scholarly journals The relationship of diet to serum cholesterol levels in young men in Antarctica

1970 ◽  
Vol 24 (1) ◽  
pp. 307-312 ◽  
Author(s):  
D. L. Easty

1. Regular estimations of dietary intake, body-weight, skinfold thickness, blood pressure and pulse rate, and serum lipids were made in twenty-four members of an Antarctic expedition over 1 year.2. The mean levels of serum total cholesterol, phospholipids, and triglycerides were 198.5 ±4.85 mg/100 ml, 221.4±5.73 mg/100 ml and 120.9±13.53 mg/100 ml respectively.3. A positive correlation was found between the total intake of fat expressed as calories and the following serum lipid levels: total cholesterol, β-cholesterol, and the cholesterol:phospholipid ratio. Significant positive correlation was also found between the latter serum levels and fat when expressed as a percentage of the total food intake.4. This correlation has not been found in small groups before, and is due to the fact that each estimation was the result of several assessments made over 1 year.5. The survey suggests that the personal serum cholesterol level may be dependent upon the habitual total intake of dietary fat and the percentage of the total calories supplied by fat.

1998 ◽  
pp. 141-145 ◽  
Author(s):  
G Michalopoulou ◽  
M Alevizaki ◽  
G Piperingos ◽  
D Mitsibounas ◽  
E Mantzos ◽  
...  

OBJECTIVE: The association between established hypothyroidism and high cholesterol levels is well known. The aim of the present study was to investigate the effect of thyroxine (T4) administration on cholesterol levels in hypercholesterolemic subjects with TSH levels within the normal range ('high-normal' TSH compared with 'low-normal' TSH). DESIGN AND METHODS: We determined TSH levels in 110 consecutive patients referred for hypercholesterolemia (serum cholesterol >7.5 mmol/l). Those with 'high-normal' TSH (2.0-4.0 microU/ml) as well as those with 'low-normal' TSH (0.40-1.99 microU/ml) were randomly assigned to receive either 25 or 50 microg T4 daily for two months. Thus, groups A and B (low-normal TSH) received 25 and 50 microg T4 respectively and groups C and D (high-normal TSH) received 25 and 50 microg T4 respectively. Serum T4, tri-iodothyronine (T3), TSH, free thyroxine index, resin T3 uptake and thyroid autoantibodies (ThAab) as well as total cholesterol, high and low density lipoprotein cholesterol (HDL, LDL), and triglycerides were determined before and at the end of the two-month treatment period. RESULTS: TSH levels were reduced in all groups. The most striking effect was observed in group D (TSH levels before: 2.77+/-0.55, after: 1.41+/-0.85 microU/ml, P < 0.01). Subjects in groups C and D had a higher probability of having positive ThAabs. A significant reduction in total cholesterol (P < 0.01) and LDL (P < 0.01) was observed after treatment only in group D. In those subjects in group D who were ThAab negative, there was no significant effect of thyroxine on cholesterol levels. CONCLUSIONS: Subjects with high-normal TSH levels combined with ThAabs may, in fact, have subclinical hypothyroidism presenting with elevated cholesterol levels. It is possible that these patients might benefit from thyroxine administration.


1958 ◽  
Vol 97 (1) ◽  
pp. 163-165 ◽  
Author(s):  
P. T. Wertlake ◽  
A. A. Wilcox ◽  
M. I. Haley ◽  
J. E. Peterson

1996 ◽  
Vol 9 (2) ◽  
pp. 53-56 ◽  
Author(s):  
Claudia A. Orengo ◽  
Mark E. Kunik ◽  
Victor A. Molinari ◽  
Thomas A. Teasdale ◽  
Richard H. Workman ◽  
...  

Several studies have reported an association between aggression and cholesterol levels. The purpose of this study was to investigate the relationship of serum cholesterol and triglyceride levels with aggression and cognitive function in elderly inpatients. One hundred ten patients consecutively admitted to the Geriatric Psychiatry inpatient unit at Houston's Veterans Affairs Hospital received comprehensive evaluations by a multidisciplinary team. Fasting serum cholesterol and triglyceride levels were obtained within 3 days of admission. In addition, two geriatric psychiatrists administered the Mini-Mental State Examination (MMSE) and the Cohen-Mansfield Agitation Inventory (CMAI). Correlation coefficients were calculated between lipid levels, CMAI total and subscale scores, and MMSE scores. Multiple linear-regression analyses were done to further investigate the relation between lipid concentrations and various confounders. We found no significant correlation between serum triglyceride levels and MMSE, CMAI total, and CMAI factor scores. In addition, we found a significant positive correlation between serum cholesterol levels and physical nonaggressive behavior, and a significant negative correlation between serum cholesterol levels and MMSE scores. We found no relationship between aggressive behavior and serum cholesterol or triglyceride levels. However, an association between high cholesterol levels and agitation exists, which may be mediated by the association between high cholesterol levels and impaired cognition.


2010 ◽  
Vol 13 (11) ◽  
pp. 1818-1825 ◽  
Author(s):  
Tove Nystad ◽  
Marita Melhus ◽  
Magritt Brustad ◽  
Eiliv Lund

AbstractObjectiveTo assess coffee consumption in the Sami and Norwegian populations and to investigate the impact of unfiltered boiled coffee consumption on serum cholesterol concentrations.DesignA cross-sectional study. Information was collected by self-administrated questionnaires and total serum cholesterol was analysed. Participants were divided into three ethnic groups: Sami I (Sami used as home language in the last three generations), Sami II (at least one Sami identity marker) and Norwegian.SettingIn an area with Sami, Kven/Finnish and Norwegian populations, the SAMINOR study, 2003–2004.SubjectsA total of 5647 men and 6347 women aged 36–79 years.ResultsMore than 90 % of the study populations were coffee drinkers. Only 22 % were unfiltered coffee consumers. Sami I had the highest proportion of participants who consumed nine or more cups of unfiltered coffee per day, although the number of participants was limited. Total coffee consumption was associated with increased total cholesterol for men (P < 0·01) and women (P < 0·0001). For those who drank only unfiltered coffee, a significant association was found only in Norwegian men, adjusted for physical activity in leisure time, BMI and smoking habits (P < 0·001). From the lowest (less than five cups) to the highest (nine or more cups) unfiltered coffee consumption category, the mean total cholesterol levels increased by 0·29 mmol/l in Norwegian men.ConclusionsUnfiltered coffee consumption was lower in the present study compared to previous reports. In general, total coffee consumption was positively associated with total cholesterol levels. However, for unfiltered coffee consumption, an association was found only in Norwegian men.


2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Marcus A. Ulleryd ◽  
Evelina Bernberg ◽  
Li Jin Yang ◽  
Göran M. L. Bergström ◽  
Maria E. Johansson

A few studies in animals and humans suggest that metoprolol (β1-selective adrenoceptor antagonist) may have a direct antiatherosclerotic effect. However, the mechanism behind this protective effect has not been established. The aim of the present study was to evaluate the effect of metoprolol on development of atherosclerosis in ApoE−/−mice and investigate its effect on the release of proinflammatory cytokines. Male ApoE−/−mice were treated with metoprolol (2.5 mg/kg/h) or saline for 11 weeks via osmotic minipumps. Atherosclerosis was assessed in thoracic aorta and aortic root. Total cholesterol levels and Th1/Th2 cytokines were analyzed in serum and macrophage content in lesions by immunohistochemistry. Metoprolol significantly reduced atherosclerotic plaque area in thoracic aorta (P<0.05versus Control). Further, metoprolol reduced serum TNFαand the chemokine CXCL1 (P<0.01versus Control for both) as well as decreasing the macrophage content in the plaques (P<0.01versus Control). Total cholesterol levels were not affected. In this study we found that a moderate dose of metoprolol significantly reduced atherosclerotic plaque area in thoracic aorta of ApoE−/−mice. Metoprolol also decreased serum levels of proinflammatory cytokines TNFαand CXCL1 and macrophage content in the plaques, showing that metoprolol has an anti-inflammatory effect.


2020 ◽  
Vol 1 (1) ◽  
pp. 18-30
Author(s):  
Reni Purnama Indah Lestari ◽  
Harna ◽  
Anugrah Novianti

High cholesterol levels constitute 56% of the factors that contribute greatly to the cause of CHD. Coronary heart disease (CHD) is a disease of the heart and blood vessels caused by narrowing of the coronary arteries. The purpose of this study to analyze the relationship of sports habits, circumference waist hip ratio, consumption pattern, level of fiber adequacy, and smoking habits with total cholesterol levels heart policlinic patients RSUD Banten. This type of research uses a cross sectional design, with a sample of 96 respondents namely heart policlinic patients. Analysis of the data used in this study is the Chi-square test. The Results show Respondents with normal nutritional status were 66.70%, respondents who consumed cholesterol-lowering drugs were 55.2%. Respondents with normal cholesterol levels were 53.10%, respondents with exercise habits were 56.25%, respondents with RLPP were at a risk of 71.87%. Respondents did not smoke as much as 66.70%. There was a relationship between exercise habits, hip waist circumference ratio, to total cholesterol levels (p <0.05). There is no relationship between smoking habits on total cholesterol levels (p> 0.05). This study concluded that the sports habits, RLPP, affect total cholesterol levels, while smoking does not affect total cholesterol levels.    


2019 ◽  
Vol 2 (2) ◽  
pp. 72
Author(s):  
Fadhil Kurniawan ◽  
Slamet Slamet ◽  
Laila Kamilla

Abstract: Cholesterol is often seen as something that is very scary and associate high levels of cholesterol in the blood with the risk of heart disease. Increasing cholesterol levels are something to avoid because it can endanger health. The purpose of this study was to examine the relationship age, sex, and obesity with total cholesterol levels on teachers SMAN 1 Sei. Raya. The design in this study using Cross-Sectional. The population of this study is all teachers SMAN 1 Sei. Raya took with total sampling method and obtained as many as 46 respondents. From each respondent obtained data onto age, sex, obesity level and measurement of total cholesterol level. Data were analyzed by univariate and bivariate with correlation test for Kendall tau with value ɑ = 0.05. The test result using Kendall tau to analyze the relationship of age, sex, and obesity with total cholesterol showed that there is no relationship between age (p = 0.648), sex (p = 0.418), and obesity (p = 0.542) with total cholesterol levels in teachers SMAN 1 Sei. Raya.Abstrak: Kolesterol sering dilihat sebagai sesuatu yang sangat menakutkan dan tingginya kadar kolesterol dalam darah dikaitan dengan risiko penyakit jantung. Peningkatan kadar kolesterol merupakan hal yang harus dihindari, karena dapat membahayakan kesehatan. Tujuan penelitian ini adalah untuk mengkaji hubungan antara umur, jenis kelamin dan kegemukan dengan kadar kolesterol total pada guru SMAN 1 Sei. Raya. Desain dalam penelitian ini menggunakan Cross Sectional. Populasi dalam penelitian ini yaitu seluruh guru SMAN 1 Sei. Raya yang diambil dengan metode total sampling dan diperoleh sebanyak 46 orang responden. Dari setiap responden diperoleh data umur, jenis kelamin, tingkat kegemukan dan pengukuran kadar kolesterol total. Data dianalisis secara univariat dan bivariat dengan uji korelasi Kendall tau dengan nilai ɑ = 0.05. Hasil uji menggunakan kendall tau untuk menganalisis hubungan umur, jenis kelamin, dan kegemukan dengan kadar kolestrol total menunjukan bahwa tidak ada hubungan antara umur (p = 0.648), jenis kelamin (p = 0.418) dan kegemukan (p = 0.542) dengan kadar kolesterol total pada guru SMAN 1 Sei. Raya.


PEDIATRICS ◽  
1990 ◽  
Vol 85 (2) ◽  
pp. 155-158
Author(s):  
Wendy Y. Craig ◽  
Glenn E. Palomaki ◽  
A. Myron Johnson ◽  
James E. Haddow

In this meta-analysis it was demonstrated that, when compared with nonsmokers of similar age, smokers in the 8- to 19-year-old age group have significantly higher serum levels of triglyceride (+11.8%), very-low-density lipoprotein (VLDL)-cholesterol (+12.4%) and low-density lipoprotein (LDL)-cholesterol (+4.1%) and significantly lower serum levels of high-density lipoprotein (HDL)-cholesterol (-8.5%) and total cholesterol (-3.7%). All of these smoking-associated changes are in the same direction as those found in adults, with the exception of total cholesterol levels, which are significantly increased in adult smokers. The extent to which mean triglyceride, LDL-cholesterol, and HDL-choles-terol levels are shifted is significantly greater in the 8-to 19-year-old smokers than in adult smokers. The changes in mean total cholesterol levels among smokers in both age groups represent only the net shifts in the lipoprotein fractions and are therefore likely to be a less sensitive indicator of the possible lipid-related excess coronary artery disease risk in smokers.


2020 ◽  
pp. 1-11
Author(s):  
Line Gaundal ◽  
Mari C. W. Myhrstad ◽  
Lena Leder ◽  
Marte Gjeitung Byfuglien ◽  
Terje Gjøvaag ◽  
...  

Abstract Replacing intake of SFA with PUFA reduces serum cholesterol levels and CVD risk. The effect on glycaemic regulation is, however, less clear. The main objective of the present study was to investigate the short-term effect of replacing dietary SFA with PUFA on glycaemic regulation. Seventeen healthy, normal-weight participants completed a 25-d double-blind, randomised and controlled two-period crossover study. Participants were allocated to either interventions with PUFA products or SFA products (control) in a random order for three consecutive days, separated by a 1·5-week washout period between the intervention periods. Glucose, insulin and TAG were measured before and after an oral glucose tolerance test. In addition, fasting total cholesterol, NEFA and plasma total fatty acid profile were measured before and after the 3-d interventions. Fasting and postprandial glucose, insulin, and TAG levels and fasting levels of NEFA and plasma fatty acid profile did not differ between the groups. However, replacing dietary SFA with PUFA significantly reduced total cholesterol levels by 8 % after 3 d (P = 0·002). Replacing dietary SFA with PUFA for only 3 d has beneficial cardio-metabolic effects by reducing cholesterol levels in healthy individuals.


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