Solithromycin (CEM-101): A New Fluoroketolide Antibiotic and Its Role in the Treatment of Gonorrhea

2017 ◽  
Vol 31 (2) ◽  
pp. 195-201 ◽  
Author(s):  
Alexandra M. Mancuso ◽  
Mona A. Gandhi ◽  
Judianne Slish
Keyword(s):  
Antibiotic Resistance ◽  
Bacterial Pneumonia ◽  
Literature Search ◽  
Macrolide Antibiotic ◽  
Side Effect Profile ◽  
Efficacy And Safety ◽  
Ribosome Binding ◽  
Mild Side Effect ◽  
Novel Antibiotics ◽  
Comprehensive Literature Search

Solithromycin is a macrolide antibiotic that has undergone review for the treatment of community-acquired bacterial pneumonia. Solithromycin is also being investigated and has shown promise for the treatment of gonorrhea. With increasing antibiotic resistance, the development of novel antibiotics to combat infections is essential. The unique ribosome-binding stability of solithromycin and mild side effect profile make this a promising new antibiotic. This article will provide an overview on the mechanism of action, clinical efficacy, and safety of this drug for the treatment of gonorrhea. Relevant data were identified through a comprehensive literature search using multiple databases using the keywords solithromycin, CEM-101, and gonorrhea.

scholarly journals Efficacy and Safety of Acupuncture against Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Yuxia Jin ◽  
Yunxia Wang ◽  
Jiayuan Zhang ◽  
Xiao Xiao ◽  
Qi Zhang
Keyword(s):  
Peripheral Neuropathy ◽  
Literature Search ◽  
Nerve Conduction Velocity ◽  
Meta Analysis ◽  
Effective Rate ◽  
Sham Acupuncture ◽  
Good Effect ◽  
Efficacy And Safety ◽  
Registration Number ◽  
Comprehensive Literature Search

Objective. To determine the effectiveness and safety of acupuncture for chemotherapy-induced peripheral neuropathy. The review has been registered on the “PROSPERO” website; the registration number is CRD42020151654. Methods. A comprehensive literature search was performed on 7 electronic databases from the time of inception to March 2020. RCTs studies on acupuncture for CIPN compared with medication or sham acupuncture were included. Statistical analysis was carried out using RevMan 5.3. Results. In total, 19 RCTs covering 1174 patients were enrolled. The results showed that acupuncture significantly increased the effective rate of CIPN compared with medicine and sham acupuncture. And acupuncture had a good effect on the recovery of nerve conduction velocity and improving pain. Among the acupoints involved in the treatment of CIPN, LI4, LI11, ST36, EX10 (Bafeng), and EX-UE 9 (Baxie) were the most commonly used. Conclusion. The use of acupuncture in the management of CIPN is safe and effective. The most used acupoints for CIPN are LI4, LI11, ST36, EX10 (Bafeng), and EX-UE 9 (Baxie).

Long-term efficacy and safety of imiquimod 5% and fluorouracil 1% creams in medical monotherapy of complex eyelid basal cell carcinomas

2021 ◽  
pp. 112067212110356
Author(s):  
Manpreet Singh ◽  
Aditi Mehta Grewal ◽  
Himanshi Singh ◽  
Manjula Sharma ◽  
Manpreet Kaur ◽  
...  
Keyword(s):  
Basal Cell ◽  
Side Effect ◽  
The Elderly ◽  
Fixed Dose ◽  
Side Effect Profile ◽  
Efficacy And Safety ◽  
Term Efficacy ◽  
Basal Cell Carcinomas ◽  
Double Blinded

Purpose: To study the long-term efficacy and safety of local application of imiquimod 5% and fluorouracil 1% creams in complex eyelid basal cell carcinomas (BCCs). Methods: A retrospective, non-comparative study in biopsy-proven, complex (involving canthi or >50% of eyelid length) eyelid BCC patients who were medically unfit for surgical procedures. All patients were medically treated with either of the creams using fixed-dose regimens for a minimum of 3 months. All received oral vitamin C 500 mg QID for 3 months as an adjunct for collagen healing. A minimum of “post-treatment” follow-up of 12 months was observed. Results: Of total 30 patients, imiquimod 5% and fluorouracil 1% were used in 16 and 14 patients, respectively. The mean age of our patients was 70.5 years. The co-morbidities included – severe coronary artery disease using blood-thinners ( n = 19), poorly controlled diabetes ( n = 12), poorly controlled hypertension ( n = 6), on nebulization ( n = 3), and tuberculosis with pulmonary fibrosis ( n = 2). Complete clinical tumor resolution was noted in 10 and 8 patients over 12 and 16.5 weeks, respectively, in imiquimod and fluorouracil groups. Periocular skin erythema, chemical conjunctivitis, and skin depigmentation were seen in all the patients of imiquimod group. On the other hand, the local side-effect profile in fluorouracil patients was limited. Conclusion: The medical treatment of complex eyelid BCC is a useful alternative to surgery in the elderly with significant co-morbidities. It provides a promising long-term relief with a tolerable side-effect profile. A prospective, randomized, double-blinded trial would provide stronger evidence for the efficacy of these drugs.

Does the ‘Two Dogs’ Method of Clandestine Synthesis Use Precursors that are not Legally Regulated on the Australian East Coast?

2021 ◽  
Vol 3 (2) ◽  
pp. 26-28
Author(s):  
Victor Chiruta ◽  
Robert Renshaw
Keyword(s):  
Literature Search ◽  
East Coast ◽  
New South ◽  
New South Wales ◽  
The State ◽  
Criminal Proceedings ◽  
Legal Provisions ◽  
South Wales ◽  
Comprehensive Literature Search

In the State of New South Wales (NSW), Australia, the prosecution in criminal proceedings is seeking deterrence punishment for offenders manufacturing 3,4-methylenedioxyamphetamine (MDA) from the precursor helional via the ‘Two Dogs’ method (TDM). The reason given by the prosecution is a presumption that the TDM does not use any unrestricted chemicals in the synthesis of MDA. A comprehensive literature search was conducted. The relevant law was searched to fact-check the assertion of the prosecution. It was found that the prosecution was incorrect. Intermediate precursors of the TDM are restricted in NSW. However, the starting precursor helional remains unscheduled in NSW, yet helional is scheduled in some other Australian States. The prosecution’s position may play a significant factor in the sentencing proceedings of offenders. Therefore, as a matter of urgency, the prosecution must review and update its position and its submissions, keeping with the factual position in relation to the legal provisions of precursors used in the TDM.

scholarly journals Role of social support in tobacco cessation

2017 ◽  
Vol 4 (11) ◽  
pp. 3942 ◽  
Author(s):  
Shruthi P. S. ◽  
Niveditha B. S. ◽  
Punith Shetty ◽  
Krishna Chaitanya ◽  
Naveen Khargekar
Keyword(s):  
Social Support ◽  
Behaviour Change ◽  
Relapse Prevention ◽  
Tobacco Cessation ◽  
Literature Search ◽  
Well Being ◽  
Psychological Well Being ◽  
Tobacco Intervention ◽  
Comprehensive Literature Search

Most tobacco intervention focus on behavioural methods to reduce dependence, the role of social support is unclear. The objective is to evaluate the evidence of social support as well as its efficacy with respect to tobacco cessation. It explores to understand the role of social support for an individual to make a behaviour change. Social support is one resource in the environment, if used effectively can be extremely beneficial for someone wanting to quit tobacco. A comprehensive literature search on the contribution of social support with respect to tobacco cessation was conducted to give a practical review for practitioners in the field. Overall, it was seen that all the studies strengthened the evidence for the role of social support in tobacco cessation. Although, more research is required in this field to comprehend the long haul advantages of social support and additionally its effects on psychological well-being as well as relapse prevention. 

scholarly journals Efficacy and Safety of Carbon Dioxide Ablative Fractional Resurfacing (CO2-AFR) Device in Moderate to Severe Atrophic Acne Scars

2017 ◽  
Vol 23 (1) ◽  
Author(s):  
Wajieha Saeed ◽  
Zahida Rani ◽  
Shazia Aslam
Keyword(s):  
Side Effects ◽  
Objective Assessment ◽  
Side Effect Profile ◽  
Efficacy And Safety ◽  
Social Psychological ◽  
Interventional Study ◽  
Dermatology Department ◽  
Acne Scars ◽  
Fractional Resurfacing ◽  
Pretreatment Assessment

<p>Acne having a prevalence of &gt; 90% in adolescents persisting in adulthood, causes inflammation and scaring. Acne scars cause severe social, psychological and cosmetic problems. There are many remedies available for acne scars with variable results. CO2-AFR laser is a new modality with more effectiveness and low side effect profile.</p><p><strong>Objective:</strong><strong>  </strong>To determine the effectiveness and safety of CO2-AFR device in the treatment of moderate to severe atrophic acne scars.</p><p><strong>Study Design:</strong><strong>  </strong>Interventional study.</p><p><strong>Place and Duration of Study:</strong><strong>  </strong>This study was conducted at Dermatology Department Unit-I, Mayo Hospital Lahore and duration was 1 year, from April 2015 to March 2016.</p><p><strong>Material and Methods:</strong><strong>  </strong>The 30 patients of either sex, having moderate to severe atrophic acne scars were enrolled in the study. Pretreatment assessment of acne scars was done by using Goodman &amp; Baron qualitative scarring grading system. Patients were treated at 4 – 5 weeks interval with maximum 5 sessions. Objective assessment for efficacy and side effects was done at each session. Data was collected on a specially designed proforma and statistical analysis carried out by using SPSS version 17.</p><p><strong>Results:</strong><strong>  </strong>Significant improvement in acne scars was observed. 14 (46.7%) patients showed good efficacy (50 – 75% reduction), 1 (3.3%) patient came out with excellent efficacy (&gt; 75%) and 14 (46.7%) patients showed fair efficacy (25 – 50% reduction in acne scars). 13.3% patients showed few delayed side effects which resolved with treatment.</p><p><strong>Conclusion:</strong><strong>  </strong>CO2-AFR device was proved to be effective and safe in the treatment of moderate to severe atrophic acne scars.</p>

scholarly journals Development on Indigenous Homelands and the Need to Get Back to Basics with Scoping: Is there Still "Unceded" Land in Northern Ontario, Canada, with Respect to Treaty No. 9 and its Adhesions?

2021 ◽  
Vol 12 (1) ◽  
pp. 1-49
Author(s):  
Leonard Tsuji ◽  
Stephen Tsuji
Keyword(s):  
Literature Search ◽  
Development Project ◽  
Lessons Learned ◽  
Development Projects ◽  
Northern Ontario ◽  
Starting Point ◽  
Library And Archives Canada ◽  
Bare Minimum ◽  
Comprehensive Literature Search

Scoping includes the establishment of unambiguous spatial boundaries for a proposed development project (e.g., a treaty) and is especially important with respect to development on Indigenous homelands. Improper scoping leads to a flawed product, such as a flawed treaty or environmental impact assessment, by excluding stakeholders from the process. A comprehensive literature search was conducted to gather (and collate) printed and online material in relation to Treaty No. 9 and its Adhesions, as well as the Line-AB. We searched academic databases as well as the Library and Archives Canada. The examination of Treaty No. 9 and its Adhesions revealed that there is unceded land in each of four separate scenarios, which are related to the Line-AB and/or emergent land in Northern Ontario, Canada. Lastly, we present lessons learned from our case study. However, since each development initiative and each Indigenous Nation is unique, these suggestions should be taken as a bare minimum or starting point for the scoping process in relation to development projects on Indigenous homelands.

scholarly journals Safety and efficiency of therapy by gene-engineering-biological preparations of rheumatoid arthritis

2018 ◽  
Vol 9 (3) ◽  
pp. 44-49
Author(s):  
E. A. Strel’tsov
Keyword(s):  
Rheumatoid Arthritis ◽  
Literature Search ◽  
Randomized Trials ◽  
Web Of Science ◽  
Genetically Engineered ◽  
Systematic Literature Search ◽  
Efficacy And Safety ◽  
Review Of The Literature ◽  
Gene Engineering

In this review of the literature, questions of the efficacy and safety of therapy with genetically engineered biological preparations for rheumatoid arthritis are discussed. The results of randomized trials of recent years are described in detail. Systematic literature search was conducted on the databases Scopus, Web of Science, MedLine, elibrary and others.

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