Association of Serum Cholesterol and Triglyceride Levels with Agitation and Cognitive Function in a Geropsychiatry Unit

1996 ◽  
Vol 9 (2) ◽  
pp. 53-56 ◽  
Author(s):  
Claudia A. Orengo ◽  
Mark E. Kunik ◽  
Victor A. Molinari ◽  
Thomas A. Teasdale ◽  
Richard H. Workman ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Serum Cholesterol ◽  
Serum Triglyceride ◽  
Correlation Coefficients ◽  
Significant Negative Correlation ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Elderly Inpatients ◽  
Comprehensive Evaluations ◽  
Relationship Of

Several studies have reported an association between aggression and cholesterol levels. The purpose of this study was to investigate the relationship of serum cholesterol and triglyceride levels with aggression and cognitive function in elderly inpatients. One hundred ten patients consecutively admitted to the Geriatric Psychiatry inpatient unit at Houston's Veterans Affairs Hospital received comprehensive evaluations by a multidisciplinary team. Fasting serum cholesterol and triglyceride levels were obtained within 3 days of admission. In addition, two geriatric psychiatrists administered the Mini-Mental State Examination (MMSE) and the Cohen-Mansfield Agitation Inventory (CMAI). Correlation coefficients were calculated between lipid levels, CMAI total and subscale scores, and MMSE scores. Multiple linear-regression analyses were done to further investigate the relation between lipid concentrations and various confounders. We found no significant correlation between serum triglyceride levels and MMSE, CMAI total, and CMAI factor scores. In addition, we found a significant positive correlation between serum cholesterol levels and physical nonaggressive behavior, and a significant negative correlation between serum cholesterol levels and MMSE scores. We found no relationship between aggressive behavior and serum cholesterol or triglyceride levels. However, an association between high cholesterol levels and agitation exists, which may be mediated by the association between high cholesterol levels and impaired cognition.

Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet

2011 ◽  
Vol 301 (6) ◽  
pp. G1031-G1043 ◽  
Author(s):  
Yoshihiro Kamada ◽  
Shinichi Kiso ◽  
Yuichi Yoshida ◽  
Norihiro Chatani ◽  
Takashi Kizu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Liver Injury ◽  
Postmenopausal Women ◽  
Serum Cholesterol ◽  
Estrogen Deficiency ◽  
Macrophage Infiltration ◽  
High Cholesterol ◽  
High Fat ◽  
Gene Expressions ◽  
Cholesterol Levels

Recent studies indicate an accelerated progression of nonalcoholic steatohepatitis (NASH) in postmenopausal women. Hypercholesterolemia, an important risk factor for NASH progression, is often observed after menopause. This study examined the effects of estrogen on NASH in ovariectomized (OVX) mice fed a high-fat and high-cholesterol (HFHC) diet. To investigate the effects of estrogen deficiency, OVX mice and sham-operated (SO) mice were fed normal chow or HFHC diet for 6 wk. Next, to investigate the effects of exogenous estrogen replenishment, OVX mice fed with HFHC diet were treated with implanted hormone release pellets (containing 17β-estradiol or placebo vehicle) for 6 wk. OVX mice on the HFHC diet showed enhanced liver injury with increased liver macrophage infiltration and elevated serum cholesterol levels compared with SO-HFHC mice. Hepatocyte monocyte chemoattractant protein-1 (MCP1) protein expression in OVX-HFHC mice was also enhanced compared with SO-HFHC mice. In addition, hepatic inflammatory gene expressions, including monocytes chemokine (C-C motif) receptor 2 (CCR2), were significantly elevated in OVX-HFHC mice. Estrogen treatment improved serum cholesterol levels, liver injury, macrophage infiltration, and inflammatory gene expressions in OVX-HFHC mice. Moreover, the elevated expression of liver CCR2 and MCP1 were decreased by estrogen treatment in OVX-HFHC mice, whereas low-density lipoprotein dose dependently enhanced CCR2 expression in THP1 monocytes. Our study demonstrated that estrogen deficiency accelerated NASH progression in OVX mice fed HFHC diet and that this effect was improved by estrogen therapy. Hypercholesterolemia in postmenopausal women would be a potential risk factor for NASH progression.

Relationship of Mental and Emotional Stress to Serum Cholesterol Levels.

1958 ◽  
Vol 97 (1) ◽  
pp. 163-165 ◽  
Author(s):  
P. T. Wertlake ◽  
A. A. Wilcox ◽  
M. I. Haley ◽  
J. E. Peterson
Keyword(s):  
Emotional Stress ◽  
Serum Cholesterol ◽  
Cholesterol Levels ◽  
Relationship Of

SERUM CHOLESTEROL LEVELS AND COGNITIVE FUNCTION ASSESSED BY P300 LATENCIES IN AN OLDER POPULATION LIVING IN THE COMMUNITY

1997 ◽  
Vol 45 (1) ◽  
pp. 122-123 ◽  
Author(s):  
Tomoko Wada ◽  
Kozo Matsubayashi ◽  
Kiyohito Okumiya ◽  
Shigeaki Kimura ◽  
Yasushi Osaki ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Serum Cholesterol ◽  
Older Population ◽  
Cholesterol Levels

Helicobacter pylori infection, serum triglyceride and serum cholesterol levels: A step atherosclerosis?

1998 ◽  
Vol 114 ◽  
pp. A218 ◽  
Author(s):  
C. Martín-de-Argila ◽  
D Boixeda ◽  
R Cantón ◽  
S Valdezate ◽  
JP Gisbert ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Serum Cholesterol ◽  
Serum Triglyceride ◽  
Helicobacter Pylori Infection ◽  
Cholesterol Levels

scholarly journals Metabolic Effects of Two Different Doses of Venlafaxine Therapy on Rats

2015 ◽  
Vol 61 (3) ◽  
pp. 196-199
Author(s):  
Imre Annamária ◽  
Kolcsár Melinda ◽  
Groşan Alexandra ◽  
M Imre ◽  
Dogaru Maria Titica
Keyword(s):  
Serum Cholesterol ◽  
Serum Triglyceride ◽  
Metabolic Effects ◽  
Control Group ◽  
Glucose Levels ◽  
Cholesterol Levels ◽  
Norepinephrine Reuptake Inhibitor ◽  
The Mean ◽  
Access To Food ◽  
Different Doses

AbstractObjectives: Venlafaxine is an antidepressant, categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI) with suspected metabolic side effects. The aim of our study was to assess these metabolic effects in rats, using two different doses of venlafaxine.Materials: Three groups of Wistar rats have been treated with venlafaxine during seven weeks. The rats have received a daily dose of 10mg/kg (D1) and 40 mg/kg (D2) while the control group (Dc) has received no treatment. Rats were given “ad libitum” access to food and water. The rats were weighted at treatment day 0, 7, 14, 21, 28, 35, 42 and 49. After completion of venlafaxine treatment, the rats were sacrificed, blood was harvested and the following biochemical parameters have been determined from the centrifuged plasma: triglycerides, glucose and total cholesterol levels.Results: Both the 10 mg/kg and the 40 mg/kg dose venlafaxine therapy resulted in a highly significant increase of rat’s weight. Compared with the control group the mean weight of D1 group has increased with 130.5 ±21.79 g (<0.01) while the mean weight of the second group increased with 94±24.16 g (p<0.01). In addition weight gain of D1 group was significantly higher than that of D2 group (p<0.01). Venlafaxine therapy induced significant increase in serum triglyceride levels (140.04±55.46 mg/dL p<0.01, 83.59±52.85 mg/dL p=0.05). This metabolic effect has been shown to be more evident in case of 10mg/kg dose therapy (p=0.03). Simultaneously, serum cholesterol levels have been reduced, however this decrease proved to be significant only in case of group D2 (p=0.03). Despite of increased triglyceride values, glucose levels were significantly decreased in both treated groups (133.33±36.18mg/dL p=0.05, 118.10±51.98 mg/dL p=0.02).Conclusions: Our results suggest that venlafaxine administrated to rats has unwished dose related metabolic effects such as significant increase in weight and hypertriglyceridemia, however serum cholesterol and plasma glucose levels appears to be decreased by this medication.

scholarly journals The relationship of diet to serum cholesterol levels in young men in Antarctica

1970 ◽  
Vol 24 (1) ◽  
pp. 307-312 ◽  
Author(s):  
D. L. Easty
Keyword(s):  
Total Cholesterol ◽  
Serum Cholesterol ◽  
Serum Levels ◽  
Skinfold Thickness ◽  
Positive Correlation ◽  
Total Intake ◽  
Total Food Intake ◽  
Cholesterol Levels ◽  
Total Food ◽  
Relationship Of

1. Regular estimations of dietary intake, body-weight, skinfold thickness, blood pressure and pulse rate, and serum lipids were made in twenty-four members of an Antarctic expedition over 1 year.2. The mean levels of serum total cholesterol, phospholipids, and triglycerides were 198.5 ±4.85 mg/100 ml, 221.4±5.73 mg/100 ml and 120.9±13.53 mg/100 ml respectively.3. A positive correlation was found between the total intake of fat expressed as calories and the following serum lipid levels: total cholesterol, β-cholesterol, and the cholesterol:phospholipid ratio. Significant positive correlation was also found between the latter serum levels and fat when expressed as a percentage of the total food intake.4. This correlation has not been found in small groups before, and is due to the fact that each estimation was the result of several assessments made over 1 year.5. The survey suggests that the personal serum cholesterol level may be dependent upon the habitual total intake of dietary fat and the percentage of the total calories supplied by fat.

scholarly journals Analysis of Serum Cholesterol, Statins and Atherosclerotic Plaque in Ruptured and Unruptured Intracranial Aneurysm

2022 ◽  
Author(s):  
Leonardo Zumerkorn Pipek ◽  
Nícollas Nunes Rabelo ◽  
Henrique Zumerkorn Pipek ◽  
Joao Paulo Mota Telles ◽  
Natalia Camargo Barbat ◽  
...  
Keyword(s):  
Intracranial Aneurysm ◽  
Atherosclerotic Plaque ◽  
Serum Cholesterol ◽  
Linear Regression Models ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Reduce Serum Cholesterol ◽  
Radiological Images ◽  
The Impact

Abstract Introduction Intracranial aneurysm (IA) is a major healthcare concern. The use of statin to reduce serum cholesterol has shown evidence to reduce cardiovascular risk in various diseases, but the impact on IA has not been described. This study aims to determine whether statin use, and serum cholesterol levels interfere with outcomes after IA event. Methods A cohort of patients with IA was analyzed. Patients social and demographics data were collected. Modified Rankin scale (mRS) score after 6 months of follow-up was the endpoint. The data regarding statins use, presence or not of atherosclerotic plaque in radiological images and serum cholesterol of 35 patients were included in our study. Linear regression models were used to determine the influence of those 6 variables in the clinical outcome. Results The prevalence of atherosclerotic plaque, high cholesterol and use of statins was 34.3%, 48.5%, and 14.2%, respectively. Statins and serum cholesterol did not impact the overall outcome, measured by mRS after 6 months (p > 0.05), but did show different tendencies when separated by IA rupture status. Serum cholesterol shows an important association with rupture of aneurysm (p = 0.0382). High cholesterol and use of statins show a tendency for worse outcome with ruptured aneurysm, and the opposite is true for unruptured aneurysm. The presence of atherosclerotic plaques was not related with worse outcomes. Conclusions Multiple and opposite mechanisms might be involved in the pathophysiology of IA. Ruptured aneurysms are associated with higher levels of serum cholesterol. Serum cholesterol and statins use were not correlated with worse outcomes, but further studies are important to clarify these relationships.

The effect of diabetes mellitus on aortic prostanoid synthesis and serum cholesterol levels in the rat fed a high cholesterol diet

Life Sciences ◽  
1990 ◽  
Vol 47 (6) ◽  
pp. 587-594 ◽  
Author(s):  
Stuart I. Myers ◽  
Lori Bartula ◽  
Mike Linzel ◽  
Tam Phan ◽  
Pa Jong Jung ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Serum Cholesterol ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Prostanoid Synthesis
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