Preliminary classification of some naturally occurring hydroxycinnamic acids through their ultraviolet spectra

1958 ◽  
Vol 75 (2) ◽  
pp. 412-417 ◽  
Author(s):  
G.K. Sutherland
Keyword(s):  
Hydroxycinnamic Acids ◽  
Ultraviolet Spectra ◽  
Naturally Occurring ◽  
Preliminary Classification

scholarly journals Modes of Interaction in Naturally Occurring Medical Encounters With General Practitioners: The “One in a Million” Study

2021 ◽  
pp. 104973232199379
Author(s):  
Olaug S. Lian ◽  
Sarah Nettleton ◽  
Åge Wifstad ◽  
Christopher Dowrick
Keyword(s):  
General Practitioners ◽  
Narrative Analysis ◽  
Mode Competition ◽  
General Applicability ◽  
Naturally Occurring ◽  
Wide Range ◽  
The One ◽  
Narrative Mode ◽  
Modes Of Interaction

In this article, we qualitatively explore the manner and style in which medical encounters between patients and general practitioners (GPs) are mutually conducted, as exhibited in situ in 10 consultations sourced from the One in a Million: Primary Care Consultations Archive in England. Our main objectives are to identify interactional modes, to develop a classification of these modes, and to uncover how modes emerge and shift both within and between consultations. Deploying an interactional perspective and a thematic and narrative analysis of consultation transcripts, we identified five distinctive interactional modes: question and answer (Q&A) mode, lecture mode, probabilistic mode, competition mode, and narrative mode. Most modes are GP-led. Mode shifts within consultations generally map on to the chronology of the medical encounter. Patient-led narrative modes are initiated by patients themselves, which demonstrates agency. Our classification of modes derives from complete naturally occurring consultations, covering a wide range of symptoms, and may have general applicability.

scholarly journals Toward a phylogenetic-based Generic Classification of Neotropical Lecythidaceae—I. Status of Bertholletia, Corythophora, Eschweilera and Lecythis

Phytotaxa ◽  
2015 ◽  
Vol 203 (2) ◽  
pp. 85 ◽  
Author(s):  
Ya-Yi Huang ◽  
Scott A. Mori ◽  
Lawrence M. Kelly
Keyword(s):  
New World ◽  
Simultaneous Analysis ◽  
Bertholletia Excelsa ◽  
Naturally Occurring

Lecythidaceae subfam. Lecythidoideae is limited to the Neotropics and is the only naturally occurring subfamily of Lecythidaceae in the New World. A subset of genera with zygomorphic flowers—Bertholletia, Corythophora, Eschweilera and Lecythis—comprises a group of about 125 species called the Bertholletia clade. A previous study based on plastid ndhF and trnL-F genes supported the monophyly of Corythophora but suggested that Eschweilera and Lecythis are not monophyletic. Using this study as a baseline, we sampled more taxa and sequenced more loci to address the taxonomic problems of the ambiguous genera and to determine relationships within the Bertholletia clade. Our results support the monophyly of the Bertholletia clade as previously circumscribed. In addition, Corythophora is monophyletic, and the two accessions of Bertholletia excelsa come out together on the tree. Results of the simultaneous analysis do not support the monophyly of Lecythis or Eschweilera. Lecythis consists of four main groups (the Lecythis pisonis, L. poiteaui, L. chartacea, and L. corrugata clades), the last of which is nested within Eschweilera, and Eschweilera consists of three clades (the Eschweilera integrifolia, E. tetrapetala, and Eschweilera parvifolia clades). We compare our results with the generic classification presented in the latest monograph of neotropical Lecythidaceae and make recommendations for a revised generic classification of the Bertholletia clade of Lecythidaceae.

scholarly journals The Landscape of Parkin Variants Reveals Pathogenic Mechanisms and Therapeutic Targets in Parkinson’s Disease

2018 ◽  
Author(s):  
Wei Yi ◽  
Emma J. MacDougall ◽  
Matthew Y. Tang ◽  
Andrea I. Krahn ◽  
Ziv Gan-Or ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Ubiquitin Ligase ◽  
E3 Ubiquitin Ligase ◽  
Specific Drug ◽  
Common Cause ◽  
Naturally Occurring ◽  
Population Databases ◽  
Early Onset Parkinson’S Disease

AbstractMutations in Parkin (PARK2), which encodes an E3 ubiquitin ligase implicated in mitophagy, are the most common cause of early onset Parkinson’s Disease (PD). Hundreds of naturally occurring Parkin variants have been reported, both in PD patient and population databases. However, the effects of the majority of these variants on the function of Parkin and in PD pathogenesis remains unknown. Here we develop a framework for classification of the pathogenicity of Parkin variants based on the integration of clinical and functional evidence – including measures of mitophagy and protein stability, and predictive structural modeling – and assess 51 naturally occurring Parkin variants accordingly. Surprisingly, only a minority of Parkin variants, even among those previously associated with PD, disrupted Parkin function. Moreover, a few of these naturally occurring Parkin variants actually enhanced mitophagy. Interestingly, impaired mitophagy in several of the most common pathogenic Parkin variants could be rescued both by naturally-occurring (p.V224A) and structure-guided designer (p.W403A; p.F146A) hyperactive Parkin variants. Together, the findings provide a coherent framework to classify Parkin variants based on pathogenicity and suggest that several pathogenic Parkin variants represent promising targets to stratify patients for genotype-specific drug design.

scholarly journals Canine Malignant Mammary Tumours II. Adenocarcinomas, Solid Carcinomas and Spindle Cell Carcinomas

1972 ◽  
Vol 9 (6) ◽  
pp. 447-470 ◽  
Author(s):  
W. Misdorp ◽  
E. Cotchin ◽  
J. F. Hampe ◽  
Anne G. Jabara ◽  
J. von Sandersleben
Keyword(s):  
Spindle Cell ◽  
Clinical Signs ◽  
Subjective Assessment ◽  
Simple Type ◽  
Well Differentiated ◽  
The Times ◽  
Lymphatic Permeation ◽  
Preliminary Classification ◽  
Mammary Adenocarcinomas

A preliminary classification of 130 canine mammary adenocarcinomas, 76 solid carcinomas, and nine spindle cell carcinomas, together with several subtypes, was constructed from pooled, selected (metastasized) material. Each tumour in this series was classified by subjective assessment of its quantitatively predominant histological picture. Many adenocarcinomas and solid carcinomas of simple type were infiltrative, and lymphatic permeation was often found. The complex types of adenocarcinomas and of solid carcinomas were expansive, and lymphatic permeation was rare. Some metastasized adenocarcinomas were well differentiated. The clinical signs, distribution of metastases and some preliminary data on the times of survival of dogs with various types of carcinomas are discussed.

A Preliminary Classification of Usage Measures in Information System Acceptance

2013 ◽  
pp. 105-129 ◽  
Author(s):  
Muhammad Z. I. Lallmahomed ◽  
Nor Zairah Ab Rahim ◽  
Roliana Ibrahim ◽  
Azizah Abdul Rahman
Keyword(s):  
Information System ◽  
Technology Acceptance ◽  
Rater Agreement ◽  
Dimensional Measure ◽  
System Use ◽  
System Acceptance ◽  
Acceptance Model ◽  
Q Sort ◽  
Preliminary Classification

In the light of a diverse body of disorganized usage measures available and the difficulty of building a cumulative research tradition, a literature review is conducted on system use in Information Systems (IS) Acceptance through the two main theories of Technology Adoption, the Technology Acceptance Model (TAM), and The Unified Theory of Use and Acceptance of Technology (UTAUT). The authors seek to understand how usage measures are being operationalised and proposed a preliminary classification of those measures that covers system and task aspects of use. A Q-Sort approach was taken to validate the authors’ classification scheme and the result indicates high inter-rater agreement. The ensuing classification is meant to help researchers in their choice of system use measures. This review also summarises the arguments for a multi-dimensional measure of use and establishes that omnibus measure such as frequency, volume and use/non-use hold prevalence. Finally, the authors provide recommendations for further research in the area of system use.

scholarly journals Dielectrophoretic classification of fibres: principles and application to glass fibres suspended in air

2019 ◽  
Vol 213 ◽  
pp. 02053
Author(s):  
Frantisek Lizal ◽  
Milan Maly ◽  
Jakub Elcner ◽  
Arpad Farkas ◽  
Ondrej Pech ◽  
...  
Keyword(s):  
Electric Field ◽  
High Speed ◽  
Deposition Velocity ◽  
Uniform Electric Field ◽  
Electrical Mobility ◽  
Mobility Separation ◽  
Neutral Particles ◽  
Naturally Occurring ◽  
Two Parameters

Particles exposed to an electric field experience forces that influence their movement. This effect can be used for filtration of air, or for size classification of aerosols. The motion of charged particles in a non-uniform electric field is called electrophoresis. Two processes are involved in this phenomenon: 1) charging of particles and 2) electrical mobility separation. If fibres are exposed to electrophoresis, they are separated on the basis of two parameters: diameter and length. Regrettably, as naturally occurring fibres are polydisperse both in diameter and length, the electrophoresis is not very efficient in length classification. In contrast, dielectrophoresis is the motion of electrically neutral particles in a non-uniform electric field due to the induced charge separation within the particles. As deposition velocity of fibres induced by dielectrophoretic force strongly depends on length and only weakly on diameter, it can be used for efficient length classification. Principles of length classification of conducting and non-conducting fibres are presented together with design of a fibre classifier. Lastly, images of motion of fibres recorded by high-speed camera are depicted.

scholarly journals Solubility, Permeability, and Dissolution Rate of Naftidrofuryl Oxalate Based on BCS Criteria

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1238
Author(s):  
Marta Kus-Slowinska ◽  
Monika Wrzaskowska ◽  
Izabela Ibragimow ◽  
Piotr Igor Czaklosz ◽  
Anna Olejnik ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Chemical Properties ◽  
Aqueous Solubility ◽  
Immediate Release ◽  
Drug Substances ◽  
High Dissolution Rate ◽  
Cerebral Diseases ◽  
Preliminary Classification

The Biopharmaceutics Classification System (BCS) was conceived to classify drug substances by their in vitro aqueous solubility and permeability properties. The essential activity of naftidrofuryl oxalate (NF) has been described as the inhibition of the serotonin receptors (5-HT2), resulting in vasodilation and decreasing blood pressure. Since the early 1980s, NF has been used to treat several venous and cerebral diseases. There is no data available on the BCS classification of NF. However, based on its physical-chemical properties, NF might be considered to belong to the 1st or the 3rd BCS class. The present study aimed to provide data concerning the solubility and permeability of NF through Caco-2 monolayers and propose its preliminary classification into BCS. We showed that NF is a highly soluble and permeable drug substance; thus, it might be suggested to belong to BCS class I. Additionally, a high dissolution rate of the encapsulated NF based on Praxilene® 100 mg formulation was revealed. Hence, it might be considered as an immediate-release (IR).

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