Incidence of Roentgen Contrast Medium Reactions after Intravenous Injection in Pre-Registration Trials and Post-Marketing Surveillances
Keyword(s):
The relative risk of adverse drug reactions of ionic versus non-ionic contrast media injected i.v. were compared for different types of trials using odds-ratio. The absolute and relative risk found in large post-marketing trials were compared with that found in the iohexol pre-registration trials. The absolute risks were 2 to 10 times higher in the pre-registration trials compared to the post-marketing surveillances. The relative risk for all adverse drug reactions was 3 to 6 times higher for ionic vs. non-ionic media and independent of pre- or post-registration studies. The odds-ratio seems to be a feasible method of comparing the relative risk of adverse reactions in various trials.
2021 ◽
pp. 276-288
1993 ◽
Vol 12
(24)
◽
pp. 2383-2393
◽
2021 ◽
Vol 5
(7)
◽
pp. RV5-RV10
2021 ◽
Vol 9
(1)
◽
pp. 34-42
2020 ◽
Vol 11
(SPL4)
◽
pp. 2903-2909
Keyword(s):