Denial and oncological pathology: Case report of a massive testicular cancer

2020 ◽  
pp. 039156032092171
Author(s):  
G Pizzuto ◽  
M Barale ◽  
O Sedigh ◽  
B Frea
Keyword(s):  
Testicular Cancer ◽  
Early Stage ◽  
Malignant Neoplasm ◽  
Pharmacological Therapy ◽  
Retroperitoneal Lymph Node Dissection ◽  
Screening Methods ◽  
Male Population ◽  
Testicular Trauma ◽  
History Of ◽  
Radical Orchiectomy

Literature: The cancer of testicles represents 1% of male neoplasms and 5% of urological malignant neoplasm. Its incidence has been growing in Western societies. Cancer of testicles usually presents as an increase of consistence in one testicles and absence of pain, as a casual ultrasound scan finding, or it could be highlighted by a scrotal injury. The surgical treatment is either radical orchiectomy or radical orchiectomy plus retroperitoneal lymph node dissection. Case presentation: The case presented concerns a 48-year-old male with a history of left testicular trauma and subsequent hypotrophy. Over the next 4 years, the patient developed a testicle size increase up to 15 cm in diameter. At diagnosis, he had retroperitoneal lymphadenopathy. The patient was, after surgery, referred to the oncology department. Conclusion: The awareness of the male population respect to testicular cancer and its screening methods (e.g. self-examination) is essential to make the diagnosis at an early stage. It is also essential to psychologically support patients undergoing surgical and/or pharmacological therapy due to risk of determining anxiety or depression compared to the whole population.

scholarly journals Testicular Cancer Awareness among Men Residing in the Maltese Islands

2020 ◽  
Author(s):  
Vincent Marmarà ◽  
Reginald Aquilina ◽  
Elyse Formosa ◽  
Gill Hubbard ◽  
Danika Marmarà
Keyword(s):  
Early Detection ◽  
Testicular Cancer ◽  
Early Stage ◽  
Information Provision ◽  
Cancer Awareness ◽  
Male Population ◽  
Interview Schedule ◽  
Level Of Knowledge ◽  
Education Campaigns ◽  
Self Examination

Abstract BackgroundTesticular cancer (TC) accounts for around one percent of all cancers in men. Early detection is of utmost importance for recovery and survivorship. Testicular self-examination (TSE) has been shown to be effective in preventing late-stage TC diagnosis. However, there is a lack of knowledge and awareness of both TC and TSE in men. Increasing such awareness may contribute towards earlier TC detection and positive outcomes. This study aims to assess the level of knowledge of a representative sample of the Maltese male population on TC and TSE. It also explores men’s willingness to learn about and perform TSE as well as their suggested approaches for TC and TSE information provision.MethodsA telephone interview approach was chosen using an interview schedule, developed based on established literature. Data were collected from a random sample of 400 male respondents aged 16 years or over and stratified according to all ages and districts of Malta. ResultsThe findings of this study indicate that Maltese males lack knowledge on TC and how to carry out TSE. Only 36.9% respondents had knowledge on how to perform TSE and 33.9% had practised TSE at least once in their lives. Higher educated, higher income and younger respondents scored better. This study also found that only 9.6% of respondents were informed by a doctor about TSE, indicating a notable gap in information provision. However, 87.3% of respondents knew that TC can be treated if identified at an early stage and 90.2% of males were ready to perform TSE on a regular basis if informed how to perform it. The majority of participants believed that increasing awareness of TC and TSE is important. ConclusionsKnowledge on TC and TSE is low in Malta. Health education campaigns are needed to inform the general population about the risks of TC and how to perform TSE. Such campaigns could improve early detection and hence a decrease in the number of advanced TC cases. The findings of this study are being used by the Ministry for Health and the Marigold Foundation to launch campaigns to raise awareness about TC and TSE.

scholarly journals Primary testicular mucinous cystadenoma: Case report and literature review

2015 ◽  
Vol 9 (11-12) ◽  
pp. 814 ◽  
Author(s):  
Mario Maciel De Lima Jr ◽  
Mario Maciel De Lima ◽  
Fabiana Granja
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Mucinous Cystadenoma ◽  
Uneventful Recovery ◽  
Therapeutic Outcomes ◽  
Testicular Trauma ◽  
History Of ◽  
Radical Orchiectomy ◽  
Mucinous Cystadenomas ◽  
High Index Of Suspicion

Testicular mucinous cystadenomas are rare in urological practice, and their histogenesis, course and management are debated. We report a primary testicular mucinous cystadenoma in a 54-year old male who presented with left testicular swelling and pain. He denied having a history of cryptorchidism, testicular trauma, infections, urinary complaints, or febrile illnesses. He did not have diabetes, but was on treatment for hypertension. The patient underwent a left inguinal radical orchiectomy, and histological examination of the resected tumour confirmed a primary testicular mucinous cystadenoma. The patient had an uneventful recovery, and is being followed up. Conclusively, urologists need to maintain a high index of suspicion of these tumours and their differentiation from metastatic tumours to ensure optimal therapeutic outcomes.

A CLINICAL CASE OF PRIMARY HYPERPARATHYROIDISM OF THE OSTEO-VISCERAL FORM

2020 ◽  
pp. 155-161
Author(s):  
Poselyugina O.B. ◽  
Kulish A.S. ◽  
Vasiliev D.F.
Keyword(s):  
Primary Hyperparathyroidism ◽  
Clinical Case ◽  
Early Stage ◽  
Diagnostic Errors ◽  
Epidemiological Studies ◽  
Medical Documentation ◽  
Screening Methods ◽  
Internal Organs ◽  
Blood Calcium ◽  
Slow Development

Introduction. Primary hyperparathyroidism is an endocrine disease resulting from a primary pathology of the parathyroid gland, characterized by increased secretion of parathyroid hormone and increased blood calcium levels. Among the endocrine diseases, primary hyperparathyroidism is the third most common after diabetes mellitus and thyroid disease. In Russia, according to epidemiological studies, primary hyperparathyroidism is found in 1% of the population, women suffer 2-3 times more often than men do, and the average age of diagnosis is 54-59 years. In the absence of a timely diagnosis, primary hyperparathyroidism causes systemic damage to internal organs: renal impairment, nephrolithiasis, esophageal affection, cardiovascular and nervous system involvement, and it leads to a violation of bone tissue integrity. The aim is to demonstrate a clinical case of a patient with primary hyperparathyroidism and to analyze the stages of diagnosis of the disease and treatment. Material and methods. The review of medical literature on the problem of diagnostics and treatment of primary hyperparathyroidism was performed, as well as an analysis of the patient’s medical documentation with this pathology. Results and discussion. A variant of complicated course of primary hyperparathyroidism of bone and visceral form is considered. About 15 years passed from the moment of appearance of the first symptoms of the disease to the development of complications of renal and bone system. Despite the slow development of the disease and availability of screening methods, hyperparathyroidism was detected at the stage of complications. This article provides a detailed analysis of the primary hyperparathyroidism history, as well as analyzes the possibilities of diagnosis, treatment and prevention of this pathology. The efficacy of the therapy has been assessed, and ways of correction have been outlined. The analysis of the reasons that made it difficult to diagnose this pathology at an early stage, before the development of serious complications of internal organs, has been carried out. Conclusions: It can be assumed that the presented clinical case will increase the awareness of physicians, especially therapists, about the primary manifestations of this pathology and the peculiarities of its detection and routing the patient, which will allow avoiding many diagnostic errors.

ABOUT THE PERIODIZATION AND CHRONOLOGY OF THE HISTORY OF TAURIC CHERSONESUS IN THE PRE-ROMAN AND THE LATE ANTIQUE PERIODS

2020 ◽  
Vol 6 (72) (3) ◽  
pp. 127-148
Author(s):  
S. V. Ushakov
Keyword(s):  
Scientific Literature ◽  
Early Stage ◽  
Late Antique ◽  
Ancient History ◽  
History Of ◽  
Transitional Time ◽  
Early Byzantine

Hundreds of scientific works are devoted to the study of the Tauric Chersonesus, but the problem of chronology and periodization of its ancient history is not sufficiently developed in historiography. Analysis of scientific literature and a number of sources concerning this subject allows to define the chronological framework and to reveal 10 stages of the history of ancient Chersonesos (as a preliminary definition). The early stage, the Foundation and formation of the Polis, is defined from the middle/last third of the VI century (or the first half of the V century BC) to the end of the V century BC. The end of the late-Antique − early-Byzantine (transitional) time in Chersonesos can be attributed to the second half of the VI – first third of the VII centuries ad).

Molecular Processes Involved in Pancreatic Cancer and Therapeutics

2020 ◽  
Vol 14 ◽  
Author(s):  
Subhajit Makar ◽  
Abhrajyoti Ghosh ◽  
Divya ◽  
Shalini Shivhare ◽  
Ashok Kumar ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Molecular Mechanisms ◽  
Early Stage ◽  
Locally Advanced ◽  
Therapeutic Strategies ◽  
Screening Methods ◽  
Pancreatic Cancer Cells ◽  
Systemic Treatments ◽  
Cancer Initiation ◽  
Novel Therapeutic Strategies

: Despite advances in the development of cytotoxic and targeted therapies, pancreatic adenocarcinoma (PAC) remains a significant cause of cancer mortality worldwide. It is also difficult to detect it at an early stage due to numbers of factors. Most of the patients are present with locally advanced or metastatic disease, which precludes curative resection. In the absence of effective screening methods, considerable efforts have been made to identify better systemic treatments during the past decade. This review describes the recent advances in molecular mechanisms involved in pancreatic cancer initiation, progression, and metastasis. Additionally, the importance of deregulated cellular signalling pathways and various cellular proteins as potential targets for developing novel therapeutic strategies against incurable forms of pancreatic cancer is reported. The emphasis is on the critical functions associated with growth factors and their receptors viz. c-MET/HGF, CTHRC1, TGF-β, JAK-STAT, cyclooxygenase pathway, WNT, CCK, MAPK-RAS-RAF, PI3K-AKT, Notch, src, IGF-1R, CDK2NA and chromatin regulation for the sustained growth, survival, and metastasis of pancreatic cancer cells. It also includes various therapeutic strategies viz. immunotherapy, surgical therapy, radiation therapy and chemotherapy.

HIGHER EDUCATION IN ANCIENT INDIA

2018 ◽  
Vol 6 (26) ◽  
Author(s):  
Satyendra Singh Chahar ◽  
Nirmal Singh
Keyword(s):  
Cultural History ◽  
Early Stage ◽  
University Education ◽  
Educational Institutions ◽  
Educational Method ◽  
Men And Women ◽  
Ancient India ◽  
Herbert Spencer ◽  
History Of ◽  
The Ideal

University education -on almost modern lines existed in India as early as 800 B.C. or even earlier. The learning or culture of ancient India was chiefly the product of her hermitages in the solitude of the forests. It was not of the cities. The learning of the forests was embodied in the books specially designated as Aranyakas "belonging to the forests." The ideal of education has been very grand, noble and high in ancient India. Its aimaccording to Herbert Spencer is the 'training for completeness of life' and ‘the molding o character of men and women for the battle of life’. The history of the educational institutions in ancient India shows a glorious dateline of her cultural history. It points to a long history altogether. In the early stage it was rural, not urban. British Sanskrit scholar Arthur Anthony Macdonell says "Some hundreds of years must have been needed for all that is found" in her culture. The aim of education was at the manifestation of the divinity in men, it touches the highest point of knowledge. In order to attain the goal the whole educational method is based on plain living and high thinking pursued through eternity.

The diagnosis of early pneumoconiosis in dust-exposed workers: comparison of chest radiography and computed tomography

2021 ◽  
pp. 028418512110225
Author(s):  
Hideyuki Hayashi ◽  
Kazuto Ashizawa ◽  
Masashi Takahashi ◽  
Katsuya Kato ◽  
Hiroaki Arakawa ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Chest Radiography ◽  
Pulmonary Emphysema ◽  
Early Stage ◽  
Pathological Changes ◽  
Occupational History ◽  
Exposed Workers ◽  
History Of ◽  
Ct Data ◽  
Positive Results

Background Chest radiography (CR) is employed as the evaluation of pneumoconiosis; however, we sometimes encounter cases in which computed tomography (CT) is more effective in detecting subtle pathological changes or cases in which CR yields false-positive results. Purpose To compare CR to CT in the diagnosis of early-stage pneumoconiosis. Material and Methods CR and CT were performed for 132 workers with an occupational history of mining. We excluded 23 cases of arc-welder’s lung. Five readers who were experienced chest radiologists or pulmonologists independently graded the pulmonary small opacities on CR of the remaining 109 cases. We then excluded 37 cases in which the CT data were not sufficient for grading. CT images of the remaining 72 cases were graded by the five readers. We also assessed the degree of pulmonary emphysema in those cases. Results The grade of profusion on CR (CR score) of all five readers was identical in only 5 of 109 cases (4.6%). The CR score coincided with that on CT in 40 of 72 cases (56%). The CT score was higher than that on CR in 13 cases (18%). On the other hand, the CT score was lower than that on CR in 19 cases (26%). The incidence of pulmonary emphysema was significantly higher in patients whose CR score was higher than their CT score. Conclusion CT is more sensitive than CR in the evaluation of early-stage pneumoconiosis. In cases with emphysema, the CR score tends to be higher in comparison to that on CT.

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