Thyroid Neoplasms in a Colony of Beagle Dogs

1989 ◽  
Vol 26 (5) ◽  
pp. 438-441 ◽  
Author(s):  
P. J. Haley ◽  
F. F. Hahn ◽  
B. A. Muggenburg ◽  
W. C. Griffith
Keyword(s):  
Malignant Tumors ◽  
Thyroid Neoplasms ◽  
Thyroid Tumor ◽  
Benign Tumors ◽  
Thyroid Tumors ◽  
Beagle Dogs ◽  
Tumor Bearing ◽  
Clinical Diagnoses ◽  
The Mean ◽  
Epidemiologic Features

The histologic, clinicopathologic, and epidemiologic features of spontaneous thyroid neoplasms were evaluated in a control population of Beagle dogs. The mean age of thyroid tumor-bearing dogs (16.2 years) as significantly higher than non-tumor-bearing dogs (13.6 years). Thirteen benign and 18 malignant tumors were identified, with the incidence of both tumors increasing rapidly near the mean age of 16.2 years for tumorbearing dogs. The age-specific incidence of tumors was 1.1% per year at 8 to 12 years, increasing to 4.0% per year by 12 to 15 years and 67% over 17 years of age. Numbers of malignant tumors were greater than benign tumors at an earlier age. Approximately 44% of the malignant tumors metastasized but only 22% resulted in death of the dog. There was no difference in tumor incidence when compared according to sex, if total tumor numbers were considered or if tumors were separated into benign and malignant categories. The age at death of tumor-bearing dogs was not increased significantly by the surgical resection of the thyroid tumors. Of dogs with thyroid tumors, 15% had clinical diagnoses of hypothyroidism, and no dogs with thyroid tumors had diagnoses of hyperthyroidism.

scholarly journals Diffusion-weighted Magnetic Resonance Imaging in the Diagnosis of Bone Tumors: Preliminary Results

2013 ◽  
Vol 3 ◽  
pp. 63 ◽  
Author(s):  
Yeliz Pekcevik ◽  
Mehmet Onur Kahya ◽  
Ahmet Kaya
Keyword(s):  
Magnetic Resonance ◽  
Bone Tumors ◽  
Malignant Tumors ◽  
Receiver Operating Curve ◽  
Benign Tumors ◽  
Single Shot ◽  
Malignant Bone Tumors ◽  
Diffusion Weighted ◽  
Adc Values ◽  
The Mean

Objective: The study aims to determine whether apparent diffusion coefficient (ADC) can help differentiate benign and malignant bone tumors. Materials and Methods: From January 2012 to February 2013, we prospectively included 26 patients. Of these 15 patients were male and 11 were female; ranging in age from 8 to 76 years (mean age, 34.5 years). Diffusion-weighted magnetic resonance (MR) imaging was obtained with a single-shot echo-planar imaging sequence using a 1.5T MR scanner. We grouped malignant lesions as primary, secondary, and primary tumor with chondroid matrix. The minimum ADC was measured in the tumors and mean minimum ADC values were selected for statistical analysis. ADC values were compared between malignant and benign tumors using the Mann-Whitney U-test and receiver operating curve analysis were done to determine optimal cut-off values. Results: The mean ADC values from the area with lowest ADC values of benign and malignant tumors were 1.99 ± 0.57 × 10−3 mm2/s and 1.02 ± 1.0 × 10−3 mm2/s, respectively. The mean minimum ADC values of benign and malignant tumors were statistically different (P = 0.029). With cut-off value of 1.37 (10−3 mm2/s), sensitivity was 77.8% and specificity was 82.4%, for distinguishing benign and malignant lesion. Benign and secondary malignant tumors showed statistically significant difference (P = 0.002). There was some overlap in ADC values between benign and malignant tumors. The mean minimum ADC values of benign and malignant chondroid tumors were high. Giant cell tumor, non-ossifying fibroma and fibrous dysplasia showed lower ADC values. Conclusion: Although there is some overlap, ADC values of benign and malignant bone tumors seem to be different. Further studies with larger patient groups are needed to find an optimal cut-off ADC value.

Endoscopic Management of Sinonasal Tumors: A Preliminary Report

2005 ◽  
Vol 19 (3) ◽  
pp. 307-315 ◽  
Author(s):  
David M. Poetker ◽  
Robert J. Toohill ◽  
Todd A. Loehrl ◽  
Timothy L. Smith
Keyword(s):  
Recurrence Rate ◽  
Chart Review ◽  
Malignant Tumors ◽  
Surgical Excision ◽  
Tumor Location ◽  
Therapeutic Modality ◽  
Endoscopic Management ◽  
Benign Tumors ◽  
The Mean

Background The increased experience with the endoscopic approach to sinonasal inflammatory disease has resulted in the increased use of endoscopes to manage many different sinonasal pathologies. Methods A chart review of patients with sinonasal tumors treated with primary endoscopic management, from January, 1993 to November, 2003 was performed. Results Forty patients were identified (26 men and 14 women). The mean age was 53.2 years, and the mean follow-up was 31.1 months. For benign tumors, 24 patients were identified with a mean age of 50.7 years, a mean follow-up of 17.5 months, and a recurrence rate of 4.2%. For malignant tumors, 16 patients were identified, with a mean age of 57.3 years, a mean follow-up of 51.5 months, and a recurrence rate of 31.3%. The overall survival rate was 87.5%. Conclusion Endoscopic surgical excision of selective sinonasal tumors may be an effective therapeutic modality. In some cases, adjuvant external procedures may be required based on tumor location.

scholarly journals Prevalence of benign and malignant tumors in thyroidectomy specimens

2020 ◽  
Vol 5 (1) ◽  
pp. e12-e12
Author(s):  
Maryam Derakhshan ◽  
Azar Baradaran ◽  
Faranak Kamrad ◽  
Amir Hossein Pezeshki ◽  
Amirreza Rafiei javazm
Keyword(s):  
Thyroid Surgery ◽  
Significant Relationship ◽  
Malignant Tumors ◽  
Cross Sectional Study ◽  
Thyroid Tumors ◽  
Chi Square ◽  
Cross Sectional ◽  
Significance Level ◽  
The Mean ◽  
Level Of Significance

Introduction: The most common type of endocrine malignancy is thyroid cancer (TC). TC is the 7th, 14th, and 11th most common cancer in women, men, and both sexes, respectively. Objectives: The aim of this research was to establish the frequency of benign and malignant tumors in thyroid surgery specimens performed in Al-Zahra hospital in Isfahan from 2011 to 2017. Patients and Methods: This is a retrospective descriptive cross-sectional study. 1345 patients who underwent thyroid surgery were enrolled using census sampling. Data were analyzed using SPSS software (IBM statistics for windows, version 16) using descriptive statistics, mean, standard deviation, frequency, chi-square, and ANOVA. A significance level of less than 0.05 was analyzed. Results: Of 1345 participants, 237 (17.6%) were males, and 1108 (82.4%) were females. The mean age of benign patients was 46.48, malignant 39.31, and healthy patients for 37.50 years. Since the level of significance is less than 0.05, there is a significant relationship between the mean age of patients and the frequency of thyroid surgery specimens. The most prevalent benign and malignant thyroid tumors were goiter (76.8%) and papillary carcinoma (92.6%), respectively. Conclusion: The results showed that there was a significant relationship between age, gender, and benign and malignant type. Also, the most prevalent benign and malignant thyroid tumors were goiter and papillary, respectively.

scholarly journals CCND1 Splice Variant as A Novel Diagnostic and Predictive Biomarker for Thyroid Cancer

Cancers ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 437 ◽  
Author(s):  
Sora Jeon ◽  
Yourha Kim ◽  
Young Jeong ◽  
Ja Bae ◽  
Chan Jung
Keyword(s):  
Thyroid Cancer ◽  
Malignant Tumors ◽  
Expression Profiles ◽  
D1 Protein ◽  
Predictive Biomarker ◽  
Benign Tumors ◽  
Thyroid Tumors ◽  
Ccnd1 Gene ◽  
Protein Levels ◽  
Cyclin D1 Protein

Cyclin D1 protein is aberrantly overexpressed in thyroid cancers, but mutations of the CCND1 gene are rare in these tumors. We investigated the CCND1 rs9344 (G870A) polymorphism and the expression profiles of wild-type CCND1a and shortened oncogenic isoform CCND1b at the mRNA and protein levels in 286 thyroid tumors. Genotype AA of rs9344 was associated with high expression of CCND1b mRNA and was more frequently found in thyroid cancer than in benign tumors. The mRNA expression levels of CCND1b were higher in papillary thyroid carcinoma (PTC) than in benign or other malignant tumors. However, the expression of CCND1a mRNA showed no association with the parameters. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was distinguished from PTC by low expression of CCND1b at mRNA and protein levels. We further observed that cyclin D1b immunostaining helped to avoid the misdiagnosis of classic PTC with predominant follicular pattern as NIFTP in a separate cohort. Nuclear cyclin D1b expression was associated with aggressive clinicopathologic features in PTC. These findings suggest that cyclin D1b overexpression can be used as a diagnostic and predictive biomarker in thyroid tumors and may be functionally involved in the development and progression of the disease.

scholarly journals Classification of Breast Ultrasound Tomography by Using Textural Analysis

2020 ◽  
Vol 17 (2) ◽  
Author(s):  
Chih-Yu Liang ◽  
Tai-Been Chen ◽  
Nan-Han Lu ◽  
Yi-Chen Shen ◽  
Kuo-Ying Liu ◽  
...  
Keyword(s):  
Roc Analysis ◽  
Malignant Tumors ◽  
Rapid Development ◽  
Ultrasound Image ◽  
Breast Ultrasound ◽  
Image Features ◽  
Benign Tumors ◽  
Ultrasound Images ◽  
The Mean

Background: Ultrasound imaging has become one of the most widely utilized adjunct tools in breast cancer screening due to its advantages. The computer-aided detection of breast ultrasound is rapid development via significant features extracted from images. Objectives: The main aim was to identify features of breast ultrasound image that can facilitate reasonable classification of ultrasound images between malignant and benign lesions. Patients and Methods: This research was a retrospective study in which 85 cases (35 malignant [positive group] and 50 benign [negative group] with diagnostic reports) with ultrasound images were collected. The B-mode ultrasound images have manually selected regions of interest (ROI) for estimated features of an image. Then, a fractal dimensional (FD) image was generated from the original ROI by using the box-counting method. Both FD and ROI images were extracted features, including mean, standard deviation, skewness, and kurtosis. These extracted features were tested as significant by t-test, receiver operating characteristic (ROC) analysis and Kappa coefficient. Results: The statistical analysis revealed that the mean texture of images performed the best in differentiating benign versus malignant tumors. As determined by the ROC analysis, the appropriate qualitative values for the mean and the LR model were 0.85 and 0.5, respectively. The sensitivity, specificity, accuracy, positive predicted value (PPV), negative predicted value (NPV), and Kappa for the mean was 0.77, 0.84, 0.81, 0.77, 0.84, and 0.61, respectively. Conclusion: The presented method was efficient in classifying malignant and benign tumors using image textures. Future studies on breast ultrasound texture analysis could focus on investigations of edge detection, texture estimation, classification models, and image features.

scholarly journals Late bone metastasis from an apparently benign oncocytic follicular thyroid tumor

2013 ◽  
Vol 2013 ◽  
Author(s):  
Mauro Boronat ◽  
Juan J Cabrera ◽  
Carmen Perera ◽  
Concepción Isla ◽  
Francisco J Nóvoa
Keyword(s):  
Bone Biopsy ◽  
Follicular Adenoma ◽  
Thyroid Neoplasms ◽  
Thyroid Tumor ◽  
Whole Body ◽  
Pathology Report ◽  
List Type ◽  
Thyroid Tumors ◽  
Serum Thyroglobulin ◽  
Focal Uptake

Summary A man underwent total thyroidectomy for goiter when he was 62 years old. The pathology report informed on a 5.5 cm oncocytic follicular adenoma and a 3.5 mm papillary microcarcinoma. Due to the papillary tumor, he was treated with ablative radioiodine therapy and suppressive doses of levothyroxine. After uneventful follow-up for 9 years, increased levels of serum thyroglobulin were detected. Further imaging studies including a whole body scan (WBS) after an empirical dose of 200 mCi 131I were negative. Two years later, a 99mTc SestaMIBI WBS and a 2-[18F]-fluoro-2-deoxy-d-glucose positron-emission tomography showed a well-delimited focal uptake in the right femur. A bone biopsy of the lesion demonstrated metastasis of follicular thyroid carcinoma. Retrospective histological reexamination of available material from the primary oncocytic thyroid tumor failed to reveal definitive traits of malignancy. Learning points Oncocytic follicular thyroid tumors are a relatively uncommon variant of follicular thyroid neoplasms mostly composed of distinctive large oxyphilic cells (Hürthle cells). Criteria for the distinction between benign and malignant oncocytic neoplasms are not different from those used in the diagnosis of ordinary follicular tumors. Some cases of apparently benign oncocytic neoplasms have been found to develop malignant behavior. Search to rule out vascular and capsular invasion should be particularly exhaustive in histological assessment of oncocytic thyroid tumors. Even so, long-term surveillance remains appropriate for patients with large apparently benign oncocytic tumors.

scholarly journals Navigation-assisted surgery for bone and soft tissue tumors with bony extension.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 10073-10073
Author(s):  
Makoto Ieguchi ◽  
Manabu Hoshi ◽  
Jun Takada ◽  
Noriaki Hidaka ◽  
Yasushi Shigeoka ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Minimally Invasive ◽  
Malignant Tumors ◽  
Soft Tissue Tumors ◽  
Benign Tumors ◽  
Navigation Systems ◽  
Extraskeletal Osteosarcoma ◽  
Registration Method ◽  
Joint Replacement Surgery ◽  
The Mean

10073 Background: In recent times,minimally invasive surgery, such as endoscopic surgery, has gained a lot of popularity.The navigation system was introduced to orthopedic surgery in the 1990s. These days, computed tomography (CT)-based navigation systems are commonly used in spine and joint replacement surgery because of their precision. The aim of our study was to evaluate the accuracy and efficacy of navigation-assisted excision of bone and soft tissue tumors. Methods: From January 2006 to December 2009, we performed navigation-assisted surgery in 16 patients (11 men and 5 women; mean age, 39 years; range, 13-70 years). We diagnosed 9 benign bone tumors and 7 malignant bone and soft tissue tumors. In 2 patients, the malignant soft tissue tumors infiltrated the adjacent bones. We performed excisional biopsies for the benign tumors and en bloc excisions for the malignant tumors. In all the cases, the point registration method was used with 10 skin markers that were placed around the tumor. Each excisional difference between the preoperative and postoperative plans was evaluated histologically or by postoperative CT. Results: The mean preoperative registration matching time was 12.8 min (range, 8-25 min). The total mean preparation time was 24 min (range, 16-35 min). The mean accuracy of this system, which was determined using the skin markers, was 0.93 mm (range, 0.6-1.5 mm). All biopsied and excised specimens were evaluated by pathologic examination and postoperative CT imaging. The mean difference between the planned margin and postoperative CT or the excised histological specimen was 0 to 4 mm. The mean follow-up period was 53.2 months (range, 10-70 months). There were no local recurrences, except for a case of chordoma that required excision of skip metastases and a case of extraskeletal osteosarcoma, in which the patient died from the disease. Conclusions: We report our experience with navigation-assisted surgery for bone and soft tissue tumors performed using skin markers. Navigation-assisted surgery was indicated in the case of sufficiently reliable, accurate, and minimally invasive resections.

scholarly journals Thyroid Follicular Adenoma with Tracheal Stenosis

2021 ◽  
Vol 6 (4) ◽  
Author(s):  
Kusunoki T ◽  
Wada R
Keyword(s):  
Tracheal Stenosis ◽  
Malignant Tumors ◽  
Follicular Adenoma ◽  
Thyroid Tumor ◽  
Thyroid Tumors ◽  
Thyroid Lymphoma ◽  
Chronic Thyroiditis ◽  
Preoperative Ct ◽  
Malignant Lesions ◽  
Benign Thyroid

Some cases of thyroid malignant tumors and thyroid lymphoma were reported to have caused tracheal stenosis and choking. Benign thyroid tumors with dyspnea due to tracheal stenosis are very rare. We experienced a benign thyroid tumor that caused tracheal stenosis and dyspnea. In the preoperative CT, there was tracheal stenosis due to enlarged bilateral thyroid lobes and the width of the stenotic lumen was 7mm. Subtotal thyroidectomy improved the dyspnea. Postoperative histopathologic examination confirmed follicular adenoma without malignant lesions or chronic thyroiditis. On postoperative CT, the tracheal stenosis had improved and the lumen had increased to 15mm. The above findings would suggest that it should be keep in mind that even benign thyroid tumors with tracheal stenosis of less than 7mm in the lumen have the possibility of causing dyspnea.

scholarly journals Epithelial Thyroid Tumors in Cows

1976 ◽  
Vol 13 (6) ◽  
pp. 401-408 ◽  
Author(s):  
J. Vítovec
Keyword(s):  
Malignant Tumors ◽  
Papillary Adenocarcinoma ◽  
Small Cell ◽  
Benign Tumors ◽  
Thyroid Tumors ◽  
Pleomorphic Cells

From 1964 to 1973, 370 tumors were collected from cows of unknown age. Ten (2.7%) of these were primary thyroid tumors. Three were malignant. The benign tumors were solitary encapsulated adenomas in the parenchyma with more or less defined trabeculae, tubular, and microfollicular pattern. One of the malignant tumors was a cystic papillary adenocarcinoma, and two were small cell carcinomas consisting of small, sometimes binuclear, pleomorphic cells.

Primary Tissue Cultures of Benign and Malignant Human Thyroid Tumors: Effect of TSH

1988 ◽  
Vol 99 (1) ◽  
pp. 10-15 ◽  
Author(s):  
L. Komlos ◽  
R. Shimberg ◽  
I. Halbrecht ◽  
Y. Zohar ◽  
M. Strauss ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Malignant Tumors ◽  
Suppressive Therapy ◽  
Human Thyroid ◽  
Benign Tumors ◽  
Thyroid Tumors ◽  
Tissue Cultures ◽  
Vitro Effect ◽  
Primary Tissue

Many thyroid carcinomas seem to be dependent upon the thyroid growth-promoting properties of the thyroid stimulating hormone (TSH). The purpose of the present investigation was to compare the in vitro effect of TSH on tissue cultures derived from malignant and benign thyroid tumors. The results indicate that TSH can affect the morphology and protein synthesis of primary tissue cultures derived from benign and malignant thyroid tumors differently. The addition of TSH to cultures derived from benign tumors resulted in a reorganization of follicle-like structures of the monolayer and in a reduction of protein synthesis. In contrast to this, monolayers derived from carcinomas of the thyroid were not able to reorganize and their protein synthesis was not inhibited in the presence of TSH. For a better understanding of TSH suppressive therapy, we suggest testing the influence of TSH on a large number of tissue cultures derived from benign and malignant tumors of the thyroid.

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