Genotoxic analysis of nickel–iron oxide in Drosophila

2020 ◽  
Vol 36 (11) ◽  
pp. 835-843
Author(s):  
Burhan Nas ◽  
Deniz Altun Çolak
Keyword(s):  
Iron Oxide ◽  
Biomedical Applications ◽  
Mutant Clone ◽  
Resonance Imaging ◽  
Genotoxic Effects ◽  
Genetic Changes ◽  
Nickel Iron ◽  
Recessive Genes ◽  
Wing Imaginal Discs ◽  
Recombination Assay

It is known that nickel–iron oxide nanocomposite (NiFe2O4NP) is used in many important areas such as modern industry, biomedical applications, magnetic resonance imaging, construction of sensors, targeted drug treatment, and photoelectric devices in our life. In this study, we have carried out a genotoxic evaluation of NiFe2O4NP (30 nm) in Drosophila melanogaster by using the wing somatic mutation and recombination assay. For this purpose, third instar larvae carrying the recessive genes ( flr3) and multiple wing hairs ( mwh) in their third chromosomes were used. The larvae were fed at concentrations ranging from 25 µg/mL to 200 µg/mL. The genotoxic effects of NiFe2O4NPs were evaluated according to mutant trichomes resulting from genetic changes (mitotic recombination, deletion, point mutation, nondisjunction) on development of the wing imaginal discs. Mutant clone evaluations were performed based on small single spots, large single spots, and twin spots classifications. The results showed that significant increases were observed in the frequency of all spots, indicating that the highest concentration of nanoparticles was able to induce genotoxic activity in the wing spot assay of D. melanogaster.

Iron Oxide Nanoparticles: An Insight into their Biomedical Applications

2015 ◽  
Vol 22 (15) ◽  
pp. 1808-1828 ◽  
Author(s):  
Diana Couto ◽  
Marisa Freitas ◽  
Felix Carvalho ◽  
Eduarda Fernandes
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Insight Into

Fluorine-mediated synthesis of anisotropic iron oxide nanostructures for efficient T2-weighted magnetic resonance imaging

Nanoscale ◽  
2021 ◽  
Author(s):  
Tao Sun ◽  
Yiding Liu ◽  
Chunyu Zhou ◽  
Liang Zhang ◽  
Xun Kang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Controlled Synthesis ◽  
Resonance Imaging ◽  
Fluoride Ions ◽  
Oxide Nanostructures ◽  
Weighted Magnetic Resonance Imaging ◽  
Shape Controlled ◽  
Novel Strategy ◽  
Iron Oxide Nanostructures

Herein, we developed a novel strategy for the shape-controlled synthesis of fluorine-doped iron oxide nanostructures with superior r2 values through the introduction of fluoride ions as a morphology controlling agent...

Biomineralized iron oxide–polydopamine hybrid nanodots for contrast-enhanced T1-weighted magnetic resonance imaging and photothermal tumor ablation

2021 ◽  
Vol 9 (7) ◽  
pp. 1781-1786
Author(s):  
Ze’ai Wang ◽  
Yanfeng Wang ◽  
Yuan Wang ◽  
Chaogang Wei ◽  
Yibin Deng ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Therapeutic Efficacy ◽  
Tumor Ablation ◽  
Resonance Imaging ◽  
Contrast Enhanced ◽  
Weighted Magnetic Resonance Imaging

Biomineralized iron oxide–polydopamine hybrid nanodots are constructed using albumin nanoreactors to facilitate contrast-enhanced T1-weighted magnetic resonance imaging as well as photothermal therapeutic efficacy.

scholarly journals Polyphosphorhydrazone-Based Radical Dendrimers

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1230
Author(s):  
Vega Lloveras ◽  
José Vidal-Gancedo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Biomedical Applications ◽  
Organic Radicals ◽  
Resonance Imaging ◽  
Metal Free ◽  
Antioxidant Agents ◽  
New Type ◽  
Paramagnetic Properties

The search for new biomedical applications of dendrimers has promoted the synthesis of new radical-based molecules. Specifically, obtaining radical dendrimers has opened the door to their use in various fields such as magnetic resonance imaging, as anti-tumor or antioxidant agents, or the possibility of developing new types of devices based on the paramagnetic properties of organic radicals. Herein, we present a mini review of radical dendrimers based on polyphosphorhydrazone, a new type of macromolecule with which, thanks to their versatility, new metal-free contrast agents are being obtained, among other possible applications.

scholarly journals Development of Molecular Magnetic Resonance Imaging Tools for Risk Stratification of Carotid Atherosclerotic Disease Using Dual-Targeted Microparticles of Iron Oxide

2021 ◽  
Author(s):  
Joyce M. S. Chan ◽  
Park Sung Jin ◽  
Michael Ng ◽  
Joanne Garnell ◽  
Chan Wan Ying ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
High Risk ◽  
Magnetic Resonance ◽  
Carotid Artery ◽  
Risk Stratification ◽  
Stroke Prevention ◽  
Inflammatory Activity ◽  
Resonance Imaging ◽  
Inflammatory Status

AbstractIdentification of patients with high-risk asymptomatic carotid plaques remains a challenging but crucial step in stroke prevention. Inflammation is the key factor that drives plaque instability. Currently, there is no imaging tool in routine clinical practice to assess the inflammatory status within atherosclerotic plaques. We have developed a molecular magnetic resonance imaging (MRI) tool to quantitatively report the inflammatory activity in atherosclerosis using dual-targeted microparticles of iron oxide (DT-MPIO) against P-selectin and VCAM-1 as a smart MRI probe. A periarterial cuff was used to generate plaques with varying degree of phenotypes, inflammation and risk levels at specific locations along the same single carotid artery in an Apolipoprotein-E-deficient mouse model. Using this platform, we demonstrated that in vivo DT-MPIO-enhanced MRI can (i) target high-risk vulnerable plaques, (ii) differentiate the heterogeneity (i.e. high vs intermediate vs low-risk plaques) within the asymptomatic plaque population and (iii) quantitatively report the inflammatory activity of local plaques in carotid artery. This novel molecular MRI tool may allow characterisation of plaque vulnerability and quantitative reporting of inflammatory status in atherosclerosis. This would permit accurate risk stratification by identifying high-risk asymptomatic individual patients for prophylactic carotid intervention, expediting early stroke prevention and paving the way for personalised management of carotid atherosclerotic disease.

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