Evidence-Based Clinical Anatomy of the Popliteofibular Ligament and Its Importance in Orthopaedic Surgery: Cadaveric Versus Magnetic Resonance Imaging Meta-analysis and Radiological Study

2020 ◽  
pp. 036354652095041
Author(s):  
Przemysław A. Pękala ◽  
Mitchell R. Mann ◽  
Jakub R. Pękala ◽  
Krzysztof A. Tomaszewski ◽  
Robert F. LaPrade
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Meta Analysis ◽  
Lower Limbs ◽  
Clinical Anatomy ◽  
Tibial Rotation ◽  
Resonance Imaging ◽  
Popliteofibular Ligament ◽  
Anatomic Structure ◽  
Mri Studies

Background: The popliteofibular ligament (PFL) is a static stabilizer of the posterolateral corner of the knee, preventing varus angulation, tibial rotation, and posterior translation. The PFL is anatomically variable, and there is no current review that outlines its prevalence rate and morphological variations. Purpose: To investigate the anatomic prevalence and morphological qualities of the PFL in various global patient populations via a meta-analysis of relevant literature involving both cadaveric dissections and patient-based research using magnetic resonance imaging (MRI) scans. Study Design: Meta-analysis. Methods: We pooled literature data detailing PFL prevalence rates and performed a retrospective MRI study of 100 knees to determine the overall PFL prevalence. Data searches and analyses were performed according to Anatomical Quality Assurance and PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Results: There were 30 cadaveric studies and 11 MRI studies (including our radiological investigation), representing a total of 1595 lower limbs. The meta-analysis of cadaveric studies showed a higher prevalence of the PFL than the meta-analysis of MRI studies, with 98.4% (95% CI, 97.5%-99.2%) and 89.0% (95% CI, 73.9%-98.6%), respectively. Our MRI investigation reported a PFL prevalence of 92.0%. Conclusion: The PFL was found to be a constant or rarely absent anatomic structure of the human knee according to the analysis of cadaveric dissection studies, and it was identified notably less on MRI, albeit not significantly. Increasing PFL anatomic knowledge, including awareness of its prevalence and morphological diversity, will improve injury diagnoses, treatment methods, and prognoses.

scholarly journals Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis

2009 ◽  
Vol 195 (3) ◽  
pp. 194-201 ◽  
Author(s):  
D. Arnone ◽  
J. Cavanagh ◽  
D. Gerber ◽  
S. M. Lawrie ◽  
K. P. Ebmeier ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Bipolar Disorder ◽  
Magnetic Resonance ◽  
Meta Analysis ◽  
Control Group ◽  
Structural Abnormality ◽  
Significant Heterogeneity ◽  
Resonance Imaging ◽  
Unrelated Control ◽  
Mri Studies

BackgroundSeveral magnetic resonance imaging (MRI) studies have identified structural abnormalities in association with bipolar disorder. The literature is, however, heterogeneous and there is remaining uncertainty about which brain areas are pivotal to the pathogenesis of the condition.AimsTo identify, appraise and summarise volumetric MRI studies of brain regions comparing bipolar disorder with an unrelated control group and individuals with schizophrenia.MethodA systematic review and random-effects meta-analysis was carried out to identify key areas of structural abnormality in bipolar disorder and whether the pattern of affected areas separated bipolar disorder from schizophrenia. Significant heterogeneity was explored using meta-regression.ResultsParticipants with bipolar disorder are characterised by whole brain and prefrontal lobe volume reductions, and also by increases in the volume of the globus pallidus and lateral ventricles. In comparison with schizophrenia, bipolar disorder is associated with smaller lateral ventricular volume and enlarged amygdala volume. Heterogeneity was widespread and could be partly explained by clinical variables and year of publication, but generally not by differences in image acquisition.ConclusionsThere appear to be robust changes in brain volume in bipolar disorder compared with healthy volunteers, although most changes do not seem to be diagnostically specific. Age and duration of illness appear to be key issues in determining the magnitude of observed effect sizes.

scholarly journals Multi-modal magnetic resonance imaging in a mouse model of concussion

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Xuan Vinh To ◽  
Fatima A. Nasrallah
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Data Collection ◽  
Mouse Model ◽  
Meta Analysis ◽  
Data Repository ◽  
Resonance Imaging ◽  
Loss Of Righting Reflex ◽  
Post Impact ◽  
Magnetic Resonance Imaging Mri

AbstractThis data collection contains Magnetic Resonance Imaging (MRI) data, including structural, diffusion, stimulus-evoked, and resting-state functional MRI and behavioural assessment results, including acute post-impact Loss-of-Righting Reflex time and acute, subacute, and longer-term Neural Severity Score, and Open Field Behaviour obtained from a mouse model of concussion. Four cohorts with 43 3–4 months old male mice in total were used: Sham (n = 14, n = 6 day 2, n = 3 day 7, n = 5 day 14), concussion day 2 (CON 2; n = 9), concussion day 7 (CON 7; n = 10), concussion day 14 (CON 14; n = 10). The data collection contains the aforementioned MRI data in compressed NIFTI format, data sheets on animal’s backgrounds and behavioural outcomes and is made publicly available from a data repository. The available data are intended to facility cross-study comparisons, meta-analysis, and science reproducibility.

scholarly journals Breast cancer and background parenchymal enhancement at breast magnetic resonance imaging: a meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Na Hu ◽  
Jinghao Zhao ◽  
Yong Li ◽  
Quanshui Fu ◽  
Linwei Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Breast Magnetic Resonance Imaging ◽  
Meta Analysis ◽  
Resonance Imaging ◽  
High Background ◽  
Background Parenchymal Enhancement ◽  
Breast Magnetic Resonance ◽  
Parenchymal Enhancement

Abstract Background The background parenchymal enhancement at breast magnetic resonance imaging use to predict breast cancer attracts many searchers to draw a possible relationship. However, the results of their relationships were conflicting. This meta-analysis was performed to assess breast cancer frequency associations with background parenchymal enhancement. Methods A systematic literature search up to January 2020 was performed to detect studies recording associations between breast cancer frequency and background parenchymal enhancement. We found thirteen studies including 13,788 women at the start with 4046 breast cancer. We calculated the odds ratio (OR) and the 95% confidence intervals (CIs) between breast cancer frequency and background parenchymal enhancement by the dichotomous technique with a random or fixed-effect model. Results Women with minimal or mild background parenchymal enhancement at breast magnetic resonance imaging did not have any risk of breast cancer compared to control women (OR, 1.20; 95% CI 0.54–2.67). However, high background parenchymal enhancement at breast magnetic resonance imaging (OR, 2.66; 95% CI 1.36–5.19) and moderate (OR, 2.51; 95% CI 1.49–4.21) was associated with a significantly higher rate of breast cancer frequency compared to control women. Conclusions Our meta-analysis showed that the women with high and moderate background parenchymal enhancement at breast magnetic resonance imaging have higher risks, up to 2.66 fold, of breast cancer. We suggest that women with high or moderate background parenchymal enhancement at breast magnetic resonance imaging to be scheduled for more frequent follow-up and screening for breast cancer to avoid any complications.

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