On the Basement Membrane of the Nephron

1965 ◽  
Vol 32 (1) ◽  
pp. 44-50
Author(s):  
Antti Paalanen
Keyword(s):  
Connective Tissue ◽  
Basement Membrane ◽  
Outer Membrane ◽  
Renal Tubule ◽  
Basement Membranes ◽  
Functional Adaptation ◽  
Renal Tubules ◽  
Elastic Tissue ◽  
Renal Corpuscle ◽  
Bowman's Capsule

This study comprises some observations about the structure of the connective tissue of the basement membrane and interstitium in some normal, post-natal human kidneys. The basis of the basement membrane is mainly a reticular, homogeneous membrane that belongs uniformly to both Bowman's capsule and the wall of the renal tubule. Outside it in the capsule is a durable collagenic membrane whose development must be considered and evincement of functional adaptation under the pressure conditions of the cavity. In renal tubules there is no such well-defined outer membrane, but in them the basement membrane has in addition collagenic traits to some extent and is thus reticular-collagenic when examined as a whole. The renal tubules are surrounded by a dense, spiraling reticular network of fibres which attaches to the connective tissue of the interstitium where fibrocytes are scarce. The network extends all the way around the renal corpuscle. There is no elastic tissue at all in the basement membranes.

Mechanical Properties of Basement Membrane

Physiology ◽  
1995 ◽  
Vol 10 (1) ◽  
pp. 30-35 ◽  
Author(s):  
LW Welling ◽  
MT Zupka ◽  
DJ Welling
Keyword(s):  
Mechanical Properties ◽  
Basement Membrane ◽  
Elastic Properties ◽  
Safety Margin ◽  
Basement Membranes ◽  
Alveolar Wall ◽  
Renal Tubules ◽  
Young’S Moduli

Basement membranes from renal tubules, capillaries, venules, and pulmonary alveolar wall all have remarkably similar elastic properties and Young's moduli. Strength and safety margin, however, are far smaller in the alveolar wall, perhaps as a result of its complexity of design.

Developmental stages of Sphaerospora ohlmacheri (Whinery, 1893) n.comb. (Myxozoa: Myxosporea) in the renal tubules of bullfrog tadpoles, Rana catesbeiana, from Lake of Two Rivers, Algonquin Park, Ontario

1986 ◽  
Vol 64 (10) ◽  
pp. 2213-2217 ◽  
Author(s):  
Sherwin S. Desser ◽  
Jǐrí Lom ◽  
Iva Dyková
Keyword(s):  
Developmental Stages ◽  
Renal Tubule ◽  
Rana Catesbeiana ◽  
Renal Tubules ◽  
Histological Sections ◽  
Tubule Cells ◽  
Bowman's Capsule

Pseudoplasmodia and mature spores of Sphaerospora ohlmacheri (Whinery, 1893) n.comb. were found in the renal tubules and in the space of the Bowman's capsule of 2nd-year tadpoles of the bullfrog, Rana catesbeiana. Fresh spores and the sporogenic stages of S. ohlmacheri from tissue imprints and histological sections are described and illustrated. Dystrophic changes of renal tubule cells characterized by degeneration associated with hyaline droplets often accompanied the presence of the parasite. Features of the genera Leptotheca, Wardia, and Sphaerospora are discussed.

scholarly journals THE HISTOGENESIS OF BASEMENT MEMBRANES

1963 ◽  
Vol 117 (3) ◽  
pp. 339-348 ◽  
Author(s):  
G. B. Pierce ◽  
A. R. Midgley ◽  
J. Sri Ram
Keyword(s):  
Epithelial Cells ◽  
Connective Tissue ◽  
Basement Membrane ◽  
Yolk Sac ◽  
Basement Membranes ◽  
Ground Substance ◽  
Epithelial Secretion ◽  
Reichert's Membrane ◽  
Yolk Sac Cells

A parietal yolk sac carcinoma of the mouse that secretes large quantities of basement membrane-like material has been used to study the formation of basement membranes. Suitably characterized fluorescein-labeled antibodies against this material stained basement membranes of epithelial structures and vessels, as well as reticulin. When absorbed with reticulin and vascular basement membranes of the spleen until these structures no longer fluoresced, the antibody still stained the basement membrane-like material of the tumor, its normal embryonic counterpart (Reichert's membrane), and the basement membranes at the bases of epithelial cells. The observation made previously that parietal yolk sac cells secreted, in the absence of connective tissue and reticulin, the basement membrane (Reichert's membrane) upon which they rested has been confirmed through the localization of ferritin-labeled antibody to the endoplasmic reticulin of the secreting cells. Since a basement membrane proven to be an epithelial secretion is antigenically similar to basement membranes at the bases of all epithelial cells studied but antigenically different from connective tissue elements, it is postulated that the basement membranes at the bases of epithelial cells in general are an epithelial secretion, and are not a condensation of ground substance as is commonly believed.

scholarly journals THE ROLE OF DISORGANIZATION OF CONNECTIVE TISSUE AND BASEMENT MEMBRANE OF RENAL TUBULAR EPITHELIUM IN THE PATHOGENESIS OF UROLITHIASIS

2020 ◽  
Vol 28 (2) ◽  
pp. 78-81
Author(s):  
Vadim A. Zubarev ◽  
Juliya M. Zabrodskaya ◽  
Anatoly I. Arkhangel'sky ◽  
Marlen E. Topuzov ◽  
Iliya V. Dovzhansky
Keyword(s):  
Connective Tissue ◽  
Basement Membrane ◽  
Stone Formation ◽  
Renal Tissue ◽  
The State ◽  
Renal Tubules ◽  
Renal Tubular Epithelium ◽  
Destructive Processes ◽  
Different Levels

According to a number of researchers, pathological changes in the structures of the renal papilla play a key role in the pathogenesis of urolithiasis. According to the results of existing studies, destructive processes in collagen are characterized by a change in the length, thickness of the fibers and their orientation in space. Collagen disorganization has enzymatic and non-enzymatic mechanisms. The aim of the study was to study the frequency and features of localization of Randall's plaques and morphological study of the state of connective tissue and the basement membrane of the epithelium of the renal tubules of different levels in urolithiasis. Microscopically studied preparations of 29 biopsies of renal tissue obtained from patients with fibro-uretero-pyeloscopy (11), percutaneous nephrolitholapaxy (18) and preparations obtained at 20 autopsies in cases without visible renal pathology. Histological preparations were stained with hematoxylin and eosin to determine the state of connective tissue fibers using Van Gieson, Mallory, Schiff-reagent, alcian blue, and Kos for calcifications. The results of the study show that the morphological signs of mucoid swelling of the connective tissue and basement membrane of the epithelium of the renal tubules of different levels in combination with the formation of microcalcifications require further study of the possible role of disorganization of the connective tissue of the renal stroma in the initiation of stone formation in the kidneys.

scholarly journals Thrombospondin: a component of microfibrils in various tissues.

1991 ◽  
Vol 39 (10) ◽  
pp. 1367-1375 ◽  
Author(s):  
B B Arbeille ◽  
F M Fauvel-Lafeve ◽  
M B Lemesle ◽  
D Tenza ◽  
Y J Legrand
Keyword(s):  
Electron Microscopy ◽  
Connective Tissue ◽  
Basement Membrane ◽  
Human Placenta ◽  
Human Platelet ◽  
Blood Platelets ◽  
Immunogold Labeling ◽  
Basement Membranes ◽  
Porcine Tissues

We used antisera directed against human platelet thrombospondin (TSP) and microfibril-associated GP 128 to localize the presence of these glycoproteins in fixed sections of human placenta or porcine arteries and skin by immunogold labeling, using electron microscopy. These two antibodies reacted with both human and porcine tissues and always recognized the same structures. In all three tissues the antibodies were associated with the basement membranes and, more precisely, with the microfibrillar structures present at the junction between the basement membrane and the adjacent connective tissue. This localization indicates that GP 128 and TSP are associated with the microfibrils, and suggests their possible role in the attachment of basement membrane to the connective tissue meshwork. Their presence in microfibrils associated with the subendothelial basement membrane in arteries may be important in regard to the thrombogenicity of the subendothelium since, after an endothelial lesion, they may be directly accessible to blood platelets.

Polycystic kidney disease: a predominance of giant nephrons

1983 ◽  
Vol 244 (1) ◽  
pp. F3-F10 ◽  
Author(s):  
J. J. Grantham
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Renal Tubule ◽  
Collecting Duct ◽  
The United States ◽  
Basement Membranes ◽  
Renal Tubules ◽  
Polycystic Kidney ◽  
Distal Loop ◽  
Normal Diameter

Polycystic kidney disease is a bilateral disorder that affects approximately 200,000-400,000 persons in the United States. The most common form of the disease is inherited as an autosomal dominant trait (ADPKD). It typically causes renal insufficiency by the fifth or sixth decade of life. The disease is characterized by the progressive enlargement of a portion of renal tubule segments (proximal, distal, loop of Henle, collecting duct). The tubules enlarge from a normal diameter of 40 microns to several centimeters in diameter, causing marked gross and microscopic anatomic distortion. The cause of the cystic change in the tubules is unknown, but current possibilities include obstruction of tubule fluid flow by hyperplastic tubule cells, increased compliance of the tubule basement membranes, and/or increased radial growth of cells in specific portions of the renal tubule. Several studies show that the epithelia of the cysts continue to transport Na+, K+, Cl-, H+, and organic cations and anions in a qualitative fashion similar to that of the tubule segment from which they were derived. ADPKD, then, is a disease in which some gigantic renal tubules, over a period of several decades, impair the function of nonaffected nephrons and thereby lead to renal failure.

Physical Properties of Isolated Perfused Renal Tubular Basement Membranes

1971 ◽  
Vol 29 ◽  
pp. 390-391
Author(s):  
Jared Grantham ◽  
Larry Welling
Keyword(s):  
Basement Membrane ◽  
Basement Membranes ◽  
Transport Mechanisms ◽  
Permeability Characteristics ◽  
Peritubular Capillaries ◽  
Strategic Location ◽  
Tubular Lumen ◽  
Glomerular Filtrate ◽  
Urine Formation ◽  
Renal Tubular

In the course of urine formation in mammalian kidneys over 90% of the glomerular filtrate moves from the tubular lumen into the peritubular capillaries by both active and passive transport mechanisms. In all of the morphologically distinct segments of the renal tubule, e.g. proximal tubule, loop of Henle and distal nephron, the tubular absorbate passes through a basement membrane which rests against the basilar surface of the epithelial cells. The basement membrane is in a strategic location to affect the geometry of the tubules and to influence the movement of tubular absorbate into the renal interstitium. In the present studies we have determined directly some of the mechanical and permeability characteristics of tubular basement membranes.

scholarly journals SARS-CoV-2 infection and recurrence of anti-glomerular basement disease: a case report

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Alexander Winkler ◽  
Emanuel Zitt ◽  
Hannelore Sprenger-Mähr ◽  
Afschin Soleiman ◽  
Manfred Cejna ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Plasma Cells ◽  
Rapidly Progressive Glomerulonephritis ◽  
Kidney Injury ◽  
Pulmonary Involvement ◽  
Pulmonary Haemorrhage ◽  
Basement Membranes ◽  
High Avidity ◽  
History Of

Abstract Background Anti-glomerular basement membrane disease (GBM) disease is a rare autoimmune disease causing rapidly progressive glomerulonephritis and pulmonary haemorrhage. Recently, an association between COVID-19 and anti-glomerular basement membrane (anti-GBM) disease has been proposed. We report on a patient with recurrence of anti-GBM disease after SARS-CoV-2 infection. Case presentation The 31-year-old woman had a past medical history of anti-GBM disease, first diagnosed 11 years ago, and a first relapse 5 years ago. She was admitted with severe dyspnoea, haemoptysis, pulmonary infiltrates and acute on chronic kidney injury. A SARS-CoV-2 PCR was positive with a high cycle threshold. Anti-GBM autoantibodies were undetectable. A kidney biopsy revealed necrotising crescentic glomerulonephritis with linear deposits of IgG, IgM and C3 along the glomerular basement membrane, confirming a recurrence of anti-GBM disease. She was treated with steroids, plasma exchange and two doses of rituximab. Pulmonary disease resolved, but the patient remained dialysis-dependent. We propose that pulmonary involvement of COVID-19 caused exposure of alveolar basement membranes leading to the production of high avidity autoantibodies by long-lived plasma cells, resulting in severe pulmonary renal syndrome. Conclusion Our case supports the assumption of a possible association between COVID-19 and anti-GBM disease.

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