Application of Transepithelial Brush Biopsy for Oral Mucosal Lesions

Introduction: developmental oral lesions represent a group of normal lesions that can be found at birth or evident in later life. These lesions include fissured and geographic tongue, Fordyce’s granules and leukoedema. Study aims: to investigate the prevalence of some developmental oral mucosal lesions among dental patients wearing dentures who were attending college of dentistry clinics in Aljouf University, and specialized dental center of ministry of health. Methods and subjects: a retrospective design was conducted to collect data from 344 wearing denture dental patients who were attending college of dentistry clinics in Aljouf University, and specialized dental center of ministry of health. A working excel sheet was created for patients and included data related to personal information such as age and gender; and oral developmental lesions. The software SPSS version 20 was used to analyze data. Statistical tests including frequency, percentages, and One way Anova were used to describe data. Significance was considered at alpha level <0.05. Study findings: the majority of participants were males (86%), the mean age was 51.60+ 3.51years. The prevalence of fissured tongue was 10.2%, geographic tongue 11.3%, Fordyce’s granules 7%, and leukoedema 7.3%. Age was significantly associated with fissured tongue (p=0.04), and Fordyce’s granules (p=0.003). Gender was not associated significantly with any of the studied lesions. Conclusion: developmental oral lesions among dental patients wearing dentures exist with varying rates of prevalence as well as it provides valuable basic data about the prevalence of oral mucosal lesions among patients seeking dental care in Aljouf area.

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Candida albicans infection in patients with oral squamous cell carcinoma

Vojnosanitetski pregled ◽

10.2298/vsp1009766c ◽

2010 ◽

Vol 67 (9) ◽

pp. 766-770 ◽

Cited By ~ 5

Author(s):

Milos Cankovic ◽

Marija Bokor-Bratic

Keyword(s):

Squamous Cell Carcinoma ◽

Candida Albicans ◽

Alcohol Consumption ◽

Oral Cancer ◽

Oral Squamous Cell Carcinoma ◽

Candida Species ◽

Control Group ◽

Oral Mucosal Lesions ◽

Mucosal Lesions ◽

Cancer Lesion

Bacground/Aim. Systemic candidiasis in intensive care units remains an improtant problem due to antifungal resistance. Patients undergoing radiotherapy for head and neck cancer are at increased risk of developing oral candidiasis and they more frequent have prior fungi colonization. Due to identification of specific risk factors predisposing to fungal infection in order to threat such patients the aim of this study was to determine the presence of Candida species in patients with oral squamous cell carcinoma and compare it to the control subjects (patients with benign oral mucosal lesions). Methods. A total number of 30 consecutive oral cancer examined patients were included in this prospective study (24 men and 6 women with a mean age of 61.47 years, range 41-81 years). The control group consisted of 30 consecutive patients with histologically proven benign oral mucosal lesions (16 men and 14 women with a mean age of 54.53 years, range 16- 83 years). The samples for mycological examination were obtained by using sterile cotton swabs from the cancer lesion surface and in the patients of the control group from the benign mucosal lesion surface. Samples were inoculated in Sabouraud' dextrose agar. For identification purposes, Mackenzie germ tube test was performend on all isolates. Results. The prevalence of Candida was significantly higher in oral cancer patients than in control subjects (?2 = 5.455, p = 0.020). Candida was found on nine of the 30 cancer surfaces; 5 (16.7%) were identified as non-albicans Candida and 4 (13.3%) as Candida albicans. In the control group, only Candida albicans was isolated from 2 (6.7%) patients. In this study, no statistically significant differences in the presence of Candida species was found with respect to gender, age, smoking, alcohol consumption, wearing of dental protheses and the site of cancer lesion. Conclusion. The increased prevalence of yeasts on the surfaces of oral carcinoma indicates a need for their suppression before any cancer treatment. There was no evidence for an association between gender, age, smoking, alcohol consumption, wearing of dental protheses, the site of cancer lesion and the yeast presence.

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