Gd-DTPA in Male Urethrography

1996 ◽  
Vol 37 (3P2) ◽  
pp. 804-805 ◽  
Author(s):  
T. Vehmas ◽  
P. Tervahartiala
Keyword(s):  
Side Effects ◽  
Contrast Media ◽  
Contrast Medium ◽  
Case History ◽  
Adverse Reactions ◽  
Urethral Diverticulum ◽  
Radiological Examination ◽  
X Ray ◽  
History Of ◽  
Good Contrast

Patients with a case history of severe side-effects from iodine-containing contrast media present problems in later radiological examination. We report here on an alternative, the first extravascular use of Gd-DTPA in an X-ray urethrography. By using the standard processing algorithm of our digital radiographic equipment and 60 ml undiluted Gd-DTPA meglumine (469 mg/ml) we achieved good contrast and could exclude the suspected urethral diverticulum in a 26-year-old man. No adverse reactions occurred. Gd-DTPA seems to offer a reasonable contrast and may be used as an alternative extravascular contrast medium in selected conventional radiographic studies.

Elimination of Low-Osmolality Contrast Media by Hemodialysis

1996 ◽  
Vol 37 (3P2) ◽  
pp. 966-971 ◽  
Author(s):  
T. Furukawa ◽  
J. Ueda ◽  
S. Takahashi ◽  
K. Sakaguchi
Keyword(s):  
Contrast Media ◽  
Contrast Medium ◽  
Adverse Reactions ◽  
Elimination Rate ◽  
Hemodialysis Patients ◽  
Hemodynamic Changes ◽  
End Stage Renal Failure ◽  
End Stage ◽  
Sampling Times ◽  
Regular Hemodialysis

Purpose: To compare the dialyzability and safety of 2 types of low-osmolality contrast media administered to end-stage renal failure patients maintained on regular hemodialysis. Material and Methods: Of 44 CT examinations, iohexol was used in 22 and ioxaglate in the other 22. Adverse reactions and hemodynamic changes were recorded. Thirty minutes after the beginning of CT investigation, hemodialysis was commenced. Elimination rate and clearance of the contrast media were measured as indices of their dialyzability. Results: After 4 hours of hemodialysis, 78.4±6.5% of iohexol and 72.4±6.0% ioxaglate were eliminated. Clearance of iohexol was higher than that of ioxaglate at all sampling times. No severe hemodynamic change nor adverse reaction were observed. Minor reactions were more frequently observed in the ioxaglate group. Conclusion: Iohexol, a nonionic monomeric contrast medium, is more advantageous for hemodialysis patients than ioxaglate, an ionic dimeric contrast medium.

Adverse Reactions following Two Separate Intravascular Injections of Contrast Media in the Same Patient

1987 ◽  
Vol 28 (1) ◽  
pp. 93-97 ◽  
Author(s):  
E. E. Sogn ◽  
T. Ødegård ◽  
T. Haider ◽  
E. Andrew
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Contrast Media ◽  
Contrast Medium ◽  
Comparative Studies ◽  
Adverse Reactions ◽  
Northern Europe ◽  
Retrospective Design ◽  
Clinical Trial Program ◽  
Recurrence Frequency

Adverse reactions following contrast medium injections in 26 non-comparative and parallel trials were extracted from the iohexol vascular clinical trial program in Northern Europe. Six hundred and forty-one patients (13–88 years old) in whom information was available about a vascular contrast medium examination before the iohexol clinical trials were included, enabling a retrospective within patient comparison of adverse reactions. Iohexol gave a lower recurrence frequency (approximately 3.5 times) of reactions than ionic monomers in patients who previously experienced adverse reactions to vascular contrast media. In order to overcome some of the drawbacks with the present retrospective design, prospective comparative studies are recommended.

scholarly journals Iodinated contrast media

2021 ◽  
Vol 9 (1) ◽  
pp. 156-167
Author(s):  
Sami S. Alshowiman ◽  
Abdullah H Sahrah ◽  
Ayman K. Alswailem ◽  
Saud F. Alotaibi ◽  
Abdulaziz A. ALtowaijiri ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Media ◽  
Adverse Reactions ◽  
Iodinated Contrast Media ◽  
Radiographic Image ◽  
Complex Molecules ◽  
X Ray ◽  
Iodinated Contrast ◽  
Number Of Patients ◽  
Life Threatening

Contrast media are the materials utilized in radiology to improve the visualization of certain body structures subjected to analysis in a medical image. Contrast media are, then, diagnostic drugs because they increase the visibility of organs and tissues and allow the identification of details that otherwise could not be observed. With the introduction of multidetector computed tomography the number of patients undergoing contrast studies has grown exponentially in recent years. In computed tomography the formation of the radiographic image is obtained with the use of contrast media containing iodine atoms, exploiting the different attenuation that the X-ray beam presents in crossing the anatomical districts. The Iodinated Contrast Media (ICM) are a category of numerous substances formed by even complex molecules that vary considerably in their properties, uses and toxic effects. Even though iodinated contrast agents have a good safety profile, it is necessary to understand that some patients can have severe, life-threatening allergic reactions because of the side effects of the chemicals. This paper describes the clinical pharmacology, use and adverse reactions of intravenous iodinated contrast media used in computerized tomography, offering all doctors, even non-radiologists, the opportunity for rapid updating.

scholarly journals Myalgia and Hematuria in Association with Clonidine and Arginine Administration for Growth Hormone Stimulation Tests

2020 ◽  
Vol 2020 ◽  
pp. 1-4 ◽  
Author(s):  
Meghan Glibbery ◽  
Adam Fleming ◽  
Rahul Chanchlani ◽  
Olufemi Abiodun Ajani ◽  
Norma Marchetti ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Side Effects ◽  
Adverse Reactions ◽  
Hormone Deficiency ◽  
Anaplastic Ependymoma ◽  
Gross Hematuria ◽  
Unusual Combination ◽  
Stimulation Tests ◽  
History Of ◽  
Growth Deceleration

Growth hormone deficiency (GHD) in children has significant impacts on growth and metabolism. Two-agent GH stimulation tests are commonly used to diagnose GHD, and these tests are generally considered safe. We report the case of a 5-year 5-month-old boy with a history of anaplastic ependymoma who underwent GH stimulation testing for growth deceleration using clonidine and arginine. He developed bilateral calf myalgia and gross hematuria within 24 hours of the tests. Myalgia and hematuria resolved spontaneously. Importantly, the literature review and database searches for hematuria identified 6 cases with clonidine and 20 cases with arginine. This case highlights an unusual combination of adverse reactions to clonidine and arginine in children undergoing GH stimulation testing to assess for GHD. Pediatric endocrinologists need to be aware of the potential for these side effects to allow appropriate management, and further studies are needed to clarify the mechanisms and frequency of these side effects. We recommend that patients and families need to be counselled about hematuria as an association of GH testing with these medications.

scholarly journals Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Theo Audi Yanto ◽  
Ian Huang ◽  
Felicia Nathania Kosasih ◽  
Nata Pratama Hardjo Lugito
Keyword(s):  
Side Effects ◽  
Extended Release ◽  
Adverse Reactions ◽  
Antidiabetic Agent ◽  
Probability Scale ◽  
Case Presentation ◽  
Gastrointestinal Side Effects ◽  
History Of ◽  
Negative Feelings ◽  
Unpleasant Experience

Background. Metformin is widely known as an antidiabetic agent which has significant gastrointestinal side effects, but nightmares and abnormal dreams as its adverse reactions are not well reported. Case Presentation. Herein we present a case of 56-year-old male patient with no known history of recurrent nightmares and sleep disorder, experiencing nightmare and abnormal dreams directly after consumption of 750 mg extended release metformin. He reported his dream as an unpleasant experience which awakened him at night with negative feelings. The nightmare only lasted for a night, but his dreams every night thereafter seemed abnormal. The dreams were vivid and indescribable. The disappearance and occurrence of abnormal dreams ensued soon after the drug was discontinued and rechallenged. The case was assessed using Naranjo Adverse Drug Reaction (ADR) probability scale and resulted as probable causality. Conclusion. Metformin might be the underlying cause of nightmare and abnormal dreams in this patient. More studies are needed to confirm the association and causality of this findings.

Immediate and LAte Adverse Reactions in Coronary Angiography

1996 ◽  
Vol 37 (1P1) ◽  
pp. 218-222 ◽  
Author(s):  
S.-G. Fransson ◽  
G. Stenport ◽  
M. Andersson
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Coronary Angiography ◽  
Contrast Media ◽  
Contrast Medium ◽  
Left Coronary Artery ◽  
Adverse Reactions ◽  
Parallel Study ◽  
Double Blind ◽  
Blood Pressures

Purpose and Methods: In 120 patients in a double-blind, randomized, parallel study, iodixanol (Visipaque), a nonionic dimer isotonic with blood, was compared with ioxaglate (Hexabrix), an ionic low-osmolar dimer, in coronary angiography regarding early and late adverse reactions. Haemodynamic and electrophysiologic parameters were also analyzed. Results: Visipaque resulted in significantly fewer early adverse contrast medium-related reactions (p<0.05). Visipaque also demonstrated significantly fewer effects on electrophysiologic parameters. Both contrast media reduced systolic and diastolic blood pressures at the 1st injection in the left coronary artery. Late adverse reactions were unusual with both contrast media and occurred only as urticaria with a frequency of 1.7%, which is lower than reported in i.v. studies. One serious adverse reaction, a myocardial infarction in a male patient with severe cardiovascular disease, occurred in the Visipaque group. This event was considered to be procedure- and disease-related rather than related to the type of contrast medium used. Conclusion: We found Visipaque safe for coronary angiography, causing fewer early adverse reactions than Hexabrix and also fewer effects on electrophysiologic parameters. Late adverse reactions seemed to be unusual with intra-arterial administration of contrast media.

scholarly journals X-Ray Contrast Media Mechanisms in the Release of Mast Cell Contents: Understanding These Leads to a Treatment for Allergies

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Elliott C. Lasser
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Contrast Media ◽  
Steric Hindrance ◽  
Cell Activation ◽  
Contrast Material ◽  
Mast Cell Activation ◽  
X Ray ◽  
Cell Release ◽  
History Of

A long history of searching for the etiology of X-ray contrast material (CM) reactions has led to the understanding that the CM do not produce anti-CM antigens. Since CM reactions are anaphylactoid in nature, however, a source for mast cell activation was sought. This resulted in the finding that concentrated CM could suppress mast cell activation by attachment to the Fc portion of IgE and IgG. This is presumed to be a steric hindrance effect. In a study of the effects of CM on BP and a study of the effects of CM in sensitized rats, it was concluded that less concentrated CM activated mast cells and that this mechanism was best explained by bridging of adjacent IgE molecules via attachment to their Fc segments. The mast cell release of heparin activating the contact system, as well as the release of histamine, is believed to be responsible for CM reactions and allergic diatheses.

Ex juvantibus approach for chronic posterior laryngitis: results of short-term pantoprazole therapy

1999 ◽  
Vol 113 (8) ◽  
pp. 734-739 ◽  
Author(s):  
Walter Habermann ◽  
Andreas Eherer ◽  
Franz Lindbichler ◽  
Johann Raith ◽  
Gerhard Friedrich
Keyword(s):  
Side Effects ◽  
Proton Pump ◽  
Case History ◽  
Therapeutic Option ◽  
Short Term ◽  
Globus Pharyngeus ◽  
Symptom Questionnaire ◽  
History Of ◽  
Pharyngeal Reflux

AbstractThe aim of this study was to investigate whether patients with chronic posterior laryngitis and symptoms of gastro-pharyngeal reflux benefit from a six-week therapy with pantoprozole. Twenty-nine out-patients with voice disorders (case history of at least two months) and simultaneous symptoms of gastropharyngeal reflux were recruited for this study. At the entry to the study a symptom questionnaire and a videolaryngo/stroboscopy were completed. The symptom questionnaire and the video-laryngo/stroboscopy were repeated after the six weeks of therapy with pantoprazole 40 mg once a day and again six weeks and three months after this follow-up, during which time the patient was without therapy.Hoarseness, globus pharyngeus, sore throat, heartburn, and coughing were the symptoms which showed a significant (p<0.05) recovery at the follow-ups (mean of hoarseness index: 7.28 to 0.92; mean of globus pharyngeus index: 3.14 to 0.58; mean of heartburn index: 2.86 to 0.5; mean of cough index: 1.72 to 0.25; mean of throat soreness index: 1.72 to 0.15). Laryngoscopy scores of the posterior laryngeal region, the glottic and the supraglottic region showed statistically significant improvement (p<0.05) after the treatment with pantoprazole. The therapeutic effect exceeded the drug administration until the last follow-up (after three months). The medication was tolerated without side-effects in all patients.A primary (ex juvantibus) therapy with proton pump inhibitors seems to be a therapeutic option for patients with long-lasting chronic inflammation of the larynx not responding to common therapy. In this case a six-week course of treatment has been shown to be sufficient.

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