scholarly journals Molecular connectivity disruptions in males with major depressive disorder

2018 ◽  
Vol 39 (8) ◽  
pp. 1623-1634 ◽  
Author(s):  
Rajapillai LI Pillai ◽  
Mengru Zhang ◽  
Jie Yang ◽  
J John Mann ◽  
Maria A Oquendo ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
High Sensitivity ◽  
Binding Potential ◽  
Molecular Connectivity ◽  
Major Depressive ◽  
Positron Emission ◽  
Healthy Control ◽  
Synaptic Receptors ◽  
Molecular Brain

In most positron emission tomography (PET) molecular brain imaging studies, regions of interest have been defined anatomically and examined in isolation. However, by defining regions based on physiology and examining relationships between them, we may derive more sensitive measures of receptor abnormalities in conditions such as major depressive disorder (MDD). Using an average of 52 normalized binding potential maps, acquired using radiotracer [11C]-WAY100635 and full arterial input analysis, we identified two molecular volumes of interest (VOIs) with contiguously high serotonin 1A receptor (5-HT1A) binding sites: the olfactory sulcus (OLFS) and a band of tissue including piriform, olfactory, and entorhinal cortex (PRF). We applied these VOIs to a separate cohort of 25 healthy control males and 16 males with MDD who received [11C]-WAY100635 imaging. Patients with MDD had significantly higher binding than controls in both VOIs, ( p < 0.01). To identify potential homeostatic disruptions in MDD, we examined molecular connectivity, i.e. the correlation between binding of raphe nucleus (RN) 5-HT1A autoreceptors and post-synaptic receptors in molecular VOIs. Molecular connectivity was significant in healthy controls ( p < 0.01), but not in patients with MDD. This disruption in molecular connectivity allowed identification of MDD cases with high sensitivity (81%) and specificity (88%).

scholarly journals Haematological and Haemostatic Changes Associated with Major Depressive Disorder among Nigerians.

2021 ◽  
Vol 5 (2) ◽  
pp. 238-245
Author(s):  
Oloruntoba A. Ekun
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Sodium Citrate ◽  
Red Cell ◽  
Major Depressive ◽  
Red Cell Indices ◽  
Healthy Control ◽  
The Mean ◽  
Number Of Individuals ◽  
Apparently Healthy

Background: A link between major depressive disorder (MDD) and haematological as well as co-agulation disorders has been postulated. This study aims to evaluate haematological and haemostatic changes among Nigerians with major depressive disorder Methods: Two hundred volunteers consisting of an equal number of individuals diagnosed with major depressive disorder (MDD) based on DMS-IV criteria and apparently healthy control participated in this study. The blood sample was collected into tri-sodium citrate K2EDTA bottles respectively and was evaluated for some haemostatic parameters , using ELISA, Clauss, Quick’s One Stage, Proctor and Rapaport’s methods. Results: The mean WBC, hemoglobin and differential lymphocyte were significantly higher among MDD total volunteers (p < 0.001). The red cell indices and platelet count were lower among MDD (p <0.001). Also the prothrombin time (PT), fibrinogen, protein-C and erythrocytes sedimentation rate (ESR) were all raised (p <0.001) among volunteers with MDD. Positive associations existed be-tween MCV and RBC (r: 0.364; p<0.001), PT and APTT (r: 0.319 p <0.001), APTT and fibrinogen (r: 0.239, p = 0.017) as well as PT and fibrinogen (r: 0.275 p = 0.006) at 95% confidence interval. Conclusion: Changes in total leucocytes count, lymphocytes values and haemostatic parameters among volunteers with depression may impacts deleterious effects on the immune response as well as haemostatic homeostasis, while decreased red cell indices may suggest occult nutritional anaemia.

scholarly journals Positron Emission Tomography Quantification of Serotonin Transporter in Suicide Attempters with Major Depressive Disorder

2013 ◽  
Vol 74 (4) ◽  
pp. 287-295 ◽  
Author(s):  
Jeffrey M. Miller ◽  
Natalie Hesselgrave ◽  
R. Todd Ogden ◽  
Gregory M. Sullivan ◽  
Maria A. Oquendo ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Serotonin Transporter ◽  
Emission Tomography ◽  
Major Depressive ◽  
Suicide Attempters ◽  
Positron Emission

scholarly journals Dopamine Type-1 Receptor Binding in Major Depressive Disorder Assessed Using Positron Emission Tomography and [11C]NNC-112

2008 ◽  
Vol 34 (5) ◽  
pp. 1277-1287 ◽  
Author(s):  
Dara M Cannon ◽  
Jacqueline M Klaver ◽  
Summer A Peck ◽  
Denise Rallis-Voak ◽  
Kristine Erickson ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Receptor Binding ◽  
Emission Tomography ◽  
Major Depressive ◽  
Positron Emission

scholarly journals Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects

2018 ◽  
Vol 235 (10) ◽  
pp. 3017-3030 ◽  
Author(s):  
Ruin Moaddel ◽  
Michelle Shardell ◽  
Mohammed Khadeer ◽  
Jacqueline Lovett ◽  
Bashkim Kadriu ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Crossover Trial ◽  
Major Depressive ◽  
Control Subjects ◽  
Metabolomic Profiling ◽  
Healthy Control

Alpha 1-antitrypsin as a Potential Biomarker for Diagnosing Major Depressive Disorder

2020 ◽  
Author(s):  
Shun-jie Bai ◽  
Jing Xie ◽  
Kunxia Chen ◽  
Huili Bai ◽  
jian-jun chen
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Antidepressant Treatment ◽  
High Sensitivity ◽  
Apolipoprotein A1 ◽  
Roc Curve Analysis ◽  
Major Depressive ◽  
Biomarker Panel ◽  
Potential Biomarker ◽  
Alpha 1 Antitrypsin

Abstract Background: Despite decades of intensive research on major depressive disorder (MDD), the pathogenesis of MDD is still unclear and the objectively diagnostic method remains unavailable. Therefore, we conducted this study to assess whether alpha 1-antitrypsin (AAT) could be a potential biomarker for diagnosing MDD.Methods: The levels of AAT, liver function-related indicators, renal function-related indicators, blood lipids-related indicators, high sensitivity C-reactive protein, homocysteine and transferrin were detected. The orthogonal partial least-squares discriminant analysis (OPLS-DA) was used to find the differential variables, Random Forest was used to identify the simplified biomarker panel, and receiver-operating characteristic (ROC) curve analysis was used to evaluate the diagnostic performance of the identified panel.Results: The 86 MDD patients and 99 healthy controls (HCs) were recruited. In total, we found nine differential variables between MDD patients and HCs, and a potential biomarker panel consisting of AAT, albumin (ALB) and apolipoprotein A1 (APOA) was identified. This panel could effectively separate MDD patients from HCs in two independent samples sets. The level of AAT was significantly negatively correlated with HDRS score and improved after antidepressant treatment. Meanwhile, MDD patients with suicide idea or behavior had significantly lower AAT levels compared to MDD patients without suicide idea or behavior.Conclusions: Our results suggested that AAT held the promise to become a potential biomarker for diagnosing MDD, and also might be a potential novel therapeutic target for MDD.

scholarly journals Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kelly Smart ◽  
Ashley Yttredahl ◽  
Maria A. Oquendo ◽  
J. John Mann ◽  
Ansel T. Hillmer ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Rating Scale ◽  
Kappa Opioid Receptor ◽  
Anterior Cingulate ◽  
Emission Tomography ◽  
Kappa Opioid ◽  
Major Depressive ◽  
Positron Emission

AbstractPreclinical studies have implicated kappa opioid receptors (KORs) in stress responses and depression-related behaviors, but evidence from human studies is limited. Here we present results of a secondary analysis of data acquired using positron emission tomography (PET) with the KOR radiotracer [11C]GR103545 in 10 unmedicated, currently depressed individuals with major depressive disorder (MDD; 32.6 ± 6.5 years, 5 women) and 13 healthy volunteers (34.8 ± 10 years, 6 women). Independent component analysis was performed to identify spatial patterns of coherent variance in KOR binding (tracer volume of distribution, VT) across all subjects. Expression of each component was compared between groups and relationships to symptoms were explored using the 17-item Hamilton Depression Rating Scale (HDRS). Three components of variation in KOR availability across ROIs were identified, spatially characterized by [11C]GR103545 VT in (1) bilateral frontal lobe; (2) occipital and parietal cortices, right hippocampus, and putamen; and (3) right anterior cingulate, right superior frontal gyrus and insula, coupled to negative loading in left middle cingulate. In MDD patients, component 3 was negatively associated with symptom severity on the HDRS (r = −0.85, p = 0.0021). There were no group-wise differences in expression of any component between patients and controls. These preliminary findings suggest that KOR signaling in cortical regions relevant to depression, particularly right anterior cingulate, could reflect MDD pathophysiology.

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