Group-based music intervention in Parkinson’s disease – findings from a mixed-methods study

Objective: To evaluate a group-based music intervention in patients with Parkinson’s disease. Design: Parallel group randomized controlled trial with qualitative triangulation. Setting: Neurorehabilitation in primary care. Subjects: Forty-six patients with Parkinson’s disease were randomized into intervention group ( n = 26), which received training with the music-based intervention, and control group ( n = 20) without training. Interventions: The intervention was delivered twice weekly for 12 weeks. Main measures: Primary outcome was Timed-Up-and-Go subtracting serial 7’s (dual-task ability). Secondary outcomes were cognition, balance, concerns about falling, freezing of gait, and quality of life. All outcomes were evaluated at baseline, post-intervention, and three months post-intervention. Focus groups and individual interviews were conducted with the intervention group and with the delivering physiotherapists. Results: No between-group differences were observed for dual-task ability. Between-group differences were observed for Falls Efficacy Scale (mean difference (MD) = 6.5 points; 95% confidence interval (CI) = 3.0 to 10.0, P = 0.001) and for Parkinson Disease Questionnaire-39 items (MD = 8.3; 95% CI = 2.7 to 13.8, P = 0.005) when compared to the control group post-intervention, but these were not maintained at three months post-intervention. Three themes were derived from the interviews: Expectations versus Results, Perspectives on Treatment Contents, and Key Factors for Success. Conclusion: Patient-reported outcomes and interviews suggest that the group-based music intervention adds value to mood, alertness, and quality of life in patients with Parkinson’s disease. The study does not support the efficacy in producing immediate or lasting gains in dual-tasking, cognition, balance, or freezing of gait.

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The effect of resistance training on the anxiety symptoms and quality of life in elderly people with Parkinson's disease: a randomized controlled trial

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20180071 ◽

2018 ◽

Vol 76 (8) ◽

pp. 499-506 ◽

Cited By ~ 7

Author(s):

Renilson Moraes Ferreira ◽

Wilson Mateus Gomes da Costa Alves ◽

Tiago Alencar de Lima ◽

Thiago Goçalves Gibson Alves ◽

Pedro Artur Madureira Alves Filho ◽

...

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Resistance Training ◽

Elderly People ◽

Intervention Group ◽

Anxiety Symptoms ◽

Control Group ◽

Resistance Training Program

ABSTRACT Objective: To assess the effects of resistance training on the anxiety symptoms and quality of life in patients with Parkinson's disease. Methods: Thirty-five elderly patients were randomly divided into two groups: 17 patients in the control group and 18 in the intervention group. All patients maintained standard pharmacological treatment for Parkinson's disease, but the intervention group participated in a 24-week resistance training program. The anxiety symptoms were assessed through the Beck's Anxiety Inventory, and quality of life by the Parkinson's Disease Questionnaire–39. Results: There was a significant reduction in anxiety level and increase in quality of life after 24 weeks of resistance training. Conclusion: The results of the present study indicate that resistance training is an effective intervention in the reduction of anxiety symptoms and improves the quality of life in elderly people with Parkinson's disease.

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Promoting urinary continence with nonpharmacological interventions in Parkinson’s disease

Pflege ◽

10.1024/1012-5302/a000845 ◽

2021 ◽

pp. 1-8

Author(s):

Myrta Kohler ◽

Jürg Schwarz ◽

Susi Saxer

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Urinary Incontinence ◽

Intervention Group ◽

Inpatient Rehabilitation ◽

Management Program ◽

Urinary Continence ◽

Control Group

Abstract. Background: The evidence of nonpharmacological interventions promoting urinary continence in Parkinson’s disease is low and rehabilitation nurses do not give it a high priority. Aim: To examine the effects of a urinary incontinence management program on continence and quality of life in persons with Parkinson’s disease in inpatient rehabilitation. The acceptance of the intervention and the knowledge of the nurses were also of interest. Methods: A nonrandomized experimental study was conducted. The data collection commenced with a control group followed by an intervention group. A structured urinary incontinence management was performed in the intervention phase. This includes incontinence assessment, care planning, individual interventions, discharge planning, and telephone support at home. Results: Urinary continence and quality of life were enhanced in both groups; however, improvements were higher in the intervention group but the differences were not significant. Knowledge of the nurses about urinary incontinence improved during the study duration. The acceptance of the intervention was high. Conclusions: A structured urinary continence management may improve urinary continence in persons suffering from Parkinson’s disease. In clinical practice it is important to perform a detailed assessment to identify problems regarding urinary incontinence.

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Effects of music-based movement therapy on motor function, balance, gait, mental health, and quality of life for patients with Parkinson’s disease: A systematic review and meta-analysis

Clinical Rehabilitation ◽

10.1177/0269215521990526 ◽

2021 ◽

pp. 026921552199052

Author(s):

Zonglei Zhou ◽

Ruzhen Zhou ◽

Wen Wei ◽

Rongsheng Luan ◽

Kunpeng Li

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Motor Function ◽

Meta Analysis ◽

Freezing Of Gait ◽

Movement Therapy ◽

Walking Velocity

Objective: To conduct a systematic review evaluating the effects of music-based movement therapy on motor function, balance, gait, mental health, and quality of life among individuals with Parkinson’s disease. Data sources: A systematic search of PubMed, Embase, Cochrane Library, Web of Science, PsycINFO, CINAHL, and Physiotherapy Evidence Database was carried out to identify eligible papers published up to December 10, 2020. Review methods: Literature selection, data extraction, and methodological quality assessment were independently performed by two investigators. Publication bias was determined by funnel plot and Egger’s regression test. “Trim and fill” analysis was performed to adjust any potential publication bias. Results: Seventeen studies involving 598 participants were included in this meta-analysis. Music-based movement therapy significantly improved motor function (Unified Parkinson’s Disease Rating Scale motor subscale, MD = −5.44, P = 0.002; Timed Up and Go Test, MD = −1.02, P = 0.001), balance (Berg Balance Scale, MD = 2.02, P < 0.001; Mini-Balance Evaluation Systems Test, MD = 2.95, P = 0.001), freezing of gait (MD = −2.35, P = 0.039), walking velocity (MD = 0.18, P < 0.001), and mental health (SMD = −0.38, P = 0.003). However, no significant effects were observed on gait cadence, stride length, and quality of life. Conclusion: The findings of this study show that music-based movement therapy is an effective treatment approach for improving motor function, balance, freezing of gait, walking velocity, and mental health for patients with Parkinson’s disease.

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Motor Symptom Asymmetry Predicts Non-motor Outcome and Quality of Life Following STN DBS in Parkinson's Disease

10.21203/rs.3.rs-871480/v1 ◽

2021 ◽

Author(s):

Julie Péron ◽

Philippe Voruz ◽

Jordan Pierce ◽

Kévin Ahrweiller ◽

Claire Haegelen ◽

...

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Motor Symptom ◽

Control Group ◽

Motor Symptoms ◽

Healthy Control ◽

The Impact ◽

Stn Dbs

Abstract Risk factors for long-term non-motor disorders and quality of life following subthalamic nucleus deep-brain stimulation (STN DBS) have not yet been fully identified. In the present study, we investigated the impact of motor symptom asymmetry in Parkinson’s disease.Data were extracted for 52 patients with Parkinson’s disease (half with left-sided motor symptoms and half with right-sided ones) who underwent bilateral STN and a matched healthy control group. Performances for cognitive tests and neuropsychiatric and quality-of-life questionnaires at 12 months post-DBS were compared with a pre-DBS baseline. Results indicated a deterioration in cognitive performance post-DBS in patients with left-sided motor symptoms. Performances of patients with right-sided motor symptoms were maintained, except for a verbal executive task. These differential effects had an impact on patients’ quality of life. The results highlight the existence of two distinct cognitive profiles of Parkinson’s disease, depending on motor symptom asymmetry. This asymmetry is a potential risk factor for non-motor adverse effects following STN DBS.

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The Therapeutic Effect of Nordic Walking on Freezing of Gait in Parkinson’s Disease: A Pilot Study

Parkinson s Disease ◽

10.1155/2019/3846279 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10

Author(s):

Agata Wróblewska ◽

Agata Gajos ◽

Urszula Smyczyńska ◽

Andrzej Bogucki

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Research Question ◽

Freezing Of Gait ◽

Intervention Group ◽

Future Research ◽

Control Group ◽

Nordic Walking ◽

Provocative Test ◽

Step Initiation

Introduction. The effectiveness of the currently utilized therapies for FoG is limited. Several studies demonstrated a beneficial impact of Nordic walking (NW) on several gait parameters in Parkinson’s disease, but only one paper reported reduction of freezing. Research Question. In the present study, the question is whether NW is an effective therapeutic intervention in FoG. Methods. Twenty PD subjects trained NW for 12 weeks, with a frequency of twice per week. Each session lasted about 60 minutes. Twenty patients in the control group did not use any form of physiotherapy (no-intervention group). Freezing of Gait Questionnaire (FOGQ), the Timed Up and Go (TUG) test, and the Provocative Test for Freezing and Motor Blocks (PTFMB) were performed at baseline, immediately after the end of NW program, and three months later. Results. The results of FOGQ, TUG, and total PTFMB revealed significant improvement after completing the exercise program, and this effect persisted at follow-up. The results of the PTFMB subtests showed a different effect of NW on particular subtypes of FoG. Start hesitation, sudden transient blocks that interrupt gait, and blocks on turning improved considerably, while motor blocks, when walking through narrow space and on reaching the target, did not respond to NW training. Significance. The results show, for the first time, that FoG during turning and step initiation, two most common forms of this gait disorder, has been significantly reduced by NW training. Different responses of particular subtypes of FoG to NW probably reflect their different pathophysiologies. Conclusions. The present study showed that NW training had a beneficial effect on FOG in PD and that the achieved improvement is long-lasting. Future research should clarify whether the observed improvement limited to FoG triggered by only some circumstances reflects different pathomechanisms of FoG subtypes.

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The major impact of freezing of gait on quality of life in Parkinson’s disease

Journal of Neurology ◽

10.1007/s00415-014-7524-3 ◽

2014 ◽

Vol 262 (1) ◽

pp. 108-115 ◽

Cited By ~ 58

Author(s):

Courtney C. Walton ◽

James M. Shine ◽

Julie M. Hall ◽

Claire O’Callaghan ◽

Loren Mowszowski ◽

...

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Freezing Of Gait

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Evaluation of quality of life and psychological aspects of Parkinson's disease patients who participate in a support group

Dementia & Neuropsychologia ◽

10.1590/1980-57642015dn93000013 ◽

2015 ◽

Vol 9 (3) ◽

pp. 295-300 ◽

Cited By ~ 4

Author(s):

Nathalie Ribeiro Artigas ◽

Vera Lúcia Widniczck Striebel ◽

Arlete Hilbig ◽

Carlos Roberto de Mello Rieder

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Social Phobia ◽

Support Group ◽

Neurodegenerative Disorder ◽

Control Group ◽

Asymmetric Distribution ◽

Cross Sectional

Parkinson's disease (PD) is a neurodegenerative disorder that can dramatically impair patient quality of life (QoL). Objective: To analyze the QoL, motor capacity, depression, anxiety and social phobia of individuals who attended a patient support group (PSG) compared to non-participants. Methods: A cross-sectional study was performed. The sample consisted of 20 individuals with PD who attended a PSG and another 20 PD patients who did not attend a support group for PD patients, serving as the control group (nPSG). All patients answered questionnaires on motor capacity (UPDRS), QoL (Parkinson's Disease Questionnaire- PDQ-39), depression (Beck Depression Inventory), anxiety (Beck Anxiety Inventory) and social phobia (Liebowitz Social Anxiety Scale). To determine data distribution, the Shapiro-Wilk test was performed. For comparison of means, Student's t-test was applied. In cases of asymmetry, the Mann-Whitney test was employed. To assess the association between the scales, Pearson's correlation coefficient (symmetric distribution) and Spearman's coefficient (asymmetric distribution) were applied. For the association between qualitative variables, Pearson's Chi-squared test was performed. A significance level of 5% (p≤0.05) was adopted. Results: Individuals in the PSG had a significantly better QoL (p=0.002), and lower depression (p=0.026), anxiety (p<0.001) and social phobia (p=0.01) scores compared to the nPSG. Conclusion: The participation of PD patients in social activities such as support groups is associated with better QoL and fewer symptoms of depression, anxiety and social phobia.

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Feasibility of a Brazilian samba protocol for patients with Parkinson's disease: a clinical non-randomized study

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20190140 ◽

2020 ◽

Vol 78 (1) ◽

pp. 13-20 ◽

Cited By ~ 1

Author(s):

Ana Cristina TILLMANN ◽

Alessandra SWAROWSKY ◽

Clynton Lourenço CORRÊA ◽

Alexandro ANDRADE ◽

Jéssica MORATELLI ◽

...

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Randomized Study ◽

General Information ◽

Control Group ◽

Action Strategies ◽

And Control ◽

Experimental Group

Abstract Background: New protocols applied in the rehabilitation of Parkinson's disease enable different action strategies for health professionals, as well as a new range of activities for these individuals. However, no valid samba protocol with activity prescription for this population was found in the literature. Objective: To investigate the feasibility of a Brazilian samba protocol in individuals with Parkinson's disease. Methods: Twenty participants, mean age of 66.4±10.7 years, diagnosed with idiopathic Parkinson 's disease, divided into: experimental group that received the intervention of Brazilian samba dance classes (10 individuals); and control group that maintained their routine activities (10 individuals). For data collection, a divided questionnaire was used: General Information; Disability stages scale; Balance and Quality of Life. Results: During class implementation, there were no falls, as all dance activities adhered to the details of the protocol steps without any changes. On average, patients completed 82.7% of activities. After 12 weeks, the experimental group had improvements in the UPDRS global score, in daily activities, and on motor examination. There was also improvement in balance scores and in the mobility domain of the quality of life in the experimental group. Conclusion: The samba protocol seems to be feasible and safe for patients with PD. Moreover, it has pleasant characteristics and offers sufficient physical benefits for combination with drug treatment. There were also benefits in social relationships and as a possible rehabilitation tool in individuals with Parkinson's disease.

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Drug utilization pattern and analysis of quality of life in Indian patients of Parkinson’s disease

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20194121 ◽

2019 ◽

Vol 8 (9) ◽

pp. 2092

Author(s):

Jugal Shah ◽

Pranav Joshi ◽

Shikha V. Sood ◽

Devang Rana ◽

Supriya D. Malhotra

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Drug Utilization ◽

Memory Loss ◽

Control Group ◽

Anticholinergic Drugs ◽

Psychological Consequences ◽

Utilization Pattern

Background: Parkinson's disease (PD) is a highly debilitating disease characterized by tremors, bradykinesia and rigidity. It leads to lowered self-esteem and psychological consequences which affect quality of life. The aim of this study is to study the drug utilization pattern and assess the quality of life in patients of Parkinson’s Disease.Methods: 40 patients of PD at least 1 month duration and 20 age-based controls were analyzed for quality of life using Parkinson’s Disease Questionnaire-39 (PDQ-39). Drug prescriptions were analyzed.Results: Mean number of anti-Parkinson drugs prescribed is 2.65±1.21. Of 106 anti-Parkinson drugs prescribed, 45% were levodopa and carbidopa combinations, followed by dopamine agonists (18%), anticholinergic drugs (15%), amantadine (12%), MAO inhibitors (5%) and COMT inhibitors (5%). There were significant problems in speech, performance of daily chores and daytime somnolence (p<0.0001). Depression, isolation, cognitive decline and memory loss were noteworthy in the patients as compared to controls (p<0.05). 25% patients felt embarrassed due to their disease; 59% felt affected by others’ opinion, 60% felt difficulty in communicating with others (p<0.05). Almost 2/3rd patients needed help in personal care as compared to the control group (p<0.0001).Conclusions: Quality of life of parkinsonian patients is severely affected in spite of them receiving a large number of drugs. This may be both due to disease progression as well as medication. Levodopa-carbidopa combination is the most prescribed medication. Use of levodopa and carbidopa combination must be evaluated properly. Newer guidelines and interventions are the need of the hour which may provide a better outcome on the quality of life of parkinsonian patients.

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DeepFoG: An IMU-Based Detection of Freezing of Gait Episodes in Parkinson’s Disease Patients via Deep Learning

Frontiers in Robotics and AI ◽

10.3389/frobt.2021.537384 ◽

2021 ◽

Vol 8 ◽

Author(s):

Thomas Bikias ◽

Dimitrios Iakovakis ◽

Stelios Hadjidimitriou ◽

Vasileios Charisis ◽

Leontios J. Hadjileontiadis

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Deep Learning ◽

Life Stress ◽

Freezing Of Gait ◽

Measurement Unit ◽

Effective Interventions ◽

Risk Of Falls

Freezing of Gait (FoG) is a movement disorder that mostly appears in the late stages of Parkinson’s Disease (PD). It causes incapability of walking, despite the PD patient’s intention, resulting in loss of coordination that increases the risk of falls and injuries and severely affects the PD patient’s quality of life. Stress, emotional stimulus, and multitasking have been encountered to be associated with the appearance of FoG episodes, while the patient’s functionality and self-confidence are constantly deteriorating. This study suggests a non-invasive method for detecting FoG episodes, by analyzing inertial measurement unit (IMU) data. Specifically, accelerometer and gyroscope data from 11 PD subjects, as captured from a single wrist-worn IMU sensor during continuous walking, are processed via Deep Learning for window-based detection of the FoG events. The proposed approach, namely DeepFoG, was evaluated in a Leave-One-Subject-Out (LOSO) cross-validation (CV) and 10-fold CV fashion schemes against its ability to correctly estimate the existence or not of a FoG episode at each data window. Experimental results have shown that DeepFoG performs satisfactorily, as it achieves 83%/88% and 86%/90% sensitivity/specificity, for LOSO CV and 10-fold CV schemes, respectively. The promising performance of the proposed DeepFoG reveals the potentiality of single-arm IMU-based real-time FoG detection that could guide effective interventions via stimuli, such as rhythmic auditory stimulation (RAS) and hand vibration. In this way, DeepFoG may scaffold the elimination of risk of falls in PD patients, sustaining their quality of life in everyday living activities.

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