Aim and Objective:
This study aimed to explore the plasma free amino acid (FAA) and carnitine levels in pregnant women with cesarean scar pregnancy (CSP), and to compare them with those of healthy pregnant women.
Materials and Methods:
This prospective and randomized controlled study was conducted in patients admitted to Harran
University Medical Faculty Hospital Obstetrics Clinic between January 2018 and January 2019. A total of 60 patients were
included in the study, and the patients were divided into two groups: CSP group (n = 30) and healthy pregnant group as the
control group (n = 30). The blood samples were taken from the participants between 7 - 12 weeks of gestation. Twentyseven carnitines and their esters and 14 FAAs were analysed by liquid chromatography – mass spectrometry (LC-MS/MS).
Results:
The mean plasma concentrations of some carnitines, including C2, C5, C5-OH, C5-DC, C6, C8-1, C12, C14, C14-
1, C14-2, C16, C16-1, C18, and C18-1 were significantly higher in CSP group than in the control group. However, other
carnitines, including C0, C3, C4, C4-DC, C5-1, C6-DC, C8, C8-DC, C10, C10-1, C18-1-OH, and C18-2 were similar in
both groups. The plasma levels of some FAAs, including Methyl Glutaryl, Leu, Met, Phe, Arg, Orn, and Glu values were
significantly higher in CSP group than in the control group. However, there was no statistically significance in other FAA
levels, including Val, Asa, Tyr, Asp, Ala, Cit, and Gly between the two groups. Additionally, Pearson’s correlation analysis
showed that there were significantly positive correlations between many FAA and carnitine values.
Conclusion:
Since several plasma carnitine and FAA levels were higher in CSP group than in the control group, we think
that scar pregnancy increases metabolic need for myometrial invasion. Also, we think that these results may be useful in
clinical practice for CSP diagnosis.
Human muscle protein turnover—why is it so variable?
