The New York Angler Cohort Study: Exposure Characterization and Reproductive and Developmental Health

1996 ◽  
Vol 12 (3-4) ◽  
pp. 327-334 ◽  
Author(s):  
John E. Vena ◽  
Germaine M. Buck ◽  
Paul Kostyniak ◽  
Pauline Mendola ◽  
Edward Fitzgerald ◽  
...  
Keyword(s):  
New York ◽  
Breast Milk ◽  
New York State ◽  
Population Based ◽  
York State ◽  
Entire Cohort ◽  
Telephone Interviews ◽  
Current Consumption ◽  
Other Substances ◽  
Developmental Health

The New York State Angler Study will evaluate the association between past and current consumption of contaminated fish from Lake Ontario and both short- and long-term health effects in a population-based cohort. It will measure fish consumption and reproductive and developmental health among 10,518 male anglers and 6,651 of their wives or partners, as well as among 913 female anglers. To characterize exposure among subgroups of the cohort, further analytical methods were developed and implemented to measure specific polychlorinated biphenyls (PCB) congeners, methylmercury, and other substances in biological samples. Exposure assessment has been completed for a stratified random sample of 321 anglers. In addition, analyses for 79 congeners of PCBs are complete for 177 anglers. A special study of duck andturtle consumers currently is underway. Telephone interviews have been completed with 2,454 of the 2,999 women who planned a pregnancy between 1991 and 1994. The entire cohort of male anglers, partners of male anglers, and female anglers has been submitted for matching with the New York State live birth and fetal death registries to obtain lifetime reproductive histories. A medical record abstraction study will assess perinatal and developmental outcomes among the 3,442 births that occurred between 1986 and 1991. Finally, a study of breast milk from currently lactating women is underway, and 215 breast milk samples have been collected from the planned pregnancy subcohort. Progress on each of the study components is discussed herein.

scholarly journals Infertility treatment and autism risk using the Modified Checklist for Autism in Toddlers (M-CHAT)

2020 ◽  
Vol 35 (3) ◽  
pp. 684-693 ◽  
Author(s):  
S L Robinson ◽  
T Parikh ◽  
T Lin ◽  
E M Bell ◽  
E Heisler ◽  
...  
Keyword(s):  
New York ◽  
Study Design ◽  
Screening Tool ◽  
New York State ◽  
Population Based ◽  
Infertility Treatment ◽  
Autism Spectrum ◽  
Fertility Treatment ◽  
York State

Abstract STUDY QUESTION Are toddlers conceived by fertility treatment at higher risk of failing a screening tool for autism spectrum disorders (ASD) than toddlers not conceived by treatment? SUMMARY ANSWER Compared with children not conceived by infertility treatment, children conceived by any infertility treatment, ovulation induction with or without intrauterine insemination (OI/IUI), or assisted reproductive technologies (ART) appeared to have had higher odds of failing an ASD screening; however, results were inconclusive and need replication. WHAT IS KNOWN ALREADY Although most of the studies which have examined risk of ASD after ART show no association, the results are mixed. Thus, further studies are needed to clarify this association. STUDY DESIGN SIZE, DURATION The Upstate KIDS Study is a population-based, prospective cohort study of children born in New York State between 2008 and 2010. Children were screened for ASD using the Modified Checklist for Autism in Toddlers (M-CHAT) at ages 18 and 24 months. PARTICIPANTS/MATERIALS, SETTING, AND METHODS The New York State live-birth registry was used to identify newborns conceived with and without fertility treatment with a 1:3 ratio, frequency matched on region of birth. At 18 and 24 months, 3183 and 3063 mothers, respectively, completed the M-CHAT questionnaire. The current analysis included 2586 singletons and 1296 twins with M-CHAT information at 18 and/or 24 months. Multivariable logistic regression with generalized estimating equations (GEE) was used to estimate odds ratios (aOR) and 95% confidence intervals (CI) after adjustment for covariates such as maternal age, education and plurality. MAIN RESULTS AND THE ROLE OF CHANCE We found that 200 (5.2%) and 115 (3.0%) children failed the M-CHAT at 18 and 24 months, respectively. The associations between use of infertility treatment and failing the M-CHAT at 18 and/or 24 months were positive but inconclusive as they failed to exclude no association (18 months aOR 1.71, 95% CI: 0.81–3.61; 24 months aOR 1.78, 95% CI: 0.66–4.81; and both 18 and 24 months aOR 1.53, 95% CI: 0.78–2.99). The relationships between OI/IUI and ART with M-CHAT failure at 18 and/or 24 months were similar to those of using any fertility treatment. In vitro fertilization with intracytoplasmic sperm injection was not consistently positively or inversely associated with M-CHAT failure at each time point (18 months aOR 1.20, 95% CI: 0.51–2.83; 24 months aOR 0.93, 95% CI: 0.37–2.31; and both 18 and 24 months aOR 1.09, 95% CI: 0.50–2.60). LIMITATIONS REASONS FOR CAUTION The M-CHAT is a screening tool used for ASD risk assessment, and therefore, M-CHAT failure does not indicate ASD diagnosis. In addition, we did not have power to detect associations of small magnitude. Finally, non-response to follow-up may bias the results. WIDER IMPLICATIONS OF THE FINDINGS Despite lack of precision, the positive associations between ART and M-CHAT failure suggest that larger population-based studies with longer follow-up are needed. STUDY FUNDING/COMPETING INTEREST(S) Supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD; contracts HHSN275201200005C, HHSN267200700019C). The sponsor played no role in the study design, data collection, data analysis or interpretation, writing of the manuscript or decision to submit the article for publication. There are no conflicts of interest to declare. TRIAL REGISTRATION NUMBER Not applicable.

scholarly journals Pilot study of population-based newborn screening for spinal muscular atrophy in New York state

2017 ◽  
Vol 20 (6) ◽  
pp. 608-613 ◽  
Author(s):  
Jennifer N Kraszewski ◽  
Denise M Kay ◽  
Colleen F Stevens ◽  
Carrie Koval ◽  
Bianca Haser ◽  
...  
Keyword(s):  
New York ◽  
Pilot Study ◽  
Spinal Muscular Atrophy ◽  
Newborn Screening ◽  
Muscular Atrophy ◽  
New York State ◽  
Population Based ◽  
York State

A population-based survey of sun lamp and tanning parlor use in New York State, 1990

1994 ◽  
Vol 31 (3) ◽  
pp. 510-512 ◽  
Author(s):  
Patricia P. Lillquist ◽  
Mark S. Baptiste ◽  
Melissa A. Witzigman ◽  
Philip C. Nasca
Keyword(s):  
New York ◽  
New York State ◽  
Population Based ◽  
York State ◽  
Population Based Survey

scholarly journals Use and risks of surgical mesh for pelvic organ prolapse surgery in women in New York state: population based cohort study

BMJ ◽  
2015 ◽  
Vol 350 (jun02 1) ◽  
pp. h2685-h2685 ◽  
Author(s):  
B. Chughtai ◽  
J. Mao ◽  
J. Buck ◽  
S. Kaplan ◽  
A. Sedrakyan
Keyword(s):  
New York ◽  
Cohort Study ◽  
Pelvic Organ Prolapse ◽  
Surgical Mesh ◽  
New York State ◽  
Pelvic Organ ◽  
Population Based ◽  
Prolapse Surgery ◽  
York State ◽  
State Population

scholarly journals Deaths from Covid-19: Who are the forgotten victims?

2020 ◽  
Author(s):  
Kieran F. Docherty ◽  
Jawad H Butt ◽  
Rudolf A. de Boer ◽  
Pooja Dewan ◽  
Lars Køber ◽  
...  
Keyword(s):  
New York ◽  
The Netherlands ◽  
New York State ◽  
Population Based ◽  
Clinical Activity ◽  
National Agency ◽  
England And Wales ◽  
York State ◽  
Global Pandemic ◽  
Excess Deaths

AbstractBackgroundWith the spreading global pandemic of coronavirus disease 2019 (Covid-19) there has been disruption to normal clinical activity in response to the increased demand on health services. There are reports of a reduction in non-Covid-19 emergency presentations. Consequentially, there are concerns that deaths from non-Covid-19 causes could increase. We examined recent reported population-based mortality rates, compared with expected rates, and compared any excess in deaths with the number of deaths attributed to Covid-19.MethodsNational agency and death registration reports were searched for numbers of deaths attributed to Covid-19 and overall mortality that had been publicly reported by 22 April 2020. Data on the number of deaths attributed to Covid-19, the total number of deaths registered in the population and the historical average over at least 3 years were collected. Data were available for 3 Northern European countries (England & Wales, Scotland and the Netherlands) and New York State, United States of America.FindingsThere was an increase in observed, compared with expected, mortality in Scotland (+73%), England and Wales (+49%), the Netherlands (+65%) and New York state (+34%). Of these deaths, only 65% in Scotland, 68 % in England and Wales, 49% in the Netherlands and 73% in New York state were attributed to Covid-19 leaving a number of excess deaths not attributed to Covid-19.InterpretationA substantial proportion of excess deaths observed during the current COVID-19 pandemic are not attributed to COVID-19 and may represent an excess of deaths due to other causes.FundingNone

scholarly journals Elevated COVID-19 outcomes among persons living with diagnosed HIV infection in New York State: Results from a population-level match of HIV, COVID-19, and hospitalization databases

2020 ◽  
Author(s):  
James M. Tesoriero ◽  
Carol-Ann E. Swain ◽  
Jennifer L. Pierce ◽  
Lucila Zamboni ◽  
Meng Wu ◽  
...  
Keyword(s):  
New York ◽  
Severe Disease ◽  
New York State ◽  
Population Level ◽  
Population Based ◽  
Disease Stage ◽  
Hospital Death ◽  
Viral Load Suppression ◽  
York State ◽  
Hiv Surveillance

AbstractBackgroundNew York State (NYS) has been an epicenter for both COVID-19 and HIV/AIDS epidemics. Persons Living with diagnosed HIV (PLWDH) may be more prone to COVID-19 infection and severe outcomes, yet few population-based studies have assessed the extent to which PLWDH are diagnosed, hospitalized, and have died with COVID-19, relative to non-PLWDH.MethodsNYS HIV surveillance, COVID-19 laboratory confirmed diagnoses, and hospitalization databases were matched. COVID-19 diagnoses, hospitalization, and in-hospital death rates comparing PLWDH to non-PLWDH were computed, with unadjusted rate ratios (RR) and indirect standardized RR (sRR), adjusting for sex, age, and region. Adjusted RR (aRR) for outcomes among PLWDH were assessed by age/CD4-defined HIV disease stage, and viral load suppression, using Poisson regression models.ResultsFrom March 1-June 7, 2020, PLWDH were more frequently diagnosed with COVID-19 than non-PLWDH in unadjusted (RR [95% confidence interval (CI)]: 1.43[1.38-1.48), 2,988 PLWDH], but not in adjusted comparisons (sRR [95% CI]: 0.94[0.91-0.97]). Per-population COVID-19 hospitalization was higher among PLWDH (RR [95% CI]: 2.61[2.45-2.79], sRR [95% CI]: 1.38[1.29-1.47], 896 PLWDH), as was in-hospital death (RR [95% CI]: 2.55[2.22-2.93], sRR [95%CI]: 1.23 [1.07-1.40], 207 PLWDH), albeit not among those hospitalized (sRR [95% CI]: 0.96[0.83-1.09]). Among PLWDH, hospitalization risk increased with disease progression from HIV Stage 1 to Stage 2 (aRR [95% CI]:1.27[1.09-1.47]) and Stage 3 (aRR [95% CI]: 1.54[1.24-1.91]), and for those virally unsuppressed (aRR [95% CI]: 1.54[1.24-1.91]).ConclusionPLWDH experienced poorer COVID-related outcomes relative to non-PLWDH, with 1-in-522 PLWDH dying with COVID-19, seemingly driven by higher rates of severe disease requiring hospitalization.

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