Immediate and LAte Adverse Reactions in Coronary Angiography

1996 ◽  
Vol 37 (1P1) ◽  
pp. 218-222 ◽  
Author(s):  
S.-G. Fransson ◽  
G. Stenport ◽  
M. Andersson
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Coronary Angiography ◽  
Contrast Media ◽  
Contrast Medium ◽  
Left Coronary Artery ◽  
Adverse Reactions ◽  
Parallel Study ◽  
Double Blind ◽  
Blood Pressures

Purpose and Methods: In 120 patients in a double-blind, randomized, parallel study, iodixanol (Visipaque), a nonionic dimer isotonic with blood, was compared with ioxaglate (Hexabrix), an ionic low-osmolar dimer, in coronary angiography regarding early and late adverse reactions. Haemodynamic and electrophysiologic parameters were also analyzed. Results: Visipaque resulted in significantly fewer early adverse contrast medium-related reactions (p<0.05). Visipaque also demonstrated significantly fewer effects on electrophysiologic parameters. Both contrast media reduced systolic and diastolic blood pressures at the 1st injection in the left coronary artery. Late adverse reactions were unusual with both contrast media and occurred only as urticaria with a frequency of 1.7%, which is lower than reported in i.v. studies. One serious adverse reaction, a myocardial infarction in a male patient with severe cardiovascular disease, occurred in the Visipaque group. This event was considered to be procedure- and disease-related rather than related to the type of contrast medium used. Conclusion: We found Visipaque safe for coronary angiography, causing fewer early adverse reactions than Hexabrix and also fewer effects on electrophysiologic parameters. Late adverse reactions seemed to be unusual with intra-arterial administration of contrast media.

Oral Contrast Media in CT of the Abdomen

1995 ◽  
Vol 36 (4-6) ◽  
pp. 396-398 ◽  
Author(s):  
Maria Lönnemark ◽  
Anders Magnusson
Keyword(s):  
Contrast Media ◽  
Contrast Medium ◽  
Contrast Effect ◽  
Oral Contrast ◽  
Double Blind ◽  
Randomised Study ◽  
Patient Tolerance ◽  
Bowel Opacification ◽  
Oral Contrast Media

In a double blind randomised study 3 different concentrations of iohexol for bowel opacification at CT of the abdomen were compared. Iohexol in a concentration of 4.5 mg I/ml, 6.75 mg I/ml and 9 mg I/ml was used. No significant differences between the 3 preparations of contrast media were found regarding the contrast effect, the distribution or patient tolerance. When using iohexol as a bowel contrast medium at CT the concentration of 4.5 mg I/ml is sufficient for bowel opacification.

Double Blind Evaluation of the Effects of Various Contrast Media on Extremity Veins in the Dog

1987 ◽  
Vol 28 (1) ◽  
pp. 107-113 ◽  
Author(s):  
F. Laerum ◽  
L. P. Dehner ◽  
J. Rysavy ◽  
K. Amplatz
Keyword(s):  
Contrast Media ◽  
Contrast Medium ◽  
Species Differences ◽  
Randomized Study ◽  
Endothelial Damage ◽  
Double Blind ◽  
Hematoxylin Eosin ◽  
Human Endothelium ◽  
Extremity Veins

Canine superficial extremity veins were examined grossly and microscopically in a double blind fashion for endothelial damage and phlebitis one hour and four days after the injection of ionic monomeric or dimeric, and non-ionic monomeric, 300 mg I/ml, contrast media. Superficial veins of all four extremities and the tail vein were injected with the same amounts of contrast medium after application of tourniquets for 20 minutes following the injections. Silver staining and prefixation of the veins were done in situ. The specimens were evaluated together with cross-sectioned, hematoxylin-eosin stained biopsies. On the basis of a randomized study of 77 dogs, endothelial damage or thrombosis caused by various contrast media as seen in man was not demonstrated. This may be due to species differences. It is postulated that canine endothelium may have a higher resistance to contrast medium injury than human endothelium.

Elimination of Low-Osmolality Contrast Media by Hemodialysis

1996 ◽  
Vol 37 (3P2) ◽  
pp. 966-971 ◽  
Author(s):  
T. Furukawa ◽  
J. Ueda ◽  
S. Takahashi ◽  
K. Sakaguchi
Keyword(s):  
Contrast Media ◽  
Contrast Medium ◽  
Adverse Reactions ◽  
Elimination Rate ◽  
Hemodialysis Patients ◽  
Hemodynamic Changes ◽  
End Stage Renal Failure ◽  
End Stage ◽  
Sampling Times ◽  
Regular Hemodialysis

Purpose: To compare the dialyzability and safety of 2 types of low-osmolality contrast media administered to end-stage renal failure patients maintained on regular hemodialysis. Material and Methods: Of 44 CT examinations, iohexol was used in 22 and ioxaglate in the other 22. Adverse reactions and hemodynamic changes were recorded. Thirty minutes after the beginning of CT investigation, hemodialysis was commenced. Elimination rate and clearance of the contrast media were measured as indices of their dialyzability. Results: After 4 hours of hemodialysis, 78.4±6.5% of iohexol and 72.4±6.0% ioxaglate were eliminated. Clearance of iohexol was higher than that of ioxaglate at all sampling times. No severe hemodynamic change nor adverse reaction were observed. Minor reactions were more frequently observed in the ioxaglate group. Conclusion: Iohexol, a nonionic monomeric contrast medium, is more advantageous for hemodialysis patients than ioxaglate, an ionic dimeric contrast medium.

Iohexol and Metrizoate in Urography of Insulin Dependent Patients

1986 ◽  
Vol 27 (3) ◽  
pp. 265-267 ◽  
Author(s):  
J. Edgren ◽  
L. Laasonen ◽  
P.-H. Groop ◽  
L. Groop
Keyword(s):  
Creatinine Clearance ◽  
Contrast Medium ◽  
Adverse Reactions ◽  
Diabetic Patients ◽  
Double Blind ◽  
Ionic Medium ◽  
Ionic Contrast ◽  
Insulin Dependent ◽  
Ionic Contrast Medium ◽  
Insulin Dependent Diabetic

A double blind urographic study with the ionic contrast medium metrizoate or the non-ionic medium iohexol was perfomed on 69 insulin dependent diabetic patients. Metrizoate caused 24 per cent and iohexol 11 per cent mild adverse reactions and metrizoate a significant decrease in creatinine clearance values. Thus iohexol turned out to be better tolerated by these diabetic patients than metrizoate. References

Adverse Reactions following Two Separate Intravascular Injections of Contrast Media in the Same Patient

1987 ◽  
Vol 28 (1) ◽  
pp. 93-97 ◽  
Author(s):  
E. E. Sogn ◽  
T. Ødegård ◽  
T. Haider ◽  
E. Andrew
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Contrast Media ◽  
Contrast Medium ◽  
Comparative Studies ◽  
Adverse Reactions ◽  
Northern Europe ◽  
Retrospective Design ◽  
Clinical Trial Program ◽  
Recurrence Frequency

Adverse reactions following contrast medium injections in 26 non-comparative and parallel trials were extracted from the iohexol vascular clinical trial program in Northern Europe. Six hundred and forty-one patients (13–88 years old) in whom information was available about a vascular contrast medium examination before the iohexol clinical trials were included, enabling a retrospective within patient comparison of adverse reactions. Iohexol gave a lower recurrence frequency (approximately 3.5 times) of reactions than ionic monomers in patients who previously experienced adverse reactions to vascular contrast media. In order to overcome some of the drawbacks with the present retrospective design, prospective comparative studies are recommended.

Gd-DTPA in Male Urethrography

1996 ◽  
Vol 37 (3P2) ◽  
pp. 804-805 ◽  
Author(s):  
T. Vehmas ◽  
P. Tervahartiala
Keyword(s):  
Side Effects ◽  
Contrast Media ◽  
Contrast Medium ◽  
Case History ◽  
Adverse Reactions ◽  
Urethral Diverticulum ◽  
Radiological Examination ◽  
X Ray ◽  
History Of ◽  
Good Contrast

Patients with a case history of severe side-effects from iodine-containing contrast media present problems in later radiological examination. We report here on an alternative, the first extravascular use of Gd-DTPA in an X-ray urethrography. By using the standard processing algorithm of our digital radiographic equipment and 60 ml undiluted Gd-DTPA meglumine (469 mg/ml) we achieved good contrast and could exclude the suspected urethral diverticulum in a 26-year-old man. No adverse reactions occurred. Gd-DTPA seems to offer a reasonable contrast and may be used as an alternative extravascular contrast medium in selected conventional radiographic studies.

scholarly journals The Incidence of Immediate and Delayed Adverse Reactions to Contrast Media Caused by Coronary Angiography Examination: A Comparison between Iopamidol and Iomeprol.

1999 ◽  
Vol 25 (5) ◽  
pp. 502-510
Author(s):  
TAKANORI MIURA ◽  
RYOJI KOJIMA ◽  
KAZUMASA NEGITA ◽  
AKIO KATSUMI ◽  
MITSURU OTA ◽  
...  
Keyword(s):  
Coronary Angiography ◽  
Contrast Media ◽  
Adverse Reactions

Water-Soluble Contrast Media in Radiography of Small Bowel Obstruction

1988 ◽  
Vol 29 (1) ◽  
pp. 53-56 ◽  
Author(s):  
A. Stordahl ◽  
F. Laerum ◽  
T. Gjølberg ◽  
I. Enge
Keyword(s):  
Small Bowel ◽  
Contrast Media ◽  
Contrast Medium ◽  
Small Bowel Obstruction ◽  
Bowel Obstruction ◽  
Water Soluble ◽  
Double Blind ◽  
Peritoneal Adhesions ◽  
Significant Difference ◽  
Better Than

Fifty patients with possible gastrointestinal obstruction, referred for enteric follow-through examination, were randomized for a double-blind, parallel comparison of the hyperosmolar contrast medium Gastrografin and the low-osmolar Omnipaque. The result was that Omnipaque retained its radiographic density in the small bowel better than Gastrografin. Omnipaque was thus a better alternative than Gastrografin in follow-through examinations of intestinal obstruction. Also, 23 patients out of 28 with small bowel obstruction due to peritoneal adhesions, had spontaneous relief of symptoms during the observation period following contrast medium ingestion with no significant difference between the two media. This indicated that enteric follow-through procedures may have a therapeutic efficacy similar to the treatment of small bowel obstruction using nasogastric suction and gastrointestinal rest. Possible mechanisms for this action of the contrast media are discussed.

scholarly journals The Incidence of Adverse Reactions to Low Osmolar Iodine Contrast Media Caused by Coronary Angiography Examination and the Detection of its Risk Factors.

1998 ◽  
Vol 24 (6) ◽  
pp. 665-672
Author(s):  
TAKANORI MIURA ◽  
RYOJI KOJIMA ◽  
KAZUMASA NEGITA ◽  
MASARU MIZUTANI ◽  
FUMIMARO TAKATSU ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Angiography ◽  
Contrast Media ◽  
Adverse Reactions

scholarly journals Usefulness of dual-axis rotational coronary angiography in primary percutaneous coronary intervention for patients with ST-elevation myocardial infarction

2020 ◽  
Author(s):  
Hideaki Suwa ◽  
Yota Koyabu ◽  
Taichi Adachi ◽  
Akira Kawai ◽  
Kazuhiko Kotani ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Coronary Angiography ◽  
Adverse Events ◽  
Contrast Medium ◽  
Radiation Exposure ◽  
Coronary Intervention ◽  
Primary Pci ◽  
Percutaneous Coronary ◽  
St Elevation

AbstractSeveral studies have shown that dual-axis rotational coronary angiography (DARCA) reduces contrast medium volume and radiation exposure compared to conventional coronary angiography (CCA). However, there are no studies comparing the safety and usefulness of DARCA in primary percutaneous coronary intervention (PCI) for patients with ST-elevation myocardial infarction (STEMI). The aim of this study was to investigate the effects of DARCA on contrast medium volume, radiation exposure, time course of treatment, and adverse events in primary PCI for patients with STEMI. A total of 82 patients undergoing primary PCI were included in this study. Subjects were propensity matched to 41 patients in the CCA group and 41 in the DARCA group. Data were retrospectively collected from in-patient medical records and the contrast medium volume and radiation exposure (dose-area product, DAP) during the PCI procedure was compared between the two groups. Contrast medium volume [100.0 (82.5–115.0) vs 110 (102.5–127.5) ml, p = 0.018, r = 0.26] and DAP [113.4 (74.3–141.1) vs 138.1 (100.5–194.7) Gy cm2, p = 0.014, r = 0.27] were significantly lower in the DARCA group, compared with the CCA group. Door to device time (68.7 ± 26.1 vs 76.5 ± 44.2 min, p = 0.33) were comparable between the two groups. There were no adverse events requiring treatment reported in either groups. DARCA may reduce contrast medium volume and radiation exposure in primary PCI for patients with STEMI, and can be used safely, without delaying reperfusion of the infarct-related coronary artery.

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