scholarly journals Dietary Iron Bioavailability: A Simple Model That Can Be Used to Derive Country-Specific Values for Adult Men and Women

2019 ◽  
Vol 41 (1) ◽  
pp. 121-130 ◽  
Author(s):  
Susan Fairweather-Tait ◽  
Cornelia Speich ◽  
Comlan Evariste S. Mitchikpè ◽  
Jack R. Dainty
Keyword(s):  
Iron Absorption ◽  
Iron Status ◽  
Iron Bioavailability ◽  
Whole Body ◽  
Dietary Iron ◽  
Iron Intake ◽  
Middle Income ◽  
Iron Losses ◽  
Using Data ◽  
The 1960S

Background: Reference intakes for iron are derived from physiological requirements, with an assumed value for dietary iron absorption. A new approach to estimate iron bioavailability, calculated from iron intake, status, and requirements was used to set European dietary reference values, but the values obtained cannot be used for low- and middle-income countries where diets are very different. Objective: We aimed to test the feasibility of using the model developed from United Kingdom and Irish data to derive a value for dietary iron bioavailability in an African country, using data collected from women of child-bearing age in Benin. We also compared the effect of using estimates of iron losses made in the 1960s with more recent data for whole body iron losses. Methods: Dietary iron intake and serum ferritin (SF), together with physiological requirements of iron, were entered into the predictive model to estimate percentage iron absorption from the diet at different levels of iron status. Results: The results obtained from the 2 different methods for calculating physiological iron requirements were similar, except at low SF concentrations. At a SF value of 30 µg/L predicted iron absorption from the African maize-based diet was 6%, compared with 18% from a Western diet, and it remained low until the SF fell below 25 µg/L. Conclusions: We used the model to estimate percentage dietary iron absorption in 30 Beninese women. The predicted values agreed with results from earlier single meal isotope studies; therefore, we conclude that the model has potential for estimating dietary iron bioavailability in men and nonpregnant women consuming different diets in other countries.

Dietary and Physiological Factors That Affect the Absorption and Bioavailability of Iron

2005 ◽  
Vol 75 (6) ◽  
pp. 375-384 ◽  
Author(s):  
Janet R. Hunt
Keyword(s):  
Iron Deficiency ◽  
Molecular Mechanisms ◽  
Iron Absorption ◽  
Iron Status ◽  
Work Capacity ◽  
Iron Bioavailability ◽  
Human Studies ◽  
Dietary Iron ◽  
Iron Availability ◽  
Blood Indices

Iron deficiency, a global health problem, impairs reproductive performance, cognitive development, and work capacity. One proposed strategy to address this problem is the improvement of dietary iron bioavailability. Knowledge of the molecular mechanisms of iron absorption is growing rapidly, with identification of mucosal iron transport and regulatory proteins. Both body iron status and dietary characteristics substantially influence iron absorption, with minimal interaction between these two factors. Iron availability can be regarded mainly as a characteristic of the diet, but comparisons between human studies of iron availability for absorption require normalization for the iron status of the subjects. The dietary characteristics that enhance or inhibit iron absorption from foods have been sensitively and quantitatively determined in human studies employing iron isotopes. People with low iron status can substantially increase their iron absorption from diets with moderate to high availability. But while iron supplementation and fortification trials can effectively increase blood indices of iron status, improvements in dietary availability alone have had minimal influence on such indices within several weeks or months. Plentiful, varied diets are the ultimate resolution to iron deficiency. Without these, more modest food-based approaches to human iron deficiency likely will need to be augmented by dietary iron fortification.

scholarly journals Estimation of Dietary Iron Bioavailability from Food Iron Intake and Iron Status

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e111824 ◽  
Author(s):  
Jack R. Dainty ◽  
Rachel Berry ◽  
Sean R. Lynch ◽  
Linda J. Harvey ◽  
Susan J. Fairweather-Tait
Keyword(s):  
Iron Status ◽  
Iron Bioavailability ◽  
Dietary Iron ◽  
Iron Intake

Iron status and dietary iron intake of female blood donors

Transfusion ◽  
2013 ◽  
Vol 54 (3pt2) ◽  
pp. 770-774 ◽  
Author(s):  
Alison O. Booth ◽  
Karen Lim ◽  
Hugh Capper ◽  
David Irving ◽  
Jenny Fisher ◽  
...  
Keyword(s):  
Blood Donors ◽  
Iron Status ◽  
Dietary Iron ◽  
Iron Intake

scholarly journals An intensified training schedule in recreational male runners is associated with increases in erythropoiesis and inflammation and a net reduction in plasma hepcidin

2018 ◽  
Vol 108 (6) ◽  
pp. 1324-1333 ◽  
Author(s):  
Diego Moretti ◽  
Samuel Mettler ◽  
Christophe Zeder ◽  
Carsten Lundby ◽  
Anneke Geurts-Moetspot ◽  
...  
Keyword(s):  
Exercise Training ◽  
Iron Absorption ◽  
Iron Status ◽  
Geometric Mean ◽  
Iron Bioavailability ◽  
Oral Iron ◽  
Low Grade ◽  
Hemoglobin Mass ◽  
Low Grade Inflammation ◽  
Iron Utilization

ABSTRACT Background Iron status is a determinant of physical performance, but training may induce both low-grade inflammation and erythropoiesis, exerting opposing influences on hepcidin and iron metabolism. To our knowledge, the combined effects on iron absorption and utilization during training have not been examined directly in humans. Objective We hypothesized that 3 wk of exercise training in recreational male runners would decrease oral iron bioavailability by increasing inflammation and hepcidin concentrations. Design In a prospective intervention, nonanemic, iron-sufficient men (n = 10) completed a 34-d study consisting of a 16-d control phase and a 22-d exercise-training phase of 8 km running every second day. We measured oral iron absorption and erythroid iron utilization using oral 57Fe and intravenous 58Fe tracers administered before and during training. We measured hemoglobin mass (mHb) and total red blood cell volume (RCV) by carbon monoxide rebreathing. Iron status, interleukin-6 (IL-6), plasma hepcidin (PHep), erythropoietin (EPO), and erythroferrone were measured before, during, and after training. Results Exercise training induced inflammation, as indicated by an increased mean ± SD IL-6 (0.87 ± 1.1 to 5.17 ± 2.2 pg/mL; P < 0.01), while also enhancing erythropoiesis, as indicated by an increase in mean EPO (0.66 ± 0.42 to 2.06 ± 1.6 IU/L), mHb (10.5 ± 1.6 to 10.8 ± 1.8 g/kg body weight), and mean RCV (30.7 ± 4.3 to 32.7 ± 4.6 mL/kg) (all P < 0.05). Training tended to increase geometric mean iron absorption by 24% (P = 0.083), consistent with a decreased mean ± SD PHep (7.25 ± 2.14 to 5.17 ± 2.24 nM; P < 0.05). The increase in mHb and erythroid iron utilization were associated with the decrease in PHep (P < 0.05). Compartmental modeling indicated that iron for the increase in mHb was obtained predominantly (>80%) from stores mobilization rather than from increased dietary absorption. Conclusions In iron-sufficient men, mild intensification of exercise intensity increases both inflammation and erythropoiesis. The net effect is to decrease hepcidin concentrations and to tend to increase oral iron absorption. This trial was registered at clinicaltrials.gov as NCT01730521.

scholarly journals Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake

2018 ◽  
Vol 15 (10) ◽  
pp. 2156 ◽  
Author(s):  
Joanna Gajewska ◽  
Jadwiga Ambroszkiewicz ◽  
Witold Klemarczyk ◽  
Ewa Głąb-Jabłońska ◽  
Halina Weker ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Status ◽  
Hematological Parameters ◽  
Daily Intake ◽  
Normal Weight ◽  
Deficiency Anemia ◽  
Dietary Iron ◽  
Iron Intake ◽  
Obese Children ◽  
Iron Concentrations

Iron metabolism may be disrupted in obesity, therefore, the present study assessed the iron status, especially ferroportin and hepcidin concentrations, as well as associations between the ferroportin-hepcidin axis and other iron markers in prepubertal obese children. The following were determined: serum ferroportin, hepcidin, ferritin, soluble transferrin receptor (sTfR), iron concentrations and values of hematological parameters as well as the daily dietary intake in 40 obese and 40 normal-weight children. The ferroportin/hepcidin and ferritin/hepcidin ratios were almost two-fold lower in obese children (p = 0.001; p = 0.026, respectively). Similar iron concentrations (13.2 vs. 15.2 µmol/L, p = 0.324), the sTfR/ferritin index (0.033 vs. 0.041, p = 0.384) and values of hematological parameters were found in obese and control groups, respectively. Iron daily intake in the obese children examined was consistent with recommendations. In this group, the ferroportin/hepcidin ratio positively correlated with energy intake (p = 0.012), dietary iron (p = 0.003) and vitamin B12 (p = 0.024). In the multivariate regression model an association between the ferroportin/hepcidin ratio and the sTfR/ferritin index in obese children (β = 0.399, p = 0.017) was found. These associations did not exist in the controls. The results obtained suggest that in obese children with sufficient iron intake, the altered ferroportin-hepcidin axis may occur without signs of iron deficiency or iron deficiency anemia. The role of other micronutrients, besides dietary iron, may also be considered in the iron status of these children.

P1116 AGE-DEPENDENT RESPONSES TO DIETARY IRON INTAKE IN INDICATORS OF IRON STATUS FROM 6 TO 18 MONTHS OF AGE

2004 ◽  
Vol 39 (Supplement 1) ◽  
pp. S481
Author(s):  
T. Lind ◽  
O. Hernell ◽  
B. L??nnerdal ◽  
H. Stenlund ◽  
M. Domell??f ◽  
...  
Keyword(s):  
Iron Status ◽  
Dietary Iron ◽  
Iron Intake ◽  
Age Dependent

scholarly journals In vivo mucosal uptake, mucosal transfer and retention of iron in mice

1997 ◽  
Vol 31 (3) ◽  
pp. 264-270 ◽  
Author(s):  
M. Santos ◽  
K. J. H. Wienk ◽  
M. W. Schilham ◽  
H. Clevers ◽  
M. de Sousa ◽  
...  
Keyword(s):  
Iron Absorption ◽  
Iron Status ◽  
Test Dose ◽  
Whole Body ◽  
Whole Body Counter ◽  
Significant Difference ◽  
Transfer And Retention ◽  
Iron Retention

An improved and sensitive method for studying iron absorption in mice with alterations in body iron stores is described. Mice with varying iron status were given a double isotope-labelled test dose containing 59Fe and 51Cr as a non-absorbable indicator, via an oroesophageal needle. Using a whole-body counter it was possible to measure in vivo the initial mucosal iron uptake and long-term iron retention and to calculate mucosal iron transfer. A significant difference was demonstrated between normal and both anaemic and dietary iron-loaded mice with regard to the various steps of iron absorption. When mice were tested twice for iron absorption, the results were highly reproducible. In conjunction with other parameters, the method described is useful in studying the mechanism and the regulation of iron absorption in mice.

scholarly journals Dietary iron intake, iron status, and gestational diabetes

2017 ◽  
Vol 106 (Supplement 6) ◽  
pp. 1672S-1680S ◽  
Author(s):  
Cuilin Zhang ◽  
Shristi Rawal
Keyword(s):  
Gestational Diabetes ◽  
Iron Status ◽  
Dietary Iron ◽  
Iron Intake
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