Frenotomy in Infants with Tongue-Tie and Breastfeeding Problems

2018 ◽  
Vol 35 (4) ◽  
pp. 706-712 ◽  
Author(s):  
Anjana Srinivasan ◽  
Alex Al Khoury ◽  
Svetlana Puzhko ◽  
Carole Dobrich ◽  
Meira Stern ◽  
...  
Keyword(s):  
Medical Community ◽  
Rank Test ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Before And After ◽  
Signed Rank Test ◽  
Breastfeeding Counseling ◽  
The Right ◽  
Breastfeeding Problems ◽  
Numeric Rating

Background: Infant tongue-tie can cause breastfeeding problems, which may be improved by frenotomy. However, controversy exists among the medical community. Research aim: To examine the influence of frenotomy on infants with posterior ankyloglossia, by quantifying the changes in breastfeeding and maternal nipple pain using standardized tools. Methods: Newborns ( N = 30) below 12 weeks of age were recruited from the Herzl–Goldfarb Breastfeeding Clinic between April 2014 and April 2015. Diagnosis of posterior ankyloglossia was made clinically. Frenotomy was performed. Mothers received breastfeeding counseling before and after the procedure. Pain and breastfeeding were assessed before the procedure, immediately after the procedure, and after 2 days, 7 days and 14 days. Breastfeeding was assessed using the LATCH Tool and by subjective questioning. Maternal nipple pain was assessed using the Numeric Rating System. Results: No complications were reported with frenotomy. There was a significant improvement in LATCH score immediately post-frenotomy, with an increase in median scores from 7.5 to 8.5 ( p < .0001, Wilcoxon signed rank test). There was a significant decrease in median pain score immediately post-frenotomy, from 3.0 on the left nipple and 3.25 on the right nipple, to 0 bilaterally ( p < .0001, Wilcoxon signed rank test). Subjective improvement in breastfeeding was reported by 90% of mothers immediately after frenotomy and 83% of mothers at Day 14. Conclusion: Frenotomy for posterior ankyloglossia may improve breastfeeding and nipple pain.

scholarly journals Amprenavir and Efavirenz Pharmacokinetics before and after the Addition of Nelfinavir, Indinavir, Ritonavir, or Saquinavir in Seronegative Individuals

2005 ◽  
Vol 49 (8) ◽  
pp. 3373-3381 ◽  
Author(s):  
Gene D. Morse ◽  
Susan Rosenkranz ◽  
Michael F. Para ◽  
Yoninah Segal ◽  
Robin DiFrancesco ◽  
...  
Keyword(s):  
Confidence Intervals ◽  
Geometric Mean ◽  
Rank Test ◽  
Control Group ◽  
Median Percentage ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Before And After ◽  
Signed Rank Test ◽  
Aids Clinical Trials

ABSTRACT Adult AIDS Clinical Trials Group 5043 examined pharmacokinetic (PK) interactions between amprenavir (APV) and efavirenz (EFV) both by themselves and when nelfinavir (NFV), indinavir (IDV), ritonavir (RTV), or saquinavir (SQV) is added. A PK study was conducted after the administration of single doses of APV (day 0). Subjects (n = 56) received 600 mg of EFV every 24 h (q24h) for 10 days and restarted APV with EFV for days 11 to 13 with a PK study on day 14. A second protease inhibitor (PI) (NFV, 1,250 mg, q12h; IDV, 1,200 mg, q12h; RTV, 100 mg, q12h; or SQV, 1,600 mg, q12h) was added to APV and EFV on day 15, and a PK study was conducted on day 21. Controls continued APV and EFV without a second PI. Among subjects, the APV areas under the curve (AUCs) on days 0, 14, and 21 were compared using the Wilcoxon signed-rank test. Ninety-percent confidence intervals around the geometric mean ratios (GMR) were calculated. APV AUCs were 46% to 61% lower (median percentage of AUC) with EFV (day 14 versus day 0; P values of <0.05). In the NFV, IDV, and RTV groups, day 21 APV AUCs with EFV were higher than AUCs for EFV alone. Ninety-percent confidence intervals around the GMR were 3.5 to 5.3 for NFV (P < 0.001), 2.8 to 4.5 for IDV (P < 0.001), and 7.8 to 11.5 for RTV (P = 0.004). Saquinavir modestly increased the APV AUCs (GMR, 1.0 to 1.4; P = 0.106). Control group AUCs were lower on day 21 compared to those on day 14 (GMR, 0.7 to 1.0; P = 0.042). African-American non-Hispanics had higher day 14 efavirenz AUCs than white non-Hispanics. We conclude that EFV lowered APV AUCs, but nelfinavir, indinavir, or ritonavir compensated for EFV induction.

scholarly journals Effect of Sertraline on Uremic Pruritus Improvement in ESRD Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Mansor Shakiba ◽  
Hoshang Sanadgol ◽  
Hamid Reza Azmoude ◽  
Mohamad Ali Mashhadi ◽  
Hassan Sharifi
Keyword(s):  
Clinical Trial ◽  
Rank Test ◽  
Uremic Pruritus ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Before And After ◽  
Signed Rank Test ◽  
The Difference ◽  
Chronic Pruritus ◽  
Esrd Patients

Background. Although uremic pruritus is a common and upsetting problem of chronic kidney disease, there is no approved treatment for it. This study was undertaken to find the efficiency of sertraline as a possible treatment for uremic pruritus.Methods. 19 ESRD patients under hemodialysis with severe chronic pruritus were randomly selected to participate in this before-after clinical trial. Before and after starting treatment with sertraline, a detailed pruritus history was obtained and pruritus graded by the 30-item inventory of pruritus that patients based on priorities grade allocated to 3 classes. Subjects were treated with sertraline 50 mg oral daily for four months, with monthly assessments of pruritus symptoms.Results. Before treatment with sertraline, the grade of pruritus in 9 (47.4%) patients was moderate and severe in 10 (52.6%) patients. After treatment, grade of pruritus in 11 (57.8%) patients was weak, 6 (31.5%) have moderate and only 2 (10.7%) patients have severe pruritus. Of 10 patients with severe pruritus, 5 (50%) patients experiencing weak pruritus, and 4 (40%) patients have moderate pruritus after treatment. Based on Wilcoxon signed-rank test, the difference between the grade of pruritus before and after treatment with sertraline was significant (P=0.001).Conclusions. Although no definitive recommendation can be made regarding treatment of uremic pruritus, we found an increased antipruritic effect of sertraline in ESRD patients.

scholarly journals PENAMBAHAN LATIHAN CORE STABILITY PADA PROGRAM PELATIHAN ATLET DAYUNG UNTUK PENINGKATAN KECEPATAN MENDAYUNG

2017 ◽  
Author(s):  
Dyno Aryo Christanto ◽  
N. Adiputra ◽  
S. Indra Lesmana ◽  
Dw P. Sutjana ◽  
Made Muliarta ◽  
...  
Keyword(s):  
Training Program ◽  
Core Stability ◽  
Rank Test ◽  
P Value ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Before And After ◽  
Post Test ◽  
Signed Rank Test ◽  
The Difference

Introduction: Generally, core stability exercise as a training program is needed in almost kind of sport including paddle, analysis of movement in any kind of paddle sport such as kayak, canoe, or even rowing have been showed that the activity of core stability muscles are really needed. Purpose: purpose of this research is to know the effectivity of core stability exercise replenishment to increase sculling speed in paddle training program. Methods: This research is experimental with treatment by subject design project, involving 15 paddle athletes which divided into two groups and consists of II periods which are, Period I and Period II. In the 1st period, the athletes were given extra core stability exercise along with their normal paddling routine mean while in the 2nd period, the athletes only doing their normal paddling routine. Each period do the trial in 6 weeks, so this reseach took 12 weeks. In 1st period, the subjects were given extra core stability training 3 times a week along with their normal paddling routine where as subjects in period II only do their normal paddling routine. Results: The used of parametric paired t test is to know the difference of sculling speed before and after the trials were given. To period I pre test value is 3.80 ± 0.26 meters/second while the post test value is 4.06 ± 0.41 meters/second and the value 0.001 (p<0.05)mean while the 2nd period use Wilcoxon signed rank test to know the difference of sculling speed between before and after the trial were given resulting pre test value 3.80 ± 0.22 meters/second and post test value 3.91 ± 0.27 meters/second while the p value is 0.004 (p<0.05). After 12 weeks of sculling speed test between both period using Wilcoxon signed rank test and resulting obvions with period I value 0.26 ± 0.20 meters/second and period II value is 0.11 ± 0.12 meters/second along with p value 0.001 (p<0.05). Conclusion: Therefore, based on the result of my research test, we can concluded that the addition of core stability exercise in paddle training program is more effective to increase sculling speed.

scholarly journals PENGARUH PEMBERIAN KOMPRES AIR HANGAT TERHADAP PENURUNAN INTENSITAS NYERI DYSMENORRHEA PADA REMAJA PUTRI DI SMA NEGERI 10 KOTA BENGKULU

2020 ◽  
Vol 2 (2) ◽  
pp. 152-161
Author(s):  
Vellyza Colin ◽  
Buyung Keraman ◽  
Dwi Rolita
Keyword(s):  
Rating Scale ◽  
Numeric Rating Scale ◽  
Rank Test ◽  
P Value ◽  
Test Design ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Post Test ◽  
Signed Rank Test ◽  
Numeric Rating

ABSTRAK Masa pubertas yaitu bagian dari proses perkembangan dengan adanya kematangan organ seksual dan kemampuan bereproduksi, yang ditandai dengan terjadinya menstruasi pertama (menarche). Menstruasi adalah perubahan secara fisiologis pada perempuan. Dysmenorrhea adalah nyeri perut yang berasal dari kram rahim dan terjadi selama menstruasi. Beberapa perempuan mengalami sakit dan kram saat haid berlangsung. Rasa sakit biasanya terjadi di perut bagian bawah. Secara umum penanganan nyeri dismenore terbagi dalam dua kategori yaitu pendekatan farmakologis dan non farmakologis. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kompres air hangat terhadap penurunan intensitas nyeri dysmenorrhea pada remaja putri di SMA Negeri 10 Kota Bengkulu. Rancangan penelitian ini adalah Pra-Eksperiment dengan desain One-Group Pre-Post Test Design, menggunakan Accidental sampling dengan jumlah sampel 30 responden. Alat yang digunakan adalah kuesioner lembar karakteristik responden dan Numeric Rating Scale (NRS) untuk mengetahui intensitas nyeri. Analisis data menggunakan wilcoxon signed-rank test.  Hasil penelitian ini terdapat pengaruh pemberian kompres air hangat terhadap penurunan intensitas nyeri dysmenorrhea pada remaja putri di SMA Negeri 10 Kota Bengkulu diperoleh nilai Z = -4.801 dengan p-value=0,000<0,05 yang berarti signifikan. Diharapkan bagi sekolah dan siswi melakukan kompres air hangat sebagai salah satu alternatif terapi non farmakologis untuk mengurangi nyeri dysmenorrhea. Kata Kunci: Kompres Air Hangat, Nyeri Dysmenorrhea, Remaja Putri

UJI BEDA PREFERENSI BELANJA IMPOR BARANG KIRIMAN ATAS PERUBAHAN BATAS PEMBEBASAN BEA MASUK

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Himawan Yusuf
Keyword(s):  
Consumer Preferences ◽  
T Test ◽  
Rank Test ◽  
P Value ◽  
Average Value ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Before And After ◽  
Initial Hypothesis ◽  
Signed Rank Test

ABSTRACT: Modification of threshold exemption from import duties was tested whether changing consumer preferences in shopping from abroad. This study uses a paired test with the initial hypothesis that there is no difference in the daily average value of imports before and after the policy is applied. The research data is only from the Customs offices which have services for shipment items (32 offices) on October 1, 2019, to March 2, 2020. Descriptive statistical results show that the average was USD135,065, then dropped to USD127,430. Based on the results, both the Paired Sample T Test and The Wilcoxon Signed Rank Test obtained a p-value of 0,000, meaning that the initial hypothesis was rejected. The adoption of this policy has changed the preferences of consumers shopping from abroad. The Government's aim to reduce the trade balance deficit and protect domestic businesses appears to be successful, however, if there are no substitute goods available in the country, the import will only move from importing consignment goods to general imports. The novelty is the variable of import duty on shopping preferences is not widely used. The limitation of this study only measures changes in spending preferences, do not in state revenue.Keywords: shopping preference, consignment, tax exemption, difference test ABSTRAK:Perubahan kebijakan batas pembebasan terhadap bea masuk dan pajak atas impor barang kiriman diuji apakah merubah preferensi konsumen dalam berbelanja barang yang dikirim langsung dari luar negeri melalui mekanisme impor barang kiriman. Penelitian ini menggunakan metode kuantitatif melalui uji berpasangan dengan hipotesis awal tidak adanya perbedaan nilai rerata impor harian baik sebelum maupun setelah kebijakan berlaku. Data penelitian hanya kantor-kantor Bea Cukai yang memiliki pelayanan atas barang kiriman (32 kantor) pada 1 Oktober 2019 sampai dengan 2 Maret 2020. Hasil statistik deskriptif menunjukkan bahwa rerata harian impor sebelum kebijakan tersebut berlaku sebesar USD135.065, kemudian turun menjadi USD127.430. Berdasarkan pengujian, baik pada Paired Sampel T Test maupun pada Wilcoxon Signed Rank Test diperoleh nilai p sebesar 0.000 (hipotesis awal ditolak). Hal ini berarti penerapan kebijakan tersebut telah merubah preferensi belanja dari luar negeri melalui impor barang kiriman. Tujuan Pemerintah untuk mengurangi defisit neraca perdagangan dan melindungi usaha dalam negeri tampaknya berhasil, namun apabila belum tersedia barang subtitusi di dalam negeri, importasi tersebut hanya akan berpindah dari impor barang kiriman menjadi impor umum. Keterbaruan pada penelitian ini adalah variabel bea masuk pada preferensi belanja belum banyak digunakan. Keterbatasan penelitian ini hanya mengukur perubahan preferensi belanja, tidak mengukur perubahan penerimaan negara.Kata Kunci: preferensi belanja, impor barang kiriman, pembebasan pajak, uji beda

5HT in Migraine Patients with Medication-Induced Headache

Cephalalgia ◽  
1993 ◽  
Vol 13 (6) ◽  
pp. 410-412 ◽  
Author(s):  
R Hering ◽  
V Glover ◽  
K Pattichis ◽  
T Catarci ◽  
TJ Steiner
Keyword(s):  
Pilot Study ◽  
Chronic Daily Headache ◽  
Rank Test ◽  
Medication Withdrawal ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Before And After ◽  
Signed Rank Test ◽  
Medication Abuse ◽  
Daily Headache

Whole blood 5HT levels were measured in seven female migraine sufferers with chronic daily headache due to medication abuse, before and after abrupt medication withdrawal. A statistically significant increase in 5HT levels, from mean 4.89 mmol/1 to mean 6.59 mmol/I ( p < 0.05, Wilcoxon signed rank test), as well as a significant improvement in the number of headache-free days ( p < 0.05, Wilcoxon signed rank test), occurred after 4 weeks of withdrawal. We conclude from this pilot study that 5HT may be important in the physiopathogenesis of chronic daily headache. Alternatively, reduced 5HT may be the result of chronic daily headache or else an epiphenomenon.

Reduced antimicrobial prescribing during autogenous staphylococcal bacterin therapy: a retrospective study in dogs with pyoderma

2019 ◽  
Vol 184 (24) ◽  
pp. 739-739 ◽  
Author(s):  
Alison Wilson ◽  
Natalie Allers ◽  
David H Lloyd ◽  
Ross Bond ◽  
Anette Loeffler
Keyword(s):  
General Practice ◽  
Retrospective Study ◽  
Antimicrobial Therapy ◽  
Rank Test ◽  
Antimicrobial Prescribing ◽  
Signed Rank ◽  
Wilcoxon Signed Rank Test ◽  
Before And After ◽  
Signed Rank Test ◽  
Medical Histories

Autogenous staphylococcal bacterins are commonly mentioned as treatment for canine recurrent pyoderma but little is known about their efficacy. This retrospective study describes use and assesses efficacy of an autogenous Staphylococcus (pseud)intermedius bacterin in dogs with pyoderma. Frequency and duration of systemic antimicrobial therapy were compared 12 months before and after starting bacterin (Wilcoxon signed-rank test) with data extracted from general practice medical histories.

scholarly journals 68Ga-DOTATATE PET-CT as a tool for radiation planning and evaluating treatment responses in the clinical management of meningiomas

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Emily S. Kowalski ◽  
Rahul Khairnar ◽  
Anton A. Gryaznov ◽  
Vivek Kesari ◽  
Antony Koroulakis ◽  
...  
Keyword(s):  
Tumor Volume ◽  
Somatostatin Receptor ◽  
Post Treatment ◽  
Rank Test ◽  
Signed Rank ◽  
Pet Ct ◽  
Wilcoxon Signed Rank Test ◽  
Before And After ◽  
Signed Rank Test ◽  
The Impact

Abstract Background and purpose Meningiomas express the somatostatin receptor (SSTR), which normal bone and brain lack. PET imaging with SSTR ligands such as 68 Ga-DOTATATE have been recently shown to aid in the imaging and identification of menginiomas. We hypothesize that 68 Ga-DOTATATE PET/CT in conjunction with MRI aids in radiation (RT) target volume delineation and evaluating treatment response. Materials and methods Nineteen patients with meningiomas underwent 68 Ga-DOTATATE PET/CT and MRI for RT planning and/or post-treatment follow-up. Meningiomas were grade I (n = 9) or not biopsied (n = 8) and frequently involved base of skull (n = 10). Ten (53%) patients received post-operative RT and 9 (47%) received fractaionted RT. In the subgroup that underwent both pre- and post-RT 68 Ga-DOTATATE PET as well as MRI (n = 10), ROVER (ABX GmbH, Radeberg, Germany) adaptive thresholding software was utilized to measure total lesion activity (mean and max) before and after treatment. Tumor volume based on MRI was calculated before and after treatment. Total lesion activity and tumor volume changes were compared using Wilcoxon signed rank test. Results 68 Ga-DOTATATE PET/CT identified intraosseous (n = 4, 22%), falcine (n = 5, 26%) and satellite lesions (n = 3, 19%) and clarified the diagnosis of meningioma, resulting in a change in management in three patients. Mean total lesion activity decreased 14.7% (median), from pre to post-RT 68 Ga-DOTATATE PET [range 97–8.5% (25–75%),S = − 26.5, p = 0.0039]. Max total lesion activity decreased 36% (median) over the same period [range 105–15% (25–75%), S = − 26.5 p = 0.0039]. In contrast, meningioma volumes based on MRI measurements did not significantly change per RECIST criteria and Wilcoxon signed rank test (S = − 3, p = 0.7422). Conclusion 68 Ga-DOTATATE PET/CT helped confirm suspected diagnoses and delineate target volumes particularly when lesions involved osseous structures and the falx. Mean and max total tumor 68 Ga-DOTATATE activity on PET/CT decreased at three months following RT despite stable tumor volumes on MRI. Future studies are warranted to (1) assess the sensitivity and specificity of 68 Ga-DOTATATE PET/CT, (2) evaluate the impact of 68 Ga-DOTATATE PET/CT-based planning on treatment outcomes, and (3) assess the prognostic significance of these post-treatment imaging changes.

scholarly journals Perbandingan Tekanan Darah Sebelum dan Sesudah Olahraga Angkat Berat

2018 ◽  
Vol 6 (2) ◽  
Author(s):  
Griffta R. Manansang ◽  
Jimmy F. Rumampuk ◽  
Maya E. W. Moningka
Keyword(s):  
Blood Pressure ◽  
Physical Exercise ◽  
Random Sampling ◽  
Weight Lifting ◽  
Rank Test ◽  
Signed Rank ◽  
Significant Difference ◽  
Wilcoxon Signed Rank Test ◽  
Before And After ◽  
Signed Rank Test

Abstract: Physical exercise involves musculoskeletal system as well as the other systems inter alia cardiovascular system, respiratory system, and excretory system. During exercise, the organs experience acute adaptation, one of which is the increased work of the heart which can be monitored through blood pressure. Blood pressure can vary depending on the situations including physical exercise. This study was aimed to obtain the difference in blood pressure of weight lifters before and after weight lifting. A non-random sampling technique was performed with a cross-sectional design. This study was conducted at Hardcore Gym Manado from November to December 2015. There were 38 subjects consisting of 27 males (71.1%) and 11 females (28.9%). The results showed that there were differences in systolic and diastolic blood pressures between before and after weight lifting, as follows: the means of systolic blood pressure before and after weight lifting were 113.947±7.8290 vs 197.315±9.4871 mmHg and the means of diastolic blood pressure before and after weight lifting were 77.157±5.3551 vs. 95.473±4.0983 mmHg. The Wilcoxon signed rank test showed a significant difference in blood pressure before and after weight lifting (P=0.000). Conclusion: There are differences in blood pressure before and after weight lifting among weight lifters.Keywords: blood pressure, weight lifting Abstrak: Olahraga tidak hanya melibatkan sistem muskuloskeletal semata, namun juga mengikutsertakan sistem lain seperti sistem kardiovaskular, sistem respirasi, sistem ekskresi. Organ-organ tubuh mengalami adaptasi akut, salah satunya meningkatkanya kerja jantung yang dapat dilihat melalui tekanan darah. Tekanan darah dapat berubah-ubah bergantung situasi seperti olahraga. Penelitian ini bertujuan untuk mengetahui perbandingan tekanan darah sebelum dan sesudah olahraga angkat berat. Penelitian ini dilakukan pada pelaku olahraga angkat berat di Hardcore Gym Manado yang dilaksanakan pada bulan November-Desember 2015. Penelitian ini menggunakan teknik non random sampling dengan desain potong lintang yang dilakukan pada 38 subyek. Subyek berjenis kelamin laki-laki sebanyak 27 orang (71,1%) dan yang berjenis kelamin perempuan sebanyak 11 orang (28,9%). Hasil penelitian menunjukkan terdapat perbedaan hasil pengukuran tekanan darah sistolik (TDS) dan tekanan darah diastolik (TDD) sebelum dan sesudah olahraga angkat berat yaitu TDS sebelum dan sesudah olahraga angkat berat sebesar 113,947±7,8290 vs 197,315±9,4871 mmHg dan TDD sebelum dan sesudah olahraga angkat berat sebesar 77,157±5,3551 vs 95,473±4,0983 mmHg. Hasil uji Wilcoxon signed rank test menunjukkan perbedaan tekanan darah sebelum dan sesudah olahraga angkat berat yang bermakna dengan nilai P=0,000. Simpulan: Terdapat perbedaan tekanan darah yang bermakna sebelum dan sesudah olahraga angkat berat pada pelaku olahraga angkat berat.Kata kunci: tekanan darah, olahraga angkat berat

scholarly journals ANALISIS ABNORMAL RETURN DAN LIKUIDITAS SAHAM SEBELUM DAN SESUDAH STOCK SPLIT PERIODE 2008-2012

2015 ◽  
Vol 11 (1) ◽  
pp. 10
Author(s):  
Wening Asriningsih
Keyword(s):  
Event Study ◽  
Abnormal Return ◽  
T Test ◽  
Rank Test ◽  
Signed Rank ◽  
Significant Difference ◽  
Wilcoxon Signed Rank Test ◽  
Stock Split ◽  
Before And After ◽  
Signed Rank Test

Abstrak: Analisis Abnormal Return dan Likuiditas Saham Sebelum dan Sesudah Stock Split Periode 2008-2012. Penelitian ini bertujuan untuk mengetahui perbedaan abnormal return dan likuiditas saham sebelum dan sesudah stock split di perusahaan yang terdaftar di Bursa Efek Indonesia periode 2008-2012. Penelitian ini menggunakan desain event study, dimana dilakukan pengamatan 10 hari sebelum dan 10 hari sesudah peristiwa. Analisis data yang digunakan dalam penelitian ini adalah Uji Paired Sampel t-test dan Uji Wilcoxon Signed Rank test. Hasil penelitian menunjukkan bahwa tidak terdapat perbedaan abnormal return namun terdapat perbedaan likuiditas yang signifikan sebelum dan sesudah stock split periode 2008-2012. Hasil penelitian ini juga menunjukkan bahwa stock split mampu meningkatkan likuiditas.Kata kunci: stock split, abnormal return, likuiditas.Abstract: The Analysis of Abnormal Return and Liquidity Before and After Stock Split in 2008-2012. This study is aimed to find out the differences abnormal return and liquidity before and after stock split at the companies listed for the period of 2008 – 2012. This study is using event study, in which the writer observed within 10 days before and 10 days after the event date. Data analysis that is uses in this research is Paired Sample t-test and Wilcoxon Signed Rank test. The result of the study show that: there was no differences in abnormal return but there was a significant difference in liquidity before and after stock split. The result of this study indicate the stock split may improve liquidity.Key words: stock split, abnormal return, liquidity

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