Emerging Role of Melatonin and Melatonin Receptor Agonists in Sleep and Delirium in Intensive Care Unit Patients

2016 ◽  
Vol 31 (7) ◽  
pp. 451-455 ◽  
Author(s):  
Yoonsun Mo ◽  
Corey E. Scheer ◽  
George T. Abdallah
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Melatonin Receptor ◽  
Receptor Agonists ◽  
Melatonin Receptor Agonists

The role of melatonin and melatonin receptor agonist in the prevention of sleep disturbances and delirium in intensive care unit – a clinical review

2020 ◽  
Vol 69 ◽  
pp. 127-134 ◽  
Author(s):  
Katarzyna Lewandowska ◽  
Marta A. Małkiewicz ◽  
Mariusz Siemiński ◽  
Wiesław J. Cubała ◽  
Paweł J. Winklewski ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Clinical Review ◽  
Receptor Agonist ◽  
Sleep Disturbances ◽  
Melatonin Receptor

What Is the Role of α 2 -Adrenergic Receptor Agonists in the Intensive Care Unit?

2010 ◽  
pp. 548-552
Author(s):  
Robert D. Sanders ◽  
Pratik P. Pandharipande ◽  
E. Wesley Ely ◽  
Mervyn Maze
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Adrenergic Receptor ◽  
Receptor Agonists

scholarly journals Insomnia in general practice: the role of doxylamine

2020 ◽  
pp. 45-53
Author(s):  
D. I. Burchakov ◽  
M. V. Tardov
Keyword(s):  
Clinical Case ◽  
Health Impact ◽  
Sleep Disruption ◽  
Melatonin Receptor ◽  
Chronic Patients ◽  
Receptor Agonists ◽  
Clinical Case Studies ◽  
Specialized Care ◽  
Melatonin Receptor Agonists

The general practitioner encounters all three forms of insomnia: idiopathic, chronic and acute. Idiopathic and chronic patients should receive specialized care by neurologist, psychiatrist or sleep disorders specialists because they require deep differential diagnosis and complex treatment. Acute insomnia patients need quick help to prevent the negative health impact and chronisation of sleep disruption. In theRussian Federation, the GP has access to three kinds of sleep drugs: benzodiazepines, melatonin receptor agonists, antihistamines. However, modern benzodiazepines are unavailable inRussiaand older benzodiazepines can lead to dependence. Melatonin receptor agonists are not effective enough for acute insomnia. Among available antihistamines, doxylamine is the most convenient option in clinical practice. Doxylamine has a good profile of safety and efficacy, it is included in the local clinical guidelines for insomnia. Also, doxylamine is the only sleep drug available for pregnant women. This paper presents a portrait of doxylamine and comments on its clinical niches and contraindications. We also discuss the pharmacology of doxylamine, drug interactions, and prescription modes. There are also three clinical case studies, presenting the typical acute insomnia patients and logic for their evaluation, underlining key clinical features of this disorder.

scholarly journals Cardioprotective Melatonin: Translating from Proof-of-Concept Studies to Therapeutic Use

2019 ◽  
Vol 20 (18) ◽  
pp. 4342 ◽  
Author(s):  
Ovidiu Constantin Baltatu ◽  
Sergio Senar ◽  
Luciana Aparecida Campos ◽  
José Cipolla-Neto
Keyword(s):  
Machine Learning ◽  
Heart Diseases ◽  
Safety Data ◽  
Proof Of Concept ◽  
Melatonin Receptor ◽  
Phase 3 ◽  
Therapeutic Role ◽  
Receptor Agonists ◽  
Melatonin Receptor Agonists

In this review we summarized the actual clinical data for a cardioprotective therapeutic role of melatonin, listed melatonin and its agonists in different stages of development, and evaluated the melatonin cardiovascular target tractability and prediction using machine learning on ChEMBL. To date, most clinical trials investigating a cardioprotective therapeutic role of melatonin are in phase 2a. Selective melatonin receptor agonists Tasimelteon, Ramelteon, and combined melatonergic-serotonin Agomelatine, and other agonists with registered structures in CHEMBL were not yet investigated as cardioprotective or cardiovascular drugs. As drug-able for these therapeutic targets, melatonin receptor agonists have the benefit over melatonin of well-characterized pharmacologic profiles and extensive safety data. Recent reports of the X-ray crystal structures of MT1 and MT2 receptors shall lead to the development of highly selective melatonin receptor agonists. Predictive models using machine learning could help to identify cardiovascular targets for melatonin. Selecting ChEMBL scores > 4.5 in cardiovascular assays, and melatonin scores > 4, we obtained 284 records from 162 cardiovascular assays carried out with 80 molecules with predicted or measured melatonin activity. Melatonin activities (agonistic or antagonistic) found in these experimental cardiovascular assays and models include arrhythmias, coronary and large vessel contractility, and hypertension. Preclinical proof-of-concept and early clinical studies (phase 2a) suggest a cardioprotective benefit from melatonin in various heart diseases. However, larger phase 3 randomized interventional studies are necessary to establish melatonin and its agonists’ actions as cardioprotective therapeutic agents.

Role of Sildenafil in the Treatment of Persistent Pulmonary Hypertension of Newborn (PPHN) - Should it Be Withdrawn from Market of Bangladesh due to Threat of being Misuses

2020 ◽  
Vol 35 (2) ◽  
pp. 100-104
Author(s):  
Maksudur Rahman ◽  
Mohammad Abdullah Al Mamun ◽  
MAK Azad Chowdhury ◽  
Abu Sayeed Munsi
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cardiac Intensive Care Unit ◽  
Cross Sectional ◽  
Cardiac Intensive Care ◽  
Hospital Protocol

Background: Recently it has been apprehended that sildenafil, a drug which has been successfully using in the treatment of PPHN and erectile dysfunction in adult, is going to be withdrawn from the market of Bangladesh due to threat of its misuses. Objective: The aim of this study was to see the extent of uses of sildenafil in the treatment of PPHN and importance of availability of this drugs in the market inspite of its probable misuses. Methods: This cross sectional study was conducted in neonatal intensive care unit (NICU), special baby care unit (SCABU) and cardiac intensive care unit (CICU) of Dhaka Shishu (Children) Hospital from June, 2017 to May 2018. Neonates with PPHN were enrolled in the study. All cases were treated with oral sildenefil for PPHN along with others management according to hospital protocol. Data along with other parameters were collected and analyzed. Results: Total 320 patients with suspected PPHN were admitted during the study period. Among them 92 (29%) cases had PPHN. Male were 49(53 %) cases and female were 43(47%) cases. Mean age at hospital admission was 29.7±13.4 hours. Based on echocardiography,13(14%) cases had mild, 38 (41%) cases moderate and 41(45%) cases severe PPHN. Mean duration of sildenafil therapy was 11.9±7.1 days. Improved from PPHN were 83 (90%) cases. Mortality was 10% (9). Conclusion: In this study it was found that the incidence of PPHN is 29% among the suspected newborns. Sildenafil is successfull in improving the oxygenation of PPHN and to decrease the mortality of neonates. DS (Child) H J 2019; 35(2) : 100-104

Sa107 THE ROLE OF FECAL OCCULT BLOOD TEST IN THE EVALUATION OF ANEMIA IN THE INTENSIVE-CARE UNIT: A RETROSPECTIVE STUDY ASSESSING THE CLINICAL UTILITY OF THE TEST

2021 ◽  
Vol 160 (6) ◽  
pp. S-423-S-424
Author(s):  
Thanita Thongtan ◽  
Anasua Deb ◽  
Ashley Maveddat ◽  
Paibul Suriyawongpaisal ◽  
Passisd Laoveeravat ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Blood Test ◽  
Clinical Utility ◽  
Fecal Occult Blood Test ◽  
Occult Blood ◽  
Fecal Occult Blood ◽  
Occult Blood Test ◽  
Fecal Occult

scholarly journals Fluorine substituted methoxyphenylalkyl amides as potent melatonin receptor agonists

MedChemComm ◽  
2019 ◽  
Vol 10 (3) ◽  
pp. 460-464 ◽  
Author(s):  
Andrew Tsotinis ◽  
Rodanthi Kompogennitaki ◽  
Ioannis Papanastasiou ◽  
Peter J. Garratt ◽  
Alina Bocianowska ◽  
...  
Keyword(s):  
Side Chain ◽  
Melatonin Receptor ◽  
Receptor Agonists ◽  
Methoxy Groups ◽  
Melatonin Receptor Agonists

A series of fluorine substituted methoxyphenylalkyl amides were prepared with different orientations of the fluorine and methoxy groups with respect to the alkylamide side chain and with alkyl sides of differing lengths (n= 1–3).

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