Assessing Correspondence Between Experimental and Nonexperimental Estimates in Within-Study Comparisons

2018 ◽  
Vol 42 (2) ◽  
pp. 214-247 ◽  
Author(s):  
Peter M. Steiner ◽  
Vivian C. Wong

In within-study comparison (WSC) designs, treatment effects from a nonexperimental design, such as an observational study or a regression-discontinuity design, are compared to results obtained from a well-designed randomized control trial with the same target population. The goal of the WSC is to assess whether nonexperimental and experimental designs yield the same results in field settings. A common analytic challenge with WSCs, however, is the choice of appropriate criteria for determining whether nonexperimental and experimental results replicate. This article examines different distance-based correspondence measures for assessing correspondence in experimental and nonexperimental estimates. Distance-based measures investigate whether the difference in estimates is small enough to claim equivalence of methods. We use a simulation study to examine the statistical properties of common correspondence measures and recommend a new and straightforward approach that combines traditional significance testing and equivalence testing in the same framework. The article concludes with practical advice on assessing and interpreting results in WSC contexts.

2014 ◽  
Vol 2 (2) ◽  
pp. 179-211 ◽  
Author(s):  
James Kai-sing Kung

Using China's Great Leap Famine as example, this article shows how political career incentives can produce disastrous outcomes under the well-intended policies of a dictator. By exploiting a regression discontinuity design, the study identifies the causal effect of membership status in the Chinese Communist Party's Central Committee—full (FM) Versus alternate members (AM)—on grain procurement. It finds that the difference in grain procurement between AMs and FMs who ranked near the discontinuity threshold is three times that between all AMs and all FMs on average. This may explain why Mao exceptionally promoted some lower-ranked but radical FMs shortly before the Leap: to create a demonstration effect in order to spur other weakly motivated FMs into action.


2021 ◽  
Vol 15 (1) ◽  
pp. e0009036
Author(s):  
Gregor J. Devine ◽  
Gonzalo M. Vazquez-Prokopec ◽  
Wilbert Bibiano-Marín ◽  
Norma Pavia-Ruz ◽  
Azael Che-Mendoza ◽  
...  

Background In the absence of vaccines or drugs, insecticides are the mainstay of Aedes-borne disease control. Their utility is challenged by the slow deployment of resources, poor community compliance and inadequate household coverage. Novel application methods are required. Methodology and principal findings A 10% w/w metofluthrin “emanator” that passively disseminates insecticide from an impregnated net was evaluated in a randomized trial of 200 houses in Mexico. The devices were introduced at a rate of 1 per room and replaced at 3-week intervals. During each of 7 consecutive deployment cycles, indoor resting mosquitoes were sampled using aspirator collections. Assessments of mosquito landing behaviours were made in a subset of houses. Pre-treatment, there were no differences in Aedes aegypti indices between houses recruited to the control and treatment arms. Immediately after metofluthrin deployment, the entomological indices between the trial arms diverged. Averaged across the trial, there were significant reductions in Abundance Rate Ratios for total Ae. aegypti, female abundance and females that contained blood meals (2.5, 2.4 and 2.3-times fewer mosquitoes respectively; P<0.001). Average efficacy was 60.2% for total adults, 58.3% for females, and 57.2% for blood-fed females. The emanators also reduced mosquito landings by 90% from 12.5 to 1.2 per 10-minute sampling period (P<0.05). Homozygous forms of the pyrethroid resistant kdr alleles V410L, V1016L and F1534C were common in the target mosquito population; found in 39%, 24% and 95% of mosquitoes collected during the trial. Conclusions/Significance This is the first randomized control trial to evaluate the entomological impact of any volatile pyrethroid on urban Ae. aegypti. It demonstrates that volatile pyrethroids can have a sustained impact on Ae. aegypti population densities and human-vector contact indoors. These effects occur despite the presence of pyrethroid-resistant alleles in the target population. Formulations like these may have considerable utility for public health vector control responses.


2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Zahra Farsi ◽  
Mahdieh Yazdani ◽  
Samantha Butler ◽  
Maryam Nezamzadeh ◽  
Jila Mirlashari

Background. The proper implementation of cardiopulmonary resuscitation (CPR) is crucial in saving patients. Purpose. This study was aimed at evaluating the difference in educating nursing students on CPR when using the traditional simulation training with a mannequin versus a more novel serious game training on the smartphone platform. Methods. This randomized control trial was conducted in 2018-2019. Through purposive sampling, 56 nursing students were selected and randomly assigned to three groups: a simulation-based CPR training, CPR training using a serious game on the smartphone platform, and a control group that received no CPR training. Each student was evaluated pre- and posttraining on CPR knowledge and skill. Results. Both the simulation and serious game training groups increased CPR abilities two weeks after training. The control group did not show improvement in skill or knowledge of CPR. The simulation and serious game intervention groups demonstrated better scores on the knowledge questionnaire and on the CPR skill demonstration in comparison to the control group. However, the simulation group and the serious game group showed no significant difference in knowledge ( 9.55 ± 2.81 vs. 7.77 ± 2.46 ; p = 0.065 ) or CPR skill demonstration ( 27.17 ± 2.81 vs. 25.72 ± 3.98 ; p = 0.988 ). The overall scores for CPR knowledge did not meet minimum expectations (70% score) in either the simulation (47.75%) or serious game (38.85%) group. However, both groups demonstrated adequate CPR skill on demonstration (simulation 87.64% and serious game 83.06%). Conclusions. Both the simulation and serious game training groups were found to increase CPR skill. CPR training would likely benefit from a multimodal approach to education.


2018 ◽  
Vol 24 (2) ◽  
pp. 111-117
Author(s):  
Rokeya Khatun ◽  
M Nowshad Ali ◽  
Chinmoy Kanti Das ◽  
Fatema Ashraf

This randomized control trial study was conducted at Rajshahi Medical College and Hospital, Bangladesh. This study includes 70 consecutive antepartum eclamptic patients who were admitted in the year 2008. The purpose of this study was to analyze the difference in maternal and perinatal outcome in caesarean and vaginal delivery and thereby describe the success rate of a particular mode of delivery in those cases. Bivariate and multivariable regression analyses were used to determine factors that were associated with assignment to, success of, and odds of maternal and neonatal outcome after caesarean and vaginal delivery.TAJ 2011; 24(2): 111-117


2006 ◽  
Vol 14 (4) ◽  
pp. 439-455 ◽  
Author(s):  
Daniel M. Butler ◽  
Matthew J. Butler

We provide an introduction to the regression discontinuity design (RDD) and use the technique to evaluate models of sequential Senate elections predicting that the winning party for one Senate seat will receive fewer votes in the next election for the other seat. Using data on U.S. Senate elections from 1946 to 2004, we find strong evidence that the outcomes of the elections for the two Senate seats are independent.


2021 ◽  
Vol 9 ◽  
Author(s):  
Yanqiong Liu ◽  
Liang Yu ◽  
Cunyi Yang ◽  
Zhenghui Li

In the context of intensifying global geopolitical disputes and trade frictions, the relationship between geopolitics and energy trade has attracted extensive attention from scholars. The complexity of geopolitical risks mainly comes from the diversity of geopolitical events, which directly leads to the different responses of energy trade in the face of geopolitical risks. The purpose of this paper is to analyze the heterogeneity of the impact of geopolitical events on energy trade based on the difference of event types. This paper uses Regression Discontinuity Design (RDD) to simulate a quasi-natural experiment. Based on the monthly data and the Geopolitical Risk index (GPR index) of 17 emerging economies from 2000 to 2020, the empirical analysis can be concluded as follows: Wars and conflicts events lead to the increase of energy trade volume; terrorist attacks have no significant impact on energy trade; international tension can cause the decline in energy trade. Additional analysis shows that the impact of geopolitical events on energy trade in emerging economies is concentrated on the demand side, and the demand is severely inelastic.


Esculapio ◽  
2021 ◽  
Vol 17 (2) ◽  
pp. 166-169
Author(s):  
Rubina Waheed ◽  
Nadia Ashraf ◽  
Nadia Sabeen ◽  
M Ikram U Allah ◽  
Qaiser Javed ◽  
...  

Objective: To compare the frequency of caesarean section due to fetal distress with Isosorbide mononitrate versus PGE2 for the induction of labour in primigravida at term. Methods: It was Randomized Control Trial conducted in Unit I, Department of Obstetrics & Gynaecology, Lahore General Hospital, Lahore from 11th April 2015 to 10th October 2015. 230 primigravida were randomized into two groups i.e. Prostaglandin E2 and Isosorbide mononitrate for induction of labour. The difference in the frequency of caesarean section due to fetal distress with Prostaglandin E2 and Isosorbide mononitrate for induction of labour in the primigravidas at term was calculated as outcome. Results: The mean age of 27.62 ± 3.909 ranging from 21 to 34 years. The frequency of cesarean section was 12.2%in Prostaglandin E2 group while 0% in Isosorbide mononitrate. There was no effect of gestational age, age of mother and number of doses on outcome. Conclusion: There is no difference in frequency of cesarean section in primigravida groups induced by either Isosorbide mononitrate versus prostaglandin E2. Wherever applicable and feasible we should opt for Isosorbide mononitrate for induction of labour. Keywords: Cesarean section, Prostaglandin E2, Isosorbide mononitrate, Dinoprostone, Induction of labour, Primigravida How to cite: Waheed R., Ashraf N., Sabeen N., U Allah I.M., Javed Q., Khalid A. Induction of Labour with Isosorbide Mononitrate Versus Prostaglandin E2 (PGE2) in Primigravidas (PGs) at term. Esculapio 2021;17(02):166-169


2020 ◽  
Vol 110 (11) ◽  
pp. 3634-3660 ◽  
Author(s):  
Abel Brodeur ◽  
Nikolai Cook ◽  
Anthony Heyes

The credibility revolution in economics has promoted causal identification using randomized control trials (RCT), difference-in-differences (DID), instrumental variables (IV) and regression discontinuity design (RDD). Applying multiple approaches to over 21,000 hypothesis tests published in 25 leading economics journals, we find that the extent of p-hacking and publication bias varies greatly by method. IV (and to a lesser extent DID) are particularly problematic. We find no evidence that (i) papers published in the Top 5 journals are different to others; (ii) the journal “revise and resubmit” process mitigates the problem; (iii) things are improving through time. (JEL A14, C12, C52)


2009 ◽  
Vol 2009 ◽  
pp. 1-3 ◽  
Author(s):  
Yongqi He ◽  
Siquan Zhu ◽  
Ming Chen ◽  
Dejiao Li

Objective. This is prospective randomized control trial to compare the mean keratometric corneal astigmatism diopter power (not surgical induced astigmatism) among preop and one-month and three-month postop phacoemulcification of either a clear temporal corneal incision or a superior scleral tunnel Incision, using only keratometric astigmatic power reading to evaluate the difference between the two cataract surgery incisions.Methods. 120 patients (134 eyes) underwent phacoemulcification were randomly assigned to two groups: Group A, the clear temporal corneal incision group, and Group B, the superior scleral tunnel incision group. SPSS11.5 Software was used for statistical analysis to compare the postsurgical changes of cornea astigmatism on keratometry.Results. The changes of corneal astigmatic diopter in Groups A and B after 3 month postop from keratometric reading were 1.04 + 0.76 and 0.94 + 0.27, respectively ( .05), which showed no statistic significance difference.Conclusion. The incision through either temporal clear cornea or superior scleral tunnel in phacoemulcification shows no statistic difference in astigmatism change on keratometry 3-month postop.


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