. We recommend complete surgical excision and careful follow-up of crateriform squamous proliferations.

A Surgical Approach to Chordomas at the Base of the Skull

1982 ◽  
Vol 90 (2) ◽  
pp. 251-255 ◽  
Author(s):  
Robert H. Miller ◽  
Gayle E. Woodson ◽  
J. Gail Neely ◽  
Edward C. Murphy
Keyword(s):  
Nasal Cavity ◽  
Skull Base ◽  
Surgical Approach ◽  
Poor Prognosis ◽  
Maxillary Antrum ◽  
Surgical Excision ◽  
Complete Surgical Excision ◽  
Base Of The Skull

Chordoma of the skull base has a poor prognosis because of the proximity of vital structures as well as the difficulty encountered in attempting complete surgical excision. This paper presents a case of massive recurrent chordoma involving the intracranial cavity, nasal cavity, and maxillary antrum. The tumor was debulked and decompressed via a transantral approach to the pterygomaxillary fossa and the base of the skull. This technique is recommended because it achieves immediate decompression and provides a space into which the inevitable regrowth of the tumor may extend.

Cervical lymphadenopathy secondary to atypical mycobacteria in children

1996 ◽  
Vol 110 (1) ◽  
pp. 48-51 ◽  
Author(s):  
R. Benson-Mitchell ◽  
G. Buchanan
Keyword(s):  
Differential Diagnosis ◽  
Lymph Node ◽  
Malignant Disease ◽  
Cervical Lymphadenopathy ◽  
Surgical Excision ◽  
Definitive Diagnosis ◽  
Atypical Mycobacteria ◽  
Complete Surgical Excision ◽  
Immunocompromised Child

AbstractNon-tuberculous mycobacterial (NTM) infections usually present as an enlarged lymph node in the neck of a non-immunocompromised child. The differential diagnosis includes bacterial adenitis, malignant disease and tuberculosis. The definitive diagnosis relies upon isolating the organisms in culture. The treatment is complete surgical excision with, or without, anti-tuberculous chemotherapyTen cases of NTM infections are presented with a discussion of the aetiology and treatment of this condition.

scholarly journals Solitary intrascrotal neurofibroma in a child: A case report

2021 ◽  
Vol 1 (2) ◽  
Author(s):  
Ghadir Jaber ◽  
Vipul Gupta ◽  
Usman Javaid ◽  
Diary Mohammed ◽  
Mamoun AlMarzouqi
Keyword(s):  
Histopathological Examination ◽  
Plexiform Neurofibroma ◽  
Surgical Excision ◽  
Age Group ◽  
Pediatric Age ◽  
Rare Entity ◽  
Tissue Mass ◽  
Pediatric Age Group ◽  
Complete Surgical Excision ◽  
Hypoechoic Mass

Background: Neurofibroma (NF) remains a rare entity among various scrotal masses in the pediatric age group. We report a case of solitary intrascrotal extra testicular plexiform neurofibroma in a 6-year-old child with the clinical management of this rare entity and review of the literature.   Case Summary: A 6-year-old male presented with incidentally noticed intrascrotal swelling. Clinical examination confirmed the presence of solitary intrascrotal swelling with normal testis. Radiological imaging showed the presence of a hypoechoic mass in the left hemiscrotum with normal both testes. Surgical exploration showed the presence of unencapsulated soft tissue mass and histopathological examination (HPE) confirmed the diagnosis of plexiform neurofibroma. Thorough evaluation ruled out features of neurofibromatosis 1 thus confirming the diagnosis of solitary intrascrotal extratesticular plexiform neurofibroma. Complete surgical excision resulted in satisfactory recovery with no recurrence on follow-up Conclusion: Neurofibroma although rare should be considered as a differential in the diagnosis of an intrascrotal mass in the pediatric age group. The benign nature of the lesion and extratesticular origin usually makes testis sparing surgical excision feasible which remains the treatment of choice with excellent prognosis and minimal chances of recurrence. A thorough histopathological examination is mandatory to rule out neurofibromatosis.

scholarly journals Malignancy within a Tail Gut Cyst: A Case of Retrorectal Carcinoid Tumour

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
A. A. Abukar ◽  
B. J. Parcell ◽  
C. B. Lim ◽  
P. V. Patil ◽  
A. Ramsanahie ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Neuroendocrine Tumour ◽  
Carcinoid Tumour ◽  
Surgical Excision ◽  
Presacral Space ◽  
Tailgut Cyst ◽  
Diagnostic Strategy ◽  
Rectal Pain ◽  
Ct Guided ◽  
Complete Surgical Excision

Purpose.Tailgut cysts with malignant transformation are rare entities. We discuss the diagnostic strategy and treatment of a malignancy within a tailgut cyst.Methods.In this study we report on the case of a 61-year-old man with a malignant neuroendocrine tumour arising within a tailgut cyst and an overview of the literature emphasising the histopathological characteristics and differential diagnosis.Results.Our patient presented with lower back pain, rectal pain, and increased urgency of defecation. MRI scan and CT-guided biopsy on histological analysis revealed a diagnosis of carcinoid tumour of the presacral space. The patient subsequently underwent an abdominoperineal excision of the rectum.Conclusions.This case highlights the importance of tailgut cysts as a differential diagnosis of presacral masses. It is a rare congenital lesion developing from remnants of the embryonic postanal gut and is predominantly benign in nature. Approximately half of cases remain asymptomatic; therefore, diagnosis is often delayed. Magnetic resonance imaging is the investigation of choice and an awareness of the possibility of malignant potential is critical to avoiding missed diagnosis and subsequent morbidity. Complete surgical excision allows accurate diagnosis, confirmation of oncological clearance, and prevention of mortality.

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