Objective Assessment of Aerosolization During Transnasal Endoscopy: A Systematic Review

Objective The goal of this systematic review is to assimilate the literature on objective assessment of particulate aerosolization during transnasal endoscopic procedures. Data Sources PubMed and hand-searched articles. Review Methods The PubMed electronic database was searched using Medical Subject Headings and free-text search terms relating to aerosolization and transnasal endoscopic procedures from inception to November 16, 2020. References were hand-searched to identify additional publications for consideration. Inclusion in the systematic review required quantification of aerosol generation during clinic transnasal endoscopic procedures. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and flowchart were followed during the systematic review. Results Eight of 900 studies met criteria for inclusion in the systematic review. Five studies tested nasal endoscopy with mixed findings on the risk of aerosol generation during this procedure. Two studies assessed flexible fiberoptic laryngoscopy and also reported mixed findings. Breathing, sneezing, speech, and spray anesthetic/decongestants were found to consistently increase aerosol generation above baseline. A number of studies tested new and general mitigation strategies and were found to be effective in decreasing aerosol generation. Conclusions The coronavirus disease 2019 pandemic has informed many considerations regarding patient and provider safety. It is valuable to understand the risk during outpatient otolaryngology procedures through the quantification of aerosolization. There are several effective methods to control aerosolization during these procedures. The findings of this systematic review will inform appropriate precautions to protect against spread of infectious agents by aerosolization.

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Clinical Information Systems as the Backbone of a Complex Information Logistics Process: Findings from the Clinical Information Systems Perspective for 2016

Yearbook of Medical Informatics ◽

10.15265/iy-2017-023 ◽

2017 ◽

Vol 26 (01) ◽

pp. 103-109 ◽

Cited By ~ 1

Author(s):

W. O. Hackl ◽

T. Ganslandt

Keyword(s):

Information Systems ◽

Clinical Information ◽

Clinical Information Systems ◽

Free Text ◽

Medical Subject Headings ◽

Search Terms ◽

Information Logistics ◽

Free Text Search ◽

Logistics Process ◽

Selection Of

Summary Objective: To summarize recent research and to propose a selection of best papers published in 2016 in the field of Clinical Information Systems (CIS). Method: The query used to retrieve the articles for the CIS section of the 2016 edition of the IMIA Yearbook of Medical Informatics was reused. It again aimed at identifying relevant publications in the field of CIS from PubMed and Web of Science and comprised search terms from the Medical Subject Headings (MeSH) catalog as well as additional free text search terms. The retrieved articles were categorized in a multi-pass review carried out by the two section editors. The final selection of candidate papers was then peer-reviewed by Yearbook editors and external reviewers. Based on the review results, the best papers were then chosen at the selection meeting with the IMIA Yearbook editorial board. Text mining, term co-occurrence mapping, and topic modelling techniques were used to get an overview on the content of the retrieved articles. Results: The query was carried out in mid-January 2017, yielding a consolidated result set of 2,190 articles published in 921 different journals. Out of them, 14 papers were nominated as candidate best papers and three of them were finally selected as the best papers of the CIS field. The content analysis of the articles revealed the broad spectrum of topics covered by CIS research. Conclusions: The CIS field is multi-dimensional and complex. It is hard to draw a well-defined outline between CIS and other domains or other sections of the IMIA Yearbook. The trends observed in the previous years are progressing. Clinical information systems are more than just sociotechnical systems for data collection, processing, exchange, presentation, and archiving. They are the backbone of a complex, trans-institutional information logistics process.

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New Problems - New Solutions: A Never Ending Story

Yearbook of Medical Informatics ◽

10.15265/iy-2016-054 ◽

2016 ◽

Vol 25 (01) ◽

pp. 146-151 ◽

Cited By ~ 1

Author(s):

T. Ganslandt ◽

W.O. Hackl ◽

Keyword(s):

Clinical Information ◽

Free Text ◽

Medical Subject Headings ◽

Search Terms ◽

Research Activities ◽

Free Text Search ◽

Problems And Solutions ◽

Mapping Techniques ◽

Selection Of

Summary Objective: To summarize recent research and to propose a selection of best papers published in 2015 in the field of Clinical Information Systems (CIS). Method: The query which had been used last year to retrieve articles for the CIS section of the IMIA Yearbook of Medical Informatics 2015 was refined. It again aimed at identifying relevant publications in the field of CIS and comprised search terms from the Medical Subject Headings (MeSH) catalog as well as additional free text search terms from PubMed and Web of Science. The retrieved articles were categorized in a multi-pass review carried out separately by the two section editors. The final selection of 15 candidate papers was then peer-reviewed by Yearbook editors and external reviewers. Based on the review results the four best papers were then selected at the best papers selection meeting with the IMIA Yearbook editorial board. To get an overview on the content of the retrieved articles we applied text mining and term co-occurrence mapping techniques. Results: The query was carried out in mid-January 2016, yielding a combined result set of 1851 articles which were published in 790 different journals. The most relevant terms from abstracts and titles of these articles were assigned to six different clusters. A majority of articles dealt with two thematic blocks, problems and solutions in the CIS field. The majority of the 2016 CIS candidate papers and all four best papers could be assigned to these two thematic blocks. Conclusions: We identified two main tracks among the CIS candidate and best papers as well as in CIS research activities in general: problems and solutions. A never ending cycle of continuous improvement.

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Errors in search strategies used in systematic reviews and their effects on information retrieval

Journal of the Medical Library Association JMLA ◽

10.5195/jmla.2019.567 ◽

2019 ◽

Vol 107 (2) ◽

Cited By ~ 20

Author(s):

José Antonio Salvador-Oliván ◽

Gonzalo Marco-Cuenca ◽

Rosario Arquero-Avilés

Keyword(s):

Systematic Reviews ◽

Search Strategies ◽

Primary Objective ◽

Free Text ◽

Medical Subject Headings ◽

Search Terms ◽

Pubmed Search ◽

Meta Analyses ◽

Mesh Database ◽

Controlled Language

Objectives: Errors in search strategies negatively affect the quality and validity of systematic reviews. The primary objective of this study was to evaluate searches performed in MEDLINE/PubMed to identify errors and determine their effects on information retrieval.Methods: A PubMed search was conducted using the systematic review filter to identify articles that were published in January of 2018. Systematic reviews or meta-analyses were selected from a systematic search for literature containing reproducible and explicit search strategies in MEDLINE/PubMed. Data were extracted from these studies related to ten types of errors and to the terms and phrases search modes.Results: The study included 137 systematic reviews in which the number of search strategies containing some type of error was very high (92.7%). Errors that affected recall were the most frequent (78.1%), and the most common search errors involved missing terms in both natural language and controlled language and those related to Medical Subject Headings (MeSH) search terms and the non-retrieval of their more specific terms.Conclusions: To improve the quality of searches and avoid errors, it is essential to plan the search strategy carefully, which includes consulting the MeSH database to identify the concepts and choose all appropriate terms, both descriptors and synonyms, and combining search techniques in the free-text and controlled-language fields, truncating the terms appropriately to retrieve all their variants.

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Clinical Information Systems as the Backbone of a Complex Information Logistics Process: Findings from the Clinical Information Systems Perspective for 2016

Yearbook of Medical Informatics ◽

10.1055/s-0037-1606488 ◽

2017 ◽

Vol 26 (01) ◽

pp. 103-108

Author(s):

W. O. Hackl ◽

T. Ganslandt

Keyword(s):

Information Systems ◽

Clinical Information ◽

Clinical Information Systems ◽

Free Text ◽

Medical Subject Headings ◽

Search Terms ◽

Information Logistics ◽

Free Text Search ◽

Logistics Process ◽

Selection Of

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What is the risk of prostate cancer mortality following negative systematic TRUS-guided biopsies? A systematic review

BMJ Open ◽

10.1136/bmjopen-2020-040965 ◽

2020 ◽

Vol 10 (12) ◽

pp. e040965

Author(s):

Sandra Miriam Kawa ◽

Signe Benzon Larsen ◽

John Thomas Helgstrand ◽

Peter Iversen ◽

Klaus Brasso ◽

...

Keyword(s):

Prostate Cancer ◽

Systematic Review ◽

Data Extraction ◽

Specific Antigen ◽

Transrectal Ultrasound ◽

Population Based ◽

Free Text ◽

Medical Subject Headings ◽

Prognostic Information ◽

Prostate Biopsies

ObjectiveTo investigate the risk of prostate cancer-specific mortality (PCSM) following initial negative systematic transrectal ultrasound-guided (TRUS) prostate biopsies.DesignSystematic review.Data sourcesPubMed and Embase were searched using a string combination with keywords/Medical Subject Headings terms and free text in the search builder. Date of search was 13 April 2020.Study selectionStudies addressing PCSM following initial negative TRUS biopsies. Randomised controlled trials and population-based studies including men with initial negative TRUS biopsies reported in English from 1990 until present were included.Data extractionData extraction was done using a predefined form by two authors independently and compared with confirm data; risk of bias was assessed using the Newcastle–Ottawa Scale for cohort studies when applicable.ResultsFour eligible studies were identified. Outcomes were reported differently in the studies as both cumulative incidence and Kaplan-Meier estimates have been used. Regardless of the study differences, all studies reported low estimated incidence of PCSM of 1.8%–5.2% in men with negative TRUS biopsies during the following 10–20 years. Main limitation in all studies was limited follow-up.ConclusionOnly a few studies have investigated the risk of PCSM following initial negative biopsies and all studies included patients before the era of MRI of the prostate. However, the studies point to the fact that the risk of PCSM is low following initial negative TRUS biopsies, and that the level of prostate-specific antigen before biopsies holds prognostic information. This may be considered when advising patients about the need for further diagnostic evaluation.PROSPERO registration numberCRD42019134548.

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Hyaluronic Acid Fillers for Midface Augmentation: A Systematic Review

Facial Plastic Surgery ◽

10.1055/s-0041-1724122 ◽

2021 ◽

Author(s):

Lily N. Trinh ◽

Amar Gupta

Keyword(s):

Systematic Review ◽

Hyaluronic Acid ◽

Subcutaneous Tissue ◽

Age Groups ◽

Medical Subject Headings ◽

Mesh Terms ◽

Full Text Review ◽

Filler Injections ◽

Subjective Measurements ◽

Meta Analyses

AbstractInjectable fillers represent one of the most requested minimally invasive treatments to rejuvenate the aging face, and its popularity is steadily rising. A vast majority of filler treatments are with hyaluronic acid (HA). The aim of this systematic review is to evaluate patient outcomes, safety profile, and administration techniques of various HA fillers for malar augmentation. A systematic review of the published literature was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and included PubMed, Embase, and Science Direct databases. Medical Subject Headings (MeSH) terms used were “cheek” OR “midface” OR “malar” and “filler” OR “hyaluronic acid” OR “Juvederm” OR “Restylane” OR “Perlane” OR “Belotero.” The initial search identified 699 articles; 256 duplicates were removed. Additional 12 studies were identified from reference lists. A total of 455 were screened by title and abstract and 387 studies were eliminated based on criteria. Also, 68 articles underwent full-text review, and 18 articles were included in the final review and involved seven different HA formulations. Men and women from many age groups were highly satisfied with their results following HA treatment for midface augmentation up to 24 months. The most common adverse events included bruising, swelling, and tenderness, and typically lasted no more than 2 weeks. Upper cheek filler injections near the zygoma should be placed in the submuscular plane while lower cheek injections should be placed in the subcutaneous tissue. HA is an attractive choice for midface augmentation due to its high patient satisfaction, long-lasting effects, and low side-effect profile. Due to the variability in technique, level of expertise, and subjective measurements across studies, one optimal regimen could not be concluded. However, midface augmentation treatment should be personalized to each patient. Additional clinical trials are required to more conclusively determine the most appropriate approach for this procedure.

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Structural and Functional MRI Brain Changes in Patients with Schizophrenia Following Electroconvulsive Therapy: A Systematic Review

Current Neuropharmacology ◽

10.2174/1570159x19666210809101248 ◽

2021 ◽

Vol 19 ◽

Author(s):

Yuchao Jiang ◽

Mingjun Duan ◽

Hui He ◽

Dezhong Yao ◽

Cheng Luo

Keyword(s):

Systematic Review ◽

Functional Mri ◽

Electroconvulsive Therapy ◽

Brain Regions ◽

Parahippocampal Gyrus ◽

Medical Subject Headings ◽

Therapeutic Mechanisms ◽

Brain Changes ◽

Meta Analyses ◽

Induced Changes

Background: Schizophrenia (SZ) is a severe psychiatric disorder typically characterized by multidimensional psychotic syndromes. Electroconvulsive therapy (ECT) is a treatment option for medication-resistant patients with SZ or to resolve acute symptoms. Although the efficacy of ECT has been demonstrated in clinical use, its therapeutic mechanisms in the brain remain elusive. Objective: This study aimed to summarize brain changes on structural magnetic resonance imaging (sMRI) and functional MRI (fMRI) after ECT. Methods: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review was carried out. The PubMed and Medline databases were systematically searched using the following medical subject headings (MeSH): (electroconvulsive therapy OR ECT) AND (schizophrenia) AND (MRI OR fMRI OR DTI OR DWI). Results: This review yielded 12 MRI studies, including 4 with sMRI, 5 with fMRI and 3 with multimodal MRI. Increases in volumes of the hippocampus and its adjacent regions (parahippocampal gyrus and amygdala) as well as insula and frontotemporal regions were noted after ECT. fMRI studies found ECT-induced changes in different brain regions/networks, including the hippocampus, amygdala, default model network, salience network and other regions/networks that are thought to highly correlate with the pathophysiologic characteristics of SZ. The results of the correlation between brain changes and symptom remissions are inconsistent Conclusion: Our review provides evidence supporting ECT-induced brain changes on sMRI and fMRI in SZ and explores the relationship between these changes and symptom remission.

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Abstract 16037: Hybrid Convergent Ablation for Atrial Fibrillation: Updated Systematic Review and Meta-analysis

Circulation ◽

10.1161/circ.142.suppl_3.16037 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

suvash shrestha ◽

David DeLurgio ◽

Andy Kiser ◽

Saumil Oza ◽

Yisachar Greenberg ◽

...

Keyword(s):

Systematic Review ◽

Patient Monitoring ◽

Event Rate ◽

Meta Analysis ◽

Adverse Event Rate ◽

Likelihood Estimator ◽

Search Terms ◽

Limited Effectiveness ◽

One Year ◽

Meta Analyses

Introduction: Hybrid convergent epicardial/endocardial ablation was developed in response to the limited effectiveness of endocardial catheter ablation for persistent (PersAF) and longstanding PersAF (LSPAF). The objective of this study was to perform a systematic review and meta-analysis of reported safety and efficacy outcomes with convergent procedures. Methods: Predefined search terms were used in PubMed; the initial search was performed in June 2019 and updated in May 2020. Abstracts and full text in English were reviewed for peer-reviewed, primary clinical studies of hybrid convergent procedures in PersAF/LSPAF. Meta-analysis was performed with using a random effects model with a restricted maximum likelihood estimator and forest plots. Heterogeneity was tested using Cochran’s Q-test. Results: The updated search yielded 325 unique results. Two articles from meta-analyses were added. Nineteen articles met inclusion with safety and/or efficacy data. Three overlapping studies were excluded. Results from the randomized CONVERGE trial were added, for a total of 1084 patients in 17 studies; 94% had PersAF or LSPAF. The 30-day major adverse event rate was 3.1% (95% CI 1.9% - 4.3%; n=1084; 17 studies), excluding pericardial effusions (PE) (non-emergent inflammatory response) and 5.1% (95% CI 3.6% - 6.6%) overall. The PEs may be mitigated by anti-inflammatory prophylaxis, pericardial drainage and appropriate patient monitoring. Freedom from AF/atrial arrhythmia at one year or later was 75.0% (95% CI 66.0%-83.9%; n=805; 14 studies) regardless of anti-arrhythmic drugs (AAD) and 64.9% (95% CI 54.7%-75.1%; n=494; 8 studies) off AADs/ absent increased dosage of failed AADs. Heterogeneity across studies was detected for effectiveness (p<0.0001), but not for safety (p=0.12). Conclusions: This meta-analysis shows high efficacy of hybrid convergent ablation at one year, even off AADs, and a reasonable safety in mostly persistent or long-standing persistent AF.

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Etiology and Surgical Management of Cervical Spinal Epidural Abscess (SEA):: A Systematic Review

Global Spine Journal ◽

10.1177/2192568218772048 ◽

2018 ◽

Vol 8 (4_suppl) ◽

pp. 59S-67S ◽

Cited By ~ 5

Author(s):

Geoffrey Stricsek ◽

Justin Iorio ◽

Yusef Mosley ◽

Srinivas Prasad ◽

Joshua Heller ◽

...

Keyword(s):

Systematic Review ◽

Epidural Abscess ◽

Management Strategies ◽

Spinal Epidural Abscess ◽

Systematic Analysis ◽

The Past ◽

Search Terms ◽

Meta Analyses ◽

Spinal Epidural ◽

Early Surgical Intervention

Study Design: Systematic analysis and review. Objective: Evaluation of the presentation, etiology, management strategies (including both surgical and nonsurgical options), and neurological functional outcomes in patients with cervical spinal epidural abscess (SEA). Methods: The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria were used to create a framework based on which articles pertaining to cervical SEA were chosen for review following a search of the Ovid and PubMed databases using the search terms “epidural abscess” and “cervical.” Included studies needed to have at least 4 patients aged 18 years or older, and to have been published within the past 20 years. Results: Database searches yielded 521 potential articles in PubMed and 974 potential articles in Ovid. After review, 11 studies were ultimately identified for inclusion in this systematic review. Surgery appears to be a well-tolerated management strategy with limited complications for patients with cervical SEA. However, the quantity of data comparing medical and surgical treatment of cervical SEA is limited and the bulk of the data is derived from low quality studies. Conclusion: Data reporting was heterogeneous among studies making it difficult to draw discrete conclusions. Early surgical intervention may be appropriate in selected patients with cervical epidural abscess, but it is not clear what distinguishes these patients from those who are successfully managed nonoperatively.

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Global epidemiology ofNeisseria gonorrhoeaein infertile populations: protocol for a systematic review

BMJ Open ◽

10.1136/bmjopen-2018-025808 ◽

2019 ◽

Vol 9 (5) ◽

pp. e025808 ◽

Cited By ~ 2

Author(s):

Hiam Chemaitelly ◽

Manale Harfouche ◽

Karel Blondeel ◽

Thabo Christopher Matsaseng ◽

James Kiarie ◽

...

Keyword(s):

Systematic Review ◽

Random Effect ◽

Health Sector ◽

Cochrane Collaboration ◽

Primary Data ◽

Free Text ◽

Sexually Transmitted ◽

Global Epidemiology ◽

Scientific Meetings ◽

Meta Analyses

IntroductionA key target of the WHO’s ‘Global Health Sector Strategy on sexually transmitted infections, 2016–2021’ is achieving 90% reduction inNeisseria gonorrhoeae(gonorrhoea for short) incidence globally by 2030. Though untreated, gonorrhoea has been linked to infertility, the epidemiology of this infection in infertile populations remains poorly understood and somewhat a neglected area of reproductive health. Our proposed systematic review aims to fill this gap by characterising comprehensively gonorrhoea infection in infertile populations globally.Methods and analysisAll available studies of gonorrhoea infection in infertile populations, including infertility clinic attendees, will be systematically reviewed informed by Cochrane Collaboration guidelines. Findings will be reported following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data sources will be searched using broad index terms exploded to cover all subheadings and free text terms with no language or year restriction. Any epidemiological measure in infertile populations based on primary data will be eligible for inclusion. Measures based on different assay types will be extracted as separate studies for different analyses. Only one biospecimen type per assay type will be considered based on a predefined priority order. Samples including fewer than 10 participants or assessing infection in the upper genital tract will be excluded. Quality assessments will be conducted for all measures included in the review. Meta-analyses will be implemented using DerSimonian-Laird random effect models to estimate the mean prevalence of gonorrhoea in infertile populations globally, and stratified by WHO region, assay type, sex, infertility type, infertility diagnosis, among other factors. Detailed heterogeneity assessment will be performed, and potential sources of between-study heterogeneity will be explored using meta-regression. Review will be conducted from 26 March 2018 to 28 July 2019.Ethics and disseminationAn institutional review board clearance is not required as all data are publicly available. The findings will be disseminated through a peer-reviewed publication and international scientific meetings/workshops with key stakeholders.PROSPERO registration numberCRD42018102934

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