Actinomycosis of the Larynx and Pharynx

1978 ◽  
Vol 86 (5) ◽  
pp. ORL-739-ORL-742 ◽  
Author(s):  
James H. Brandenburg ◽  
William W. Finch ◽  
Wayne R. Kirkham
Keyword(s):  
Medical Center ◽  
Cricoid Cartilage ◽  
The Body ◽  
Clinical Aspects ◽  
Review Of The Literature ◽  
University Of Wisconsin ◽  
Penicillin Therapy ◽  
History Of ◽  
Laryngeal Stridor

This paper presents a case report of a 67-year-old man who was seen in the Otolaryngology Clinic, University of Wisconsin Medical Center with a seven-month history of dyspnea and laryngeal stridor. On examination there were several slightly tender firm submucosal nodules in the soft palate and left tonsilar area and a 1.5-cm polypoid subglottic mass arising from the body of the cricoid cartilage. Because of the marked airway obstruction, a tracheotomy was necessary. The laryngeal polypoid mass was removed and biopsies were obtained from the submucosal nodular masses of the palate. Microscopic examination of the tissue revealed the lesions to be caseating granulomas, and actinomycosis was identified on the cultures. The patient received long-term penicillin therapy and has remained asymptomatic. A discussion of the biologic and clinical aspects of actinomycosis is included. A review of the literature revealed only one other description of endolaryngeal actinomycosis.

scholarly journals Influence of Postoperative Changes in Sarcopenia on Long-Term Survival in Non-Metastatic Colorectal Cancer Patients

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2410
Author(s):  
Chungyeop Lee ◽  
In-Ja Park ◽  
Kyung-Won Kim ◽  
Yongbin Shin ◽  
Seok-Byung Lim ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Medical Center ◽  
The Body ◽  
Term Survival ◽  
Postoperative Changes ◽  
Asan Medical ◽  
Colorectal Cancer Patients

The effect of perioperative sarcopenic changes on prognosis remains unclear. We conducted a retrospective cohort study with 2333 non-metastatic colorectal cancer patients treated between January 2009 and December 2012 at the Asan Medical Center. The body composition at diagnosis was measured via abdominopelvic computed tomography (CT) using Asan-J software. Patients underwent CT scans preoperatively, as well as at 6 months–1 year and 2–3 years postoperatively. The primary outcome was the association between perioperative sarcopenic changes and survival. According to sarcopenic criteria, 1155 (49.5%), 890 (38.2%), and 893 (38.3%) patients had sarcopenia preoperatively, 6 months–1 year, and 2–3 years postoperatively, respectively. The 5-year overall survival (OS) (95.8% vs. 92.1%, hazard ratio (HR) = 2.234, p < 0.001) and 5-year recurrence-free survival (RFS) (93.2% vs. 86.2%, HR = 2.251, p < 0.001) rates were significantly lower in patients with preoperative sarcopenia. Both OS and RFS were lower in patients with persistent sarcopenia 2–3 years postoperatively than in those who recovered (OS: 96.2% vs. 90.2%, p = 0.001; RFS: 91.1% vs. 83.9%, p = 0.002). In multivariate analysis, postoperative sarcopenia was confirmed as an independent factor associated with decreased OS and RFS. Pre- and postoperative sarcopenia and changes in the condition during surveillance were associated with oncological outcomes.

Acute exudative paraneoplastic polymorphous vitelliform maculopathy in a patient with thymoma, myasthenia gravis, and polymyositis

2021 ◽  
pp. 112067212199404
Author(s):  
He Yu ◽  
Xinyu Ma ◽  
Nianting Tong ◽  
Zhanyu Zhou ◽  
Yu Zhang
Keyword(s):  
Myasthenia Gravis ◽  
Medical Center ◽  
Postoperative Radiotherapy ◽  
Clinical Manifestations ◽  
Subretinal Fluid ◽  
Metastatic Tumor ◽  
The Body ◽  
Pleural Thickening ◽  
History Of ◽  
Clinically Significant

Importance: This is the first reported case of acute exudative paraneoplastic polymorphous vitelliform maculopathy (AEPPVM) in a patient with thymoma, accompanied by myasthenia gravis (MG) and polymyositis. Objective: To examine the pathogenesis of ocular disease in a patient with yolk-like fundus lesions and thymoma, MG, and polymyositis throughout the body based on clinical manifestations, diagnosis, differential diagnosis, and genetic testing to determine the appropriate treatment course. Design, setting, and participants: We describe a 63-year-old woman who presented to our tertiary medical center with a 3-month history of reduced visual acuity in both eyes. Concurrent fundoscopy revealed a 2.0 × 1.7-mm, unifocal, yellow, round vitelliform lesion in the macular region, surrounded by multifocal, shallow, yellow-white pockets of subretinal fluid. The patient’s medical history included thymoma with thymectomy treatment, combined with pericardiectomy and postoperative radiotherapy (20 years prior), followed by a diagnosis of MG with suspect thymic association (15 years prior). Three years prior, the patient had been diagnosed with polymyositis related to paraneoplastic syndrome; 1 year prior, she had been examined for pleural thickening due to suspected metastatic tumor. Results: On her most recent follow-up visit at 3 months after initial diagnosis, the patient was stable with no clinically significant progression in ocular or systemic conditions.

scholarly journals Slavery and Its Transformations: Prolegomena for a Global and Comparative Research Agenda

2021 ◽  
Vol 63 (3) ◽  
pp. 566-598
Author(s):  
Matthias van Rossum
Keyword(s):  
Comparative Research ◽  
Research Agenda ◽  
Analytical Framework ◽  
The Body ◽  
Indonesian Archipelago ◽  
Research Perspectives ◽  
History Of ◽  
The Indian Ocean ◽  
Contemporary Development

AbstractThis article argues that we need to move beyond the “Atlantic” and “formal” bias in our understanding of the history of slavery. It explores ways forward toward developing a better understanding of the long-term global transformations of slavery. Firstly, it claims we should revisit the historical and contemporary development of slavery by adopting a wider scope that accounts for the adaptable and persistent character of different forms of slavery. Secondly, it stresses the importance of substantially expanding the body of empirical observations on trajectories of slavery regimes, especially outside the Atlantic, and most notable in the Indian Ocean and Indonesian Archipelago worlds, where different slavery regimes existed and developed in interaction. Thirdly, it proposes an integrated analytical framework that will overcome the current fragmentation of research perspectives and allow for a more comparative analysis of the trajectories of slavery regimes in their highly diverse formal and especially informal manifestations. Fourth, the article shows how an integrated framework will enable a collaborative research agenda that focuses not only on comparisons, but also on connections and interactions. It calls for a closer integration of the histories of informal slavery regimes into the wider body of existing scholarship on slavery and its transformations in the Atlantic and other more intensely studied formal slavery regimes. In this way, we can renew and extend our understandings of slavery's long-term, global transformations.

scholarly journals THE VALUE OF PENICILLIN IN THE TREATMENT OF AGRANULOCYTOSIS CAUSED BY THIOURACIL

Blood ◽  
1946 ◽  
Vol 1 (1) ◽  
pp. 53-66 ◽  
Author(s):  
MARY CATHERINE TYSON ◽  
PETER VOGEL ◽  
NATHAN ROSENTHAL
Keyword(s):  
Bone Marrow ◽  
Antibacterial Agents ◽  
Bone Marrow Cells ◽  
The Body ◽  
Bacterial Invasion ◽  
Beneficial Effects ◽  
Penicillin Therapy ◽  
History Of ◽  
Per Se ◽  
Hemopoietic System

Abstract Thiouracil has been found to be an effective drug in the treatment of hyperthyroidism. Agranulocytosis following its use occurred in nine cases, four of which terminated fatally. In five others a complete and rapid recovery took place following penicillin therapy. The latter drug is believed to be ideal for all cases of agranulocytosis, and especially those in which chemotherapy has been used and may have been responsible for the condition. Thus far we have not seen any report of any untoward effect on the hemopoietic system from the use of penicillin. The use of antibacterial agents for the treatment of agranulocytosis was suggested by Dameshek and Wolfson21 in 1942. It was believed by these authors that patients with agranulocytosis died not of the leukopenia per se but of the sepsis which developed secondarily to the lack of granulocytes. Two very severe cases of aminopyrine agranulocytosis treated with sulfathiazole made complete recoveries. For the treatment of sulfonamide agranulocytosis, it was suggested that a preparation differing from that which had already been used be given. With the discovery of penicillin, and its complete lack of possible deleterious effect on the bone marrow, its use was suggested by Dameshek17 (1944). A report on the beneficial effects of this medication in a case of sulfonamide agranulocytosis was later reported by Dameshek and Knowlton18 and similar cases by Sprague and Ferguson19 and by Meredith and Fink.20 Since sulfonamides may cause further toxic effect on the bone marrow, we feel that their use should be avoided in the treatment of agranulocytosis, especially where a history of previous use is obtained. We do not agree with others21, 22 who continue the use of sulfonamides in the treatment of leukopenia or agranulocytosis where these very drugs may have been responsible for the condition. It would seem better judgment to use penicillin, which by combating the bacterial invasion of the body and the consequent toxemia enables the patient to survive until the bone marrow cells regenerate.

scholarly journals Celiac Disease Diagnosed in an Older Adult Patient with a Complex Neuropsychiatric Involvement: A Case Report and Review of the Literature

2020 ◽  
Vol 10 (7) ◽  
pp. 426
Author(s):  
Emma Falato ◽  
Fioravante Capone ◽  
Federico Ranieri ◽  
Lucia Florio ◽  
Marzia Corbetto ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Case Report ◽  
Older Adult ◽  
Clinical Picture ◽  
Neurological Involvement ◽  
Extraintestinal Manifestations ◽  
Review Of The Literature ◽  
History Of ◽  
Delusional Jealousy

We present a case of celiac disease (CD) diagnosis in a 75-year-old woman with a long-term history of chronic delusional jealousy and a complex neurological involvement. The case describes a very unusual clinical picture, provides some clinical clues, and highlights the importance of being aware of CD extraintestinal manifestations in order to get a timely diagnosis.

scholarly journals Editorial

2005 ◽  
Vol 22 (2) ◽  
pp. i-iv
Author(s):  
Katherine Bullock
Keyword(s):  
Arab World ◽  
Medical Center ◽  
Knowledge Society ◽  
The Body ◽  
Modern World ◽  
Ibn Sina ◽  
Muslim Countries ◽  
The Face ◽  
History Of ◽  
Independent Thought

As Mehmet Mahfuz Söylemez documents in his “The Jundishapur School:Its History, Structure, and Functions,” Southwest Asia has long been a sitefor a cross-fertilization of ideas that have led to productive societies.Although Jundishapur’s excellence as a medical center predates the comingof Islam, it nevertheless played a key role in transmitting knowledge toMuslim physicians as well as contributing to Baghdad’s development as anup-and-coming center of excellence. In an open and welcoming climate,the scholars and physicians of Jundishapur and Baghdad fostered a learningenvironment that allowed Muslim civilizations to flourish.Today’s Muslims often look back to such “golden ages” with wistfulness,admiration, and frustration. Given the constant defeats and subjugationfaced by Muslim countries since western colonization, this wistfulness is notsurprising. In order to bolster their identity to defend themselves against thiscontinuing subjugation, Muslims often offer this glorious past to anIslamophobic world: “We are not barbarians! See what Muslim civilizationwas capable of!” And in the face of Eurocentric curricula that largely denyany role to a non-European civilization in the history of ideas since Plato,such reminders are crucial.But as Dieter Weiss’ “Paths toward an Arab Knowledge Society” inadvertentlyhighlights, such wistfulness is underscored by an ignorance of justwhat it takes to produce a golden age. For a society to flourish, it must createthe conditions that enable its inhabitants to engage in knowledge creation:the freedom to think, debate, and discuss. While he focuses only onthe Arab world, one would have to be blind to reality not to realize that thesame deplorable situation can be found in most Muslim countries today.Imagine what kind of Muslim cultural and political society must haveexisted for Ibn Sina, who produced great medical and philosophical workswhile denying the resurrection of the body. Compare that with the assassinations,death threats, and the like facing contemporary writers who engagein independent thought about Islam and the modern world. Think of the roleof caliph Ma’mun’s bayt al-hikmah (House of Wisdom), where Christians,Muslims, and scholars who followed other religions worked side-by-side to ...

scholarly journals Development of Diabetes Type 3 After SARS-COV-2 Pancreatic B Cell Injury

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A373-A373
Author(s):  
Francisco Jose Zayas ◽  
Marianne Hernandez-Negron ◽  
Michelle Marie Mangual Garcia
Keyword(s):  
Blood Glucose ◽  
Previous History ◽  
Endocrine System ◽  
Diabetes Type ◽  
The Body ◽  
C Peptide ◽  
Organ Systems ◽  
History Of ◽  
Type 3

Abstract SARS-COV-2 has caused millions of deaths in less than one year, yet little is known about the long-term consequences survivors may suffer. The novel coronavirus uses the ACE2 receptor to infect human cells, allowing it to target organ systems with such receptors including the respiratory, cardiovascular, gastrointestinal and endocrine system. The purpose of this case report is to describe the long-term implications COVID-19 may cause in the endocrine system. A 46-year-old woman was referred to our clinic due to abrupt uncontrolled blood glucose levels ranging from 200-550mg/dL after being infected with COVID-19 for approximately 10 weeks. She has a past medical history of Diabetes Mellitus Type 2 which was diagnosed 3 years ago and was well controlled with diet. Present history reveals polyuria, polydipsia, tiredness and a decreased appetite. Laboratory values show HbA1C 12, negative islet cell antibodies/GAD antibodies, low C-peptide, high TSH, normal FT4 and positive anti-TPO antibodies/thyroglobulin antibodies. The sudden loss of blood glucose control along with low c peptide levels without evidence of autoimmunity support the diagnosis of Pancreatic Diabetes. SARS-COV-2 infection may cause Diabetes Type 3, rendering a patient dependent on insulin use for life. Covid-19 survivors, with or without a previous history of endocrinopathy, should be evaluated for possible long-term sequels of infection as the virus targets tissues throughout the body.

scholarly journals The natural history of congenital myotonic dystrophy: mortality and long term clinical aspects.

1993 ◽  
Vol 68 (2) ◽  
pp. 177-181 ◽  
Author(s):  
W Reardon ◽  
R Newcombe ◽  
I Fenton ◽  
J Sibert ◽  
P S Harper
Keyword(s):  
Natural History ◽  
Myotonic Dystrophy ◽  
Clinical Aspects ◽  
Congenital Myotonic Dystrophy ◽  
History Of

scholarly journals Syphilitic glomerulonephritis: case report and review of the literature

2015 ◽  
Vol 156 (1) ◽  
pp. 32-35
Author(s):  
Norbert Wikonkál ◽  
Patrícia Nagy ◽  
Béla Tóth ◽  
Márta Marschalkó ◽  
András Tislér ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Complete Resolution ◽  
Urine Analysis ◽  
Clinical Symptoms ◽  
Rare Complication ◽  
Review Of The Literature ◽  
Protein Loss ◽  
Penicillin Therapy ◽  
History Of ◽  
Penicillin Treatment

The authors report the history of a patient with syphilitic glomerulonephritis, a rare complication of syphilis. The patient was admitted to the hospital with clinical symptoms of neurosyphilis. During his hospital stay urine analysis revealed an extremely high proteinuria, that had not been known before. Intravenous penicillin treatment improved the renal protein loss, but it took a total of six months until complete resolution was achieved. The serology that confirmed the syphilis, the concomitant nephrotic syndrome and the improvement after penicillin therapy met the criteria of syphilitic glomerulonephritis. This case prompted the authors to review the literature about this rare complication of syphilis that has a great clinical significance. Orv. Hetil., 2015, 156(1), 32–35.

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